Molecular subtypes MRNA_CNMF MRNA_CHIERARCHICAL CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL nCNV (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Amp Peak 1(1p34.2) 58 (16%) 300 0.027997 1 0.48064 1 0.00027276 0.193 0.70971 1 0.4193 1 0.66819 1 0.04845 1 0.24108 1 0.29888 1 0.49421 1 Amp Peak 2(1q21.2) 186 (52%) 172 0.041886 1 0.0061823 1 7.3203e-07 0.000561 0.0012847 0.865 0.15526 1 0.057554 1 0.00068518 0.472 0.00048787 0.34 0.30475 1 0.056204 1 Amp Peak 3(2p16.1) 194 (54%) 164 0.00030485 0.215 0.0016452 1 2.412e-09 1.88e-06 7.0048e-05 0.0513 0.96653 1 0.74078 1 0.00033312 0.235 0.0011329 0.764 0.87945 1 0.031189 1 Amp Peak 4(2q31.2) 121 (34%) 237 0.020695 1 0.00094798 0.643 6.7367e-05 0.0494 4.9417e-06 0.00375 0.73767 1 0.91188 1 0.00080111 0.548 0.00093222 0.633 0.46534 1 0.25204 1 Amp Peak 5(3p11.1) 73 (20%) 285 0.074773 1 0.84409 1 0.67333 1 0.82621 1 0.20236 1 0.00083089 0.567 0.05549 1 0.44422 1 0.41045 1 0.94669 1 Amp Peak 6(3q26.33) 330 (92%) 28 0.00042663 0.299 1.7146e-05 0.0129 1.6279e-09 1.27e-06 0.00011311 0.0818 0.21321 1 0.094447 1 3.8139e-05 0.0283 0.00016431 0.118 0.2054 1 9.108e-05 0.0662 Amp Peak 7(4q12) 85 (24%) 273 0.67906 1 0.75873 1 0.0054816 1 0.2835 1 0.31214 1 0.088313 1 0.55476 1 0.74982 1 0.18505 1 0.57687 1 Amp Peak 8(5p15.33) 281 (78%) 77 0.85286 1 0.86716 1 8.3753e-06 0.00632 0.0036028 1 0.49766 1 0.42237 1 0.38708 1 0.32784 1 0.84118 1 0.26253 1 Amp Peak 9(5p12) 236 (66%) 122 0.91917 1 0.51401 1 1.3826e-09 1.08e-06 0.0066607 1 0.6689 1 1 1 0.063491 1 0.58557 1 0.041292 1 0.2193 1 Amp Peak 10(6q12) 107 (30%) 251 1 1 0.87303 1 0.069033 1 0.25977 1 0.34877 1 0.49551 1 0.39467 1 0.23611 1 0.5946 1 0.15472 1 Amp Peak 11(7p11.2) 174 (49%) 184 0.18606 1 0.09391 1 0.0016773 1 0.0025384 1 0.64222 1 0.85005 1 0.075977 1 0.014833 1 0.70005 1 0.1233 1 Amp Peak 12(7q21.2) 188 (53%) 170 0.10132 1 0.24997 1 3.3631e-10 2.64e-07 8.3452e-06 0.00631 0.040829 1 0.21491 1 0.016544 1 0.022055 1 0.2468 1 0.037662 1 Amp Peak 13(8p11.23) 168 (47%) 190 0.0081177 1 0.16822 1 0.11314 1 0.10015 1 0.21654 1 0.087117 1 0.0063053 1 0.71976 1 0.13452 1 0.62015 1 Amp Peak 14(8q24.21) 248 (69%) 110 0.8715 1 0.64417 1 0.33855 1 0.5892 1 0.9575 1 0.76758 1 0.7345 1 0.42772 1 0.4907 1 0.93231 1 Amp Peak 15(9p24.1) 67 (19%) 291 0.37518 1 0.029533 1 0.00058577 0.405 0.22826 1 0.0017579 1 0.0057256 1 0.041333 1 