		Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
TP53	34 (15%)	191	0.16762	1	0.026897	1	0.35597	1	0.15873	1	0.09957	1	0.24559	1	0.39214	1	0.15338	1
BRAF	115 (51%)	110	9.5946e-08	9.84e-05	0.05716	1	0.017402	1	0.0073078	1	0.0049551	1	4.6664e-05	0.0478	0.083098	1	0.17324	1
C15ORF23	14 (6%)	211	0.10437	1	0.21493	1	0.83814	1	0.81515	1	0.93974	1	0.058114	1	0.82482	1	0.91992	1
CDKN2A	31 (14%)	194	0.15341	1	0.27522	1	0.4169	1	0.77049	1	0.78295	1	0.15053	1	0.82283	1	1	1
NRAS	65 (29%)	160	0.00052961	0.542	0.038322	1	0.089874	1	0.32086	1	0.86672	1	0.47767	1	0.73878	1	0.86299	1
OXA1L	6 (3%)	219	0.28761	1	0.58248	1	0.61661	1	0.47481	1	0.68128	1	0.1824	1	0.11907	1	0.35483	1
STK19	10 (4%)	215	0.92075	1	0.13301	1	0.23766	1	0.99927	1	0.78084	1	0.69494	1	0.83908	1	0.78875	1
PTEN	18 (8%)	207	0.67418	1	0.24327	1	0.14881	1	0.1352	1	1	1	0.12464	1	0.76978	1	0.33327	1
RAC1	16 (7%)	209	0.76275	1	0.9456	1	0.94048	1	0.4504	1	0.46713	1	1	1	0.44121	1	0.11197	1
ACSM2B	36 (16%)	189	0.45378	1	0.43622	1	0.81548	1	0.4015	1	0.37516	1	0.37743	1	0.065931	1	0.66053	1
CADM2	22 (10%)	203	0.66046	1	0.17467	1	0.15346	1	0.35266	1	1	1	0.24617	1	0.43446	1	0.022726	1
OR51S1	26 (12%)	199	0.36561	1	0.64876	1	0.89774	1	0.11298	1	0.54513	1	0.49798	1	0.68734	1	0.90734	1
LCE1B	13 (6%)	212	0.15827	1	0.62646	1	0.22113	1	0.89236	1	0.51723	1	0.56424	1	1	1	0.9153	1
IDH1	11 (5%)	214	0.36724	1	0.17994	1	0.10374	1	0.28059	1	0.5407	1	0.84973	1	0.096421	1	0.13292	1
TAF1A	14 (6%)	211	0.44865	1	0.69178	1	0.44606	1	0.054988	1	0.54642	1	0.19599	1	0.40066	1	0.91992	1
NAP1L2	21 (9%)	204	0.60081	1	0.73965	1	0.78954	1	0.80931	1	0.84384	1	0.54771	1	0.38584	1	1	1
MUC7	19 (8%)	206	1	1	0.46799	1	0.14324	1	0.70607	1	0.50493	1	0.26109	1	0.17049	1	0.075753	1
PPP6C	17 (8%)	208	0.50806	1	0.37064	1	0.095201	1	0.77953	1	0.51549	1	0.36399	1	0.099551	1	0.10796	1
FRG2B	17 (8%)	208	1	1	0.77279	1	0.97516	1	0.99688	1	0.60215	1	0.60385	1	0.84755	1	0.44533	1
USP29	35 (16%)	190	0.91974	1	0.9455	1	0.88257	1	0.7195	1	0.97173	1	1	1	0.70238	1	0.60755	1
PRB4	18 (8%)	207	0.38497	1	0.64303	1	0.13661	1	0.19099	1	0.015215	1	0.18358	1	0.66182	1	0.23804	1
HIST1H2AA	10 (4%)	215	0.3627	1	0.71234	1	0.65519	1	0.72061	1	0.2534	1	0.83739	1	0.15404	1	0.3308	1
RPTN	38 (17%)	187	0.33216	1	0.16719	1	0.37959	1	0.36663	1	0.0271	1	0.38207	1	0.36817	1	0.46941	1
ZNF479	22 (10%)	203	0.72115	1	1	1	0.74139	1	0.11208	1	0.65227	1	0.79378	1	0.055886	1	0.53807	1
C8A	26 (12%)	199	0.70142	1	0.083537	1	0.30192	1	0.39362	1	0.10009	1	0.7636	1	0.057958	1	0.17114	1
