Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL23-mediated signaling events	19.0	1180.0	60.0	-0.648	0.012	1000.0	-1000.0	-0.176	-1000.0
HIF-1-alpha transcription factor network	18.0	1391.0	76.0	-0.586	0.019	1000.0	-1000.0	-0.181	-1000.0
p75(NTR)-mediated signaling	16.0	2082.0	125.0	-0.236	0.033	1000.0	-1000.0	-0.11	-1000.0
IL4-mediated signaling events	16.0	1490.0	91.0	-0.78	0.675	1000.0	-1000.0	-0.161	-1000.0
Signaling mediated by p38-alpha and p38-beta	16.0	708.0	44.0	-0.211	0.012	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by the Hedgehog family	15.0	813.0	52.0	-0.27	0.081	1000.0	-1000.0	-0.055	-1000.0
Syndecan-1-mediated signaling events	14.0	487.0	34.0	-0.198	0.012	1000.0	-1000.0	-0.059	-1000.0
Glypican 2 network	13.0	55.0	4.0	-0.078	-0.06	1000.0	-1000.0	-0.025	-1000.0
BMP receptor signaling	12.0	1002.0	81.0	-0.253	0.027	1000.0	-1000.0	-0.096	-1000.0
Glypican 1 network	12.0	597.0	48.0	-0.154	0.013	1000.0	-1000.0	-0.043	-1000.0
Glucocorticoid receptor regulatory network	11.0	1350.0	114.0	-0.648	0.318	1000.0	-1000.0	-0.077	-1000.0
IL12-mediated signaling events	10.0	899.0	87.0	-0.303	0.1	1000.0	-1000.0	-0.132	-1000.0
FOXA2 and FOXA3 transcription factor networks	10.0	467.0	46.0	-0.41	0.018	1000.0	-1000.0	-0.133	-1000.0
TCR signaling in naïve CD8+ T cells	10.0	975.0	93.0	-0.164	0.089	1000.0	-1000.0	-0.089	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	10.0	1254.0	120.0	-0.297	0.211	1000.0	-1000.0	-0.073	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	9.0	309.0	34.0	-0.09	0.012	1000.0	-1000.0	-0.054	-1000.0
Endothelins	9.0	926.0	96.0	-0.24	0.035	1000.0	-1000.0	-0.087	-1000.0
Effects of Botulinum toxin	9.0	242.0	26.0	-0.187	0.012	1000.0	-1000.0	-0.061	-1000.0
Wnt signaling	9.0	65.0	7.0	-0.09	0.012	1000.0	-1000.0	-0.029	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	9.0	660.0	68.0	-0.358	0.073	1000.0	-1000.0	-0.14	-1000.0
BCR signaling pathway	9.0	924.0	99.0	-0.183	0.025	1000.0	-1000.0	-0.091	-1000.0
EGFR-dependent Endothelin signaling events	9.0	190.0	21.0	-0.126	0.018	1000.0	-1000.0	-0.068	-1000.0
Syndecan-2-mediated signaling events	8.0	601.0	69.0	-0.133	0.021	1000.0	-1000.0	-0.039	-1000.0
amb2 Integrin signaling	8.0	723.0	82.0	-0.138	0.016	1000.0	-1000.0	-0.086	-1000.0
Signaling events regulated by Ret tyrosine kinase	8.0	665.0	82.0	-0.127	0.012	1000.0	-1000.0	-0.085	-1000.0
Integrins in angiogenesis	8.0	685.0	84.0	-0.182	0.021	1000.0	-1000.0	-0.093	-1000.0
Calcium signaling in the CD4+ TCR pathway	8.0	254.0	31.0	-0.254	0.012	1000.0	-1000.0	-0.09	-1000.0
IL27-mediated signaling events	8.0	418.0	51.0	-0.155	0.085	1000.0	-1000.0	-0.076	-1000.0
Syndecan-4-mediated signaling events	8.0	587.0	67.0	-0.153	0.022	1000.0	-1000.0	-0.089	-1000.0
Plasma membrane estrogen receptor signaling	8.0	711.0	86.0	-0.116	0.067	1000.0	-1000.0	-0.086	-1000.0
Class IB PI3K non-lipid kinase events	8.0	24.0	3.0	-0.03	-1000.0	1000.0	-1000.0	-0.015	-1000.0
