Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.032 0.091 -9999.0 0.0 -0.179 64.0 64.0 epithelial cell differentiation -0.001 0.098 -9999.0 0.0 -0.157 63.0 63.0 CYFIP2 0.014 0.067 -9999.0 0.0 -0.315 9.0 9.0 ENAH -0.046 0.065 0.265 1.0 -0.233 3.0 4.0 EGFR 0.024 0.061 -9999.0 0.0 -0.315 6.0 6.0 EPHA2 0.02 0.056 0.124 3.0 -0.315 6.0 9.0 MYO6 -0.047 0.077 0.21 5.0 -0.156 63.0 68.0 CTNNB1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.042 0.049 -9999.0 0.0 -0.18 9.0 9.0 AQP5 -0.026 0.091 0.427 1.0 -0.431 4.0 5.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.045 0.074 0.208 5.0 -9999.0 0.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.043 0.079 0.221 5.0 -0.157 56.0 61.0 EGF -0.028 0.139 -9999.0 0.0 -0.315 43.0 43.0 NCKAP1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.049 0.115 0.384 1.0 -0.339 20.0 21.0 cortical microtubule organization -0.001 0.098 -9999.0 0.0 -0.157 63.0 63.0 GO:0000145 -0.044 0.069 0.196 5.0 -9999.0 0.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.003 0.102 -9999.0 0.0 -0.159 63.0 63.0 MLLT4 0.022 0.033 -9999.0 0.0 -0.315 2.0 2.0 ARF6/GDP -0.055 0.057 -9999.0 0.0 -0.149 59.0 59.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.056 0.047 -9999.0 0.0 -0.166 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.034 0.068 0.21 4.0 -9999.0 0.0 4.0 PVRL2 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.042 0.072 0.216 4.0 -0.154 55.0 59.0 ARF6/GTP 0.061 0.049 -9999.0 0.0 -0.157 6.0 6.0 CDH1 -0.061 0.156 0.124 12.0 -0.315 63.0 75.0 EGFR/EGFR/EGF/EGF -0.038 0.113 -9999.0 0.0 -0.171 89.0 89.0 RhoA/GDP 0.001 0.096 -9999.0 0.0 -0.153 63.0 63.0 actin cytoskeleton organization -0.052 0.076 0.194 5.0 -0.16 55.0 60.0 IGF-1R heterotetramer 0.025 0.032 -9999.0 0.0 -0.314 2.0 2.0 GIT1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.025 0.032 -9999.0 0.0 -0.315 2.0 2.0 IGF1 0.008 0.086 0.124 4.0 -0.315 15.0 19.0 DIAPH1 -0.031 0.212 -9999.0 0.0 -0.532 32.0 32.0 Wnt receptor signaling pathway 0.001 0.098 0.157 63.0 -9999.0 0.0 63.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.055 0.058 -9999.0 0.0 -0.15 59.0 59.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.05 0.076 0.195 5.0 -0.163 55.0 60.0 EFNA1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.05 0.072 0.202 5.0 -9999.0 0.0 5.0 Ephrin A1/EPHA2 -0.009 0.089 -9999.0 0.0 -0.151 62.0 62.0 SEC6/SEC8 -0.048 0.059 -9999.0 0.0 -0.151 50.0 50.0 MGAT3 -0.044 0.08 0.222 5.0 -0.159 56.0 61.0 HGF/MET -0.022 0.106 -9999.0 0.0 -0.168 73.0 73.0 HGF 0.015 0.077 0.124 13.0 -0.315 11.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.032 0.092 -9999.0 0.0 -0.18 64.0 64.0 actin cable formation -0.017 0.106 0.27 13.0 -0.234 7.0 20.0 KIAA1543 -0.048 0.074 0.198 5.0 -0.191 6.0 11.0 KIFC3 -0.048 0.072 0.235 3.0 -0.154 62.0 65.0 NCK1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.048 0.076 0.21 5.0 -0.154 65.0 70.0 NCK1/GIT1 0.04 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.001 0.098 -9999.0 0.0 -0.157 63.0 63.0 EXOC4 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.046 0.075 0.21 5.0 -0.154 62.0 67.0 PIP5K1C -0.045 0.075 0.21 5.0 -9999.0 0.0 5.0 LIMA1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.034 0.095 0.335 5.0 -9999.0 0.0 5.0 adherens junction assembly -0.046 0.089 0.319 2.0 -0.304 8.0 10.0 IGF-1R heterotetramer/IGF1 -0.017 0.102 -9999.0 0.0 -0.161 73.0 73.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.034 0.028 -9999.0 0.0 -0.219 2.0 2.0 MET 0.001 0.096 0.124 7.0 -0.315 19.0 26.0 PLEKHA7 -0.048 0.079 0.21 5.0 -0.288 2.0 7.0 mol:GTP 0.054 0.046 -9999.0 0.0 -0.165 6.0 6.0 establishment of epithelial cell apical/basal polarity -0.018 0.108 0.253 13.0 -9999.0 0.0 13.0 cortical actin cytoskeleton stabilization -0.032 0.091 -9999.0 0.0 -0.179 64.0 64.0 regulation of cell-cell adhesion -0.052 0.076 0.194 5.0 -0.16 55.0 60.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.032 0.092 -9999.0 0.0 -0.18 64.0 64.0