0.0029351 1 0.56116 1 0.38974 1 Amp Peak 16(9p13.3) 98 (27%) 260 0.16996 1 0.37287 1 0.010746 1 0.3878 1 0.077857 1 0.009373 1 0.021999 1 0.18844 1 0.40751 1 0.88918 1 Amp Peak 17(11q13.3) 131 (37%) 227 0.06969 1 0.030551 1 0.025564 1 0.0014782 0.992 0.18394 1 0.064128 1 0.012508 1 0.13883 1 0.15003 1 0.33037 1 Amp Peak 18(12p13.33) 177 (49%) 181 0.010156 1 0.057062 1 0.00025451 0.18 0.011248 1 0.35259 1 0.71121 1 0.00057533 0.399 0.0051835 1 0.67408 1 0.42873 1 Amp Peak 19(12q15) 132 (37%) 226 0.31238 1 0.5273 1 0.0087421 1 0.010511 1 0.80579 1 0.40853 1 0.10546 1 0.049145 1 0.56467 1 0.92632 1 Amp Peak 20(13q34) 64 (18%) 294 0.96435 1 0.048907 1 0.39591 1 0.16602 1 0.82393 1 0.19554 1 0.80276 1 0.40688 1 0.072351 1 0.2508 1 Amp Peak 21(14q13.3) 110 (31%) 248 0.34486 1 0.24581 1 0.52831 1 0.4696 1 0.50914 1 0.020208 1 0.61652 1 0.084716 1 0.016709 1 0.080992 1 Amp Peak 22(15q26.3) 128 (36%) 230 0.15118 1 0.02098 1 5.6345e-07 0.000433 1.784e-05 0.0134 0.3118 1 0.01616 1 0.00062217 0.429 0.0042628 1 0.017505 1 7.1387e-05 0.0521 Amp Peak 23(17q25.1) 171 (48%) 187 0.017661 1 0.060794 1 1.8694e-06 0.00143 0.00014806 0.107 0.29661 1 0.32262 1 0.027422 1 0.0080673 1 0.75564 1 0.74216 1 Amp Peak 24(18p11.32) 122 (34%) 236 0.060239 1 0.0062845 1 0.00014769 0.106 0.032789 1 0.22631 1 0.8444 1 0.60707 1 0.1765 1 0.52637 1 0.16253 1 Amp Peak 25(18q11.2) 115 (32%) 243 0.00045553 0.318 0.0022679 1 0.00023059 0.164 0.0041485 1 0.25187 1 0.77128 1 0.0043758 1 0.00057779 0.4 0.36947 1 0.0092619 1 Amp Peak 26(19q12) 149 (42%) 209 0.45483 1 0.24902 1 0.00011105 0.0804 0.44499 1 0.27364 1 0.024412 1 0.19265 1 0.081975 1 0.94942 1 0.68582 1 Amp Peak 27(19q13.2) 157 (44%) 201 0.47272 1 0.90909 1 0.00044692 0.313 0.25029 1 0.31842 1 0.13123 1 0.45374 1 0.033569 1 0.9747 1 0.28552 1 Amp Peak 28(20p12.2) 193 (54%) 165 0.00098685 0.668 0.0042983 1 4.62e-08 3.58e-05 0.0014115 0.949 0.95039 1 0.29284 1 0.1497 1 0.013404 1 0.48835 1 0.24628 1 Amp Peak 29(20q11.21) 206 (58%) 152 0.99122 1 0.84394 1 0.002749 1 0.038807 1 0.74317 1 0.69747 1 0.59324 1 0.54885 1 0.93707 1 0.61494 1 Amp Peak 30(22q11.21) 177 (49%) 181 0.11066 1 0.12309 1 0.014625 1 0.0029124 1 0.87358 1 0.33909 1 0.067121 1 0.067683 1 0.81595 1 0.13245 1 Amp Peak 31(Xq28) 92 (26%) 266 0.64364 1 0.51458 1 0.23994 1 0.098096 1 0.054611 1 0.072204 1 0.14256 1 0.22516 1 0.75361 1 0.80444 1 Del Peak 