Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	89.0	4631.0	52.0	-0.673	0.381	1000.0	-1000.0	-0.104	-1000.0
Angiopoietin receptor Tie2-mediated signaling	88.0	7755.0	88.0	-0.786	0.051	1000.0	-1000.0	-0.135	-1000.0
FOXM1 transcription factor network	79.0	4045.0	51.0	-0.816	0.011	1000.0	-1000.0	-0.215	-1000.0
Aurora B signaling	72.0	4871.0	67.0	-0.621	0.01	1000.0	-1000.0	-0.082	-1000.0
Aurora C signaling	52.0	368.0	7.0	-0.445	0.005	1000.0	-1000.0	-0.05	-1000.0
Endothelins	41.0	3958.0	96.0	-0.432	0.064	1000.0	-1000.0	-0.098	-1000.0
TCGA08_p53	35.0	246.0	7.0	-0.22	0.111	1000.0	-1000.0	-0.013	-1000.0
TCGA08_retinoblastoma	32.0	256.0	8.0	-0.311	0.095	1000.0	-1000.0	-0.037	-1000.0
amb2 Integrin signaling	30.0	2507.0	82.0	-0.71	0.01	1000.0	-1000.0	-0.102	-1000.0
Thromboxane A2 receptor signaling	28.0	2952.0	105.0	-0.174	0.041	1000.0	-1000.0	-0.092	-1000.0
Glucocorticoid receptor regulatory network	28.0	3268.0	114.0	-0.645	0.393	1000.0	-1000.0	-0.096	-1000.0
Signaling events regulated by Ret tyrosine kinase	26.0	2189.0	82.0	-0.224	0.01	1000.0	-1000.0	-0.105	-1000.0
Glypican 2 network	26.0	104.0	4.0	-0.064	-1000.0	1000.0	-1000.0	-0.049	-1000.0
Visual signal transduction: Cones	25.0	953.0	38.0	-0.256	0.01	1000.0	-1000.0	-0.078	-1000.0
Fc-epsilon receptor I signaling in mast cells	25.0	2464.0	97.0	-0.243	0.034	1000.0	-1000.0	-0.11	-1000.0
IL4-mediated signaling events	23.0	2168.0	91.0	-0.79	0.415	1000.0	-1000.0	-0.2	-1000.0
BMP receptor signaling	20.0	1665.0	81.0	-0.442	0.042	1000.0	-1000.0	-0.116	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	20.0	1066.0	52.0	-0.417	0.062	1000.0	-1000.0	-0.087	-1000.0
Canonical Wnt signaling pathway	20.0	1035.0	51.0	-0.507	0.179	1000.0	-1000.0	-0.074	-1000.0
Nongenotropic Androgen signaling	20.0	1078.0	52.0	-0.158	0.073	1000.0	-1000.0	-0.08	-1000.0
FOXA2 and FOXA3 transcription factor networks	19.0	906.0	46.0	-0.807	0.069	1000.0	-1000.0	-0.132	-1000.0
PLK1 signaling events	19.0	1637.0	85.0	-0.387	0.059	1000.0	-1000.0	-0.075	-1000.0
Arf6 signaling events	18.0	1155.0	62.0	-0.295	0.016	1000.0	-1000.0	-0.086	-1000.0
Presenilin action in Notch and Wnt signaling	18.0	1141.0	61.0	-0.506	0.021	1000.0	-1000.0	-0.082	-1000.0
Glypican 1 network	18.0	898.0	48.0	-0.241	0.014	1000.0	-1000.0	-0.06	-1000.0
Integrins in angiogenesis	18.0	1568.0	84.0	-0.494	0.036	1000.0	-1000.0	-0.12	-1000.0
LPA4-mediated signaling events	16.0	201.0	12.0	-0.169	0.015	1000.0	-1000.0	-0.044	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	16.0	1317.0	78.0	-0.109	0.034	1000.0	-1000.0	-0.095	-1000.0
Nectin adhesion pathway	15.0	969.0	63.0	-0.238	0.01	1000.0	-1000.0	-0.089	-1000.0
Syndecan-3-mediated signaling events	15.0	559.0	35.0	-0.356	0.01	1000.0	-1000.0	-0.089	-1000.0
Signaling mediated by p38-alpha and p38-beta	15.0	667.0	44.0	-0.117	0.01	1000.0	-1000.0	-0.066	-1000.0
Coregulation of Androgen receptor activity	14.0	1115.0	76.0	-0.398	0.026	1000.0	-1000.0	-0.072	-1000.0
