E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.038 0.15 -9999.0 0.0 -0.432 44.0 44.0 KLHL20 0.042 0.115 0.307 41.0 -0.259 14.0 55.0 CYFIP2 0.05 0.047 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.001 0.118 0.312 7.0 -0.301 26.0 33.0 ENAH -0.033 0.143 -9999.0 0.0 -0.431 37.0 37.0 AP1M1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.052 -9999.0 0.0 -0.544 4.0 4.0 CDC42/GTP 0.009 0.076 -9999.0 0.0 -0.276 3.0 3.0 ABI1/Sra1/Nap1 -0.016 0.04 -9999.0 0.0 -0.172 14.0 14.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.049 0.095 -9999.0 0.0 -0.311 26.0 26.0 RAPGEF1 -0.031 0.143 0.311 2.0 -0.398 40.0 42.0 CTNND1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.032 0.164 -9999.0 0.0 -0.439 51.0 51.0 CRK -0.028 0.145 0.346 1.0 -0.418 44.0 45.0 E-cadherin/gamma catenin/alpha catenin 0.037 0.089 -9999.0 0.0 -0.344 21.0 21.0 alphaE/beta7 Integrin 0.046 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.055 0.042 -9999.0 0.0 -0.31 3.0 3.0 DLG1 -0.041 0.159 -9999.0 0.0 -0.431 50.0 50.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.021 0.061 -9999.0 0.0 -0.201 13.0 13.0 MLLT4 0.029 0.046 -9999.0 0.0 -0.543 3.0 3.0 ARF6/GTP/NME1/Tiam1 0.058 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.022 0.081 -9999.0 0.0 -0.26 13.0 13.0 ARF6 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.02 0.095 -9999.0 0.0 -0.317 33.0 33.0 TIAM1 0.035 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.046 0.089 -9999.0 0.0 -0.293 26.0 26.0 AKT1 -0.007 0.057 -9999.0 0.0 -0.197 1.0 1.0 PIK3R1 -0.02 0.166 -9999.0 0.0 -0.544 47.0 47.0 CDH1 0.006 0.118 -9999.0 0.0 -0.544 22.0 22.0 RhoA/GDP -0.0 0.117 0.305 7.0 -0.302 25.0 32.0 actin cytoskeleton organization 0.037 0.094 0.257 43.0 -0.188 13.0 56.0 CDC42/GDP -0.0 0.117 0.305 7.0 -0.302 25.0 32.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.004 0.067 -9999.0 0.0 -0.252 24.0 24.0 ITGB7 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.05 0.096 -9999.0 0.0 -0.312 26.0 26.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.032 0.082 -9999.0 0.0 -0.291 26.0 26.0 mol:GDP -0.019 0.124 0.309 7.0 -0.338 33.0 40.0 CDC42/GTP/IQGAP1 0.043 0.013 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.007 0.12 0.319 5.0 -0.31 24.0 29.0 RAC1/GTP/IQGAP1 0.044 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.049 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.016 0.068 0.203 26.0 -0.226 11.0 37.0 NME1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.037 0.158 -9999.0 0.0 -0.44 47.0 47.0 regulation of cell-cell adhesion -0.001 0.061 -9999.0 0.0 -0.242 3.0 3.0 WASF2 0.02 0.044 0.119 32.0 -0.11 4.0 36.0 Rap1/GTP 0.012 0.087 0.259 3.0 -0.311 3.0 6.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.059 0.092 -9999.0 0.0 -0.3 21.0 21.0 CCND1 0.017 0.08 0.238 23.0 -0.284 11.0 34.0 VAV2 -0.02 0.193 0.389 3.0 -0.618 20.0 23.0 RAP1/GDP 0.009 0.1 0.311 3.0 -0.349 4.0 7.0 adherens junction assembly -0.035 0.155 -9999.0 0.0 -0.426 47.0 47.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.044 0.089 -9999.0 0.0 -0.289 24.0 24.0 E-cadherin/beta catenin -0.007 0.089 -9999.0 0.0 -0.336 33.0 33.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.039 0.157 -9999.0 0.0 -0.432 49.0 49.0 PIK3CA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP 0.013 0.145 0.28 60.0 -0.409 19.0 79.0 E-cadherin/beta catenin/alpha catenin 0.036 0.096 -9999.0 0.0 -0.34 26.0 26.0 ITGAE 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.033 0.168 -9999.0 0.0 -0.448 51.0 51.0