1(1p36.32) 155 (43%) 203 1.2758e-06 0.000976 1.2929e-08 1e-05 3.3385e-28 2.64e-25 4.7761e-16 3.77e-13 0.41877 1 0.0042054 1 1.0225e-10 8.04e-08 6.7545e-09 5.26e-06 0.023689 1 0.0010335 0.699 Del Peak 2(1p13.2) 156 (44%) 202 0.00023715 0.169 0.0005497 0.382 6.4672e-14 5.1e-11 6.5198e-09 5.09e-06 0.10687 1 0.1149 1 2.352e-05 0.0175 7.0749e-05 0.0517 0.19647 1 0.0096663 1 Del Peak 3(2p25.3) 34 (9%) 324 0.046105 1 0.17884 1 0.089917 1 0.36742 1 0.10989 1 0.7888 1 0.31965 1 0.22609 1 0.10548 1 0.064084 1 Del Peak 4(2q22.1) 96 (27%) 262 0.25483 1 0.31825 1 0.00021665 0.155 0.021581 1 0.65269 1 0.2097 1 0.18815 1 0.23144 1 0.68255 1 0.46017 1 Del Peak 5(2q36.2) 116 (32%) 242 0.00023576 0.168 4.7565e-05 0.0352 5.3215e-12 4.19e-09 0.00035165 0.248 0.13844 1 0.11332 1 8.4879e-05 0.0619 6.1471e-06 0.00466 0.94402 1 0.62414 1 Del Peak 6(3p25.3) 285 (80%) 73 0.54042 1 0.17616 1 0.029151 1 0.0040693 1 0.62364 1 0.2119 1 0.32711 1 0.008757 1 0.65508 1 0.013733 1 Del Peak 7(3p13) 310 (87%) 48 0.41881 1 0.54863 1 9.6788e-05 0.0703 0.0021125 1 0.9102 1 0.012673 1 0.36874 1 0.013408 1 0.87166 1 0.0082614 1 Del Peak 8(3p12.1) 280 (78%) 78 0.32181 1 0.041333 1 1.4599e-07 0.000113 2.7885e-05 0.0207 0.68789 1 0.10871 1 0.15465 1 0.0023519 1 0.17413 1 0.10066 1 Del Peak 9(4p15.31) 219 (61%) 139 0.00080707 0.551 0.001708 1 1.2105e-05 0.00912 0.0040584 1 0.67503 1 0.045415 1 0.088333 1 0.0514 1 0.40326 1 1 1 Del Peak 10(4q22.1) 199 (56%) 159 0.0068481 1 0.057857 1 0.00047348 0.33 0.040538 1 0.14712 1 0.34581 1 0.025247 1 0.0063574 1 0.36978 1 0.13363 1 Del Peak 11(4q32.3) 226 (63%) 132 0.0096682 1 0.025274 1 2.972e-07 0.000229 0.01118 1 0.10165 1 0.58456 1 0.005697 1 0.036026 1 0.4381 1 0.14446 1 Del Peak 12(4q35.2) 229 (64%) 129 0.10047 1 0.20573 1 1.0708e-06 0.00082 0.0025875 1 0.455 1 0.56096 1 0.0053154 1 0.10683 1 0.67091 1 0.33818 1 Del Peak 13(5q11.2) 265 (74%) 93 0.84151 1 0.30269 1 5.706e-10 4.47e-07 0.00026557 0.188 1 1 0.23658 1 0.24758 1 0.56007 1 0.88754 1 0.00016172 0.116 Del Peak 14(5q31.1) 277 (77%) 81 0.33159 1 0.2283 1 6.2132e-07 0.000477 3.2542e-05 0.0241 0.3522 1 0.20864 1 0.25406 1 0.40095 1 0.59267 1 0.0083154 1 Del Peak 15(6p25.3) 90 (25%) 268 0.21975 1 0.10989 1 0.016912 1 0.0006916 0.475 0.54156 1 0.0096737 1 0.010038 1 0.020398 1 0.23807 1 0.17921 1 Del Peak 16(6q26) 93 (26%) 265 0.065853 1 0.0029759 1 0.0090105 1 0.0016764 