Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling mediated by p38-alpha and p38-beta	17.0	759.0	44.0	-0.152	0.027	1000.0	-1000.0	-0.035	-1000.0
HIF-1-alpha transcription factor network	16.0	1253.0	76.0	-0.388	0.033	1000.0	-1000.0	-0.112	-1000.0
IL23-mediated signaling events	15.0	923.0	60.0	-0.535	0.027	1000.0	-1000.0	-0.083	-1000.0
IL4-mediated signaling events	14.0	1348.0	91.0	-0.606	0.541	1000.0	-1000.0	-0.12	-1000.0
p75(NTR)-mediated signaling	12.0	1623.0	125.0	-0.13	0.065	1000.0	-1000.0	-0.075	-1000.0
Glypican 2 network	12.0	49.0	4.0	-0.05	-0.033	1000.0	-1000.0	0.001	-1000.0
Syndecan-1-mediated signaling events	11.0	391.0	34.0	-0.107	0.027	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by the Hedgehog family	10.0	531.0	52.0	-0.194	0.038	1000.0	-1000.0	-0.039	-1000.0
Glucocorticoid receptor regulatory network	10.0	1184.0	114.0	-0.517	0.251	1000.0	-1000.0	-0.054	-1000.0
Ephrin B reverse signaling	10.0	505.0	48.0	-0.071	0.053	1000.0	-1000.0	-0.024	-1000.0
Endothelins	10.0	980.0	96.0	-0.161	0.06	1000.0	-1000.0	-0.058	-1000.0
TCR signaling in naïve CD8+ T cells	10.0	971.0	93.0	-0.131	0.049	1000.0	-1000.0	-0.056	-1000.0
Wnt signaling	10.0	71.0	7.0	-0.062	0.026	1000.0	-1000.0	-0.019	-1000.0
IL12-mediated signaling events	9.0	793.0	87.0	-0.209	0.056	1000.0	-1000.0	-0.075	-1000.0
BMP receptor signaling	9.0	762.0	81.0	-0.158	0.044	1000.0	-1000.0	-0.054	-1000.0
EPHB forward signaling	9.0	832.0	85.0	-0.08	0.071	1000.0	-1000.0	-0.067	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	9.0	652.0	68.0	-0.26	0.069	1000.0	-1000.0	-0.073	-1000.0
IGF1 pathway	9.0	516.0	57.0	-0.081	0.048	1000.0	-1000.0	-0.05	-1000.0
Noncanonical Wnt signaling pathway	8.0	215.0	26.0	-0.077	0.026	1000.0	-1000.0	-0.049	-1000.0
Fc-epsilon receptor I signaling in mast cells	8.0	797.0	97.0	-0.074	0.04	1000.0	-1000.0	-0.064	-1000.0
Nectin adhesion pathway	8.0	513.0	63.0	-0.09	0.047	1000.0	-1000.0	-0.056	-1000.0
Calcium signaling in the CD4+ TCR pathway	8.0	268.0	31.0	-0.195	0.026	1000.0	-1000.0	-0.045	-1000.0
LPA receptor mediated events	8.0	868.0	102.0	-0.109	0.03	1000.0	-1000.0	-0.066	-1000.0
BCR signaling pathway	8.0	870.0	99.0	-0.104	0.056	1000.0	-1000.0	-0.052	-1000.0
EGFR-dependent Endothelin signaling events	8.0	177.0	21.0	-0.069	0.037	1000.0	-1000.0	-0.038	-1000.0
Syndecan-4-mediated signaling events	8.0	539.0	67.0	-0.107	0.031	1000.0	-1000.0	-0.04	-1000.0
Plasma membrane estrogen receptor signaling	8.0	704.0	86.0	-0.105	0.098	1000.0	-1000.0	-0.062	-1000.0
Class IB PI3K non-lipid kinase events	8.0	24.0	3.0	-0.007	-1000.0	1000.0	-1000.0	-0.005	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	7.0	256.0	34.0	-0.05	0.027	1000.0	-1000.0	-0.039	-1000.0
Osteopontin-mediated events	7.0	296.0	38.0	-0.066	0.027	1000.0	-1000.0	-0.041	-1000.0
Thromboxane A2 receptor signaling	7.0	821.0	105.0	-0.071	0.039	1000.0	-1000.0	-0.053	-1000.0
