Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.016 0.019 -9999.0 0.0 -0.271 1.0 1.0 epithelial cell differentiation 0.041 0.028 -9999.0 0.0 -0.331 1.0 1.0 CYFIP2 0.009 0.085 -9999.0 0.0 -0.596 5.0 5.0 ENAH 0.009 0.074 0.273 5.0 -9999.0 0.0 5.0 EGFR 0.015 0.109 0.381 6.0 -0.596 6.0 12.0 EPHA2 0.015 0.066 -9999.0 0.0 -0.596 3.0 3.0 MYO6 -0.009 0.034 -9999.0 0.0 -0.321 1.0 1.0 CTNNB1 0.02 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.033 0.056 -9999.0 0.0 -0.384 4.0 4.0 AQP5 -0.125 0.223 -9999.0 0.0 -0.501 65.0 65.0 CTNND1 0.022 0.001 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.01 0.032 -9999.0 0.0 -0.316 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.106 0.149 -9999.0 0.0 -0.32 81.0 81.0 EGF 0.002 0.107 -9999.0 0.0 -0.596 8.0 8.0 NCKAP1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.075 0.187 -9999.0 0.0 -0.502 40.0 40.0 cortical microtubule organization 0.041 0.028 -9999.0 0.0 -0.331 1.0 1.0 GO:0000145 -0.01 0.03 -9999.0 0.0 -0.302 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.046 0.029 -9999.0 0.0 -0.334 1.0 1.0 MLLT4 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.021 0.036 -9999.0 0.0 -0.292 4.0 4.0 ARF6 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.04 0.049 -9999.0 0.0 -0.354 3.0 3.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.002 0.019 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.01 0.032 -9999.0 0.0 -0.321 1.0 1.0 ARF6/GTP 0.042 0.05 -9999.0 0.0 -0.333 3.0 3.0 CDH1 0.019 0.039 -9999.0 0.0 -0.596 1.0 1.0 EGFR/EGFR/EGF/EGF 0.017 0.089 -9999.0 0.0 -0.336 14.0 14.0 RhoA/GDP 0.042 0.028 -9999.0 0.0 -0.318 1.0 1.0 actin cytoskeleton organization -0.011 0.029 -9999.0 0.0 -0.301 1.0 1.0 IGF-1R heterotetramer 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.022 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.013 0.077 -9999.0 0.0 -0.596 4.0 4.0 DIAPH1 -0.013 0.157 -9999.0 0.0 -0.568 10.0 10.0 Wnt receptor signaling pathway -0.041 0.028 0.331 1.0 -9999.0 0.0 1.0 RHOA 0.02 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.021 0.036 -9999.0 0.0 -0.295 4.0 4.0 CTNNA1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.012 0.029 -9999.0 0.0 -0.307 1.0 1.0 EFNA1 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.007 0.018 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 0.031 0.047 -9999.0 0.0 -0.317 4.0 4.0 SEC6/SEC8 -0.016 0.021 -9999.0 0.0 -0.303 1.0 1.0 MGAT3 -0.108 0.151 -9999.0 0.0 -0.325 81.0 81.0 HGF/MET -0.023 0.135 -9999.0 0.0 -0.317 43.0 43.0 HGF -0.082 0.231 -9999.0 0.0 -0.596 43.0 43.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.016 0.019 -9999.0 0.0 -0.273 1.0 1.0 actin cable formation 0.05 0.099 0.299 14.0 -9999.0 0.0 14.0 KIAA1543 -0.009 0.032 -9999.0 0.0 -0.307 1.0 1.0 KIFC3 -0.011 0.031 -9999.0 0.0 -0.321 1.0 1.0 NCK1 0.019 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.017 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.01 0.033 -9999.0 0.0 -0.304 1.0 1.0 NCK1/GIT1 0.027 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.041 0.028 -9999.0 0.0 -0.331 1.0 1.0 EXOC4 0.022 0.002 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.009 0.034 -9999.0 0.0 -0.321 1.0 1.0 PIP5K1C -0.01 0.032 -9999.0 0.0 -0.321 1.0 1.0 LIMA1 0.022 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.017 0.09 0.309 8.0 -9999.0 0.0 8.0 adherens junction assembly -0.007 0.066 0.257 1.0 -0.684 1.0 2.0 IGF-1R heterotetramer/IGF1 0.031 0.05 -9999.0 0.0 -0.31 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.018 0.059 0.381 1.0 -0.596 2.0 3.0 PLEKHA7 -0.009 0.034 -9999.0 0.0 -0.321 1.0 1.0 mol:GTP 0.038 0.049 -9999.0 0.0 -0.352 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.026 0.089 0.345 5.0 -9999.0 0.0 5.0 cortical actin cytoskeleton stabilization 0.016 0.019 -9999.0 0.0 -0.271 1.0 1.0 regulation of cell-cell adhesion -0.011 0.029 -9999.0 0.0 -0.301 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.016 0.019 -9999.0 0.0 -0.273 1.0 1.0