Osteopontin-mediated events	7.0	268.0	38.0	-0.118	0.012	1000.0	-1000.0	-0.101	-1000.0
Thromboxane A2 receptor signaling	7.0	748.0	105.0	-0.126	0.024	1000.0	-1000.0	-0.069	-1000.0
Fc-epsilon receptor I signaling in mast cells	7.0	734.0	97.0	-0.135	0.028	1000.0	-1000.0	-0.082	-1000.0
Nectin adhesion pathway	7.0	490.0	63.0	-0.099	0.023	1000.0	-1000.0	-0.075	-1000.0
S1P5 pathway	7.0	120.0	17.0	-0.095	0.073	1000.0	-1000.0	-0.043	-1000.0
LPA receptor mediated events	7.0	750.0	102.0	-0.114	0.017	1000.0	-1000.0	-0.091	-1000.0
IGF1 pathway	7.0	430.0	57.0	-0.12	0.022	1000.0	-1000.0	-0.09	-1000.0
LPA4-mediated signaling events	6.0	79.0	12.0	-0.082	0.018	1000.0	-1000.0	-0.033	-1000.0
Coregulation of Androgen receptor activity	6.0	502.0	76.0	-0.227	0.022	1000.0	-1000.0	-0.044	-1000.0
ErbB4 signaling events	6.0	481.0	69.0	-0.189	0.073	1000.0	-1000.0	-0.101	-1000.0
Ephrin A  reverse signaling	6.0	46.0	7.0	-0.027	-0.0	1000.0	-1000.0	-0.023	-1000.0
Arf6 signaling events	6.0	375.0	62.0	-0.126	0.021	1000.0	-1000.0	-0.074	-1000.0
PDGFR-alpha signaling pathway	6.0	279.0	44.0	-0.065	0.021	1000.0	-1000.0	-0.062	-1000.0
Reelin signaling pathway	6.0	382.0	56.0	-0.163	0.018	1000.0	-1000.0	-0.084	-1000.0
Ephrin B reverse signaling	6.0	306.0	48.0	-0.117	0.086	1000.0	-1000.0	-0.07	-1000.0
Nongenotropic Androgen signaling	6.0	312.0	52.0	-0.118	0.017	1000.0	-1000.0	-0.06	-1000.0
IL6-mediated signaling events	6.0	497.0	75.0	-0.136	0.045	1000.0	-1000.0	-0.092	-1000.0
Caspase cascade in apoptosis	5.0	424.0	74.0	-0.086	0.031	1000.0	-1000.0	-0.045	-1000.0
Noncanonical Wnt signaling pathway	5.0	151.0	26.0	-0.097	0.012	1000.0	-1000.0	-0.059	-1000.0
Cellular roles of Anthrax toxin	5.0	224.0	39.0	-0.084	0.012	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by PTP1B	5.0	431.0	76.0	-0.191	0.02	1000.0	-1000.0	-0.082	-1000.0
Presenilin action in Notch and Wnt signaling	5.0	326.0	61.0	-0.164	0.028	1000.0	-1000.0	-0.065	-1000.0
IL1-mediated signaling events	5.0	359.0	62.0	-0.162	0.058	1000.0	-1000.0	-0.093	-1000.0
Syndecan-3-mediated signaling events	5.0	206.0	35.0	-0.177	0.033	1000.0	-1000.0	-0.047	-1000.0
Canonical Wnt signaling pathway	5.0	298.0	51.0	-0.164	0.062	1000.0	-1000.0	-0.063	-1000.0
EPHB forward signaling	5.0	493.0	85.0	-0.119	0.094	1000.0	-1000.0	-0.092	-1000.0
Angiopoietin receptor Tie2-mediated signaling	5.0	458.0	88.0	-0.132	0.029	1000.0	-1000.0	-0.113	-1000.0
Visual signal transduction: Rods	5.0	294.0	52.0	-0.177	0.012	1000.0	-1000.0	-0.085	-1000.0
Sphingosine 1-phosphate (S1P) pathway	4.0	135.0	28.0	-0.095	0.027	1000.0	-1000.0	-0.038	-1000.0
Visual signal transduction: Cones	4.0	187.0	38.0	-0.083	0.012	1000.0	-1000.0	-0.064	-1000.0
JNK signaling in the CD4+ TCR pathway	4.0	82.0	17.0	-0.031	0.012	1000.0	-1000.0	-0.038	-1000.0
Hedgehog signaling events mediated by Gli proteins	4.0	260.0	65.0	-0.327	0.038	1000.0	-1000.0	-0.068	-1000.0
TRAIL signaling pathway	4.0	212.0	48.0	-0.037	0.02	1000.0	-1000.0	-0.068	-1000.0
S1P1 pathway	4.0	147.0	36.0	-0.088	0.012	1000.0	-1000.0	-0.055	-1000.0
