Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.001 0.019 -9999.0 0.0 -0.31 1.0 1.0 epithelial cell differentiation -0.002 0.025 -9999.0 0.0 -0.409 1.0 1.0 CYFIP2 -0.004 0.104 -9999.0 0.0 -0.746 5.0 5.0 ENAH 0.058 0.037 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.022 0.148 -9999.0 0.0 -0.688 12.0 12.0 EPHA2 0.002 0.081 -9999.0 0.0 -0.746 3.0 3.0 MYO6 0.034 0.026 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.009 0.067 -9999.0 0.0 -0.483 5.0 5.0 AQP5 -0.152 0.245 -9999.0 0.0 -0.548 71.0 71.0 CTNND1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.033 0.026 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.105 0.202 -9999.0 0.0 -0.391 85.0 85.0 EGF -0.013 0.131 -9999.0 0.0 -0.746 8.0 8.0 NCKAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.088 0.204 -9999.0 0.0 -0.556 41.0 41.0 cortical microtubule organization -0.002 0.025 -9999.0 0.0 -0.409 1.0 1.0 GO:0000145 0.033 0.025 -9999.0 0.0 -0.364 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.002 0.026 -9999.0 0.0 -0.414 1.0 1.0 MLLT4 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.005 0.04 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.005 0.047 -9999.0 0.0 -0.437 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.044 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.034 0.026 -9999.0 0.0 -0.387 1.0 1.0 ARF6/GTP -0.005 0.043 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.008 0.047 -9999.0 0.0 -0.746 1.0 1.0 EGFR/EGFR/EGF/EGF -0.029 0.102 -9999.0 0.0 -0.764 1.0 1.0 RhoA/GDP -0.001 0.024 -9999.0 0.0 -0.383 1.0 1.0 actin cytoskeleton organization 0.039 0.025 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.001 0.093 -9999.0 0.0 -0.746 4.0 4.0 DIAPH1 -0.013 0.088 -9999.0 0.0 -0.641 5.0 5.0 Wnt receptor signaling pathway 0.002 0.025 0.409 1.0 -9999.0 0.0 1.0 RHOA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.005 0.039 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.04 0.026 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.04 0.025 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.006 0.046 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.001 0.021 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.107 0.205 -9999.0 0.0 -0.79 1.0 1.0 HGF/MET -0.069 0.149 -9999.0 0.0 -0.76 1.0 1.0 HGF -0.118 0.284 -9999.0 0.0 -0.746 44.0 44.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.001 0.019 -9999.0 0.0 -0.312 1.0 1.0 actin cable formation 0.071 0.035 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.04 0.025 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 0.034 0.026 -9999.0 0.0 -0.387 1.0 1.0 NCK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.034 0.026 -9999.0 0.0 -0.387 1.0 1.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.002 0.025 -9999.0 0.0 -0.409 1.0 1.0 EXOC4 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.034 0.026 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.034 0.026 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.004 0.034 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.055 0.024 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.007 0.051 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.002 0.077 -9999.0 0.0 -0.708 3.0 3.0 PLEKHA7 0.034 0.026 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.005 0.046 -9999.0 0.0 -0.434 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.057 0.024 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.001 0.019 -9999.0 0.0 -0.31 1.0 1.0 regulation of cell-cell adhesion 0.039 0.025 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.001 0.019 -9999.0 0.0 -0.312 1.0 1.0