1 0.88496 1 0.86624 1 0.068692 1 0.14099 1 0.22561 1 0.10826 1 Del Peak 17(7q11.22) 35 (10%) 323 0.90823 1 0.40489 1 0.00038523 0.271 0.39377 1 0.95817 1 0.80009 1 0.046282 1 0.064437 1 0.80375 1 0.526 1 Del Peak 18(7q36.1) 73 (20%) 285 0.39297 1 0.56933 1 0.01427 1 0.38122 1 1 1 0.28601 1 0.11462 1 0.38834 1 0.36058 1 0.82792 1 Del Peak 19(8p23.2) 243 (68%) 115 0.86415 1 0.45866 1 0.00493 1 0.29491 1 0.38219 1 0.19557 1 0.15724 1 0.071999 1 0.45134 1 0.16658 1 Del Peak 20(9p23) 234 (65%) 124 0.005614 1 0.0029131 1 1.2081e-07 9.35e-05 0.10899 1 0.1339 1 0.18469 1 0.026141 1 0.087611 1 1 1 0.090096 1 Del Peak 21(9p21.3) 272 (76%) 86 0.37246 1 0.17169 1 3.2303e-06 0.00246 0.51738 1 0.67917 1 0.37927 1 0.16414 1 0.84599 1 0.86514 1 0.33662 1 Del Peak 22(9q21.11) 174 (49%) 184 0.00017721 0.127 4.9247e-05 0.0363 2.034e-07 0.000157 1.4151e-06 0.00108 0.57062 1 0.2396 1 4.4373e-06 0.00337 2.3951e-07 0.000185 0.044487 1 3.1585e-05 0.0235 Del Peak 23(10p15.3) 160 (45%) 198 0.37287 1 0.44184 1 0.0015018 1 0.00093137 0.633 0.40724 1 0.3908 1 0.0038329 1 0.016525 1 0.10443 1 0.0018531 1 Del Peak 24(10q23.31) 184 (51%) 174 0.039232 1 0.0038632 1 0.00019018 0.136 6.4182e-05 0.0472 0.28335 1 0.30267 1 0.0001037 0.0752 2.6262e-05 0.0196 0.46028 1 0.027698 1 Del Peak 25(11p15.5) 173 (48%) 185 0.00068877 0.474 0.052775 1 6.0397e-05 0.0445 0.011711 1 0.00044866 0.314 2.3365e-05 0.0175 0.019994 1 0.036223 1 0.025269 1 0.029138 1 Del Peak 26(11q22.1) 108 (30%) 250 0.49319 1 0.28778 1 0.0028054 1 0.077483 1 0.086811 1 0.97458 1 0.24499 1 0.42281 1 0.2778 1 0.052627 1 Del Peak 27(11q25) 131 (37%) 227 0.7979 1 0.42926 1 0.022871 1 0.38088 1 0.10894 1 0.86738 1 0.44743 1 0.40585 1 0.1848 1 0.17063 1 Del Peak 28(12q24.31) 57 (16%) 301 0.96498 1 0.33211 1 0.59815 1 0.30319 1 0.35883 1 0.20317 1 0.90035 1 0.68912 1 0.11839 1 0.30228 1 Del Peak 29(13q12.11) 240 (67%) 118 0.054743 1 0.61102 1 0.033756 1 0.15618 1 1 1 0.19261 1 0.69982 1 0.21445 1 0.95768 1 0.98657 1 Del Peak 30(13q14.2) 251 (70%) 107 0.051249 1 0.096235 1 0.0007298 0.501 0.12904 1 0.84956 1 0.54703 1 0.028092 1 0.14722 1 0.65383 1 0.54299 1 Del Peak 31(14q11.2) 130 (36%) 228 0.054625 1 0.29339 1 0.038313 1 0.32128 1 0.24278 1 0.15205 1 0.0026496 1 0.0021291 1 0.33337 1 0.17156 1 Del Peak 32(15q12) 122 (34%) 236 0.72495 1 0.22782 1 0.33369 1 0.31682 1 0.06973 1 0.0067351 1 0.13225 1 