S1P5 pathway	7.0	120.0	17.0	-0.075	0.052	1000.0	-1000.0	-0.025	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	7.0	918.0	120.0	-0.181	0.12	1000.0	-1000.0	-0.051	-1000.0
ErbB4 signaling events	6.0	426.0	69.0	-0.119	0.036	1000.0	-1000.0	-0.045	-1000.0
Arf6 signaling events	6.0	405.0	62.0	-0.069	0.041	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by PTP1B	6.0	485.0	76.0	-0.119	0.044	1000.0	-1000.0	-0.04	-1000.0
FOXA2 and FOXA3 transcription factor networks	6.0	310.0	46.0	-0.252	0.032	1000.0	-1000.0	-0.092	-1000.0
Glypican 1 network	6.0	291.0	48.0	-0.09	0.039	1000.0	-1000.0	-0.031	-1000.0
IFN-gamma pathway	6.0	425.0	68.0	-0.091	0.04	1000.0	-1000.0	-0.062	-1000.0
amb2 Integrin signaling	6.0	540.0	82.0	-0.085	0.036	1000.0	-1000.0	-0.04	-1000.0
Signaling events regulated by Ret tyrosine kinase	6.0	569.0	82.0	-0.053	0.027	1000.0	-1000.0	-0.063	-1000.0
Effects of Botulinum toxin	6.0	165.0	26.0	-0.087	0.028	1000.0	-1000.0	-0.016	-1000.0
IL27-mediated signaling events	6.0	331.0	51.0	-0.146	0.076	1000.0	-1000.0	-0.048	-1000.0
IL6-mediated signaling events	6.0	486.0	75.0	-0.115	0.059	1000.0	-1000.0	-0.052	-1000.0
Caspase cascade in apoptosis	5.0	391.0	74.0	-0.075	0.047	1000.0	-1000.0	-0.04	-1000.0
Syndecan-2-mediated signaling events	5.0	363.0	69.0	-0.067	0.039	1000.0	-1000.0	-0.041	-1000.0
Reelin signaling pathway	5.0	329.0	56.0	-0.083	0.054	1000.0	-1000.0	-0.048	-1000.0
IL1-mediated signaling events	5.0	321.0	62.0	-0.102	0.049	1000.0	-1000.0	-0.048	-1000.0
Integrins in angiogenesis	5.0	468.0	84.0	-0.117	0.051	1000.0	-1000.0	-0.05	-1000.0
Canonical Wnt signaling pathway	5.0	269.0	51.0	-0.105	0.055	1000.0	-1000.0	-0.052	-1000.0
Nongenotropic Androgen signaling	5.0	290.0	52.0	-0.062	0.033	1000.0	-1000.0	-0.038	-1000.0
Angiopoietin receptor Tie2-mediated signaling	5.0	468.0	88.0	-0.096	0.031	1000.0	-1000.0	-0.061	-1000.0
Visual signal transduction: Rods	5.0	263.0	52.0	-0.085	0.03	1000.0	-1000.0	-0.045	-1000.0
Regulation of Androgen receptor activity	5.0	363.0	70.0	-0.214	0.042	1000.0	-1000.0	-0.054	-1000.0
Coregulation of Androgen receptor activity	4.0	338.0	76.0	-0.183	0.047	1000.0	-1000.0	-0.029	-1000.0
Sphingosine 1-phosphate (S1P) pathway	4.0	126.0	28.0	-0.075	0.054	1000.0	-1000.0	-0.026	-1000.0
JNK signaling in the CD4+ TCR pathway	4.0	74.0	17.0	-0.037	0.03	1000.0	-1000.0	-0.046	-1000.0
Cellular roles of Anthrax toxin	4.0	192.0	39.0	-0.05	0.026	1000.0	-1000.0	-0.022	-1000.0
Hedgehog signaling events mediated by Gli proteins	4.0	322.0	65.0	-0.259	0.063	1000.0	-1000.0	-0.046	-1000.0
Presenilin action in Notch and Wnt signaling	4.0	279.0	61.0	-0.108	0.065	1000.0	-1000.0	-0.051	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	4.0	211.0	52.0	-0.036	0.068	1000.0	-1000.0	-0.047	-1000.0
TCGA08_retinoblastoma	4.0	33.0	8.0	-0.009	0.008	1000.0	-1000.0	-0.004	-1000.0
S1P3 pathway	4.0	175.0	42.0	-0.043	0.04	1000.0	-1000.0	-0.036	-1000.0
S1P4 pathway	4.0	121.0	25.0	-0.075	0.044	1000.0	-1000.0	-0.034	-1000.0
LPA4-mediated signaling events	3.0	39.0	12.0	-0.039	0.016	1000.0	-1000.0	-0.03	-1000.0
