Clinical Features Time to Death AGE GENDER HISTOLOGICAL.TYPE PATHOLOGY.T PATHOLOGY.N PATHOLOGICSPREAD(M) TUMOR.STAGE COMPLETENESS.OF.RESECTION NUMBER.OF.LYMPH.NODES nMutated (%) nWild-Type logrank test_P logrank test_Q t-test_P t-test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q t-test_P t-test_Q APC 103 (66%) 52 0.29119 1 0.62727 1 0.042003 1 0.6453 1 0.79681 1 0.94408 1 0.16479 1 0.27176 1 0.037754 1 0.56132 1 BRAF 20 (13%) 135 0.82036 1 0.025741 1 0.058612 1 1.0725e-05 0.0126 0.14865 1 0.75484 1 0.40139 1 0.53621 1 0.59006 1 0.82241 1 FBXW7 29 (19%) 126 0.84105 1 0.036182 1 0.15427 1 0.0032433 1 0.11225 1 0.60408 1 0.01692 1 0.0024286 1 0.079487 1 0.77412 1 KRAS 58 (37%) 97 0.22643 1 0.0030383 1 0.24609 1 0.64754 1 1 1 0.45095 1 0.31745 1 0.60558 1 0.31535 1 0.40044 1 NRAS 15 (10%) 140 0.28093 1 0.16836 1 0.026914 1 1 1 0.48867 1 0.082979 1 0.46902 1 0.73222 1 0.27565 1 0.13381 1 PIK3CA 26 (17%) 129 0.66099 1 0.19814 1 0.83028 1 0.13448 1 0.55419 1 0.010663 1 0.33319 1 0.028007 1 0.44478 1 0.00023607 0.274 TP53 75 (48%) 80 0.69571 1 0.072841 1 0.33634 1 0.0038329 1 0.55723 1 0.25387 1 0.55755 1 0.10249 1 0.80254 1 0.12171 1 SMAD4 18 (12%) 137 0.58722 1 0.83346 1 0.62541 1 0.14928 1 0.94945 1 0.83354 1 1 1 0.63679 1 0.77166 1 0.41445 1 FAM123B 19 (12%) 136 0.71748 1 0.52673 1 0.81134 1 0.48903 1 0.6748 1 0.26814 1 1 1 0.47119 1 1 1 0.65501 1 TTN 69 (45%) 86 0.62485 1 0.2672 1 0.42099 1 0.023714 1 0.28142 1 0.16563 1 0.28819 1 0.22223 1 1 1 0.96593 1 WBSCR17 17 (11%) 138 0.38961 1 0.064093 1 0.80285 1 1 1 0.77735 1 0.93783 1 0.73197 1 0.0503 1 0.21216 1 0.32096 1 ACVR1B 13 (8%) 142 0.75857 1 0.7499 1 0.78048 1 0.03451 1 0.024202 1 1 1 0.72133 1 0.63548 1 1 1 0.51189 1 TNFRSF10C 6 (4%) 149 NA NA 0.9784 1 0.68133 1 0.59036 1 0.096793 1 0.24383 1 0.073583 1 0.011682 1 0.10469 1 0.17762 1 SMAD2 10 (6%) 145 0.61738 1 0.80546 1 0.32745 1 0.19524 1 0.40104 1 0.74392 1 0.63621 1 0.45281 1 0.4038 1 0.28138 1 MAP2K4 9 (6%) 146 0.01813 1 0.24343 1 0.74565 1 0.61285 1 0.5036 1 0.63698 1 0.39959 1 0.38157 1 0.63877 1 0.18682 1 PCBP1 4 (3%) 151 NA NA 0.0045315 1 1 1 1 1 0.31182 1 0.64084 1 0.034685 1 0.44794 1 1 1 0.13543 1 FAT4 29 (19%) 126 0.52881 1 0.095454 1 0.54274 1 0.15502 1 0.67247 1 1 1 0.28751 1 0.11087 1 0.118 1 0.40942 1 LRP1B 30 (19%) 125 0.80542 