IL2 signaling events mediated by PI3K	4.0	233.0	58.0	-0.084	0.02	1000.0	-1000.0	-0.089	-1000.0
TCGA08_retinoblastoma	4.0	39.0	8.0	-0.01	0.01	1000.0	-1000.0	-0.018	-1000.0
Regulation of Telomerase	4.0	425.0	102.0	-0.149	0.036	1000.0	-1000.0	-0.095	-1000.0
S1P4 pathway	4.0	107.0	25.0	-0.095	0.018	1000.0	-1000.0	-0.057	-1000.0
Regulation of Androgen receptor activity	4.0	349.0	70.0	-0.264	0.027	1000.0	-1000.0	-0.065	-1000.0
BARD1 signaling events	3.0	208.0	57.0	-0.044	0.034	1000.0	-1000.0	-0.059	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	3.0	176.0	54.0	-0.082	0.024	1000.0	-1000.0	-0.101	-1000.0
IFN-gamma pathway	3.0	267.0	68.0	-0.149	0.018	1000.0	-1000.0	-0.104	-1000.0
Ceramide signaling pathway	3.0	244.0	76.0	-0.126	0.038	1000.0	-1000.0	-0.047	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	173.0	52.0	-0.099	0.04	1000.0	-1000.0	-0.054	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	46.0	15.0	-0.014	0.023	1000.0	-1000.0	-0.039	-1000.0
Retinoic acid receptors-mediated signaling	3.0	175.0	58.0	-0.098	0.017	1000.0	-1000.0	-0.07	-1000.0
IL2 signaling events mediated by STAT5	3.0	82.0	22.0	-0.049	0.022	1000.0	-1000.0	-0.054	-1000.0
Class I PI3K signaling events	3.0	221.0	73.0	-0.099	0.019	1000.0	-1000.0	-0.063	-1000.0
S1P3 pathway	3.0	135.0	42.0	-0.056	0.025	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	3.0	307.0	78.0	-0.062	0.031	1000.0	-1000.0	-0.093	-1000.0
Ras signaling in the CD4+ TCR pathway	3.0	64.0	17.0	-0.025	0.02	1000.0	-1000.0	-0.042	-1000.0
ErbB2/ErbB3 signaling events	2.0	168.0	65.0	-0.102	0.021	1000.0	-1000.0	-0.073	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	403.0	136.0	-0.187	0.08	1000.0	-1000.0	-0.073	-1000.0
PLK2 and PLK4 events	2.0	6.0	3.0	-0.003	0.012	1000.0	-1000.0	-0.019	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	197.0	85.0	-0.043	0.024	1000.0	-1000.0	-0.079	-1000.0
Aurora A signaling	2.0	126.0	60.0	-0.172	0.036	1000.0	-1000.0	-0.051	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	84.0	37.0	-0.061	0.025	1000.0	-1000.0	-0.062	-1000.0
Signaling events mediated by HDAC Class III	2.0	94.0	40.0	-0.166	0.021	1000.0	-1000.0	-0.04	-1000.0
FAS signaling pathway (CD95)	2.0	114.0	47.0	-0.055	0.015	1000.0	-1000.0	-0.046	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	96.0	45.0	-0.061	0.035	1000.0	-1000.0	-0.1	-1000.0
Regulation of p38-alpha and p38-beta	2.0	119.0	54.0	-0.099	0.031	1000.0	-1000.0	-0.062	-1000.0
TCGA08_rtk_signaling	2.0	52.0	26.0	-0.04	0.037	1000.0	-1000.0	-0.02	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	200.0	74.0	-0.185	0.061	1000.0	-1000.0	-0.088	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	79.0	33.0	-0.107	0.03	1000.0	-1000.0	-0.055	-1000.0
Rapid glucocorticoid signaling	2.0	58.0	20.0	-0.05	0.013	1000.0	-1000.0	-0.022	-1000.0
PDGFR-beta signaling pathway	2.0	231.0	97.0	-0.065	0.033	1000.0	-1000.0	-0.082	-1000.0
p38 MAPK signaling pathway	2.0	117.0	44.0	-0.137	0.023	1000.0	-1000.0	-0.068	-1000.0