Visual signal transduction: Rods	14.0	757.0	52.0	-0.301	0.01	1000.0	-1000.0	-0.09	-1000.0
ErbB4 signaling events	13.0	898.0	69.0	-0.434	0.212	1000.0	-1000.0	-0.106	-1000.0
HIF-1-alpha transcription factor network	13.0	991.0	76.0	-0.48	0.018	1000.0	-1000.0	-0.227	-1000.0
Reelin signaling pathway	13.0	728.0	56.0	-0.146	0.01	1000.0	-1000.0	-0.109	-1000.0
IL23-mediated signaling events	13.0	828.0	60.0	-0.253	0.017	1000.0	-1000.0	-0.193	-1000.0
Osteopontin-mediated events	12.0	492.0	38.0	-0.399	0.013	1000.0	-1000.0	-0.128	-1000.0
Calcium signaling in the CD4+ TCR pathway	12.0	393.0	31.0	-0.223	0.012	1000.0	-1000.0	-0.138	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	12.0	1472.0	120.0	-0.285	0.154	1000.0	-1000.0	-0.093	-1000.0
Regulation of Androgen receptor activity	12.0	860.0	70.0	-0.427	0.026	1000.0	-1000.0	-0.091	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	11.0	379.0	33.0	-0.296	0.011	1000.0	-1000.0	-0.087	-1000.0
Syndecan-1-mediated signaling events	10.0	369.0	34.0	-0.392	0.01	1000.0	-1000.0	-0.093	-1000.0
Ephrin A  reverse signaling	10.0	70.0	7.0	-0.027	0.01	1000.0	-1000.0	-0.041	-1000.0
Aurora A signaling	10.0	606.0	60.0	-0.492	0.036	1000.0	-1000.0	-0.082	-1000.0
p75(NTR)-mediated signaling	10.0	1264.0	125.0	-0.38	0.01	1000.0	-1000.0	-0.13	-1000.0
Wnt signaling	10.0	73.0	7.0	-0.06	0.01	1000.0	-1000.0	-0.061	-1000.0
IL6-mediated signaling events	10.0	790.0	75.0	-0.49	0.053	1000.0	-1000.0	-0.123	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	10.0	709.0	68.0	-0.233	0.019	1000.0	-1000.0	-0.167	-1000.0
IL12-mediated signaling events	9.0	807.0	87.0	-0.21	0.024	1000.0	-1000.0	-0.162	-1000.0
PDGFR-alpha signaling pathway	9.0	406.0	44.0	-0.215	0.023	1000.0	-1000.0	-0.072	-1000.0
HIF-2-alpha transcription factor network	9.0	403.0	43.0	-0.404	0.229	1000.0	-1000.0	-0.115	-1000.0
Plasma membrane estrogen receptor signaling	9.0	797.0	86.0	-0.157	0.033	1000.0	-1000.0	-0.105	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	8.0	446.0	54.0	-0.136	0.021	1000.0	-1000.0	-0.123	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	7.0	605.0	85.0	-0.121	0.019	1000.0	-1000.0	-0.101	-1000.0
TCR signaling in naïve CD8+ T cells	7.0	677.0	93.0	-0.051	0.042	1000.0	-1000.0	-0.109	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	7.0	909.0	125.0	-0.215	0.012	1000.0	-1000.0	-0.132	-1000.0
EGFR-dependent Endothelin signaling events	7.0	160.0	21.0	-0.069	0.01	1000.0	-1000.0	-0.086	-1000.0
Regulation of nuclear SMAD2/3 signaling	6.0	932.0	136.0	-0.348	0.1	1000.0	-1000.0	-0.106	-1000.0
Effects of Botulinum toxin	6.0	178.0	26.0	-0.071	0.01	1000.0	-1000.0	-0.074	-1000.0
Noncanonical Wnt signaling pathway	5.0	140.0	26.0	-0.069	0.01	1000.0	-1000.0	-0.099	-1000.0
Syndecan-2-mediated signaling events	5.0	373.0	69.0	-0.164	0.037	1000.0	-1000.0	-0.086	-1000.0
Signaling events mediated by HDAC Class III	5.0	219.0	40.0	-0.124	0.053	1000.0	-1000.0	-0.054	-1000.0
Caspase cascade in apoptosis	4.0	364.0	74.0	-0.096	0.037	1000.0	-1000.0	-0.08	-1000.0