1 0.14372 1 0.22832 1 0.0032433 1 0.66155 1 0.40703 1 0.80943 1 0.40575 1 0.68307 1 0.18544 1 NRXN1 17 (11%) 138 0.73387 1 0.5919 1 0.60851 1 1 1 0.058981 1 0.042254 1 0.73197 1 0.05987 1 0.75654 1 5.7588e-05 0.0672 GRIA1 14 (9%) 141 0.43505 1 0.8402 1 0.10064 1 1 1 0.52411 1 0.92866 1 0.075713 1 0.55232 1 0.72845 1 0.3125 1 SDK1 25 (16%) 130 0.59965 1 0.24793 1 0.51986 1 0.066255 1 0.78076 1 0.53959 1 1 1 0.67135 1 0.49742 1 0.71786 1 SOX9 9 (6%) 146 NA NA 0.28018 1 0.74565 1 1 1 0.23129 1 0.89896 1 1 1 0.25499 1 1 1 0.33427 1 DMD 27 (17%) 128 0.76285 1 0.51676 1 0.14329 1 0.015938 1 0.12742 1 0.61588 1 0.029734 1 0.00021973 0.255 0.1392 1 0.13293 1 CNTN6 15 (10%) 140 0.49332 1 0.22279 1 0.061948 1 0.70791 1 0.17099 1 0.21043 1 0.21733 1 0.21551 1 0.048234 1 0.00076096 0.882 GABRA5 8 (5%) 147 0.16521 1 0.51829 1 0.49473 1 1 1 0.41593 1 0.88619 1 1 1 0.91518 1 1 1 0.23625 1 OR2M4 8 (5%) 147 0.58718 1 0.59184 1 0.49473 1 0.35739 1 0.88424 1 1 1 1 1 0.91518 1 0.63877 1 0.60897 1 OR6N1 8 (5%) 147 0.91444 1 0.98601 1 1 1 1 1 1 1 0.88619 1 1 1 1 1 1 1 0.66325 1 PCDH9 16 (10%) 139 0.22185 1 0.67832 1 0.42946 1 0.71978 1 0.73043 1 0.76395 1 0.72539 1 0.045564 1 1 1 0.020149 1 TXNDC3 10 (6%) 145 0.32989 1 0.51679 1 0.53368 1 0.65876 1 1 1 0.90081 1 0.40074 1 0.69691 1 0.65086 1 0.34217 1 MGC26647 7 (5%) 148 0.86303 1 0.88343 1 0.27615 1 0.30499 1 0.21628 1 0.4951 1 0.61264 1 0.55169 1 0.63253 1 0.079773 1 FAM22F 8 (5%) 147 0.058164 1 0.63252 1 0.0064695 1 1 1 0.018689 1 0.6873 1 0.099955 1 0.08875 1 0.13267 1 0.52255 1 ACVR2A 8 (5%) 147 0.24206 1 0.70288 1 0.033746 1 1 1 0.88424 1 0.36867 1 1 1 0.5497 1 1 1 1.6885e-06 0.00198 TCF7L2 11 (7%) 144 0.34654 1 0.34287 1 0.36829 1 0.21424 1 0.44592 1 1 1 1 1 0.8839 1 1 1 0.31904 1 AFF2 15 (10%) 140 0.80773 1 0.29125 1 0.5884 1 0.063884 1 0.4758 1 0.75157 1 0.21733 1 0.11548 1 0.34971 1 0.12732 1 CNBD1 6 (4%) 149 0.58239 1 0.73625 1 0.44233 1 1 1 0.68885 1 0.16011 1 0.6122 1 0.1304 1 1 1 5.8642e-09 6.94e-06 OTOL1 7 (5%) 148 0.35273 1 0.1705 1 0.71929 1 1 1 0.062472 1 0.26724 1 0.61264 1 0.50697 1 0.63253 1 0.31308 1 KCNA4 10 (6%) 145 0.94369 1 0.1548 1 0.53368 1 0.052537 1 0.82269 1 0.74392 1 0.40074 1 0.40266 1 0.65086 1 0.52684 1 ISL1 8 (5%) 147 0.54821 1 0.97456 1 0.71929 1 0.35739 1 0.88424 1 0.10041 1 1 1 