Pathway Name Avg Num Perturbations Total Perturbations Num Entities Min Mean Truth Max Mean Truth Min Mean Within Max Mean Within Min Mean Any Max Mean Within FOXA2 and FOXA3 transcription factor networks 9.0 430.0 46.0 -0.835 0.034 1000.0 -1000.0 -0.149 -1000.0 Signaling events mediated by the Hedgehog family 6.0 328.0 52.0 -0.262 0.252 1000.0 -1000.0 -0.111 -1000.0 IL23-mediated signaling events 6.0 383.0 60.0 -0.538 0.01 1000.0 -1000.0 -0.203 -1000.0 Ephrin A reverse signaling 5.0 38.0 7.0 -0.12 0.0 1000.0 -1000.0 -0.04 -1000.0 Glypican 1 network 4.0 201.0 48.0 -0.243 0.013 1000.0 -1000.0 -0.067 -1000.0 Wnt signaling 4.0 29.0 7.0 -0.117 -0.031 1000.0 -1000.0 -0.046 -1000.0 Visual signal transduction: Rods 4.0 233.0 52.0 -0.28 0.009 1000.0 -1000.0 -0.103 -1000.0 Nephrin/Neph1 signaling in the kidney podocyte 3.0 133.0 34.0 -0.156 0.009 1000.0 -1000.0 -0.08 -1000.0 Syndecan-1-mediated signaling events 3.0 114.0 34.0 -0.195 0.009 1000.0 -1000.0 -0.093 -1000.0 Visual signal transduction: Cones 3.0 139.0 38.0 -0.264 0.009 1000.0 -1000.0 -0.081 -1000.0 p75(NTR)-mediated signaling 3.0 477.0 125.0 -0.327 0.009 1000.0 -1000.0 -0.131 -1000.0 IL4-mediated signaling events 3.0 356.0 91.0 -0.674 0.488 1000.0 -1000.0 -0.221 -1000.0 BMP receptor signaling 3.0 317.0 81.0 -0.377 0.021 1000.0 -1000.0 -0.119 -1000.0 Glucocorticoid receptor regulatory network 3.0 356.0 114.0 -0.594 0.314 1000.0 -1000.0 -0.094 -1000.0 Signaling events regulated by Ret tyrosine kinase 3.0 324.0 82.0 -0.238 0.009 1000.0 -1000.0 -0.116 -1000.0 Effects of Botulinum toxin 3.0 80.0 26.0 -0.204 0.009 1000.0 -1000.0 -0.083 -1000.0 TCGA08_retinoblastoma 3.0 30.0 8.0 -0.108 0.039 1000.0 -1000.0 -0.025 -1000.0 Syndecan-4-mediated signaling events 3.0 213.0 67.0 -0.175 0.03 1000.0 -1000.0 -0.123 -1000.0 LPA4-mediated signaling events 2.0 25.0 12.0 -0.082 0.015 1000.0 -1000.0 -0.039 -1000.0 IL12-mediated signaling events 2.0 181.0 87.0 -0.214 0.031 1000.0 -1000.0 -0.17 -1000.0 ErbB4 signaling events 2.0 187.0 69.0 -0.217 0.071 1000.0 -1000.0 -0.116 -1000.0 Noncanonical Wnt signaling pathway 2.0 60.0 26.0 -0.117 0.009 1000.0 -1000.0 -0.114 -1000.0 Fc-epsilon receptor I signaling in mast cells 2.0 234.0 97.0 -0.187 0.028 1000.0 -1000.0 -0.12 -1000.0 amb2 Integrin signaling 2.0 225.0 82.0 -0.301 0.009 1000.0 -1000.0 -0.109 -1000.0 Reelin signaling pathway 2.0 142.0 56.0 -0.171 0.009 1000.0 -1000.0 -0.108 -1000.0 IL1-mediated signaling events 2.0 144.0 62.0 -0.268 0.053 1000.0 -1000.0 -0.129 -1000.0 TCGA08_p53 2.0 18.0 7.0 -0.08 0.037 1000.0 -1000.0 -0.02 -1000.0 Signaling mediated by p38-alpha and p38-beta 2.0 90.0 44.0 -0.169 0.009 1000.0 -1000.0 -0.064 -1000.0 TCR signaling in naïve CD8+ T cells 2.0 230.0 93.0 -0.169 0.086 1000.0 -1000.0 -0.115 -1000.0 EPHB forward signaling 2.0 213.0 85.0 -0.179 0.125 1000.0 -1000.0 -0.122 -1000.0 Glypican 2 network 2.0 9.0 4.0 -0.042 -0.039 1000.0 -1000.0 -0.043 -1000.0 BCR signaling pathway 2.0 200.0 99.0 -0.151 0.022 1000.0 -1000.0 -0.117 -1000.0 Neurotrophic factor-mediated Trk