0.35649 1 0.099644 1 0.73786 1 Del Peak 33(16p13.3) 129 (36%) 229 0.23929 1 0.24492 1 0.0031756 1 0.36161 1 0.13524 1 0.49585 1 0.53052 1 0.24668 1 0.64255 1 0.16405 1 Del Peak 34(16q23.1) 144 (40%) 214 0.94193 1 0.65907 1 0.050565 1 0.31246 1 0.33635 1 0.86078 1 0.20485 1 0.026365 1 0.44087 1 0.58066 1 Del Peak 35(17p11.2) 185 (52%) 173 0.19384 1 0.4015 1 0.0039969 1 0.13557 1 0.13543 1 0.010067 1 0.36815 1 0.86032 1 0.069741 1 0.022024 1 Del Peak 36(17q11.2) 89 (25%) 269 1.2614e-05 0.00949 6.4433e-05 0.0473 9.3487e-09 7.27e-06 0.057932 1 0.45035 1 0.57718 1 0.00012202 0.0881 7.1613e-06 0.00542 0.40625 1 0.015373 1 Del Peak 37(17q25.3) 68 (19%) 290 0.004927 1 0.022034 1 0.00046787 0.327 0.079649 1 0.78241 1 0.97196 1 0.042335 1 0.00055337 0.384 0.58099 1 0.010792 1 Del Peak 38(18q23) 164 (46%) 194 0.50803 1 0.78802 1 0.51711 1 0.97048 1 0.85764 1 0.32501 1 0.2296 1 0.11539 1 0.80441 1 0.53628 1 Del Peak 39(19p13.3) 163 (46%) 195 0.33425 1 0.023076 1 0.00022732 0.162 0.1402 1 0.092838 1 0.40379 1 0.16017 1 0.012363 1 0.017892 1 0.047846 1 Del Peak 40(19q13.33) 96 (27%) 262 0.61681 1 0.06944 1 4.7591e-05 0.0352 0.0002493 0.177 0.27239 1 0.63492 1 0.43647 1 0.2122 1 0.33997 1 0.11881 1 Del Peak 41(19q13.43) 96 (27%) 262 0.64362 1 0.20683 1 9.0848e-05 0.0661 0.0007966 0.546 0.46604 1 0.46966 1 0.46535 1 0.15388 1 0.21643 1 0.30814 1 Del Peak 42(21q11.2) 176 (49%) 182 0.55805 1 0.22347 1 0.0058036 1 0.064673 1 0.96621 1 0.9036 1 0.90836 1 0.48476 1 0.20301 1 0.23308 1 Del Peak 43(21q22.3) 205 (57%) 153 0.95746 1 0.1932 1 2.2127e-08 1.72e-05 0.0010919 0.737 0.47843 1 0.1399 1 0.5636 1 0.30219 1 0.0087121 1 0.47399 1 Del Peak 44(22q11.21) 62 (17%) 296 0.09039 1 0.0093024 1 0.17242 1 0.34185 1 0.12526 1 0.11442 1 0.59809 1 0.7479 1 0.14887 1 0.10087 1 Del Peak 45(Xp22.2) 114 (32%) 244 0.59895 1 0.3507 1 1.573e-05 0.0118 0.016352 1 0.34318 1 0.66417 1 0.13988 1 0.12171 1 0.19485 1 0.26702 1 Del Peak 46(Xp21.1) 118 (33%) 240 0.35378 1 0.14801 1 2.0008e-05 0.015 0.0018051 1 0.38089 1 0.57002 1 0.077879 1 0.0071601 1 0.40668 1 0.10924 1 Del Peak 47(Xp11.3) 116 (32%) 242 0.06204 1 0.17505 1 2.8184e-06 0.00215 5.1573e-05 0.038 0.082309 1 0.077418 1 0.014157 1 0.017529 1 0.13253 1 0.19908 1 Del Peak 48(Xq22.3) 91 (25%) 267 0.0085301 1 0.10522 1 1.0311e-05 0.00777 0.00086092 0.586 0.74472 1 0.93472 1 0.051315 1 0.48519 1 0.71622 1 0.95432 1