Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.194 0.313 -9999.0 0.0 -0.638 32.0 32.0 IHH -0.096 0.194 -9999.0 0.0 -0.556 16.0 16.0 SHH Np/Cholesterol/GAS1 -0.078 0.169 -9999.0 0.0 -0.344 31.0 31.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.078 0.168 0.342 31.0 -9999.0 0.0 31.0 SMO/beta Arrestin2 -0.136 0.219 -9999.0 0.0 -0.588 14.0 14.0 SMO -0.149 0.23 -9999.0 0.0 -0.562 19.0 19.0 AKT1 -0.061 0.128 -9999.0 0.0 -0.545 3.0 3.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.043 0.17 -9999.0 0.0 -0.565 11.0 11.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.147 0.226 -9999.0 0.0 -0.552 19.0 19.0 STIL -0.124 0.217 -9999.0 0.0 -0.52 19.0 19.0 DHH N/PTCH2 -0.015 0.118 -9999.0 0.0 -0.447 8.0 8.0 DHH N/PTCH1 -0.115 0.201 -9999.0 0.0 -0.515 16.0 16.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.011 0.114 -9999.0 0.0 -0.61 4.0 4.0 PTHLH -0.27 0.432 -9999.0 0.0 -1.004 25.0 25.0 determination of left/right symmetry -0.147 0.226 -9999.0 0.0 -0.552 19.0 19.0 PIK3R1 -0.013 0.119 -9999.0 0.0 -0.569 5.0 5.0 skeletal system development -0.266 0.424 -9999.0 0.0 -0.987 25.0 25.0 IHH N/Hhip -0.098 0.192 -9999.0 0.0 -0.436 26.0 26.0 DHH N/Hhip -0.05 0.162 -9999.0 0.0 -0.426 17.0 17.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.147 0.226 -9999.0 0.0 -0.552 19.0 19.0 pancreas development -0.06 0.178 -9999.0 0.0 -0.522 15.0 15.0 HHAT -0.005 0.103 -9999.0 0.0 -0.639 3.0 3.0 PI3K -0.001 0.088 -9999.0 0.0 -0.411 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.058 0.189 -9999.0 0.0 -0.565 14.0 14.0 somite specification -0.147 0.226 -9999.0 0.0 -0.552 19.0 19.0 SHH Np/Cholesterol/PTCH1 -0.138 0.228 -9999.0 0.0 -0.49 26.0 26.0 SHH Np/Cholesterol/PTCH2 -0.052 0.144 -9999.0 0.0 -0.336 23.0 23.0 SHH Np/Cholesterol/Megalin -0.075 0.163 -9999.0 0.0 -0.343 29.0 29.0 SHH -0.059 0.165 -9999.0 0.0 -0.417 20.0 20.0 catabolic process -0.122 0.212 -9999.0 0.0 -0.546 15.0 15.0 SMO/Vitamin D3 -0.154 0.234 -9999.0 0.0 -0.607 17.0 17.0 SHH Np/Cholesterol/Hhip -0.081 0.176 -9999.0 0.0 -0.377 28.0 28.0 LRP2 -0.05 0.168 -9999.0 0.0 -0.523 13.0 13.0 receptor-mediated endocytosis -0.165 0.219 -9999.0 0.0 -0.574 19.0 19.0 SHH Np/Cholesterol/BOC -0.07 0.156 -9999.0 0.0 -0.325 30.0 30.0 SHH Np/Cholesterol/CDO -0.048 0.142 -9999.0 0.0 -0.334 22.0 22.0 mesenchymal cell differentiation 0.081 0.174 0.374 28.0 -9999.0 0.0 28.0 mol:Vitamin D3 -0.137 0.23 -9999.0 0.0 -0.506 24.0 24.0 IHH N/PTCH2 -0.06 0.152 -9999.0 0.0 -0.376 19.0 19.0 CDON -0.004 0.098 -9999.0 0.0 -0.6 3.0 3.0 IHH N/PTCH1 -0.123 0.214 -9999.0 0.0 -0.551 15.0 15.0 Megalin/LRPAP1 -0.027 0.122 -9999.0 0.0 -0.371 13.0 13.0 PTCH2 -0.01 0.114 -9999.0 0.0 -0.61 4.0 4.0 SHH Np/Cholesterol -0.053 0.125 -9999.0 0.0 -0.324 20.0 20.0 PTCH1 -0.123 0.213 -9999.0 0.0 -0.548 15.0 15.0 HHIP -0.061 0.178 -9999.0 0.0 -0.523 15.0 15.0