Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.023 0.092 -9999.0 0.0 -0.392 2.0 2.0 epithelial cell differentiation -0.035 0.14 -9999.0 0.0 -0.596 2.0 2.0 CYFIP2 -0.087 0.278 -9999.0 0.0 -0.98 3.0 3.0 ENAH 0.02 0.113 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.029 0.166 -9999.0 0.0 -0.98 1.0 1.0 EPHA2 -0.029 0.166 -9999.0 0.0 -0.98 1.0 1.0 MYO6 -0.033 0.134 -9999.0 0.0 -0.569 2.0 2.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.061 0.195 -9999.0 0.0 -0.686 3.0 3.0 AQP5 -0.027 0.107 -9999.0 0.0 -0.496 1.0 1.0 CTNND1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.033 0.131 -9999.0 0.0 -0.558 2.0 2.0 regulation of calcium-dependent cell-cell adhesion -0.021 0.142 -9999.0 0.0 -0.558 2.0 2.0 EGF 0.111 0.141 0.29 13.0 -9999.0 0.0 13.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.05 0.162 -9999.0 0.0 -0.561 3.0 3.0 cortical microtubule organization -0.035 0.14 -9999.0 0.0 -0.596 2.0 2.0 GO:0000145 -0.031 0.125 -9999.0 0.0 -0.531 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.036 0.142 -9999.0 0.0 -0.604 2.0 2.0 MLLT4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.042 0.135 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.019 0.107 -9999.0 0.0 -0.633 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.031 0.124 -9999.0 0.0 -0.527 2.0 2.0 PVRL2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.033 0.134 -9999.0 0.0 -0.569 2.0 2.0 ARF6/GTP -0.017 0.099 -9999.0 0.0 -0.587 1.0 1.0 CDH1 -0.058 0.231 -9999.0 0.0 -0.98 2.0 2.0 EGFR/EGFR/EGF/EGF -0.011 0.217 -9999.0 0.0 -0.816 2.0 2.0 RhoA/GDP -0.033 0.132 -9999.0 0.0 -0.561 2.0 2.0 actin cytoskeleton organization -0.031 0.126 -9999.0 0.0 -0.534 2.0 2.0 IGF-1R heterotetramer 0.009 0.049 0.29 1.0 -9999.0 0.0 1.0 GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.009 0.049 0.29 1.0 -9999.0 0.0 1.0 IGF1 -0.49 0.49 -9999.0 0.0 -0.98 17.0 17.0 DIAPH1 -0.069 0.207 -9999.0 0.0 -0.734 3.0 3.0 Wnt receptor signaling pathway 0.035 0.14 0.596 2.0 -9999.0 0.0 2.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.042 0.136 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.032 0.129 -9999.0 0.0 -0.55 2.0 2.0 EFNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.032 0.126 -9999.0 0.0 -0.536 2.0 2.0 Ephrin A1/EPHA2 -0.049 0.156 -9999.0 0.0 -0.55 3.0 3.0 SEC6/SEC8 -0.03 0.119 -9999.0 0.0 -0.505 2.0 2.0 MGAT3 -0.022 0.144 -9999.0 0.0 -0.569 2.0 2.0 HGF/MET -0.26 0.332 -9999.0 0.0 -0.631 14.0 14.0 HGF -0.404 0.483 -9999.0 0.0 -0.98 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.023 0.093 -9999.0 0.0 -0.396 2.0 2.0 actin cable formation 0.022 0.104 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.032 0.126 -9999.0 0.0 -0.536 2.0 2.0 KIFC3 -0.033 0.134 -9999.0 0.0 -0.569 2.0 2.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.033 0.134 -9999.0 0.0 -0.569 2.0 2.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.035 0.14 -9999.0 0.0 -0.596 2.0 2.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.033 0.134 -9999.0 0.0 -0.569 2.0 2.0 PIP5K1C -0.033 0.134 -9999.0 0.0 -0.569 2.0 2.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.036 0.117 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.012 0.127 -9999.0 0.0 -0.492 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.309 0.305 -9999.0 0.0 -0.585 18.0 18.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.033 0.134 -9999.0 0.0 -0.569 2.0 2.0 mol:GTP -0.018 0.106 -9999.0 0.0 -0.627 1.0 1.0 establishment of epithelial cell apical/basal polarity -0.028 0.113 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.023 0.092 -9999.0 0.0 -0.392 2.0 2.0 regulation of cell-cell adhesion -0.031 0.126 -9999.0 0.0 -0.534 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.023 0.093 -9999.0 0.0 -0.396 2.0 2.0