Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.11 0.251 -9999.0 0.0 -0.738 13.0 13.0 IHH -0.082 0.165 -9999.0 0.0 -0.403 24.0 24.0 SHH Np/Cholesterol/GAS1 -0.157 0.223 -9999.0 0.0 -0.464 37.0 37.0 LRPAP1 0.009 0.035 -9999.0 0.0 -0.381 1.0 1.0 dorsoventral neural tube patterning 0.156 0.222 0.46 37.0 -9999.0 0.0 37.0 SMO/beta Arrestin2 -0.09 0.178 -9999.0 0.0 -0.513 11.0 11.0 SMO -0.101 0.187 -9999.0 0.0 -0.534 12.0 12.0 AKT1 -0.029 0.083 -9999.0 0.0 -0.304 2.0 2.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.01 0.099 -9999.0 0.0 -0.43 6.0 6.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.1 0.184 -9999.0 0.0 -0.524 12.0 12.0 STIL -0.122 0.18 -9999.0 0.0 -0.433 20.0 20.0 DHH N/PTCH2 -0.039 0.158 -9999.0 0.0 -0.47 14.0 14.0 DHH N/PTCH1 -0.073 0.158 -9999.0 0.0 -0.435 15.0 15.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.023 0.149 -9999.0 0.0 -0.679 6.0 6.0 PTHLH -0.162 0.364 -9999.0 0.0 -1.094 13.0 13.0 determination of left/right symmetry -0.1 0.184 -9999.0 0.0 -0.524 12.0 12.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.159 0.356 -9999.0 0.0 -1.071 13.0 13.0 IHH N/Hhip -0.134 0.214 -9999.0 0.0 -0.423 37.0 37.0 DHH N/Hhip -0.102 0.207 -9999.0 0.0 -0.406 34.0 34.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.1 0.184 -9999.0 0.0 -0.524 12.0 12.0 pancreas development -0.117 0.235 -9999.0 0.0 -0.509 30.0 30.0 HHAT 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.116 0.254 -9999.0 0.0 -0.587 26.0 26.0 somite specification -0.1 0.184 -9999.0 0.0 -0.524 12.0 12.0 SHH Np/Cholesterol/PTCH1 -0.135 0.188 -9999.0 0.0 -0.422 29.0 29.0 SHH Np/Cholesterol/PTCH2 -0.108 0.185 -9999.0 0.0 -0.412 29.0 29.0 SHH Np/Cholesterol/Megalin -0.125 0.193 -9999.0 0.0 -0.453 25.0 25.0 SHH -0.118 0.205 -9999.0 0.0 -0.506 22.0 22.0 catabolic process -0.066 0.15 -9999.0 0.0 -0.468 10.0 10.0 SMO/Vitamin D3 -0.143 0.201 -9999.0 0.0 -0.484 21.0 21.0 SHH Np/Cholesterol/Hhip -0.157 0.224 -9999.0 0.0 -0.463 37.0 37.0 LRP2 -0.062 0.178 -9999.0 0.0 -0.459 19.0 19.0 receptor-mediated endocytosis -0.16 0.206 -9999.0 0.0 -0.503 25.0 25.0 SHH Np/Cholesterol/BOC -0.096 0.17 -9999.0 0.0 -0.409 23.0 23.0 SHH Np/Cholesterol/CDO -0.105 0.184 -9999.0 0.0 -0.422 26.0 26.0 mesenchymal cell differentiation 0.155 0.222 0.459 37.0 -9999.0 0.0 37.0 mol:Vitamin D3 -0.134 0.189 -9999.0 0.0 -0.461 20.0 20.0 IHH N/PTCH2 -0.067 0.151 -9999.0 0.0 -0.499 8.0 8.0 CDON -0.023 0.145 -9999.0 0.0 -0.594 7.0 7.0 IHH N/PTCH1 -0.067 0.152 -9999.0 0.0 -0.473 10.0 10.0 Megalin/LRPAP1 -0.037 0.132 -9999.0 0.0 -0.505 5.0 5.0 PTCH2 -0.028 0.156 -9999.0 0.0 -0.604 8.0 8.0 SHH Np/Cholesterol -0.098 0.157 -9999.0 0.0 -0.4 22.0 22.0 PTCH1 -0.067 0.151 -9999.0 0.0 -0.47 10.0 10.0 HHIP -0.118 0.236 -9999.0 0.0 -0.51 30.0 30.0