receptor signaling 2.0 259.0 120.0 -0.279 0.145 1000.0 -1000.0 -0.101 -1000.0 ErbB2/ErbB3 signaling events 1.0 94.0 65.0 -0.151 0.02 1000.0 -1000.0 -0.096 -1000.0 Caspase cascade in apoptosis 1.0 136.0 74.0 -0.125 0.026 1000.0 -1000.0 -0.064 -1000.0 Coregulation of Androgen receptor activity 1.0 82.0 76.0 -0.117 0.026 1000.0 -1000.0 -0.062 -1000.0 PLK2 and PLK4 events 1.0 4.0 3.0 -0.011 -0.007 1000.0 -1000.0 -0.027 -1000.0 Osteopontin-mediated events 1.0 59.0 38.0 -0.094 0.013 1000.0 -1000.0 -0.137 -1000.0 Lissencephaly gene (LIS1) in neuronal migration and development 1.0 77.0 54.0 -0.15 0.019 1000.0 -1000.0 -0.131 -1000.0 Thromboxane A2 receptor signaling 1.0 134.0 105.0 -0.113 0.023 1000.0 -1000.0 -0.095 -1000.0 HIF-1-alpha transcription factor network 1.0 120.0 76.0 -0.434 0.015 1000.0 -1000.0 -0.281 -1000.0 Syndecan-2-mediated signaling events 1.0 113.0 69.0 -0.189 0.031 1000.0 -1000.0 -0.083 -1000.0 Cellular roles of Anthrax toxin 1.0 40.0 39.0 -0.083 0.013 1000.0 -1000.0 -0.034 -1000.0 Arf6 signaling events 1.0 76.0 62.0 -0.255 0.015 1000.0 -1000.0 -0.084 -1000.0 Signaling events mediated by PTP1B 1.0 86.0 76.0 -0.167 0.015 1000.0 -1000.0 -0.111 -1000.0 Presenilin action in Notch and Wnt signaling 1.0 85.0 61.0 -0.37 0.034 1000.0 -1000.0 -0.101 -1000.0 Aurora C signaling 1.0 7.0 7.0 -0.048 0.0 1000.0 -1000.0 -0.056 -1000.0 Nectin adhesion pathway 1.0 94.0 63.0 -0.096 0.012 1000.0 -1000.0 -0.093 -1000.0 Signaling events mediated by HDAC Class III 1.0 49.0 40.0 -0.192 0.017 1000.0 -1000.0 -0.056 -1000.0 TRAIL signaling pathway 1.0 52.0 48.0 -0.077 0.029 1000.0 -1000.0 -0.087 -1000.0 RXR and RAR heterodimerization with other nuclear receptor 1.0 63.0 52.0 -0.167 0.018 1000.0 -1000.0 -0.076 -1000.0 Ephrin B reverse signaling 1.0 79.0 48.0 -0.126 0.126 1000.0 -1000.0 -0.085 -1000.0 Endothelins 1.0 190.0 96.0 -0.232 0.052 1000.0 -1000.0 -0.119 -1000.0 Retinoic acid receptors-mediated signaling 1.0 79.0 58.0 -0.135 0.017 1000.0 -1000.0 -0.092 -1000.0 Syndecan-3-mediated signaling events 1.0 51.0 35.0 -0.189 0.009 1000.0 -1000.0 -0.084 -1000.0 IL2 signaling events mediated by PI3K 1.0 67.0 58.0 -0.169 0.035 1000.0 -1000.0 -0.118 -1000.0 Canonical Wnt signaling pathway 1.0 81.0 51.0 -0.37 0.053 1000.0 -1000.0 -0.093 -1000.0 Calcium signaling in the CD4+ TCR pathway 1.0 39.0 31.0 -0.164 0.011 1000.0 -1000.0 -0.127 -1000.0 Nongenotropic Androgen signaling 1.0 71.0 52.0 -0.077 0.009 1000.0 -1000.0 -0.093 -1000.0 IL27-mediated signaling events 1.0 84.0 51.0 -0.233 0.013 1000.0 -1000.0 -0.115 -1000.0 IL6-mediated signaling events 1.0 89.0 75.0 -0.217 0.035 1000.0 -1000.0 -0.125 -1000.0 Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1.0 124.0 68.0 -0.245 0.022 1000.0 -1000.0 -0.186 -1000.0 Stabilization and expansion of the E-cadherin adherens junction 1.0 83.0 74.0 -0.232 0.048 1000.0 -1000.0 -0.127 -1000.0 IL2 signaling events mediated by STAT5 1.0 24.0 22.0 -0.057 0.025 1000.0 -1000.0 -0.081 -1000.0 Regulation of Telomerase 1.0 146.0 102.0 -0.264 0.029 1000.0 -1000.0 -0.143 -1000.0 EGFR-dependent Endothelin signaling events 1.0 39.0 21.0 -0.113 0.009 1000.0 -1000.0 -0.095 -1000.0 Class IB PI3K non-lipid kinase events 1.0 3.0 3.0 -0.011 -1000.0 1000.0 -1000.0 -0.024 -1000.0 FOXM1 transcription factor network 1.0 56.0 51.0 -0.117 0.142 1000.0 -1000.0 -0.249 -1000.0 Regulation of Androgen receptor activity 1.0 73.0 70.0 -0.281 0.02 1000.0 -1000.0 -0.098 -1000.0 Ras signaling in the CD4+ TCR pathway 1.0 18.0 17.0 -0.029 0.011 1000.0 -1000.0 -0.073 -1000.0 Aurora B signaling 1.0 69.0 67.0 -0.229 0.01 1000.0 -1000.0 -0.093 -1000.0 Regulation of nuclear SMAD2/3 signaling 0.0 90.0 136.0 -0.126 0.056 1000.0 -1000.0 -0.11 -1000.0 Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0.0 0.0 23.0 0.0 0.036 1000.0 -1000.0 -0.093 -1000.0 Canonical NF-kappaB pathway 0.0 9.0 39.0 -0.054 0.061 1000.0 -1000.0 -0.109 -1000.0 Signaling events mediated by HDAC Class II 0.0 11.0 75.0 -0.031 0.021 1000.0 -1000.0 -0.083 -1000.0 BARD1 signaling events 0.0 37.0 57.0 -0.039 0.036 1000.0 -1000.0 -0.091 -1000.0 Sphingosine 1-phosphate (S1P) pathway 0.0 14.0 28.0 -0.065 0.018 1000.0 -1000.0 -0.081 -1000.0 Circadian rhythm pathway 0.0 2.0 22.0 -0.015 0.035 1000.0 -1000.0 -0.082 -1000.0 JNK signaling in the CD4+ TCR pathway 0.0 14.0 17.0 -0.035 0.018 1000.0 -1000.0 -0.081 -1000.0 a4b1 and a4b7 Integrin signaling 0.0 4.0 5.0 -0.028 -0.011 1000.0 -1000.0 -0.051 -1000.0 Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 0.0 33.0 85.0 -0.04 0.038 1000.0 -1000.0 -0.104 -1000.0 Hedgehog signaling events mediated by Gli proteins 0.0 58.0 65.0 -0.172 0.037 1000.0 -1000.0 -0.089 -1000.0 Aurora A signaling 0.0 49.0 60.0 -0.185 0.02 1000.0 -1000.0 -0.078 -1000.0 Arf6 downstream pathway 0.0 30.0 43.0 -0.028 0.02 1000.0 -1000.0 -0.062 -1000.0 EPO signaling pathway 0.0 12.0 55.0 -0.038 0.054 1000.0 -1000.0 -0.129 -1000.0 PLK1 signaling events 0.0 61.0 85.0 -0.043 0.013 1000.0 -1000.0 -0.065 -1000.0 Insulin-mediated glucose transport 0.0 4.0 32.0 -0.023 0.026 1000.0 -1000.0 -0.079 -1000.0 PDGFR-alpha signaling pathway 0.0 12.0 44.0 -0.027 0.025 1000.0 -1000.0 -0.093 -1000.0 mTOR signaling pathway 0.0 7.0 53.0 -0.011 0.028 1000.0 -1000.0 -0.082 -1000.0 IFN-gamma pathway 0.0 49.0 68.0 -0.114 0.028 1000.0 -1000.0 -0.138 -1000.0 Class I PI3K signaling events mediated by Akt 0.0 11.0 68.0 -0.033 0.038 1000.0 -1000.0 -0.09 -1000.0 Ceramide signaling pathway 0.0 32.0 76.0 -0.113 0.029 1000.0 -1000.0 -0.083 -1000.0 Paxillin-independent events mediated by a4b1 and a4b7 0.0 32.0 37.0 -0.125 0.014 1000.0 -1000.0 -0.106 -1000.0 S1P5 pathway 0.0 12.0 17.0 -0.065 0.036 1000.0 -1000.0 -0.078 -1000.0 ceramide signaling pathway 0.0 7.0 49.0 -0.054 0.03 1000.0 -1000.0 -0.08 -1000.0 HIF-2-alpha transcription factor network 0.0 24.0 43.0 -0.094 0.096 1000.0 -1000.0 -0.136 -1000.0 Role of Calcineurin-dependent NFAT signaling in lymphocytes 0.0 24.0 83.0 -0.137 0.039 1000.0 -1000.0 -0.104 -1000.0 S1P1 pathway 0.0 33.0 36.0 -0.1 0.013 1000.0 -1000.0 -0.081 -1000.0 Signaling events mediated by