FUT9	22 (10%)	203	0.28817	1	0.038679	1	0.48684	1	0.84998	1	0.47706	1	0.096177	1	0.25368	1	0.71073	1
ZNF679	18 (8%)	207	0.5583	1	0.78041	1	0.63207	1	0.67328	1	0.1967	1	0.52655	1	0.34857	1	0.53628	1
NRK	28 (12%)	197	0.90428	1	0.90374	1	0.63199	1	0.30302	1	0.26204	1	1	1	0.54707	1	0.83533	1
CDH9	32 (14%)	193	0.88784	1	0.14053	1	0.25142	1	0.57663	1	0.78928	1	0.63376	1	0.00063419	0.649	0.30143	1
PRAMEF11	21 (9%)	204	0.80797	1	0.058473	1	0.93714	1	0.95985	1	0.14481	1	0.60048	1	0.58194	1	0.79081	1
DDX3X	18 (8%)	207	0.58555	1	0.95308	1	0.22927	1	0.17407	1	0.37545	1	0.52655	1	0.90251	1	0.27429	1
GRXCR1	18 (8%)	207	0.90877	1	0.067023	1	0.41596	1	0.94992	1	0.044334	1	0.94863	1	0.33033	1	0.27429	1
PRB2	29 (13%)	196	0.55476	1	0.57207	1	0.77334	1	0.74067	1	0.010563	1	0.22411	1	0.22302	1	0.21302	1
ELF5	7 (3%)	218	0.71075	1	1	1	0.93308	1	0.52135	1	0.39837	1	0.603	1	0.15359	1	0.19723	1
IL32	9 (4%)	216	0.39171	1	0.11426	1	0.68976	1	0.14866	1	0.76151	1	0.90467	1	0.74763	1	0.88108	1
LUZP2	19 (8%)	206	1	1	0.46799	1	0.20488	1	0.75752	1	1	1	0.32506	1	0.092607	1	0.32726	1
PDE1A	30 (13%)	195	0.49807	1	0.90905	1	0.52333	1	0.38376	1	0.032054	1	0.47062	1	0.71388	1	0.050573	1
RBM11	12 (5%)	213	0.18569	1	0.059947	1	0.79259	1	0.87229	1	0.70426	1	0.081152	1	0.31417	1	0.55973	1
GLRB	22 (10%)	203	0.25537	1	0.5125	1	0.053194	1	0.032994	1	0.38946	1	0.02851	1	0.49613	1	0.16384	1
PRB1	21 (9%)	204	0.50282	1	0.62274	1	0.12694	1	0.089679	1	0.33801	1	0.18308	1	0.72635	1	0.48856	1
KIAA1257	14 (6%)	211	0.42016	1	1	1	0.6373	1	0.77513	1	0.93974	1	0.93668	1	0.2112	1	0.50786	1
USP17L2	18 (8%)	207	0.261	1	0.11013	1	0.18531	1	0.26038	1	0.044334	1	0.14663	1	0.53515	1	0.81741	1
SPAG16	16 (7%)	209	0.48679	1	1	1	0.13249	1	0.28869	1	0.058196	1	0.01767	1	0.11242	1	0.27235	1
OR4M2	22 (10%)	203	1	1	0.95972	1	0.067813	1	0.4546	1	0.35673	1	0.87611	1	0.1911	1	0.63877	1
GFRAL	28 (12%)	197	0.34034	1	0.30492	1	0.681	1	0.76374	1	0.84674	1	0.035524	1	0.7283	1	0.79858	1
UNC119B	6 (3%)	219	0.44842	1	0.39786	1	0.21512	1	0.91489	1	0.37934	1	0.27021	1	1	1	0.44425	1
PHGDH	8 (4%)	217	0.66823	1	1	1	1	1	0.42468	1	0.90361	1	0.89408	1	0.51625	1	0.40591	1
STXBP5L	42 (19%)	183	0.37026	1	0.92963	1	0.83685	1	0.61675	1	0.14536	1	0.42234	1	0.23541	1	0.76775	1
TRAT1	12 (5%)	213	0.93195	1	0.36494	1	0.73237	1	0.6789	1	0.34043	1	0.77999	1	0.47216	1	0.55973	1
ZNF844	9 (4%)	216	1	1	1	1	0.65519	1	0.91489	1	0.90361	1	1	1	0.90955	1	0.77735	1
TTN	171 (76%)	54	0.40255	1	0.019848	1	0.41453	1	0.091227	1	0.077166	1	0.24922	1	0.20356	1	0.13675	1
