Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.054 0.015 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.023 0.082 0.482 9.0 -9999.0 0.0 9.0 EGFR 0.017 0.079 -9999.0 0.0 -0.689 5.0 5.0 EPHA2 0.025 0.014 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 0.033 0.072 0.445 10.0 -9999.0 0.0 10.0 CTNNB1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.051 0.013 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 0.002 0.112 -9999.0 0.0 -0.543 15.0 15.0 CTNND1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.025 0.052 0.408 6.0 -9999.0 0.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.009 0.061 0.39 6.0 -9999.0 0.0 6.0 EGF -0.072 0.243 -9999.0 0.0 -0.683 55.0 55.0 NCKAP1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.042 0.173 -9999.0 0.0 -0.541 40.0 40.0 cortical microtubule organization 0.054 0.015 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.014 0.052 0.399 6.0 -9999.0 0.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.059 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP 0.006 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.06 0.023 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.015 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.02 0.019 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.066 0.026 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.011 0.146 -9999.0 0.0 -0.367 58.0 58.0 RhoA/GDP 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.022 0.056 0.415 7.0 -9999.0 0.0 7.0 IGF-1R heterotetramer 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.12 0.286 -9999.0 0.0 -0.685 82.0 82.0 DIAPH1 0.049 0.048 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.054 0.015 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP 0.005 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.022 0.057 0.417 7.0 -9999.0 0.0 7.0 EFNA1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.014 0.043 0.356 2.0 -0.368 2.0 4.0 Ephrin A1/EPHA2 0.046 0.018 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.014 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.009 0.062 0.392 6.0 -9999.0 0.0 6.0 HGF/MET -0.009 0.152 -9999.0 0.0 -0.388 54.0 54.0 HGF -0.077 0.25 -9999.0 0.0 -0.689 58.0 58.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.069 0.141 0.521 25.0 -0.328 1.0 26.0 KIAA1543 0.013 0.053 0.371 6.0 -0.362 1.0 7.0 KIFC3 0.021 0.023 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.024 0.038 0.355 3.0 -9999.0 0.0 3.0 NCK1/GIT1 0.037 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.054 0.015 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.021 0.023 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.052 0.411 6.0 -9999.0 0.0 6.0 LIMA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.045 0.106 0.445 19.0 -9999.0 0.0 19.0 adherens junction assembly 0.028 0.091 0.463 12.0 -0.335 1.0 13.0 IGF-1R heterotetramer/IGF1 -0.033 0.164 -9999.0 0.0 -0.367 77.0 77.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.037 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.034 0.073 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.026 0.053 0.381 6.0 -0.379 1.0 7.0 mol:GTP 0.058 0.023 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.031 0.066 0.478 6.0 -9999.0 0.0 6.0 cortical actin cytoskeleton stabilization 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.022 0.056 0.415 7.0 -9999.0 0.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0