0.42382 1 1 1 0.77033 1 MGC42105 10 (6%) 145 0.5972 1 0.97461 1 0.53368 1 0.65876 1 0.25064 1 0.47725 1 0.62142 1 0.59005 1 1 1 0.049954 1 ACOT4 3 (2%) 152 NA NA 0.02939 1 1 1 0.40506 1 0.033203 1 1 1 0.37651 1 0.47728 1 0.36604 1 0.6468 1 CDH11 13 (8%) 142 0.54473 1 0.98174 1 0.56401 1 1 1 1 1 0.48311 1 0.69989 1 0.63474 1 0.70685 1 0.36153 1 ATM 21 (14%) 134 0.74871 1 0.89075 1 0.10579 1 0.33097 1 0.78087 1 0.42089 1 0.40139 1 0.18255 1 0.59006 1 0.18079 1 TPTE 11 (7%) 144 0.6228 1 0.78481 1 0.36829 1 0.073641 1 0.64881 1 0.41924 1 1 1 0.83238 1 1 1 0.62968 1 BTNL8 3 (2%) 152 NA NA 0.012089 1 0.62011 1 1 1 0.70372 1 0.56943 1 1 1 0.56073 1 1 1 6.1013e-09 7.2e-06 KLHL4 12 (8%) 143 0.20025 1 0.12047 1 0.24597 1 0.098542 1 0.073809 1 1 1 0.2808 1 0.083589 1 0.066972 1 0.86685 1 ROBO1 14 (9%) 141 0.6702 1 0.3876 1 0.78048 1 0.006762 1 0.2083 1 0.73724 1 0.72166 1 0.041774 1 1 1 0.040232 1 GGT1 3 (2%) 152 NA NA 0.86529 1 0.62011 1 1 1 0.70372 1 0.56943 1 1 1 0.56073 1 1 1 6.1013e-09 7.2e-06 FLG 26 (17%) 129 0.24206 1 0.6046 1 0.67269 1 0.027421 1 0.13604 1 0.12267 1 0.32614 1 0.19591 1 0.13543 1 0.073864 1 PCDHB2 13 (8%) 142 0.30673 1 0.84657 1 0.40165 1 1 1 0.75861 1 0.56816 1 0.69989 1 0.84717 1 1 1 0.45658 1 POSTN 11 (7%) 144 0.065637 1 0.9294 1 1 1 0.073641 1 1 1 0.23074 1 0.40074 1 0.24839 1 0.65086 1 0.37749 1 OR51V1 9 (6%) 146 0.3919 1 0.84876 1 0.32745 1 0.0053574 1 0.047105 1 0.22352 1 0.39959 1 0.020307 1 0.65086 1 0.25193 1 GRIK3 14 (9%) 141 0.5361 1 3.0417e-05 0.0356 0.40165 1 0.46517 1 0.87555 1 0.26478 1 1 1 0.29183 1 0.70685 1 0.0018543 1 LRRN3 9 (6%) 146 0.99662 1 0.57266 1 0.74565 1 1 1 0.5036 1 0.2498 1 0.080166 1 0.49352 1 1 1 0.26778 1 PRDM9 11 (7%) 144 0.41253 1 0.64501 1 0.36829 1 0.65876 1 0.18331 1 0.62474 1 0.033937 1 0.44527 1 0.4507 1 0.39851 1 ADAM29 9 (6%) 146 0.22183 1 0.65085 1 0.098041 1 1 1 0.045155 1 0.28115 1 0.065556 1 0.03613 1 1 1 0.0006732 0.781 KIAA1486 9 (6%) 146 0.13661 1 0.79969 1 0.74565 1 0.15243 1 0.16876 1 0.56348 1 0.39959 1 0.15537 1 0.07198 1 0.55494 1 PSG8 8 (5%) 147 0.2869 1 0.7942 1 1 1 0.61285 1 0.33916 1 0.88619 1 1 1 0.57596 1 0.057718 1 0.21029 1 NCKAP5 13 (8%) 142 0.69371 1 0.91807 1 0.78048 1 0.43332 1 0.2659 1 0.56816 1 0.69989 1 0.81695 1 0.68611 1 0.88899 1 C8B 9 (6%) 146 0.28516 1 0.15894 1 0.098041 