Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.018 0.118 -9999.0 0.0 -0.447 12.0 12.0 IHH 0.033 0.053 0.145 6.0 -0.137 16.0 22.0 SHH Np/Cholesterol/GAS1 0.016 0.028 -9999.0 0.0 -0.168 4.0 4.0 LRPAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.016 0.027 0.167 4.0 -9999.0 0.0 4.0 SMO/beta Arrestin2 0.013 0.129 -9999.0 0.0 -0.355 12.0 12.0 SMO -0.01 0.118 -9999.0 0.0 -0.373 13.0 13.0 AKT1 0.001 0.102 -9999.0 0.0 -0.365 10.0 10.0 ARRB2 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.024 0.06 0.124 13.0 -0.315 6.0 19.0 ADRBK1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.01 0.117 -9999.0 0.0 -0.368 13.0 13.0 STIL 0.023 0.089 0.186 31.0 -0.229 13.0 44.0 DHH N/PTCH2 0.037 0.066 0.181 2.0 -0.219 12.0 14.0 DHH N/PTCH1 0.026 0.108 -9999.0 0.0 -0.292 20.0 20.0 PIK3CA 0.025 0.032 -9999.0 0.0 -0.315 2.0 2.0 DHH 0.027 0.071 0.124 25.0 -0.315 8.0 33.0 PTHLH -0.0 0.175 -9999.0 0.0 -0.621 15.0 15.0 determination of left/right symmetry -0.01 0.117 -9999.0 0.0 -0.368 13.0 13.0 PIK3R1 0.025 0.032 -9999.0 0.0 -0.315 2.0 2.0 skeletal system development 0.0 0.173 -9999.0 0.0 -0.615 15.0 15.0 IHH N/Hhip 0.045 0.043 0.19 3.0 -0.084 6.0 9.0 DHH N/Hhip 0.042 0.058 0.181 3.0 -0.219 8.0 11.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.01 0.117 -9999.0 0.0 -0.368 13.0 13.0 pancreas development 0.032 0.026 0.124 16.0 -9999.0 0.0 16.0 HHAT 0.019 0.05 -9999.0 0.0 -0.315 5.0 5.0 PI3K 0.036 0.039 -9999.0 0.0 -0.279 3.0 3.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.024 0.033 0.124 1.0 -0.315 2.0 3.0 somite specification -0.01 0.117 -9999.0 0.0 -0.368 13.0 13.0 SHH Np/Cholesterol/PTCH1 0.01 0.069 -9999.0 0.0 -0.224 15.0 15.0 SHH Np/Cholesterol/PTCH2 0.017 0.036 0.159 2.0 -0.169 6.0 8.0 SHH Np/Cholesterol/Megalin 0.003 0.102 0.194 12.0 -0.171 49.0 61.0 SHH -0.013 0.027 -9999.0 0.0 -0.222 3.0 3.0 catabolic process 0.011 0.104 0.178 1.0 -0.355 16.0 17.0 SMO/Vitamin D3 0.01 0.099 0.212 13.0 -0.28 14.0 27.0 SHH Np/Cholesterol/Hhip 0.016 0.039 0.167 5.0 -0.167 3.0 8.0 LRP2 -0.027 0.171 -9999.0 0.0 -0.315 58.0 58.0 receptor-mediated endocytosis -0.025 0.119 0.207 3.0 -0.303 22.0 25.0 SHH Np/Cholesterol/BOC 0.018 0.04 0.202 1.0 -0.169 7.0 8.0 SHH Np/Cholesterol/CDO 0.014 0.035 -9999.0 0.0 -0.197 5.0 5.0 mesenchymal cell differentiation -0.015 0.038 0.166 3.0 -0.165 5.0 8.0 mol:Vitamin D3 0.038 0.099 0.214 32.0 -0.238 13.0 45.0 IHH N/PTCH2 0.039 0.053 0.204 1.0 -0.236 4.0 5.0 CDON 0.021 0.04 -9999.0 0.0 -0.315 3.0 3.0 IHH N/PTCH1 0.023 0.109 0.23 1.0 -0.357 16.0 17.0 Megalin/LRPAP1 -0.003 0.128 -9999.0 0.0 -0.219 58.0 58.0 PTCH2 0.025 0.048 0.124 6.0 -0.315 4.0 10.0 SHH Np/Cholesterol 0.01 0.021 -9999.0 0.0 -0.165 3.0 3.0 PTCH1 0.011 0.104 0.178 1.0 -0.356 16.0 17.0 HHIP 0.032 0.026 0.124 16.0 -9999.0 0.0 16.0