Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.011 0.073 -9999.0 0.0 -0.287 7.0 7.0 epithelial cell differentiation -0.021 0.084 -9999.0 0.0 -0.361 7.0 7.0 CYFIP2 -0.017 0.132 -9999.0 0.0 -0.58 6.0 6.0 ENAH 0.03 0.096 -9999.0 0.0 -0.469 2.0 2.0 EGFR -0.05 0.18 -9999.0 0.0 -0.53 14.0 14.0 EPHA2 -0.016 0.137 -9999.0 0.0 -0.679 5.0 5.0 MYO6 0.013 0.087 -9999.0 0.0 -0.341 7.0 7.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.006 0.085 -9999.0 0.0 -0.429 4.0 4.0 AQP5 -0.028 0.08 -9999.0 0.0 -0.412 2.0 2.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.013 0.086 -9999.0 0.0 -0.336 7.0 7.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.123 -9999.0 0.0 -0.352 12.0 12.0 EGF -0.064 0.165 -9999.0 0.0 -0.408 22.0 22.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.104 0.222 -9999.0 0.0 -0.611 18.0 18.0 cortical microtubule organization -0.021 0.084 -9999.0 0.0 -0.361 7.0 7.0 GO:0000145 0.012 0.082 -9999.0 0.0 -0.321 7.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.007 0.092 -9999.0 0.0 -0.365 7.0 7.0 MLLT4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.033 0.116 -9999.0 0.0 -0.712 2.0 2.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.006 0.11 -9999.0 0.0 -0.449 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.022 0.086 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.001 0.088 -9999.0 0.0 -0.679 2.0 2.0 ZYX 0.01 0.093 -9999.0 0.0 -0.342 8.0 8.0 ARF6/GTP -0.022 0.095 -9999.0 0.0 -0.413 6.0 6.0 CDH1 -0.027 0.161 -9999.0 0.0 -0.679 7.0 7.0 EGFR/EGFR/EGF/EGF -0.075 0.138 -9999.0 0.0 -0.401 14.0 14.0 RhoA/GDP -0.019 0.078 -9999.0 0.0 -0.337 7.0 7.0 actin cytoskeleton organization 0.016 0.089 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer -0.022 0.149 -9999.0 0.0 -0.678 6.0 6.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.022 0.15 -9999.0 0.0 -0.679 6.0 6.0 IGF1 -0.111 0.228 -9999.0 0.0 -0.49 30.0 30.0 DIAPH1 -0.024 0.112 -9999.0 0.0 -0.624 4.0 4.0 Wnt receptor signaling pathway 0.021 0.084 0.361 7.0 -9999.0 0.0 7.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.033 0.116 -9999.0 0.0 -0.711 2.0 2.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.016 0.091 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 -0.002 0.094 -9999.0 0.0 -0.58 3.0 3.0 LPP 0.019 0.084 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.039 0.135 -9999.0 0.0 -0.419 11.0 11.0 SEC6/SEC8 -0.022 0.077 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.022 0.125 -9999.0 0.0 -0.358 12.0 12.0 HGF/MET -0.067 0.131 -9999.0 0.0 -0.494 3.0 3.0 HGF -0.092 0.221 -9999.0 0.0 -0.517 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.011 0.074 -9999.0 0.0 -0.289 7.0 7.0 actin cable formation 0.043 0.089 -9999.0 0.0 -0.347 3.0 3.0 KIAA1543 -0.015 0.184 -9999.0 0.0 -0.79 5.0 5.0 KIFC3 0.01 0.093 -9999.0 0.0 -0.342 8.0 8.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.013 0.087 -9999.0 0.0 -0.341 7.0 7.0 NCK1/GIT1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.021 0.084 -9999.0 0.0 -0.361 7.0 7.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.013 0.087 -9999.0 0.0 -0.341 7.0 7.0 PIP5K1C 0.013 0.087 -9999.0 0.0 -0.341 7.0 7.0 LIMA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.023 0.112 -9999.0 0.0 -0.585 2.0 2.0 adherens junction assembly -0.003 0.178 -9999.0 0.0 -0.678 6.0 6.0 IGF-1R heterotetramer/IGF1 -0.087 0.15 -9999.0 0.0 -0.532 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.01 0.066 -9999.0 0.0 -0.505 2.0 2.0 MET 0.007 0.062 -9999.0 0.0 -0.679 1.0 1.0 PLEKHA7 -0.008 0.151 -9999.0 0.0 -0.486 10.0 10.0 mol:GTP 0.005 0.109 -9999.0 0.0 -0.446 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.031 0.088 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.011 0.073 -9999.0 0.0 -0.287 7.0 7.0 regulation of cell-cell adhesion 0.016 0.089 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.011 0.074 -9999.0 0.0 -0.289 7.0 7.0