1 0.15243 1 0.5036 1 1 1 0.63621 1 0.49352 1 1 1 0.99915 1 DNAH5 28 (18%) 127 0.81184 1 0.83905 1 0.41073 1 0.77086 1 0.53703 1 0.37046 1 0.80918 1 0.23034 1 0.68307 1 0.091854 1 CASP8 10 (6%) 145 0.41723 1 0.046949 1 1 1 0.19524 1 0.14745 1 0.12468 1 0.40074 1 0.1563 1 0.44423 1 2.2635e-06 0.00266 CCDC160 5 (3%) 150 NA NA 0.77654 1 0.20962 1 1 1 0.14357 1 0.2948 1 0.54756 1 0.60159 1 0.53476 1 0.27752 1 DCAF4L2 9 (6%) 146 0.95059 1 0.95859 1 1 1 0.022016 1 0.066773 1 0.79908 1 0.62142 1 0.8123 1 0.63877 1 0.45284 1 DKK2 5 (3%) 150 NA NA 0.7274 1 0.68133 1 0.58183 1 0.741 1 0.2948 1 1 1 0.64534 1 1 1 0.27752 1 EPHA3 13 (8%) 142 0.4552 1 0.42912 1 0.40165 1 0.40494 1 0.4681 1 1 1 1 1 0.57219 1 0.68611 1 0.76639 1 ERBB4 14 (9%) 141 0.0025018 1 0.98872 1 0.10064 1 0.43332 1 0.014251 1 0.051356 1 0.2832 1 0.10799 1 0.46297 1 6.4793e-06 0.00759 GUCY1A3 10 (6%) 145 0.11009 1 0.066783 1 1 1 0.052537 1 0.16984 1 0.67092 1 0.39959 1 0.19776 1 0.65086 1 0.6772 1 IFT80 7 (5%) 148 0.9112 1 0.85204 1 1 1 0.30499 1 0.86706 1 0.32104 1 0.61264 1 0.55169 1 1 1 3.0145e-07 0.000355 INHBA 7 (5%) 148 0.88394 1 0.47388 1 0.44233 1 0.001123 1 0.16932 1 0.64504 1 0.61264 1 0.27507 1 0.63253 1 0.58608 1 KLK2 3 (2%) 152 NA NA 0.22907 1 1 1 0.40506 1 1 1 1 1 1 1 0.86887 1 1 1 0.5719 1 LPPR4 11 (7%) 144 0.59161 1 0.2362 1 0.76523 1 0.68543 1 0.41057 1 0.026647 1 1 1 0.83238 1 1 1 0.066912 1 OR7C1 6 (4%) 149 NA NA 0.21796 1 0.44233 1 0.17714 1 0.27364 1 1 1 1 1 0.83274 1 1 1 0.65604 1 SCN7A 12 (8%) 143 0.60027 1 0.77185 1 0.56401 1 0.38144 1 0.044466 1 0.16273 1 1 1 0.017146 1 1 1 0.95132 1 TGFBR2 7 (5%) 148 0.76836 1 0.41163 1 0.71929 1 0.079131 1 0.73683 1 0.56528 1 0.61264 1 0.75263 1 0.63253 1 0.78885 1 TRPS1 13 (8%) 142 0.67536 1 0.15271 1 0.56401 1 0.127 1 0.06277 1 0.19816 1 0.2808 1 0.17774 1 0.46297 1 0.073972 1 OR8J1 4 (3%) 151 0.3549 1 0.27278 1 0.36686 1 1 1 0.31182 1 0.48327 1 1 1 0.35629 1 1 1 6.0225e-09 7.12e-06 RIMS2 12 (8%) 143 0.22773 1 0.99567 1 0.56401 1 0.098542 1 0.27623 1 0.91878 1 0.67676 1 0.57648 1 0.68611 1 0.50433 1 SFMBT2 12 (8%) 143 0.37917 1 0.59072 1 0.76523 1 0.40494 1 0.24139 1 0.83882 1 0.67676 1 0.94243 1 0.68611 1 0.57633 1 IL18R1 8 (5%) 147 0.4968 1 0.83085 1 1 1 0.1134 1 0.080251 1 0.28604 1 0.62142 1 0.26846 1 0.63253 1 0.77466 1 PCDH17 