E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.012 0.1 -9999.0 0.0 -0.28 42.0 42.0 KLHL20 -0.008 0.074 0.174 1.0 -0.228 22.0 23.0 CYFIP2 0.014 0.067 -9999.0 0.0 -0.403 9.0 9.0 Rac1/GDP 0.002 0.075 -9999.0 0.0 -0.267 11.0 11.0 ENAH -0.018 0.1 -9999.0 0.0 -0.282 42.0 42.0 AP1M1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.025 0.001 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.023 0.023 -9999.0 0.0 -0.403 1.0 1.0 CDC42/GTP 0.018 0.035 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.021 0.045 -9999.0 0.0 -0.156 23.0 23.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.046 0.054 -9999.0 0.0 -0.216 12.0 12.0 RAPGEF1 -0.007 0.08 -9999.0 0.0 -0.336 8.0 8.0 CTNND1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.009 0.108 -9999.0 0.0 -0.288 45.0 45.0 CRK -0.008 0.083 -9999.0 0.0 -0.315 13.0 13.0 E-cadherin/gamma catenin/alpha catenin 0.039 0.048 -9999.0 0.0 -0.325 5.0 5.0 alphaE/beta7 Integrin 0.029 0.043 -9999.0 0.0 -0.285 6.0 6.0 IQGAP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.048 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.01 0.097 -9999.0 0.0 -0.286 38.0 38.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.001 0.03 -9999.0 0.0 -0.202 3.0 3.0 MLLT4 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.039 0.041 -9999.0 0.0 -0.215 8.0 8.0 PI3K 0.002 0.039 -9999.0 0.0 -0.261 3.0 3.0 ARF6 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.027 0.051 -9999.0 0.0 -0.378 5.0 5.0 TIAM1 0.016 0.063 -9999.0 0.0 -0.403 8.0 8.0 E-cadherin(dimer)/Ca2+ 0.048 0.039 -9999.0 0.0 -0.203 6.0 6.0 AKT1 -0.009 0.025 0.099 1.0 -0.163 2.0 3.0 PIK3R1 0.003 0.091 -9999.0 0.0 -0.403 17.0 17.0 CDH1 0.017 0.05 -9999.0 0.0 -0.403 5.0 5.0 RhoA/GDP 0.004 0.073 -9999.0 0.0 -0.265 10.0 10.0 actin cytoskeleton organization -0.004 0.056 0.15 3.0 -0.169 20.0 23.0 CDC42/GDP 0.005 0.074 -9999.0 0.0 -0.266 11.0 11.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.039 -9999.0 0.0 -0.289 5.0 5.0 ITGB7 0.017 0.055 -9999.0 0.0 -0.324 8.0 8.0 RAC1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.052 0.042 -9999.0 0.0 -0.216 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.035 0.035 -9999.0 0.0 -0.2 6.0 6.0 mol:GDP -0.011 0.08 -9999.0 0.0 -0.293 14.0 14.0 CDC42/GTP/IQGAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.022 0.032 -9999.0 0.0 -0.403 2.0 2.0 p120 catenin/RhoA/GDP 0.011 0.076 -9999.0 0.0 -0.272 9.0 9.0 RAC1/GTP/IQGAP1 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.001 0.051 0.137 3.0 -0.174 16.0 19.0 NME1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.007 0.093 -9999.0 0.0 -0.285 35.0 35.0 regulation of cell-cell adhesion 0.011 0.03 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.001 0.031 -9999.0 0.0 -0.113 3.0 3.0 Rap1/GTP 0.022 0.044 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.055 0.061 -9999.0 0.0 -0.24 11.0 11.0 CCND1 -0.002 0.062 0.157 3.0 -0.216 16.0 19.0 VAV2 -0.037 0.185 -9999.0 0.0 -0.611 26.0 26.0 RAP1/GDP 0.019 0.065 0.206 1.0 -0.294 3.0 4.0 adherens junction assembly -0.006 0.091 -9999.0 0.0 -0.277 35.0 35.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.039 0.056 -9999.0 0.0 -0.228 12.0 12.0 E-cadherin/beta catenin 0.007 0.039 -9999.0 0.0 -0.288 6.0 6.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.014 0.102 -9999.0 0.0 -0.285 42.0 42.0 PIK3CA 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.027 0.11 -9999.0 0.0 -0.355 26.0 26.0 E-cadherin/beta catenin/alpha catenin 0.04 0.04 -9999.0 0.0 -0.237 6.0 6.0 ITGAE 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.01 0.109 -9999.0 0.0 -0.293 45.0 45.0