Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.09 0.186 -9999.0 0.0 -0.579 32.0 32.0 IHH -0.132 0.202 -9999.0 0.0 -0.438 104.0 104.0 SHH Np/Cholesterol/GAS1 -0.038 0.101 -9999.0 0.0 -0.242 65.0 65.0 LRPAP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.037 0.1 0.24 65.0 -9999.0 0.0 65.0 SMO/beta Arrestin2 -0.092 0.191 -9999.0 0.0 -0.366 96.0 96.0 SMO -0.108 0.19 -9999.0 0.0 -0.377 103.0 103.0 AKT1 -0.052 0.161 -9999.0 0.0 -0.498 29.0 29.0 ARRB2 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.015 0.05 -9999.0 0.0 -0.403 4.0 4.0 ADRBK1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.106 0.187 -9999.0 0.0 -0.372 103.0 103.0 STIL -0.071 0.16 0.185 25.0 -0.331 62.0 87.0 DHH N/PTCH2 0.009 0.092 -9999.0 0.0 -0.315 25.0 25.0 DHH N/PTCH1 -0.075 0.149 -9999.0 0.0 -0.265 121.0 121.0 PIK3CA 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.001 0.094 -9999.0 0.0 -0.403 18.0 18.0 PTHLH -0.122 0.234 -9999.0 0.0 -0.62 41.0 41.0 determination of left/right symmetry -0.106 0.187 -9999.0 0.0 -0.372 103.0 103.0 PIK3R1 0.003 0.091 -9999.0 0.0 -0.403 17.0 17.0 skeletal system development -0.121 0.231 -9999.0 0.0 -0.614 41.0 41.0 IHH N/Hhip -0.098 0.182 -9999.0 0.0 -0.328 125.0 125.0 DHH N/Hhip -0.03 0.129 -9999.0 0.0 -0.301 63.0 63.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.106 0.187 -9999.0 0.0 -0.372 103.0 103.0 pancreas development -0.042 0.147 -9999.0 0.0 -0.403 50.0 50.0 HHAT 0.011 0.067 -9999.0 0.0 -0.403 9.0 9.0 PI3K 0.025 0.052 -9999.0 0.0 -0.285 9.0 9.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.024 0.121 -9999.0 0.0 -0.403 31.0 31.0 somite specification -0.106 0.187 -9999.0 0.0 -0.372 103.0 103.0 SHH Np/Cholesterol/PTCH1 -0.087 0.151 -9999.0 0.0 -0.286 105.0 105.0 SHH Np/Cholesterol/PTCH2 -0.021 0.092 -9999.0 0.0 -0.244 47.0 47.0 SHH Np/Cholesterol/Megalin -0.058 0.113 -9999.0 0.0 -0.249 83.0 83.0 SHH -0.035 0.103 -9999.0 0.0 -0.302 44.0 44.0 catabolic process -0.076 0.15 -9999.0 0.0 -0.287 110.0 110.0 SMO/Vitamin D3 -0.083 0.195 -9999.0 0.0 -0.342 106.0 106.0 SHH Np/Cholesterol/Hhip -0.048 0.115 -9999.0 0.0 -0.255 77.0 77.0 LRP2 -0.071 0.154 -9999.0 0.0 -0.403 60.0 60.0 receptor-mediated endocytosis -0.119 0.196 -9999.0 0.0 -0.424 73.0 73.0 SHH Np/Cholesterol/BOC -0.02 0.088 -9999.0 0.0 -0.236 46.0 46.0 SHH Np/Cholesterol/CDO -0.019 0.092 -9999.0 0.0 -0.248 45.0 45.0 mesenchymal cell differentiation 0.048 0.114 0.253 77.0 -9999.0 0.0 77.0 mol:Vitamin D3 -0.065 0.175 0.205 34.0 -0.29 102.0 136.0 IHH N/PTCH2 -0.059 0.142 -9999.0 0.0 -0.27 106.0 106.0 CDON 0.017 0.052 -9999.0 0.0 -0.403 5.0 5.0 IHH N/PTCH1 -0.074 0.16 -9999.0 0.0 -0.284 121.0 121.0 Megalin/LRPAP1 -0.038 0.116 -9999.0 0.0 -0.285 60.0 60.0 PTCH2 0.011 0.072 -9999.0 0.0 -0.403 10.0 10.0 SHH Np/Cholesterol -0.022 0.08 -9999.0 0.0 -0.228 44.0 44.0 PTCH1 -0.076 0.151 -9999.0 0.0 -0.288 110.0 110.0 HHIP -0.042 0.147 -9999.0 0.0 -0.403 50.0 50.0