ErbB2/ErbB3 signaling events	3.0	249.0	65.0	-0.05	0.037	1000.0	-1000.0	-0.051	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	418.0	136.0	-0.129	0.082	1000.0	-1000.0	-0.038	-1000.0
BARD1 signaling events	3.0	198.0	57.0	-0.024	0.047	1000.0	-1000.0	-0.049	-1000.0
Visual signal transduction: Cones	3.0	136.0	38.0	-0.062	0.035	1000.0	-1000.0	-0.019	-1000.0
Ephrin A  reverse signaling	3.0	21.0	7.0	-0.013	0.012	1000.0	-1000.0	-0.017	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	288.0	85.0	-0.042	0.034	1000.0	-1000.0	-0.048	-1000.0
PDGFR-alpha signaling pathway	3.0	172.0	44.0	-0.041	0.035	1000.0	-1000.0	-0.041	-1000.0
mTOR signaling pathway	3.0	210.0	53.0	-0.031	0.054	1000.0	-1000.0	-0.043	-1000.0
Ceramide signaling pathway	3.0	271.0	76.0	-0.079	0.074	1000.0	-1000.0	-0.039	-1000.0
TRAIL signaling pathway	3.0	177.0	48.0	-0.025	0.036	1000.0	-1000.0	-0.04	-1000.0
S1P1 pathway	3.0	141.0	36.0	-0.102	0.027	1000.0	-1000.0	-0.053	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	55.0	15.0	-0.018	0.026	1000.0	-1000.0	-0.035	-1000.0
Syndecan-3-mediated signaling events	3.0	123.0	35.0	-0.085	0.065	1000.0	-1000.0	-0.034	-1000.0
IL2 signaling events mediated by PI3K	3.0	220.0	58.0	-0.036	0.045	1000.0	-1000.0	-0.052	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	3.0	264.0	74.0	-0.135	0.059	1000.0	-1000.0	-0.071	-1000.0
IL2 signaling events mediated by STAT5	3.0	69.0	22.0	-0.048	0.036	1000.0	-1000.0	-0.042	-1000.0
Class I PI3K signaling events	3.0	234.0	73.0	-0.04	0.044	1000.0	-1000.0	-0.044	-1000.0
Regulation of Telomerase	3.0	339.0	102.0	-0.109	0.063	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	3.0	288.0	78.0	-0.046	0.038	1000.0	-1000.0	-0.059	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	153.0	54.0	-0.034	0.037	1000.0	-1000.0	-0.056	-1000.0
EPO signaling pathway	2.0	129.0	55.0	-0.012	0.054	1000.0	-1000.0	-0.049	-1000.0
PLK1 signaling events	2.0	190.0	85.0	-0.024	0.076	1000.0	-1000.0	-0.032	-1000.0
ceramide signaling pathway	2.0	115.0	49.0	-0.022	0.04	1000.0	-1000.0	-0.042	-1000.0
FAS signaling pathway (CD95)	2.0	123.0	47.0	-0.017	0.045	1000.0	-1000.0	-0.045	-1000.0
Retinoic acid receptors-mediated signaling	2.0	146.0	58.0	-0.054	0.051	1000.0	-1000.0	-0.044	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	117.0	45.0	-0.029	0.062	1000.0	-1000.0	-0.052	-1000.0
Regulation of p38-alpha and p38-beta	2.0	151.0	54.0	-0.042	0.064	1000.0	-1000.0	-0.051	-1000.0
TCGA08_rtk_signaling	2.0	77.0	26.0	-0.06	0.072	1000.0	-1000.0	-0.015	-1000.0
Insulin Pathway	2.0	179.0	74.0	-0.093	0.065	1000.0	-1000.0	-0.042	-1000.0
VEGFR1 specific signals	2.0	115.0	56.0	-0.022	0.048	1000.0	-1000.0	-0.054	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	92.0	33.0	-0.061	0.062	1000.0	-1000.0	-0.035	-1000.0
Rapid glucocorticoid signaling	2.0	43.0	20.0	-0.021	0.033	1000.0	-1000.0	-0.005	-1000.0
PDGFR-beta signaling pathway	2.0	263.0	97.0	-0.062	0.064	1000.0	-1000.0	-0.06	-1000.0