COPG2	9 (4%)	216	0.31924	1	0.91442	1	0.28667	1	0.25113	1	0.76151	1	1	1	0.74763	1	0.77735	1
DSG3	41 (18%)	184	0.53997	1	0.97578	1	0.78194	1	0.30194	1	0.70999	1	0.85309	1	0.23627	1	0.71509	1
GML	9 (4%)	216	0.17649	1	0.38693	1	0.94036	1	0.41776	1	0.91352	1	0.35795	1	0.24707	1	0.77735	1
HHLA2	14 (6%)	211	0.10437	1	0.4699	1	0.43389	1	0.0037974	1	1	1	0.31754	1	0.19564	1	0.64577	1
LILRB4	27 (12%)	198	0.21397	1	1	1	0.22443	1	0.66839	1	0.46801	1	0.33607	1	0.59852	1	0.46948	1
SLC38A4	25 (11%)	200	0.008452	1	0.77174	1	0.98339	1	0.9622	1	0.048878	1	0.27624	1	0.43859	1	0.60057	1
OR2L3	14 (6%)	211	0.60895	1	0.014789	1	0.7448	1	0.46765	1	0.83878	1	0.36207	1	0.77091	1	0.35996	1
HBD	9 (4%)	216	0.58016	1	1	1	0.83208	1	0.24089	1	0.053919	1	0.096078	1	0.40959	1	1	1
TBC1D3B	5 (2%)	220	0.22606	1	0.74505	1	0.060642	1	0.25787	1	0.8614	1	1	1	0.844	1	0.63804	1
TCEB3C	26 (12%)	199	0.52371	1	0.3127	1	0.34342	1	0.54305	1	0.1818	1	0.13679	1	0.35854	1	0.32136	1
CYLC2	19 (8%)	206	0.35359	1	0.56877	1	0.093435	1	0.12103	1	0.19708	1	0.2503	1	0.28226	1	0.45253	1
HBG2	7 (3%)	218	0.33997	1	0.55836	1	0.23446	1	0.33919	1	0.29878	1	0.78509	1	0.25043	1	0.28923	1
LOC649330	22 (10%)	203	0.24474	1	0.47167	1	0.7912	1	0.75565	1	0.0845	1	0.7331	1	0.84056	1	0.67427	1
FIGLA	3 (1%)	222	0.63189	1	0.62791	1	NA	NA	NA	NA	0.51638	1	0.43363	1	0.42752	1	0.69312	1
PARM1	17 (8%)	208	0.85564	1	1	1	0.72566	1	0.13108	1	0.8631	1	0.60385	1	0.23564	1	0.41698	1
CCK	6 (3%)	219	0.58397	1	0.66194	1	0.32162	1	0.072431	1	0.51737	1	1	1	0.57806	1	0.70209	1
ZFP106	10 (4%)	215	0.84963	1	0.77653	1	0.26377	1	0.26395	1	0.61127	1	0.76131	1	0.13952	1	0.5733	1
UGT2B15	19 (8%)	206	0.33632	1	0.38239	1	0.76688	1	0.73423	1	0.47275	1	0.74008	1	0.34768	1	0.72784	1
FGF16	7 (3%)	218	1	1	0.89714	1	0.0047925	1	0.014242	1	1	1	0.78509	1	0.12717	1	0.86567	1
NUDT4	5 (2%)	220	1	1	0.37488	1	0.36102	1	0.14505	1	1	1	0.84122	1	0.35575	1	0.48925	1
DSG1	37 (16%)	188	0.60359	1	0.52441	1	0.084114	1	0.057477	1	0.39245	1	0.59538	1	0.6927	1	0.23428	1
ARL16	7 (3%)	218	0.18005	1	0.34357	1	0.13983	1	0.6493	1	0.51169	1	0.603	1	0.78922	1	0.86567	1
VEGFC	16 (7%)	209	0.64913	1	0.1435	1	0.34852	1	0.025517	1	0.16667	1	0.3182	1	0.026446	1	0.077519	1
PSG4	23 (10%)	202	0.48903	1	0.96096	1	0.42552	1	0.38712	1	0.55492	1	0.95833	1	0.14944	1	0.11103	1
DEFB119	6 (3%)	219	1	1	0.77077	1	0.49345	1	0.88457	1	0.87545	1	0.64219	1	0.43515	1	1	1
KLHL4	20 (9%)	205	0.79937	1	0.53211	1	0.76225	1	0.86292	1	0.22411	1	0.038636	1	0.90904	1	0.34232	1
