Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
BRAF	183 (57%)	140	0.0033755	0.874	1.0841e-37	2.98e-35	3.5959e-07	9.6e-05	3.7109e-13	1.01e-10	4.0306e-46	1.12e-43	1.5559e-39	4.29e-37	1.3372e-43	3.7e-41	2.1578e-45	6e-43
EMG1	6 (2%)	317	0.5565	1	0.86227	1	0.26709	1	0.14737	1	1	1	1	1	1	1	0.16622	1
HRAS	12 (4%)	311	0.00010667	0.0279	2.483e-06	0.000658	0.00022371	0.0582	0.0034895	0.9	1.3711e-05	0.00361	6.7883e-06	0.00179	1.4914e-06	0.000397	3.3819e-07	9.06e-05
NRAS	26 (8%)	297	0.0097998	1	6.625e-14	1.82e-11	1	1	0.00020871	0.0545	4.6976e-11	1.26e-08	4.0258e-11	1.09e-08	1.6362e-12	4.43e-10	1.7599e-13	4.8e-11
PTTG1IP	4 (1%)	319	1	1	1	1	NA	NA	NA	NA	0.2423	1	0.25238	1	0.47085	1	0.037917	1
RPTN	8 (2%)	315	1	1	0.68775	1	0.3274	1	0.48546	1	0.024895	1	0.41549	1	0.74144	1	1	1
EIF1AX	5 (2%)	318	1	1	0.027987	1	0.44414	1	0.11518	1	0.062103	1	0.010868	1	0.061561	1	0.23426	1
CCDC15	5 (2%)	318	1	1	0.17035	1	1	1	0.77814	1	0.13179	1	0.13568	1	0.62757	1	0.52668	1
ZNF845	6 (2%)	317	0.5565	1	0.61523	1	0.64018	1	0.34982	1	0.94332	1	0.16605	1	0.37963	1	0.32716	1
ZNF878	4 (1%)	319	1	1	0.45564	1	NA	NA	NA	NA	0.045357	1	0.83282	1	0.6936	1	1	1
TG	16 (5%)	307	1	1	0.025477	1	0.28647	1	0.27253	1	0.4061	1	0.29326	1	0.042627	1	0.024364	1
PRB2	6 (2%)	317	1	1	0.61523	1	0.080929	1	1	1	0.47352	1	0.72276	1	0.52542	1	0.59441	1
R3HDM2	4 (1%)	319	0.013374	1	0.049477	1	NA	NA	NA	NA	0.069868	1	0.038822	1	0.02016	1	0.0078812	1
IL32	3 (1%)	320	1	1	0.39016	1	NA	NA	NA	NA	1	1	0.78003	1	0.2064	1	0.64098	1
TMCO2	3 (1%)	320	1	1	0.54525	1	0.77776	1	0.185	1	0.49189	1	0.30268	1	0.4127	1	0.77889	1
PPTC7	3 (1%)	320	0.078988	1	0.083503	1	NA	NA	NA	NA	0.17163	1	0.091632	1	0.30644	1	0.39485	1
MUC7	5 (2%)	318	1	1	0.27352	1	0.68429	1	0.77814	1	0.80451	1	0.84764	1	0.45288	1	0.63218	1
LYPD3	3 (1%)	320	0.54956	1	0.54525	1	NA	NA	NA	NA	0.49189	1	0.30268	1	0.6498	1	0.77889	1
TMEM90B	3 (1%)	320	0.13634	1	1	1	NA	NA	NA	NA	1	1	0.78003	1	1	1	1	1
ZNF799	5 (2%)	318	0.47319	1	0.8341	1	0.50965	1	1	1	0.59189	1	0.84764	1	0.45288	1	1	1
PPM1D	5 (2%)	318	1	1	1	1	0.77776	1	0.34982	1	0.69331	1	0.84764	1	0.86845	1	0.28094	1
MAP3K3	4 (1%)	319	0.38082	1	0.27644	1	0.3934	1	0.14737	1	0.27362	1	0.1845	1	0.47085	1	0.39142	1
TROAP	3 (1%)	320	1	1	0.39016	1	0.77776	1	1	1	0.74564	1	1	1	0.30644	1	0.39485	1
SYNPO2L	3 (1%)	320	0.54956	1	1	1	NA	NA	NA	NA	1	1	0.78003	1	1	1	1	1
ATAD2	4 (1%)	319	1	1	0.61185	1	NA	NA	NA	NA	0.80791	1	1	1	0.6936	1	1	1
KRAS	3 (1%)	320	1	1	0.083503	1	NA	NA	NA	NA	0.17163	1	0.091632	1	0.064236	1	0.026746	1
SLC5A11	3 (1%)	320	0.54956	1	0.71598	1	NA	NA	NA	NA	NA	NA	NA	NA	0.30644	1	0.39485	1
PRG4	4 (1%)	319	0.23211	1	0.36173	1	NA	NA	NA	NA	0.01279	1	0.14194	1	0.47085	1	0.55778	1
SCUBE2	3 (1%)	320	NA	NA	0.24569	1	NA	NA	NA	NA	0.31416	1	0.30268	1	0.6498	1	0.51111	1
ZNF479	3 (1%)	320	1	1	0.39016	1	NA	NA	NA	NA	1	1	0.78003	1	1	1	1	1
SREBF2	3 (1%)	320	1	1	0.39016	1	NA	NA	NA	NA	0.56789	1	1	1	0.4127	1	0.77889	1
SLC26A11	3 (1%)	320	0.078988	1	1	1	NA	NA	NA	NA	0.36782	1	0.78003	1	0.77684	1	0.29181	1
TSC22D1	3 (1%)	320	1	1	1	1	NA	NA	NA	NA	0.74564	1	1	1	1	1	0.64098	1
ANKRD30A	5 (2%)	318	1	1	0.43002	1	NA	NA	NA	NA	0.74877	1	0.50714	1	0.74196	1	0.86549	1
FAM155A	4 (1%)	319	0.14361	1	0.61185	1	0.77776	1	1	1	NA	NA	NA	NA	0.33151	1	0.83226	1
SLA	3 (1%)	320	0.54956	1	0.083503	1	0.29	1	0.34982	1	0.17163	1	0.091632	1	0.064236	1	0.026746	1
ZFHX3	10 (3%)	313	0.17835	1	0.7372	1	0.48319	1	0.53308	1	0.79434	1	0.4373	1	0.61502	1	0.72686	1
ARMCX3	3 (1%)	320	0.54956	1	0.39016	1	NA	NA	NA	NA	0.64643	1	0.21335	1	0.52759	1	0.19938	1
SLC25A45	3 (1%)	320	0.13634	1	1	1	NA	NA	NA	NA	NA	NA	NA	NA	0.2064	1	0.64098	1
COL5A3	6 (2%)	317	0.75763	1	1	1	0.77776	1	1	1	0.044045	1	0.75254	1	0.8755	1	0.51853	1
CDC27	3 (1%)	320	1	1	1	1	NA	NA	NA	NA	0.36782	1	0.044618	1	0.77684	1	1	1