Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.124 0.247 -9999.0 0.0 -0.604 20.0 20.0 IHH -0.041 0.107 -9999.0 0.0 -0.324 7.0 7.0 SHH Np/Cholesterol/GAS1 -0.038 0.12 -9999.0 0.0 -0.352 12.0 12.0 LRPAP1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.038 0.119 0.349 12.0 -9999.0 0.0 12.0 SMO/beta Arrestin2 -0.112 0.196 -9999.0 0.0 -0.459 17.0 17.0 SMO -0.114 0.195 -9999.0 0.0 -0.495 15.0 15.0 AKT1 -0.062 0.15 -9999.0 0.0 -0.582 6.0 6.0 ARRB2 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.01 0.12 -9999.0 0.0 -0.377 9.0 9.0 ADRBK1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.113 0.192 -9999.0 0.0 -0.488 15.0 15.0 STIL -0.077 0.153 -9999.0 0.0 -0.362 18.0 18.0 DHH N/PTCH2 0.01 0.106 -9999.0 0.0 -0.418 6.0 6.0 DHH N/PTCH1 -0.071 0.154 -9999.0 0.0 -0.374 16.0 16.0 PIK3CA 0.018 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.005 0.099 -9999.0 0.0 -0.481 4.0 4.0 PTHLH -0.194 0.373 -9999.0 0.0 -0.928 21.0 21.0 determination of left/right symmetry -0.113 0.192 -9999.0 0.0 -0.488 15.0 15.0 PIK3R1 0.01 0.085 -9999.0 0.0 -0.395 4.0 4.0 skeletal system development -0.191 0.367 -9999.0 0.0 -0.915 21.0 21.0 IHH N/Hhip -0.031 0.094 -9999.0 0.0 -0.239 9.0 9.0 DHH N/Hhip -0.001 0.101 -9999.0 0.0 -0.412 4.0 4.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.113 0.192 -9999.0 0.0 -0.488 15.0 15.0 pancreas development -0.016 0.079 -9999.0 0.0 -0.225 13.0 13.0 HHAT 0.01 0.096 -9999.0 0.0 -0.566 3.0 3.0 PI3K 0.015 0.064 -9999.0 0.0 -0.418 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.018 0.136 -9999.0 0.0 -0.356 13.0 13.0 somite specification -0.113 0.192 -9999.0 0.0 -0.488 15.0 15.0 SHH Np/Cholesterol/PTCH1 -0.086 0.156 -9999.0 0.0 -0.366 20.0 20.0 SHH Np/Cholesterol/PTCH2 -0.023 0.103 -9999.0 0.0 -0.317 10.0 10.0 SHH Np/Cholesterol/Megalin -0.028 0.099 -9999.0 0.0 -0.295 10.0 10.0 SHH -0.04 0.108 -9999.0 0.0 -0.419 7.0 7.0 catabolic process -0.077 0.154 -9999.0 0.0 -0.377 19.0 19.0 SMO/Vitamin D3 -0.101 0.179 -9999.0 0.0 -0.464 15.0 15.0 SHH Np/Cholesterol/Hhip -0.035 0.101 -9999.0 0.0 -0.275 13.0 13.0 LRP2 -0.008 0.077 -9999.0 0.0 -0.225 12.0 12.0 receptor-mediated endocytosis -0.105 0.173 -9999.0 0.0 -0.458 15.0 15.0 SHH Np/Cholesterol/BOC -0.035 0.115 -9999.0 0.0 -0.357 10.0 10.0 SHH Np/Cholesterol/CDO -0.025 0.103 -9999.0 0.0 -0.339 9.0 9.0 mesenchymal cell differentiation 0.035 0.1 0.273 13.0 -9999.0 0.0 13.0 mol:Vitamin D3 -0.076 0.164 -9999.0 0.0 -0.378 18.0 18.0 IHH N/PTCH2 -0.019 0.103 -9999.0 0.0 -0.428 4.0 4.0 CDON 0.01 0.082 -9999.0 0.0 -0.566 2.0 2.0 IHH N/PTCH1 -0.061 0.163 -9999.0 0.0 -0.379 19.0 19.0 Megalin/LRPAP1 0.015 0.058 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.008 0.099 -9999.0 0.0 -0.481 4.0 4.0 SHH Np/Cholesterol -0.021 0.088 -9999.0 0.0 -0.326 7.0 7.0 PTCH1 -0.077 0.155 -9999.0 0.0 -0.378 19.0 19.0 HHIP -0.016 0.079 -9999.0 0.0 -0.225 13.0 13.0