Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.175 0.265 -9999.0 0.0 -0.706 54.0 54.0 IHH -0.259 0.27 -9999.0 0.0 -0.523 184.0 184.0 SHH Np/Cholesterol/GAS1 -0.104 0.175 -9999.0 0.0 -0.314 138.0 138.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.103 0.174 0.312 138.0 -9999.0 0.0 138.0 SMO/beta Arrestin2 -0.156 0.219 -9999.0 0.0 -0.519 60.0 60.0 SMO -0.17 0.23 -9999.0 0.0 -0.538 65.0 65.0 AKT1 -0.083 0.153 -9999.0 0.0 -0.554 20.0 20.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.019 0.119 -9999.0 0.0 -0.469 24.0 24.0 ADRBK1 0.011 0.024 -9999.0 0.0 -0.451 1.0 1.0 heart looping -0.168 0.226 -9999.0 0.0 -0.529 65.0 65.0 STIL -0.157 0.204 -9999.0 0.0 -0.504 67.0 67.0 DHH N/PTCH2 -0.026 0.134 -9999.0 0.0 -0.407 38.0 38.0 DHH N/PTCH1 -0.15 0.193 -9999.0 0.0 -0.512 45.0 45.0 PIK3CA 0.01 0.034 -9999.0 0.0 -0.451 2.0 2.0 DHH -0.024 0.132 -9999.0 0.0 -0.514 25.0 25.0 PTHLH -0.204 0.313 -9999.0 0.0 -0.843 49.0 49.0 determination of left/right symmetry -0.168 0.226 -9999.0 0.0 -0.529 65.0 65.0 PIK3R1 -0.018 0.124 -9999.0 0.0 -0.522 21.0 21.0 skeletal system development -0.201 0.309 -9999.0 0.0 -0.831 49.0 49.0 IHH N/Hhip -0.223 0.235 -9999.0 0.0 -0.393 215.0 215.0 DHH N/Hhip -0.088 0.181 -9999.0 0.0 -0.383 97.0 97.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.168 0.226 -9999.0 0.0 -0.529 65.0 65.0 pancreas development -0.099 0.214 -9999.0 0.0 -0.511 78.0 78.0 HHAT -0.004 0.093 -9999.0 0.0 -0.538 11.0 11.0 PI3K -0.006 0.093 -9999.0 0.0 -0.366 23.0 23.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.09 0.203 -9999.0 0.0 -0.491 75.0 75.0 somite specification -0.168 0.226 -9999.0 0.0 -0.529 65.0 65.0 SHH Np/Cholesterol/PTCH1 -0.17 0.214 -9999.0 0.0 -0.524 71.0 71.0 SHH Np/Cholesterol/PTCH2 -0.063 0.148 -9999.0 0.0 -0.298 97.0 97.0 SHH Np/Cholesterol/Megalin -0.158 0.188 -9999.0 0.0 -0.315 197.0 197.0 SHH -0.072 0.169 -9999.0 0.0 -0.374 85.0 85.0 catabolic process -0.154 0.198 -9999.0 0.0 -0.537 37.0 37.0 SMO/Vitamin D3 -0.179 0.232 -9999.0 0.0 -0.572 67.0 67.0 SHH Np/Cholesterol/Hhip -0.11 0.175 -9999.0 0.0 -0.308 147.0 147.0 LRP2 -0.189 0.246 -9999.0 0.0 -0.487 149.0 149.0 receptor-mediated endocytosis -0.237 0.241 -9999.0 0.0 -0.553 101.0 101.0 SHH Np/Cholesterol/BOC -0.065 0.152 -9999.0 0.0 -0.298 100.0 100.0 SHH Np/Cholesterol/CDO -0.058 0.151 -9999.0 0.0 -0.306 89.0 89.0 mesenchymal cell differentiation 0.109 0.174 0.306 147.0 -9999.0 0.0 147.0 mol:Vitamin D3 -0.17 0.216 -9999.0 0.0 -0.527 71.0 71.0 IHH N/PTCH2 -0.163 0.184 -9999.0 0.0 -0.327 192.0 192.0 CDON -0.005 0.092 -9999.0 0.0 -0.485 13.0 13.0 IHH N/PTCH1 -0.155 0.201 -9999.0 0.0 -0.544 37.0 37.0 Megalin/LRPAP1 -0.127 0.178 -9999.0 0.0 -0.342 149.0 149.0 PTCH2 -0.014 0.113 -9999.0 0.0 -0.497 19.0 19.0 SHH Np/Cholesterol -0.056 0.131 -9999.0 0.0 -0.288 85.0 85.0 PTCH1 -0.154 0.199 -9999.0 0.0 -0.539 37.0 37.0 HHIP -0.099 0.214 -9999.0 0.0 -0.511 78.0 78.0