Canonical NF-kappaB pathway	1.0	47.0	39.0	-0.044	0.062	1000.0	-1000.0	-0.09	-1000.0
Signaling events mediated by HDAC Class II	1.0	91.0	75.0	-0.074	0.033	1000.0	-1000.0	-0.045	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	8.0	5.0	0.002	0.01	1000.0	-1000.0	-0.03	-1000.0
EPO signaling pathway	1.0	65.0	55.0	-0.03	0.045	1000.0	-1000.0	-0.1	-1000.0
mTOR signaling pathway	1.0	72.0	53.0	-0.017	0.021	1000.0	-1000.0	-0.057	-1000.0
ceramide signaling pathway	1.0	73.0	49.0	-0.045	0.027	1000.0	-1000.0	-0.049	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	105.0	83.0	-0.065	0.052	1000.0	-1000.0	-0.072	-1000.0
TCGA08_p53	1.0	9.0	7.0	-0.007	0.012	1000.0	-1000.0	-0.015	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	40.0	36.0	-0.061	0.031	1000.0	-1000.0	-0.079	-1000.0
Atypical NF-kappaB pathway	1.0	35.0	31.0	-0.013	0.038	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	149.0	125.0	-0.073	0.049	1000.0	-1000.0	-0.098	-1000.0
Insulin Pathway	1.0	145.0	74.0	-0.132	0.033	1000.0	-1000.0	-0.091	-1000.0
Signaling events mediated by PRL	1.0	61.0	34.0	-0.096	0.029	1000.0	-1000.0	-0.037	-1000.0
E-cadherin signaling in keratinocytes	1.0	52.0	43.0	-0.028	0.033	1000.0	-1000.0	-0.064	-1000.0
FOXM1 transcription factor network	1.0	78.0	51.0	-0.092	0.134	1000.0	-1000.0	-0.186	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	20.0	23.0	-0.033	0.04	1000.0	-1000.0	-0.059	-1000.0
Circadian rhythm pathway	0.0	18.0	22.0	-0.013	0.039	1000.0	-1000.0	-0.06	-1000.0
Arf6 downstream pathway	0.0	38.0	43.0	-0.026	0.025	1000.0	-1000.0	-0.042	-1000.0
Aurora C signaling	0.0	6.0	7.0	-0.005	0.013	1000.0	-1000.0	-0.028	-1000.0
PLK1 signaling events	0.0	28.0	85.0	-0.011	0.033	1000.0	-1000.0	-0.043	-1000.0
Insulin-mediated glucose transport	0.0	28.0	32.0	-0.033	0.045	1000.0	-1000.0	-0.065	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	29.0	68.0	-0.033	0.044	1000.0	-1000.0	-0.058	-1000.0
HIF-2-alpha transcription factor network	0.0	32.0	43.0	-0.081	0.089	1000.0	-1000.0	-0.1	-1000.0
Signaling events mediated by HDAC Class I	0.0	83.0	104.0	-0.044	0.049	1000.0	-1000.0	-0.064	-1000.0
FoxO family signaling	0.0	37.0	64.0	-0.058	0.126	1000.0	-1000.0	-0.07	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	64.0	76.0	-0.034	0.05	1000.0	-1000.0	-0.084	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.0	0.03	1000.0	-1000.0	-0.054	-1000.0
Arf6 trafficking events	0.0	34.0	71.0	-0.028	0.039	1000.0	-1000.0	-0.08	-1000.0
VEGFR1 specific signals	0.0	39.0	56.0	-0.031	0.041	1000.0	-1000.0	-0.063	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.0	0.018	1000.0	-1000.0	-0.039	-1000.0
Arf1 pathway	0.0	12.0	54.0	-0.02	0.025	1000.0	-1000.0	-0.044	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	-0.0	0.033	1000.0	-1000.0	-0.039	-1000.0
Aurora B signaling	0.0	56.0	67.0	-0.069	0.033	1000.0	-1000.0	-0.076	-1000.0
Total	628	41175	7203	-16.3970221482	-994.66308806	131000	-131000	-9.11132504809	-131000