Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.043 0.174 -9999.0 0.0 -0.506 8.0 8.0 IHH -0.003 0.122 -9999.0 0.0 -0.46 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.023 0.106 -9999.0 0.0 -0.216 16.0 16.0 LRPAP1 0.031 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.023 0.106 0.215 16.0 -9999.0 0.0 16.0 SMO/beta Arrestin2 -0.027 0.165 -9999.0 0.0 -0.479 5.0 5.0 SMO -0.047 0.163 -9999.0 0.0 -0.428 8.0 8.0 AKT1 -0.044 0.177 -9999.0 0.0 -0.596 5.0 5.0 ARRB2 0.025 0.013 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.029 0.052 -9999.0 0.0 -0.388 1.0 1.0 ADRBK1 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.046 0.16 -9999.0 0.0 -0.422 8.0 8.0 STIL -0.028 0.142 0.344 1.0 -0.346 8.0 9.0 DHH N/PTCH2 0.011 0.104 -9999.0 0.0 -0.278 8.0 8.0 DHH N/PTCH1 -0.022 0.143 -9999.0 0.0 -0.315 10.0 10.0 PIK3CA 0.026 0.049 -9999.0 0.0 -0.388 1.0 1.0 DHH -0.004 0.117 -9999.0 0.0 -0.388 6.0 6.0 PTHLH -0.075 0.256 -9999.0 0.0 -0.752 8.0 8.0 determination of left/right symmetry -0.046 0.16 -9999.0 0.0 -0.422 8.0 8.0 PIK3R1 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.074 0.253 -9999.0 0.0 -0.743 8.0 8.0 IHH N/Hhip -0.018 0.148 -9999.0 0.0 -0.343 11.0 11.0 DHH N/Hhip -0.017 0.153 -9999.0 0.0 -0.358 11.0 11.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.046 0.16 -9999.0 0.0 -0.422 8.0 8.0 pancreas development -0.02 0.141 -9999.0 0.0 -0.388 9.0 9.0 HHAT 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.041 0.04 -9999.0 0.0 -0.278 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.021 0.16 -9999.0 0.0 -0.388 11.0 11.0 somite specification -0.046 0.16 -9999.0 0.0 -0.422 8.0 8.0 SHH Np/Cholesterol/PTCH1 -0.027 0.138 -9999.0 0.0 -0.332 10.0 10.0 SHH Np/Cholesterol/PTCH2 0.002 0.079 -9999.0 0.0 -0.247 6.0 6.0 SHH Np/Cholesterol/Megalin 0.006 0.064 -9999.0 0.0 -0.218 5.0 5.0 SHH -0.031 0.061 -9999.0 0.0 -0.278 4.0 4.0 catabolic process -0.021 0.132 -9999.0 0.0 -0.328 10.0 10.0 SMO/Vitamin D3 -0.045 0.159 -9999.0 0.0 -0.411 9.0 9.0 SHH Np/Cholesterol/Hhip -0.019 0.105 -9999.0 0.0 -0.242 12.0 12.0 LRP2 0.03 0.017 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.049 0.158 -9999.0 0.0 -0.43 8.0 8.0 SHH Np/Cholesterol/BOC 0.006 0.069 -9999.0 0.0 -0.213 6.0 6.0 SHH Np/Cholesterol/CDO 0.008 0.062 -9999.0 0.0 -0.21 5.0 5.0 mesenchymal cell differentiation 0.019 0.105 0.241 12.0 -9999.0 0.0 12.0 mol:Vitamin D3 -0.02 0.151 0.365 1.0 -0.333 10.0 11.0 IHH N/PTCH2 0.014 0.106 -9999.0 0.0 -0.293 6.0 6.0 CDON 0.024 0.05 -9999.0 0.0 -0.388 1.0 1.0 IHH N/PTCH1 -0.009 0.138 -9999.0 0.0 -0.33 10.0 10.0 Megalin/LRPAP1 0.045 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.022 0.071 -9999.0 0.0 -0.388 2.0 2.0 SHH Np/Cholesterol -0.001 0.057 -9999.0 0.0 -0.205 5.0 5.0 PTCH1 -0.021 0.133 -9999.0 0.0 -0.329 10.0 10.0 HHIP -0.02 0.141 -9999.0 0.0 -0.388 9.0 9.0