Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.002 0.079 -9999.0 0.0 -0.314 2.0 2.0 epithelial cell differentiation 0.017 0.112 -9999.0 0.0 -0.425 2.0 2.0 CYFIP2 -0.043 0.215 -9999.0 0.0 -0.734 3.0 3.0 ENAH -0.01 0.079 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.001 0.128 -9999.0 0.0 -0.734 1.0 1.0 EPHA2 0.0 0.128 -9999.0 0.0 -0.734 1.0 1.0 MYO6 -0.014 0.099 -9999.0 0.0 -0.41 2.0 2.0 CTNNB1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.006 0.138 -9999.0 0.0 -0.428 3.0 3.0 AQP5 -0.018 0.093 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.013 0.098 -9999.0 0.0 -0.403 2.0 2.0 regulation of calcium-dependent cell-cell adhesion -0.001 0.112 -9999.0 0.0 -0.403 2.0 2.0 EGF 0.152 0.18 0.396 12.0 -9999.0 0.0 12.0 NCKAP1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.029 0.126 -9999.0 0.0 -0.496 1.0 1.0 cortical microtubule organization 0.017 0.112 -9999.0 0.0 -0.425 2.0 2.0 GO:0000145 -0.027 0.089 -9999.0 0.0 -0.385 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.021 0.114 -9999.0 0.0 -0.429 2.0 2.0 MLLT4 0.02 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.033 0.091 -9999.0 0.0 -0.364 2.0 2.0 ARF6 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.035 0.06 -9999.0 0.0 -0.275 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.014 0.091 -9999.0 0.0 -0.377 2.0 2.0 PVRL2 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.013 0.099 -9999.0 0.0 -0.41 2.0 2.0 ARF6/GTP 0.038 0.06 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.023 0.178 -9999.0 0.0 -0.734 2.0 2.0 EGFR/EGFR/EGF/EGF 0.04 0.166 -9999.0 0.0 -0.552 2.0 2.0 RhoA/GDP 0.02 0.108 -9999.0 0.0 -0.405 2.0 2.0 actin cytoskeleton organization -0.019 0.094 -9999.0 0.0 -0.394 2.0 2.0 IGF-1R heterotetramer 0.035 0.063 0.395 1.0 -9999.0 0.0 1.0 GIT1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.035 0.063 0.396 1.0 -9999.0 0.0 1.0 IGF1 -0.355 0.379 -9999.0 0.0 -0.734 17.0 17.0 DIAPH1 -0.039 0.211 -9999.0 0.0 -0.656 3.0 3.0 Wnt receptor signaling pathway -0.017 0.112 0.425 2.0 -9999.0 0.0 2.0 RHOA 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.034 0.091 -9999.0 0.0 -0.368 2.0 2.0 CTNNA1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.019 0.096 -9999.0 0.0 -0.404 2.0 2.0 EFNA1 0.017 0.01 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.028 0.091 -9999.0 0.0 -0.392 2.0 2.0 Ephrin A1/EPHA2 -0.003 0.111 -9999.0 0.0 -0.399 2.0 2.0 SEC6/SEC8 -0.014 0.092 -9999.0 0.0 -0.379 2.0 2.0 MGAT3 -0.001 0.113 -9999.0 0.0 -0.41 2.0 2.0 HGF/MET -0.166 0.257 -9999.0 0.0 -0.456 14.0 14.0 HGF -0.289 0.372 -9999.0 0.0 -0.734 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.002 0.08 -9999.0 0.0 -0.316 2.0 2.0 actin cable formation 0.025 0.112 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.027 0.091 -9999.0 0.0 -0.391 2.0 2.0 KIFC3 -0.013 0.099 -9999.0 0.0 -0.41 2.0 2.0 NCK1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.013 0.099 -9999.0 0.0 -0.41 2.0 2.0 NCK1/GIT1 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.017 0.112 -9999.0 0.0 -0.425 2.0 2.0 EXOC4 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.013 0.099 -9999.0 0.0 -0.41 2.0 2.0 PIP5K1C -0.013 0.099 -9999.0 0.0 -0.41 2.0 2.0 LIMA1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.005 0.113 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.026 0.094 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.2 0.241 -9999.0 0.0 -0.419 18.0 18.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.03 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.013 0.099 -9999.0 0.0 -0.41 2.0 2.0 mol:GTP 0.034 0.059 -9999.0 0.0 -0.273 1.0 1.0 establishment of epithelial cell apical/basal polarity -0.012 0.108 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.002 0.079 -9999.0 0.0 -0.314 2.0 2.0 regulation of cell-cell adhesion -0.019 0.094 -9999.0 0.0 -0.394 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.002 0.08 -9999.0 0.0 -0.316 2.0 2.0