Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.035 0.178 -9999.0 0.0 -0.527 21.0 21.0 IHH -0.004 0.057 -9999.0 0.0 -0.27 5.0 5.0 SHH Np/Cholesterol/GAS1 0.004 0.047 -9999.0 0.0 -0.206 8.0 8.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.004 0.047 0.205 8.0 -9999.0 0.0 8.0 SMO/beta Arrestin2 -0.03 0.14 -9999.0 0.0 -0.419 15.0 15.0 SMO -0.038 0.146 -9999.0 0.0 -0.395 21.0 21.0 AKT1 -0.004 0.077 -9999.0 0.0 -0.247 7.0 7.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.012 0.089 -9999.0 0.0 -0.302 19.0 19.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.037 0.145 -9999.0 0.0 -0.39 21.0 21.0 STIL -0.009 0.097 -9999.0 0.0 -0.336 10.0 10.0 DHH N/PTCH2 -0.02 0.089 -9999.0 0.0 -0.203 42.0 42.0 DHH N/PTCH1 -0.029 0.128 -9999.0 0.0 -0.314 26.0 26.0 PIK3CA 0.01 0.039 -9999.0 0.0 -0.404 2.0 2.0 DHH -0.031 0.11 -9999.0 0.0 -0.29 34.0 34.0 PTHLH -0.049 0.233 -9999.0 0.0 -0.778 18.0 18.0 determination of left/right symmetry -0.037 0.145 -9999.0 0.0 -0.39 21.0 21.0 PIK3R1 0.01 0.039 -9999.0 0.0 -0.404 2.0 2.0 skeletal system development -0.048 0.23 -9999.0 0.0 -0.769 18.0 18.0 IHH N/Hhip -0.005 0.064 -9999.0 0.0 -0.216 16.0 16.0 DHH N/Hhip -0.026 0.088 -9999.0 0.0 -0.193 47.0 47.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.037 0.145 -9999.0 0.0 -0.39 21.0 21.0 pancreas development -0.009 0.067 -9999.0 0.0 -0.255 16.0 16.0 HHAT 0.004 0.061 -9999.0 0.0 -0.404 5.0 5.0 PI3K 0.015 0.045 -9999.0 0.0 -0.358 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.007 0.05 -9999.0 0.0 -0.367 4.0 4.0 somite specification -0.037 0.145 -9999.0 0.0 -0.39 21.0 21.0 SHH Np/Cholesterol/PTCH1 -0.013 0.102 -9999.0 0.0 -0.282 20.0 20.0 SHH Np/Cholesterol/PTCH2 0.0 0.053 -9999.0 0.0 -0.21 10.0 10.0 SHH Np/Cholesterol/Megalin -0.091 0.105 -9999.0 0.0 -0.231 60.0 60.0 SHH -0.001 0.053 -9999.0 0.0 -0.209 13.0 13.0 catabolic process -0.015 0.121 -9999.0 0.0 -0.369 18.0 18.0 SMO/Vitamin D3 -0.023 0.119 -9999.0 0.0 -0.333 21.0 21.0 SHH Np/Cholesterol/Hhip -0.004 0.054 -9999.0 0.0 -0.234 7.0 7.0 LRP2 -0.178 0.174 -9999.0 0.0 -0.32 133.0 133.0 receptor-mediated endocytosis -0.085 0.144 -9999.0 0.0 -0.379 29.0 29.0 SHH Np/Cholesterol/BOC -0.006 0.059 -9999.0 0.0 -0.208 11.0 11.0 SHH Np/Cholesterol/CDO 0.005 0.05 -9999.0 0.0 -0.236 7.0 7.0 mesenchymal cell differentiation 0.004 0.054 0.233 7.0 -9999.0 0.0 7.0 mol:Vitamin D3 -0.01 0.103 -9999.0 0.0 -0.283 20.0 20.0 IHH N/PTCH2 0.001 0.065 -9999.0 0.0 -0.271 10.0 10.0 CDON 0.008 0.047 -9999.0 0.0 -0.404 3.0 3.0 IHH N/PTCH1 -0.013 0.123 -9999.0 0.0 -0.371 18.0 18.0 Megalin/LRPAP1 -0.114 0.122 -9999.0 0.0 -0.213 133.0 133.0 PTCH2 -0.001 0.068 -9999.0 0.0 -0.315 10.0 10.0 SHH Np/Cholesterol 0.001 0.04 -9999.0 0.0 -0.213 5.0 5.0 PTCH1 -0.015 0.122 -9999.0 0.0 -0.371 18.0 18.0 HHIP -0.009 0.067 -9999.0 0.0 -0.255 16.0 16.0