Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.01 0.058 -9999.0 0.0 -0.34 25.0 25.0 epithelial cell differentiation -0.014 0.08 -9999.0 0.0 -0.478 24.0 24.0 CYFIP2 -0.01 0.061 -9999.0 0.0 -0.321 25.0 25.0 ENAH 0.056 0.064 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.292 0.398 -9999.0 0.0 -0.838 291.0 291.0 EPHA2 -0.006 0.071 -9999.0 0.0 -0.838 6.0 6.0 MYO6 -0.014 0.077 -9999.0 0.0 -0.453 25.0 25.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.005 0.035 -9999.0 0.0 -0.559 2.0 2.0 AQP5 -0.256 0.307 -9999.0 0.0 -0.615 346.0 346.0 CTNND1 -0.0 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.013 0.074 -9999.0 0.0 -0.445 24.0 24.0 regulation of calcium-dependent cell-cell adhesion -0.037 0.126 -9999.0 0.0 -0.458 68.0 68.0 EGF -0.167 0.334 -9999.0 0.0 -0.838 167.0 167.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.041 0.149 -9999.0 0.0 -0.609 44.0 44.0 cortical microtubule organization -0.014 0.08 -9999.0 0.0 -0.478 24.0 24.0 GO:0000145 0.024 0.077 -9999.0 0.0 -0.424 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.014 0.081 -9999.0 0.0 -0.483 24.0 24.0 MLLT4 -0.003 0.05 -9999.0 0.0 -0.838 3.0 3.0 ARF6/GDP -0.014 0.069 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.004 0.044 -9999.0 0.0 -0.509 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.036 0.079 -9999.0 0.0 -0.416 24.0 24.0 PVRL2 -0.001 0.016 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.013 0.075 -9999.0 0.0 -0.453 24.0 24.0 ARF6/GTP -0.004 0.04 -9999.0 0.0 -0.468 6.0 6.0 CDH1 -0.024 0.14 -9999.0 0.0 -0.838 24.0 24.0 EGFR/EGFR/EGF/EGF -0.253 0.275 -9999.0 0.0 -0.502 422.0 422.0 RhoA/GDP -0.013 0.075 -9999.0 0.0 -0.447 24.0 24.0 actin cytoskeleton organization 0.031 0.08 -9999.0 0.0 -0.425 25.0 25.0 IGF-1R heterotetramer -0.02 0.119 -9999.0 0.0 -0.836 16.0 16.0 GIT1 -0.001 0.019 -9999.0 0.0 -0.277 4.0 4.0 IGF1R -0.02 0.119 -9999.0 0.0 -0.838 16.0 16.0 IGF1 -0.185 0.348 -9999.0 0.0 -0.838 186.0 186.0 DIAPH1 -0.001 0.035 -9999.0 0.0 -0.68 2.0 2.0 Wnt receptor signaling pathway 0.014 0.08 0.478 24.0 -9999.0 0.0 24.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.014 0.07 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.013 0.074 -9999.0 0.0 -0.437 25.0 25.0 EFNA1 -0.0 0.01 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.031 0.082 -9999.0 0.0 -0.425 26.0 26.0 Ephrin A1/EPHA2 -0.016 0.081 -9999.0 0.0 -0.434 30.0 30.0 SEC6/SEC8 -0.013 0.07 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.038 0.128 -9999.0 0.0 -0.466 68.0 68.0 HGF/MET -0.114 0.217 -9999.0 0.0 -0.489 195.0 195.0 HGF -0.05 0.198 -9999.0 0.0 -0.838 50.0 50.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.01 0.058 -9999.0 0.0 -0.343 25.0 25.0 actin cable formation 0.071 0.06 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.031 0.089 -9999.0 0.0 -0.459 24.0 24.0 KIFC3 -0.014 0.079 -9999.0 0.0 -0.453 26.0 26.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.014 0.077 -9999.0 0.0 -0.453 25.0 25.0 NCK1/GIT1 -0.001 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.014 0.08 -9999.0 0.0 -0.478 24.0 24.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.013 0.075 -9999.0 0.0 -0.453 24.0 24.0 PIP5K1C -0.013 0.075 -9999.0 0.0 -0.453 24.0 24.0 LIMA1 -0.001 0.029 -9999.0 0.0 -0.838 1.0 1.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.012 0.06 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.047 0.085 -9999.0 0.0 -0.634 3.0 3.0 IGF-1R heterotetramer/IGF1 -0.119 0.207 -9999.0 0.0 -0.462 215.0 215.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.003 0.04 -9999.0 0.0 -0.645 3.0 3.0 MET -0.143 0.315 -9999.0 0.0 -0.834 144.0 144.0 PLEKHA7 -0.014 0.08 -9999.0 0.0 -0.472 24.0 24.0 mol:GTP -0.004 0.043 -9999.0 0.0 -0.505 6.0 6.0 establishment of epithelial cell apical/basal polarity -0.012 0.066 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.01 0.058 -9999.0 0.0 -0.34 25.0 25.0 regulation of cell-cell adhesion 0.031 0.08 -9999.0 0.0 -0.425 25.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.01 0.058 -9999.0 0.0 -0.343 25.0 25.0