Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.014 0.188 -9999.0 0.0 -0.59 11.0 11.0 IHH 0.034 0.055 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.055 0.133 -9999.0 0.0 -0.284 29.0 29.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.054 0.133 0.283 29.0 -9999.0 0.0 29.0 SMO/beta Arrestin2 -0.028 0.151 -9999.0 0.0 -0.513 5.0 5.0 SMO -0.039 0.152 -9999.0 0.0 -0.418 10.0 10.0 AKT1 -0.015 0.111 -9999.0 0.0 -0.364 6.0 6.0 ARRB2 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.028 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.038 0.149 -9999.0 0.0 -0.412 10.0 10.0 STIL -0.047 0.116 -9999.0 0.0 -0.255 19.0 19.0 DHH N/PTCH2 0.001 0.117 -9999.0 0.0 -0.351 12.0 12.0 DHH N/PTCH1 0.002 0.112 -9999.0 0.0 -0.273 16.0 16.0 PIK3CA 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.003 0.11 -9999.0 0.0 -0.482 6.0 6.0 PTHLH -0.049 0.28 -9999.0 0.0 -0.911 11.0 11.0 determination of left/right symmetry -0.038 0.149 -9999.0 0.0 -0.412 10.0 10.0 PIK3R1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.048 0.276 -9999.0 0.0 -0.898 11.0 11.0 IHH N/Hhip -0.001 0.14 -9999.0 0.0 -0.387 13.0 13.0 DHH N/Hhip -0.02 0.148 -9999.0 0.0 -0.366 18.0 18.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.038 0.149 -9999.0 0.0 -0.412 10.0 10.0 pancreas development -0.026 0.16 -9999.0 0.0 -0.482 13.0 13.0 HHAT 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.036 0.015 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.018 0.148 -9999.0 0.0 -0.482 11.0 11.0 somite specification -0.038 0.149 -9999.0 0.0 -0.412 10.0 10.0 SHH Np/Cholesterol/PTCH1 -0.039 0.124 -9999.0 0.0 -0.251 29.0 29.0 SHH Np/Cholesterol/PTCH2 -0.038 0.127 -9999.0 0.0 -0.282 25.0 25.0 SHH Np/Cholesterol/Megalin -0.035 0.129 -9999.0 0.0 -0.292 23.0 23.0 SHH -0.064 0.129 -9999.0 0.0 -0.351 20.0 20.0 catabolic process 0.004 0.105 -9999.0 0.0 -0.319 11.0 11.0 SMO/Vitamin D3 -0.05 0.144 -9999.0 0.0 -0.362 11.0 11.0 SHH Np/Cholesterol/Hhip -0.055 0.148 -9999.0 0.0 -0.306 29.0 29.0 LRP2 0.008 0.104 -9999.0 0.0 -0.482 5.0 5.0 receptor-mediated endocytosis -0.062 0.153 -9999.0 0.0 -0.446 9.0 9.0 SHH Np/Cholesterol/BOC -0.022 0.107 -9999.0 0.0 -0.272 18.0 18.0 SHH Np/Cholesterol/CDO -0.032 0.119 -9999.0 0.0 -0.284 21.0 21.0 mesenchymal cell differentiation 0.055 0.147 0.304 29.0 -9999.0 0.0 29.0 mol:Vitamin D3 -0.034 0.13 0.364 1.0 -0.251 29.0 30.0 IHH N/PTCH2 0.021 0.1 -9999.0 0.0 -0.382 6.0 6.0 CDON 0.015 0.08 -9999.0 0.0 -0.482 3.0 3.0 IHH N/PTCH1 0.017 0.11 -9999.0 0.0 -0.321 11.0 11.0 Megalin/LRPAP1 0.028 0.073 -9999.0 0.0 -0.351 4.0 4.0 PTCH2 0.003 0.111 -9999.0 0.0 -0.482 6.0 6.0 SHH Np/Cholesterol -0.04 0.102 -9999.0 0.0 -0.269 20.0 20.0 PTCH1 0.004 0.105 -9999.0 0.0 -0.32 11.0 11.0 HHIP -0.026 0.16 -9999.0 0.0 -0.482 13.0 13.0