Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.011 0.045 -9999.0 0.0 -0.27 16.0 16.0 epithelial cell differentiation 0.036 0.056 -9999.0 0.0 -0.334 14.0 14.0 CYFIP2 0.03 0.045 0.267 22.0 -0.601 1.0 23.0 ENAH -0.005 0.06 0.273 8.0 -9999.0 0.0 8.0 EGFR -0.188 0.296 -9999.0 0.0 -0.601 281.0 281.0 EPHA2 0.02 0.049 -9999.0 0.0 -0.601 5.0 5.0 MYO6 -0.014 0.052 -9999.0 0.0 -0.324 15.0 15.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.05 0.032 -9999.0 0.0 -0.388 1.0 1.0 AQP5 -0.202 0.271 0.335 1.0 -0.517 341.0 342.0 CTNND1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.013 0.05 -9999.0 0.0 -0.319 14.0 14.0 regulation of calcium-dependent cell-cell adhesion -0.027 0.08 -9999.0 0.0 -0.324 48.0 48.0 EGF -0.091 0.243 0.267 2.0 -0.601 153.0 155.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.019 0.122 0.292 1.0 -0.481 43.0 44.0 cortical microtubule organization 0.036 0.056 -9999.0 0.0 -0.334 14.0 14.0 GO:0000145 -0.013 0.047 -9999.0 0.0 -0.304 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.04 0.058 -9999.0 0.0 -0.337 14.0 14.0 MLLT4 0.022 0.023 -9999.0 0.0 -0.601 1.0 1.0 ARF6/GDP -0.022 0.042 -9999.0 0.0 -0.295 16.0 16.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.044 0.043 -9999.0 0.0 -0.354 5.0 5.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.004 0.049 -9999.0 0.0 -0.306 14.0 14.0 PVRL2 0.024 0.009 0.267 1.0 -9999.0 0.0 1.0 ZYX -0.014 0.05 -9999.0 0.0 -0.322 14.0 14.0 ARF6/GTP 0.048 0.044 -9999.0 0.0 -0.332 5.0 5.0 CDH1 0.011 0.081 -9999.0 0.0 -0.601 14.0 14.0 EGFR/EGFR/EGF/EGF -0.149 0.207 -9999.0 0.0 -0.354 390.0 390.0 RhoA/GDP 0.037 0.055 -9999.0 0.0 -0.32 14.0 14.0 actin cytoskeleton organization -0.015 0.049 -9999.0 0.0 -0.314 15.0 15.0 IGF-1R heterotetramer 0.013 0.082 0.266 2.0 -0.6 14.0 16.0 GIT1 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.013 0.082 0.267 2.0 -0.601 14.0 16.0 IGF1 -0.109 0.256 -9999.0 0.0 -0.601 177.0 177.0 DIAPH1 0.025 0.105 -9999.0 0.0 -0.544 14.0 14.0 Wnt receptor signaling pathway -0.036 0.056 0.334 14.0 -9999.0 0.0 14.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.022 0.042 -9999.0 0.0 -0.297 15.0 15.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.016 0.05 -9999.0 0.0 -0.321 15.0 15.0 EFNA1 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.015 0.05 -9999.0 0.0 -0.312 15.0 15.0 Ephrin A1/EPHA2 0.024 0.057 -9999.0 0.0 -0.315 17.0 17.0 SEC6/SEC8 -0.023 0.041 -9999.0 0.0 -0.304 15.0 15.0 MGAT3 -0.027 0.081 -9999.0 0.0 -0.329 48.0 48.0 HGF/MET -0.043 0.163 -9999.0 0.0 -0.344 176.0 176.0 HGF -0.01 0.143 -9999.0 0.0 -0.601 46.0 46.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.011 0.046 -9999.0 0.0 -0.272 16.0 16.0 actin cable formation 0.04 0.095 0.31 27.0 -0.304 1.0 28.0 KIAA1543 -0.014 0.051 -9999.0 0.0 -0.329 14.0 14.0 KIFC3 -0.014 0.048 -9999.0 0.0 -0.323 14.0 14.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.013 0.05 -9999.0 0.0 -0.323 14.0 14.0 NCK1/GIT1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.036 0.056 -9999.0 0.0 -0.334 14.0 14.0 EXOC4 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.013 0.05 -9999.0 0.0 -0.323 14.0 14.0 PIP5K1C -0.014 0.051 -9999.0 0.0 -0.323 14.0 14.0 LIMA1 0.024 0.022 -9999.0 0.0 -0.601 1.0 1.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.015 0.088 0.296 20.0 -9999.0 0.0 20.0 adherens junction assembly -0.026 0.107 0.276 2.0 -0.628 14.0 16.0 IGF-1R heterotetramer/IGF1 -0.047 0.156 -9999.0 0.0 -0.327 183.0 183.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.033 0.024 -9999.0 0.0 -0.281 3.0 3.0 MET -0.079 0.232 -9999.0 0.0 -0.601 136.0 136.0 PLEKHA7 -0.014 0.054 -9999.0 0.0 -0.345 14.0 14.0 mol:GTP 0.042 0.042 -9999.0 0.0 -0.352 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.009 0.066 0.349 5.0 -9999.0 0.0 5.0 cortical actin cytoskeleton stabilization 0.011 0.045 -9999.0 0.0 -0.27 16.0 16.0 regulation of cell-cell adhesion -0.015 0.049 -9999.0 0.0 -0.314 15.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.011 0.046 -9999.0 0.0 -0.272 16.0 16.0