HDAC Class I 0.0 26.0 104.0 -0.054 0.037 1000.0 -1000.0 -0.094 -1000.0 FoxO family signaling 0.0 47.0 64.0 -0.124 0.076 1000.0 -1000.0 -0.106 -1000.0 FAS signaling pathway (CD95) 0.0 43.0 47.0 -0.192 0.011 1000.0 -1000.0 -0.073 -1000.0 Signaling mediated by p38-gamma and p38-delta 0.0 9.0 15.0 -0.022 0.023 1000.0 -1000.0 -0.057 -1000.0 Paxillin-dependent events mediated by a4b1 0.0 14.0 36.0 -0.028 0.018 1000.0 -1000.0 -0.093 -1000.0 Atypical NF-kappaB pathway 0.0 5.0 31.0 -0.042 0.021 1000.0 -1000.0 -0.091 -1000.0 Integrins in angiogenesis 0.0 73.0 84.0 -0.12 0.031 1000.0 -1000.0 -0.115 -1000.0 HIV-1 Nef: Negative effector of Fas and TNF-alpha 0.0 19.0 45.0 -0.088 0.04 1000.0 -1000.0 -0.12 -1000.0 Regulation of p38-alpha and p38-beta 0.0 28.0 54.0 -0.083 0.009 1000.0 -1000.0 -0.094 -1000.0 Signaling events mediated by VEGFR1 and VEGFR2 0.0 8.0 125.0 -0.022 0.071 1000.0 -1000.0 -0.144 -1000.0 TCGA08_rtk_signaling 0.0 13.0 26.0 -0.046 0.028 1000.0 -1000.0 -0.031 -1000.0 LPA receptor mediated events 0.0 91.0 102.0 -0.104 0.024 1000.0 -1000.0 -0.128 -1000.0 E-cadherin signaling in the nascent adherens junction 0.0 39.0 76.0 -0.028 0.03 1000.0 -1000.0 -0.114 -1000.0 Sumoylation by RanBP2 regulates transcriptional repression 0.0 1.0 27.0 -0.006 0.022 1000.0 -1000.0 -0.074 -1000.0 Class I PI3K signaling events 0.0 39.0 73.0 -0.083 0.028 1000.0 -1000.0 -0.105 -1000.0 Arf6 trafficking events 0.0 21.0 71.0 -0.085 0.033 1000.0 -1000.0 -0.097 -1000.0 IGF1 pathway 0.0 14.0 57.0 -0.083 0.015 1000.0 -1000.0 -0.133 -1000.0 Insulin Pathway 0.0 26.0 74.0 -0.137 0.028 1000.0 -1000.0 -0.124 -1000.0 Plasma membrane estrogen receptor signaling 0.0 74.0 86.0 -0.083 0.023 1000.0 -1000.0 -0.109 -1000.0 VEGFR1 specific signals 0.0 5.0 56.0 -0.013 0.048 1000.0 -1000.0 -0.103 -1000.0 S1P3 pathway 0.0 26.0 42.0 -0.064 0.02 1000.0 -1000.0 -0.081 -1000.0 Angiopoietin receptor Tie2-mediated signaling 0.0 65.0 88.0 -0.254 0.071 1000.0 -1000.0 -0.155 -1000.0 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 0.0 27.0 33.0 -0.109 0.029 1000.0 -1000.0 -0.082 -1000.0 Rapid glucocorticoid signaling 0.0 9.0 20.0 -0.022 0.009 1000.0 -1000.0 -0.051 -1000.0 PDGFR-beta signaling pathway 0.0 21.0 97.0 -0.062 0.042 1000.0 -1000.0 -0.108 -1000.0 Signaling events mediated by PRL 0.0 30.0 34.0 -0.132 0.021 1000.0 -1000.0 -0.07 -1000.0 E-cadherin signaling in keratinocytes 0.0 16.0 43.0 -0.023 0.03 1000.0 -1000.0 -0.11 -1000.0 S1P4 pathway 0.0 12.0 25.0 -0.065 0.025 1000.0 -1000.0 -0.074 -1000.0 E-cadherin signaling events 0.0 4.0 5.0 -0.02 0.009 1000.0 -1000.0 -0.052 -1000.0 Signaling events mediated by Stem cell factor receptor (c-Kit) 0.0 74.0 78.0 -0.052 0.028 1000.0 -1000.0 -0.103 -1000.0 p38 MAPK signaling pathway 0.0 12.0 44.0 -0.057 0.024 1000.0 -1000.0 -0.085 -1000.0 Arf1 pathway 0.0 0.0 54.0 -0.0 0.027 1000.0 -1000.0 -0.059 -1000.0 Alternative NF-kappaB pathway 0.0 3.0 13.0 -0.015 0.009 1000.0 -1000.0 -0.075 -1000.0 Total 139 10799 7203 -18.7766057098 -995.348957147 131000 -131000 -12.8313283844 -131000