Signaling events mediated by PTP1B	4.0	320.0	76.0	-0.112	0.029	1000.0	-1000.0	-0.103	-1000.0
Hedgehog signaling events mediated by Gli proteins	4.0	307.0	65.0	-0.613	0.066	1000.0	-1000.0	-0.082	-1000.0
FAS signaling pathway (CD95)	4.0	233.0	47.0	-0.189	0.01	1000.0	-1000.0	-0.061	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	310.0	74.0	-0.152	0.071	1000.0	-1000.0	-0.108	-1000.0
IL2 signaling events mediated by STAT5	4.0	91.0	22.0	-0.161	0.064	1000.0	-1000.0	-0.066	-1000.0
Syndecan-4-mediated signaling events	4.0	332.0	67.0	-0.174	0.011	1000.0	-1000.0	-0.098	-1000.0
S1P4 pathway	4.0	119.0	25.0	-0.06	0.01	1000.0	-1000.0	-0.066	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	81.0	17.0	-0.026	0.01	1000.0	-1000.0	-0.056	-1000.0
Sphingosine 1-phosphate (S1P) pathway	3.0	99.0	28.0	-0.157	0.021	1000.0	-1000.0	-0.071	-1000.0
JNK signaling in the CD4+ TCR pathway	3.0	61.0	17.0	-0.025	0.03	1000.0	-1000.0	-0.083	-1000.0
IL1-mediated signaling events	3.0	195.0	62.0	-0.083	0.047	1000.0	-1000.0	-0.126	-1000.0
Ephrin B reverse signaling	3.0	160.0	48.0	-0.064	0.037	1000.0	-1000.0	-0.101	-1000.0
Retinoic acid receptors-mediated signaling	3.0	191.0	58.0	-0.235	0.039	1000.0	-1000.0	-0.093	-1000.0
IL27-mediated signaling events	3.0	158.0	51.0	-0.117	0.012	1000.0	-1000.0	-0.109	-1000.0
LPA receptor mediated events	3.0	343.0	102.0	-0.121	0.039	1000.0	-1000.0	-0.114	-1000.0
BCR signaling pathway	3.0	349.0	99.0	-0.069	0.045	1000.0	-1000.0	-0.123	-1000.0
Insulin Pathway	3.0	236.0	74.0	-0.129	0.033	1000.0	-1000.0	-0.121	-1000.0
S1P3 pathway	3.0	128.0	42.0	-0.157	0.046	1000.0	-1000.0	-0.076	-1000.0
Class IB PI3K non-lipid kinase events	3.0	9.0	3.0	-0.002	0.002	1000.0	-1000.0	-0.02	-1000.0
ErbB2/ErbB3 signaling events	2.0	170.0	65.0	-0.088	0.049	1000.0	-1000.0	-0.089	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	2.0	89.0	34.0	-0.024	0.013	1000.0	-1000.0	-0.083	-1000.0
Signaling events mediated by HDAC Class II	2.0	220.0	75.0	-0.104	0.01	1000.0	-1000.0	-0.076	-1000.0
BARD1 signaling events	2.0	141.0	57.0	-0.121	0.023	1000.0	-1000.0	-0.091	-1000.0
Cellular roles of Anthrax toxin	2.0	102.0	39.0	-0.089	0.018	1000.0	-1000.0	-0.042	-1000.0
IFN-gamma pathway	2.0	170.0	68.0	-0.074	0.062	1000.0	-1000.0	-0.132	-1000.0
TRAIL signaling pathway	2.0	122.0	48.0	-0.054	0.048	1000.0	-1000.0	-0.088	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	178.0	83.0	-0.112	0.051	1000.0	-1000.0	-0.098	-1000.0
S1P1 pathway	2.0	106.0	36.0	-0.041	0.022	1000.0	-1000.0	-0.095	-1000.0
Signaling events mediated by HDAC Class I	2.0	298.0	104.0	-0.104	0.043	1000.0	-1000.0	-0.088	-1000.0
IL2 signaling events mediated by PI3K	2.0	143.0	58.0	-0.204	0.078	1000.0	-1000.0	-0.103	-1000.0
Regulation of p38-alpha and p38-beta	2.0	131.0	54.0	-0.054	0.044	1000.0	-1000.0	-0.081	-1000.0
Arf6 trafficking events	2.0	186.0	71.0	-0.106	0.033	1000.0	-1000.0	-0.087	-1000.0
Regulation of Telomerase	2.0	231.0	102.0	-0.124	0.031	1000.0	-1000.0	-0.13	-1000.0
