Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.093 0.212 -9999.0 0.0 -0.416 107.0 107.0 IHH -0.168 0.326 -9999.0 0.0 -0.716 105.0 105.0 SHH Np/Cholesterol/GAS1 -0.058 0.164 -9999.0 0.0 -0.408 70.0 70.0 LRPAP1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.057 0.163 0.405 70.0 -9999.0 0.0 70.0 SMO/beta Arrestin2 -0.082 0.209 -9999.0 0.0 -0.422 95.0 95.0 SMO -0.101 0.211 -9999.0 0.0 -0.444 99.0 99.0 AKT1 -0.017 0.099 -9999.0 0.0 -0.341 1.0 1.0 ARRB2 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.014 0.093 -9999.0 0.0 -0.689 7.0 7.0 ADRBK1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.099 0.209 -9999.0 0.0 -0.437 100.0 100.0 STIL -0.072 0.159 0.266 1.0 -0.329 93.0 94.0 DHH N/PTCH2 -0.053 0.207 -9999.0 0.0 -0.518 66.0 66.0 DHH N/PTCH1 -0.083 0.193 -9999.0 0.0 -0.378 110.0 110.0 PIK3CA 0.025 0.036 -9999.0 0.0 -0.689 1.0 1.0 DHH 0.02 0.062 -9999.0 0.0 -0.689 3.0 3.0 PTHLH -0.143 0.313 -9999.0 0.0 -1.068 25.0 25.0 determination of left/right symmetry -0.099 0.209 -9999.0 0.0 -0.437 100.0 100.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.141 0.308 -9999.0 0.0 -1.048 25.0 25.0 IHH N/Hhip -0.307 0.341 -9999.0 0.0 -0.605 216.0 216.0 DHH N/Hhip -0.177 0.272 -9999.0 0.0 -0.521 154.0 154.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.099 0.209 -9999.0 0.0 -0.437 100.0 100.0 pancreas development -0.254 0.339 -9999.0 0.0 -0.686 154.0 154.0 HHAT 0.023 0.036 -9999.0 0.0 -0.689 1.0 1.0 PI3K 0.037 0.029 -9999.0 0.0 -0.522 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.107 0.27 -9999.0 0.0 -0.642 80.0 80.0 somite specification -0.099 0.209 -9999.0 0.0 -0.437 100.0 100.0 SHH Np/Cholesterol/PTCH1 -0.076 0.164 -9999.0 0.0 -0.342 96.0 96.0 SHH Np/Cholesterol/PTCH2 -0.046 0.155 -9999.0 0.0 -0.393 65.0 65.0 SHH Np/Cholesterol/Megalin -0.08 0.182 -9999.0 0.0 -0.398 97.0 97.0 SHH -0.005 0.031 -9999.0 0.0 -0.522 1.0 1.0 catabolic process -0.101 0.208 -9999.0 0.0 -0.412 120.0 120.0 SMO/Vitamin D3 -0.081 0.187 -9999.0 0.0 -0.386 96.0 96.0 SHH Np/Cholesterol/Hhip -0.144 0.207 -9999.0 0.0 -0.404 154.0 154.0 LRP2 -0.148 0.306 -9999.0 0.0 -0.68 100.0 100.0 receptor-mediated endocytosis -0.144 0.211 -9999.0 0.0 -0.452 80.0 80.0 SHH Np/Cholesterol/BOC 0.012 0.059 -9999.0 0.0 -0.379 8.0 8.0 SHH Np/Cholesterol/CDO -0.098 0.191 -9999.0 0.0 -0.393 116.0 116.0 mesenchymal cell differentiation 0.143 0.205 0.401 154.0 -9999.0 0.0 154.0 mol:Vitamin D3 -0.071 0.171 -9999.0 0.0 -0.346 96.0 96.0 IHH N/PTCH2 -0.183 0.297 -9999.0 0.0 -0.549 151.0 151.0 CDON -0.179 0.323 -9999.0 0.0 -0.689 116.0 116.0 IHH N/PTCH1 -0.098 0.213 -9999.0 0.0 -0.417 120.0 120.0 Megalin/LRPAP1 -0.098 0.238 -9999.0 0.0 -0.512 100.0 100.0 PTCH2 -0.088 0.261 -9999.0 0.0 -0.684 65.0 65.0 SHH Np/Cholesterol 0.009 0.025 -9999.0 0.0 -0.415 1.0 1.0 PTCH1 -0.101 0.209 -9999.0 0.0 -0.414 120.0 120.0 HHIP -0.255 0.339 -9999.0 0.0 -0.687 154.0 154.0