Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.447 0.29 -9999.0 0.0 -0.717 115.0 115.0 IHH -0.474 0.386 -9999.0 0.0 -0.818 143.0 143.0 SHH Np/Cholesterol/GAS1 -0.085 0.181 -9999.0 0.0 -0.46 46.0 46.0 LRPAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.084 0.179 0.457 46.0 -9999.0 0.0 46.0 SMO/beta Arrestin2 -0.377 0.254 -9999.0 0.0 -0.615 123.0 123.0 SMO -0.398 0.275 -9999.0 0.0 -0.619 147.0 147.0 AKT1 -0.156 0.108 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.008 0.047 -9999.0 0.0 -0.746 1.0 1.0 ADRBK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.391 0.269 -9999.0 0.0 -0.608 147.0 147.0 STIL -0.352 0.256 -9999.0 0.0 -0.706 56.0 56.0 DHH N/PTCH2 -0.061 0.174 -9999.0 0.0 -0.56 28.0 28.0 DHH N/PTCH1 -0.388 0.246 -9999.0 0.0 -0.595 132.0 132.0 PIK3CA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.064 0.223 -9999.0 0.0 -0.746 25.0 25.0 PTHLH -0.614 0.359 -9999.0 0.0 -0.968 115.0 115.0 determination of left/right symmetry -0.391 0.269 -9999.0 0.0 -0.608 147.0 147.0 PIK3R1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.606 0.352 -9999.0 0.0 -0.953 115.0 115.0 IHH N/Hhip -0.673 0.373 -9999.0 0.0 -0.829 209.0 209.0 DHH N/Hhip -0.438 0.299 -9999.0 0.0 -0.611 185.0 185.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.391 0.269 -9999.0 0.0 -0.608 147.0 147.0 pancreas development -0.513 0.348 -9999.0 0.0 -0.744 179.0 179.0 HHAT 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.001 0.093 -9999.0 0.0 -0.746 4.0 4.0 somite specification -0.391 0.269 -9999.0 0.0 -0.608 147.0 147.0 SHH Np/Cholesterol/PTCH1 -0.375 0.261 -9999.0 0.0 -0.589 134.0 134.0 SHH Np/Cholesterol/PTCH2 -0.083 0.175 -9999.0 0.0 -0.451 45.0 45.0 SHH Np/Cholesterol/Megalin -0.318 0.28 -9999.0 0.0 -0.517 157.0 157.0 SHH -0.084 0.221 -9999.0 0.0 -0.558 46.0 46.0 catabolic process -0.385 0.254 -9999.0 0.0 -0.587 147.0 147.0 SMO/Vitamin D3 -0.396 0.275 -9999.0 0.0 -0.623 134.0 134.0 SHH Np/Cholesterol/Hhip -0.385 0.26 -9999.0 0.0 -0.515 192.0 192.0 LRP2 -0.4 0.377 -9999.0 0.0 -0.746 140.0 140.0 receptor-mediated endocytosis -0.531 0.322 -9999.0 0.0 -0.753 153.0 153.0 SHH Np/Cholesterol/BOC -0.08 0.169 -9999.0 0.0 -0.444 44.0 44.0 SHH Np/Cholesterol/CDO -0.085 0.174 -9999.0 0.0 -0.444 47.0 47.0 mesenchymal cell differentiation 0.381 0.258 0.51 192.0 -9999.0 0.0 192.0 mol:Vitamin D3 -0.374 0.27 -9999.0 0.0 -0.595 134.0 134.0 IHH N/PTCH2 -0.308 0.271 -9999.0 0.0 -0.545 143.0 143.0 CDON -0.001 0.093 -9999.0 0.0 -0.746 4.0 4.0 IHH N/PTCH1 -0.39 0.258 -9999.0 0.0 -0.595 147.0 147.0 Megalin/LRPAP1 -0.306 0.281 -9999.0 0.0 -0.563 140.0 140.0 PTCH2 0.002 0.077 -9999.0 0.0 -0.708 3.0 3.0 SHH Np/Cholesterol -0.079 0.171 -9999.0 0.0 -0.446 46.0 46.0 PTCH1 -0.387 0.256 -9999.0 0.0 -0.589 147.0 147.0 HHIP -0.514 0.348 -9999.0 0.0 -0.746 179.0 179.0