EIF3D	4 (2%)	221	0.83167	1	0.83668	1	0.24582	1	0.43577	1	1	1	0.35828	1	0.53777	1	0.43994	1
OR2W1	16 (7%)	209	0.15672	1	0.71898	1	0.24411	1	0.088793	1	0.71095	1	1	1	0.66499	1	0.80038	1
OR4N2	21 (9%)	204	0.3404	1	0.14391	1	0.6395	1	0.36353	1	0.023709	1	0.43343	1	0.16512	1	0.024889	1
CCDC11	17 (8%)	208	0.90315	1	0.064408	1	0.26486	1	0.2116	1	0.10589	1	0.18885	1	0.0042583	1	0.93284	1
LIN7A	10 (4%)	215	0.92075	1	0.26747	1	0.55574	1	0.64788	1	0.17747	1	0.5845	1	0.012651	1	0.3887	1
RAPGEF5	11 (5%)	214	1	1	0.45923	1	0.60379	1	0.49445	1	0.34043	1	0.51797	1	0.12942	1	0.05587	1
CD2	16 (7%)	209	0.39511	1	0.57866	1	0.77572	1	0.51583	1	1	1	0.70194	1	0.46929	1	0.68141	1
C2ORF40	7 (3%)	218	0.23607	1	0.798	1	0.94036	1	0.7248	1	0.51169	1	0.89052	1	0.88496	1	0.73535	1
SGCZ	19 (8%)	206	0.62584	1	0.62524	1	0.86565	1	0.70019	1	0.37428	1	0.27774	1	0.86466	1	0.7761	1
SPANXN2	14 (6%)	211	0.28311	1	0.69178	1	0.58421	1	0.17084	1	0.42697	1	0.083137	1	0.4272	1	0.19954	1
TLL1	42 (19%)	183	0.97605	1	0.018293	1	0.6177	1	0.042055	1	0.060768	1	0.24298	1	0.58477	1	0.43387	1
C9ORF119	7 (3%)	218	1	1	0.1776	1	0.47567	1	0.56303	1	0.39837	1	0.46442	1	0.61012	1	0.86567	1
CCDC54	13 (6%)	212	0.081183	1	0.33374	1	0.29449	1	0.86254	1	0.13032	1	0.082378	1	0.25333	1	0.75844	1
DEFB118	8 (4%)	217	0.19663	1	0.31557	1	0.93308	1	0.26947	1	0.74127	1	0.72737	1	0.72222	1	0.87124	1
HTR3B	16 (7%)	209	0.016933	1	0.13495	1	0.026117	1	0.05977	1	0.00073963	0.756	0.15419	1	0.36834	1	0.11197	1
MARCH11	10 (4%)	215	0.84963	1	1	1	0.37779	1	0.72061	1	0.17747	1	0.1018	1	0.91481	1	0.89306	1
MKX	14 (6%)	211	0.13948	1	0.20003	1	0.58305	1	0.97102	1	0.065626	1	0.15522	1	0.052586	1	0.29366	1
OR5H2	14 (6%)	211	0.78336	1	1	1	0.45805	1	0.51845	1	0.83878	1	0.41503	1	0.6335	1	0.29366	1
SIGLEC14	11 (5%)	214	0.36724	1	0.33836	1	0.035758	1	0.46418	1	0.58184	1	0.92342	1	0.616	1	0.89634	1
TUBB8	12 (5%)	213	0.7037	1	0.86673	1	0.21413	1	0.13784	1	0.5407	1	0.65885	1	0.55195	1	0.10837	1
ZIM3	23 (10%)	202	0.19414	1	0.14008	1	0.67513	1	0.43126	1	0.076062	1	0.17455	1	0.15656	1	0.71731	1
PRC1	13 (6%)	212	0.9377	1	0.41954	1	0.056371	1	0.71626	1	0.22921	1	0.65487	1	0.50164	1	0.6375	1
MUM1L1	25 (11%)	200	0.55488	1	0.80154	1	0.73829	1	0.091809	1	0.64413	1	0.43115	1	0.51743	1	0.81593	1
TRIM58	15 (7%)	210	0.5613	1	0.89082	1	0.81512	1	0.86076	1	0.63692	1	0.73085	1	0.25045	1	1	1
ANKRD20A4	4 (2%)	221	0.38535	1	0.45433	1	0.32162	1	0.13465	1	0.10876	1	0.67884	1	0.53777	1	1	1
OR5J2	13 (6%)	212	0.63308	1	0.55002	1	0.31161	1	0.4999	1	1	1	0.65487	1	0.036594	1	0.6375	1
