Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.013 0.096 -9999.0 0.0 -0.546 3.0 3.0 IHH 0.001 0.1 -9999.0 0.0 -0.243 17.0 17.0 SHH Np/Cholesterol/GAS1 -0.04 0.112 -9999.0 0.0 -0.262 25.0 25.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.04 0.111 0.26 25.0 -9999.0 0.0 25.0 SMO/beta Arrestin2 0.023 0.069 -9999.0 0.0 -0.352 1.0 1.0 SMO 0.008 0.063 -9999.0 0.0 -0.345 2.0 2.0 AKT1 0.014 0.066 -9999.0 0.0 -0.351 1.0 1.0 ARRB2 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.023 0.041 -9999.0 0.0 -0.457 1.0 1.0 ADRBK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.009 0.063 -9999.0 0.0 -0.341 2.0 2.0 STIL -0.026 0.114 0.26 2.0 -0.35 4.0 6.0 DHH N/PTCH2 0.033 0.047 -9999.0 0.0 -0.272 3.0 3.0 DHH N/PTCH1 0.019 0.069 -9999.0 0.0 -0.266 3.0 3.0 PIK3CA 0.023 0.023 -9999.0 0.0 -0.234 1.0 1.0 DHH 0.018 0.061 -9999.0 0.0 -0.383 3.0 3.0 PTHLH 0.009 0.129 -9999.0 0.0 -0.779 3.0 3.0 determination of left/right symmetry 0.009 0.063 -9999.0 0.0 -0.341 2.0 2.0 PIK3R1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.009 0.128 -9999.0 0.0 -0.77 3.0 3.0 IHH N/Hhip 0.0 0.117 -9999.0 0.0 -0.415 8.0 8.0 DHH N/Hhip 0.011 0.096 -9999.0 0.0 -0.329 10.0 10.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.009 0.063 -9999.0 0.0 -0.341 2.0 2.0 pancreas development -0.001 0.112 -9999.0 0.0 -0.456 8.0 8.0 HHAT 0.019 0.058 -9999.0 0.0 -0.457 2.0 2.0 PI3K 0.032 0.023 -9999.0 0.0 -0.158 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.008 0.125 -9999.0 0.0 -0.457 10.0 10.0 somite specification 0.009 0.063 -9999.0 0.0 -0.341 2.0 2.0 SHH Np/Cholesterol/PTCH1 -0.024 0.097 -9999.0 0.0 -0.332 3.0 3.0 SHH Np/Cholesterol/PTCH2 -0.026 0.097 -9999.0 0.0 -0.256 18.0 18.0 SHH Np/Cholesterol/Megalin -0.062 0.134 -9999.0 0.0 -0.286 32.0 32.0 SHH -0.045 0.121 0.233 1.0 -0.333 18.0 19.0 catabolic process 0.012 0.061 -9999.0 0.0 -0.299 3.0 3.0 SMO/Vitamin D3 -0.011 0.105 0.305 3.0 -0.483 1.0 4.0 SHH Np/Cholesterol/Hhip -0.036 0.117 -9999.0 0.0 -0.287 21.0 21.0 LRP2 -0.04 0.163 -9999.0 0.0 -0.435 20.0 20.0 receptor-mediated endocytosis -0.05 0.125 -9999.0 0.0 -0.447 6.0 6.0 SHH Np/Cholesterol/BOC -0.025 0.098 -9999.0 0.0 -0.26 18.0 18.0 SHH Np/Cholesterol/CDO -0.028 0.097 -9999.0 0.0 -0.254 18.0 18.0 mesenchymal cell differentiation 0.036 0.116 0.285 21.0 -9999.0 0.0 21.0 mol:Vitamin D3 -0.01 0.114 0.379 1.0 -0.368 2.0 3.0 IHH N/PTCH2 0.022 0.064 -9999.0 0.0 -0.26 2.0 2.0 CDON 0.017 0.055 -9999.0 0.0 -0.29 4.0 4.0 IHH N/PTCH1 0.034 0.063 -9999.0 0.0 -0.301 3.0 3.0 Megalin/LRPAP1 -0.012 0.124 -9999.0 0.0 -0.31 20.0 20.0 PTCH2 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.032 0.092 -9999.0 0.0 -0.253 18.0 18.0 PTCH1 0.012 0.061 -9999.0 0.0 -0.3 3.0 3.0 HHIP -0.001 0.112 -9999.0 0.0 -0.457 8.0 8.0