VEGFR1 specific signals	2.0	115.0	56.0	-0.215	0.044	1000.0	-1000.0	-0.123	-1000.0
Signaling events mediated by PRL	2.0	96.0	34.0	-0.121	0.024	1000.0	-1000.0	-0.075	-1000.0
p38 MAPK signaling pathway	2.0	112.0	44.0	-0.074	0.036	1000.0	-1000.0	-0.084	-1000.0
Circadian rhythm pathway	1.0	39.0	22.0	-0.039	0.04	1000.0	-1000.0	-0.075	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	58.0	45.0	-0.019	0.069	1000.0	-1000.0	-0.113	-1000.0
EPHB forward signaling	1.0	111.0	85.0	-0.064	0.039	1000.0	-1000.0	-0.127	-1000.0
TCGA08_rtk_signaling	1.0	32.0	26.0	-0.025	0.042	1000.0	-1000.0	-0.034	-1000.0
Class I PI3K signaling events	1.0	120.0	73.0	-0.042	0.037	1000.0	-1000.0	-0.09	-1000.0
IGF1 pathway	1.0	76.0	57.0	-0.044	0.047	1000.0	-1000.0	-0.128	-1000.0
PDGFR-beta signaling pathway	1.0	139.0	97.0	-0.043	0.055	1000.0	-1000.0	-0.115	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.0	0.042	1000.0	-1000.0	-0.091	-1000.0
Canonical NF-kappaB pathway	0.0	21.0	39.0	-0.017	0.075	1000.0	-1000.0	-0.102	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.01	0.021	1000.0	-1000.0	-0.026	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	4.0	5.0	-0.004	0.01	1000.0	-1000.0	-0.05	-1000.0
Arf6 downstream pathway	0.0	8.0	43.0	-0.026	0.026	1000.0	-1000.0	-0.057	-1000.0
EPO signaling pathway	0.0	36.0	55.0	-0.009	0.067	1000.0	-1000.0	-0.126	-1000.0
Insulin-mediated glucose transport	0.0	26.0	32.0	-0.045	0.037	1000.0	-1000.0	-0.081	-1000.0
mTOR signaling pathway	0.0	7.0	53.0	-0.001	0.031	1000.0	-1000.0	-0.077	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	26.0	68.0	-0.045	0.045	1000.0	-1000.0	-0.093	-1000.0
Ceramide signaling pathway	0.0	73.0	76.0	-0.015	0.043	1000.0	-1000.0	-0.074	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	25.0	37.0	-0.005	0.033	1000.0	-1000.0	-0.103	-1000.0
S1P5 pathway	0.0	14.0	17.0	-0.007	0.01	1000.0	-1000.0	-0.068	-1000.0
ceramide signaling pathway	0.0	20.0	49.0	-0.015	0.045	1000.0	-1000.0	-0.071	-1000.0
FoxO family signaling	0.0	44.0	64.0	-0.11	0.084	1000.0	-1000.0	-0.106	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	9.0	15.0	-0.0	0.031	1000.0	-1000.0	-0.051	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	9.0	36.0	-0.004	0.021	1000.0	-1000.0	-0.093	-1000.0
Atypical NF-kappaB pathway	0.0	9.0	31.0	-0.002	0.031	1000.0	-1000.0	-0.086	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	53.0	76.0	-0.009	0.054	1000.0	-1000.0	-0.1	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.026	1000.0	-1000.0	-0.066	-1000.0
Rapid glucocorticoid signaling	0.0	7.0	20.0	-0.003	0.01	1000.0	-1000.0	-0.058	-1000.0
E-cadherin signaling in keratinocytes	0.0	34.0	43.0	-0.022	0.047	1000.0	-1000.0	-0.106	-1000.0
E-cadherin signaling events	0.0	3.0	5.0	-0.002	0.01	1000.0	-1000.0	-0.05	-1000.0
Arf1 pathway	0.0	13.0	54.0	-0.011	0.023	1000.0	-1000.0	-0.051	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	-0.002	0.01	1000.0	-1000.0	-0.083	-1000.0
Total	1384	86159	7203	-25.7968629698	-993.969540033	131000	-131000	-12.186218711	-131000