CLEC14A	18 (8%)	207	0.04246	1	0.49542	1	0.1432	1	0.48327	1	0.21581	1	0.72794	1	0.66182	1	0.93459	1
FAM19A1	8 (4%)	217	0.15606	1	0.38625	1	0.45835	1	0.11246	1	0.48738	1	1	1	0.90352	1	0.56897	1
GK2	28 (12%)	197	0.79191	1	0.60282	1	0.32804	1	0.1868	1	0.37879	1	0.48525	1	0.38176	1	0.87249	1
LONRF2	16 (7%)	209	0.89763	1	0.34259	1	0.94532	1	0.98763	1	0.89866	1	1	1	0.89262	1	0.50419	1
HAPLN1	11 (5%)	214	1	1	0.095855	1	0.77155	1	0.88158	1	0.92594	1	0.77999	1	0.47787	1	0.59449	1
NAP1L4	9 (4%)	216	0.020453	1	0.04602	1	0.035758	1	0.59993	1	0.6335	1	0.32289	1	0.74763	1	0.88108	1
CLCC1	13 (6%)	212	0.9377	1	0.36086	1	0.53285	1	0.1437	1	0.11164	1	0.2336	1	0.043986	1	0.58099	1
OR52J3	13 (6%)	212	0.30101	1	0.27768	1	0.36701	1	0.46386	1	0.51723	1	0.93125	1	1	1	0.17138	1
TMCO5A	8 (4%)	217	0.0088529	1	0.46957	1	0.16386	1	0.095561	1	0.034901	1	0.26124	1	0.90352	1	0.76146	1
C4ORF22	11 (5%)	214	0.63313	1	0.92527	1	0.59267	1	0.28125	1	0.92594	1	0.84973	1	0.045162	1	0.29688	1
MAP2K1	11 (5%)	214	0.15694	1	0.065751	1	0.055753	1	0.12432	1	0.0669	1	0.0056506	1	0.47787	1	0.42362	1
OR7D2	17 (8%)	208	0.5347	1	0.35045	1	0.77805	1	0.83786	1	0.031727	1	1	1	0.46087	1	0.75117	1
CXCR2	11 (5%)	214	0.85951	1	0.49473	1	0.86642	1	0.95232	1	0.5407	1	1	1	0.616	1	0.89634	1
RBM22	7 (3%)	218	0.44156	1	0.1776	1	NA	NA	NA	NA	0.39837	1	0.46442	1	1	1	0.86567	1
CX3CL1	4 (2%)	221	0.14298	1	0.13935	1	NA	NA	NA	NA	1	1	0.67884	1	0.076818	1	0.43994	1
IGF2BP3	6 (3%)	219	0.87926	1	1	1	0.86833	1	0.64558	1	0.51737	1	0.87488	1	0.14718	1	0.8439	1
KLRC3	10 (4%)	215	1	1	0.55826	1	0.51662	1	0.011316	1	0.61127	1	0.11299	1	0.44278	1	1	1
LRRIQ4	19 (8%)	206	0.19982	1	0.095723	1	0.11068	1	0.35677	1	0.86268	1	0.8535	1	0.17049	1	0.0085253	1
NR1H4	11 (5%)	214	0.26348	1	0.33836	1	0.37364	1	0.36239	1	0.92594	1	0.92342	1	0.72915	1	0.42362	1
OR4A15	21 (9%)	204	0.43707	1	0.32096	1	1	1	0.20157	1	0.025852	1	0.29472	1	0.28984	1	0.27835	1
MAGEA4	10 (4%)	215	0.39768	1	0.55826	1	0.01435	1	0.35295	1	0.17747	1	0.26359	1	0.64864	1	0.71119	1
DGAT2L6	10 (4%)	215	0.50849	1	0.71234	1	0.85315	1	0.11049	1	0.30413	1	0.5845	1	0.48388	1	0.3887	1
RGS18	8 (4%)	217	0.35006	1	0.89934	1	0.12159	1	0.40267	1	0.35785	1	0.72737	1	0.41941	1	0.66471	1
TSGA13	9 (4%)	216	0.52999	1	0.57919	1	0.11789	1	0.33261	1	0.6335	1	0.55349	1	0.6157	1	0.68892	1
OPN5	7 (3%)	218	0.20775	1	0.89714	1	1	1	0.34283	1	0.51169	1	0.603	1	1	1	0.86567	1
SPINK13	7 (3%)	218	0.29909	1	0.23271	1	0.89235	1	0.45681	1	0.29878	1	0.68521	1	0.53416	1	0.51601	1