FOXM1 transcription factor network	2.0	114.0	51.0	-0.015	0.125	1000.0	-1000.0	-0.128	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	46.0	17.0	-0.0	0.047	1000.0	-1000.0	-0.038	-1000.0
Canonical NF-kappaB pathway	1.0	46.0	39.0	-0.01	0.059	1000.0	-1000.0	-0.037	-1000.0
PLK2 and PLK4 events	1.0	4.0	3.0	0.006	0.026	1000.0	-1000.0	-0.017	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	84.0	68.0	-0.042	0.06	1000.0	-1000.0	-0.038	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	70.0	37.0	-0.034	0.06	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by HDAC Class III	1.0	57.0	40.0	-0.081	0.049	1000.0	-1000.0	-0.02	-1000.0
HIF-2-alpha transcription factor network	1.0	67.0	43.0	-0.075	0.077	1000.0	-1000.0	-0.065	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	130.0	83.0	-0.02	0.059	1000.0	-1000.0	-0.037	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	45.0	36.0	-0.048	0.05	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	208.0	125.0	-0.029	0.059	1000.0	-1000.0	-0.061	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	87.0	76.0	-0.029	0.065	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by PRL	1.0	46.0	34.0	-0.057	0.046	1000.0	-1000.0	-0.047	-1000.0
E-cadherin signaling in keratinocytes	1.0	64.0	43.0	-0.039	0.045	1000.0	-1000.0	-0.042	-1000.0
p38 MAPK signaling pathway	1.0	84.0	44.0	-0.065	0.05	1000.0	-1000.0	-0.031	-1000.0
Aurora B signaling	1.0	98.0	67.0	-0.114	0.073	1000.0	-1000.0	-0.034	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	19.0	23.0	-0.01	0.047	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by HDAC Class II	0.0	59.0	75.0	-0.037	0.064	1000.0	-1000.0	-0.027	-1000.0
Circadian rhythm pathway	0.0	11.0	22.0	-0.009	0.041	1000.0	-1000.0	-0.028	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	4.0	5.0	0.019	0.036	1000.0	-1000.0	0.003	-1000.0
Aurora A signaling	0.0	58.0	60.0	-0.085	0.066	1000.0	-1000.0	-0.024	-1000.0
Arf6 downstream pathway	0.0	36.0	43.0	-0.04	0.054	1000.0	-1000.0	-0.033	-1000.0
Aurora C signaling	0.0	6.0	7.0	0.0	0.035	1000.0	-1000.0	-0.013	-1000.0
Insulin-mediated glucose transport	0.0	30.0	32.0	-0.016	0.05	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by HDAC Class I	0.0	68.0	104.0	-0.049	0.062	1000.0	-1000.0	-0.034	-1000.0
TCGA08_p53	0.0	5.0	7.0	-0.001	0.026	1000.0	-1000.0	-0.008	-1000.0
FoxO family signaling	0.0	52.0	64.0	-0.033	0.068	1000.0	-1000.0	-0.066	-1000.0
Atypical NF-kappaB pathway	0.0	29.0	31.0	-0.0	0.042	1000.0	-1000.0	-0.022	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	7.0	27.0	-0.0	0.055	1000.0	-1000.0	-0.035	-1000.0
Arf6 trafficking events	0.0	46.0	71.0	-0.044	0.05	1000.0	-1000.0	-0.034	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.025	0.047	1000.0	-1000.0	0.002	-1000.0
Arf1 pathway	0.0	20.0	54.0	-0.001	0.036	1000.0	-1000.0	-0.018	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.069	1000.0	-1000.0	-0.002	-1000.0
Total	579	38863	7203	-11.0196004642	-993.119192546	131000	-131000	-5.65856951016	-131000