14 (9%) 141 0.1813 1 0.32317 1 1 1 0.69884 1 0.82094 1 0.14736 1 0.2832 1 0.10411 1 0.34971 1 0.029868 1 FLRT2 11 (7%) 144 0.63965 1 0.76939 1 0.36829 1 0.65876 1 0.062593 1 0.69091 1 0.40962 1 0.27365 1 0.4507 1 0.13957 1 ZC3H13 17 (11%) 138 0.84093 1 0.31765 1 1 1 0.02237 1 0.20924 1 0.93783 1 0.22088 1 0.25011 1 0.36775 1 0.37175 1 PTEN 4 (3%) 151 NA NA 0.12324 1 1 1 0.50089 1 0.31182 1 0.81942 1 0.37651 1 0.4147 1 0.36604 1 0.49216 1 ZFHX4 17 (11%) 138 2.4765e-05 0.029 0.77763 1 0.45304 1 0.28444 1 0.014826 1 0.39952 1 0.72539 1 0.45234 1 0.75209 1 0.037983 1 NRXN3 15 (10%) 140 0.84184 1 0.48508 1 1 1 0.25921 1 0.883 1 0.28805 1 0.29126 1 0.37599 1 1 1 0.06436 1 LIFR 13 (8%) 142 0.11393 1 0.66619 1 0.56401 1 0.43332 1 0.10299 1 0.78571 1 1 1 1 1 0.70685 1 0.038933 1 ZNF429 7 (5%) 148 0.6228 1 0.21982 1 0.11653 1 1 1 0.062472 1 0.32104 1 0.6122 1 0.67057 1 1 1 0.00010984 0.128 OR2M2 6 (4%) 149 0.21887 1 0.42817 1 0.11653 1 0.02822 1 0.038123 1 1 1 0.17053 1 0.20416 1 0.18118 1 0.19837 1 TMEM132D 15 (10%) 140 0.91049 1 0.69001 1 0.18577 1 0.063884 1 0.78933 1 0.55979 1 0.29126 1 0.068526 1 0.34971 1 0.82628 1 SAT1 4 (3%) 151 NA NA 0.26496 1 0.058507 1 0.50089 1 1 1 1 1 1 1 0.90144 1 1 1 0.86895 1 CDH18 10 (6%) 145 0.17909 1 0.65117 1 0.056205 1 0.65876 1 0.16984 1 0.47725 1 1 1 0.64392 1 1 1 0.011451 1 P2RY10 6 (4%) 149 0.38664 1 0.47086 1 1 1 0.24046 1 0.68885 1 0.36763 1 1 1 0.64534 1 1 1 0.011341 1 SYT16 6 (4%) 149 0.50709 1 0.58689 1 0.68133 1 0.24046 1 1 1 0.62392 1 0.6122 1 0.63444 1 1 1 0.64572 1 DKK4 4 (3%) 151 0.058164 1 0.85852 1 1 1 0.11757 1 0.31182 1 0.48327 1 1 1 0.4009 1 1 1 6.0225e-09 7.12e-06 NALCN 14 (9%) 141 0.30177 1 0.68041 1 1 1 0.69333 1 0.77361 1 0.14736 1 0.2808 1 0.009595 1 1 1 6.7902e-05 0.0792 SULT1C4 3 (2%) 152 0.029971 1 0.93148 1 1 1 0.065096 1 0.19899 1 0.56943 1 1 1 0.56073 1 1 1 6.1013e-09 7.2e-06 UMOD 7 (5%) 148 0.49341 1 0.5562 1 1 1 0.30499 1 0.31255 1 0.32104 1 0.61264 1 0.41157 1 0.63253 1 0.00010984 0.128 CPXCR1 6 (4%) 149 0.32697 1 0.64349 1 0.11653 1 1 1 0.482 1 0.017768 1 0.6122 1 0.23193 1 0.081003 1 0.024597 1 PDZRN4 12 (8%) 143 0.80103 1 0.15949 1 0.24597 1 0.0040808 1 0.27623 1 0.54382 1 1 1 0.85781 1 1 1 0.33654 1 USP17L2 7 (5%) 148 0.30172 1 0.80476 1 1 1 1 1 0.62288 1 0.096141 1 0.61264 1 0.12454 1 0.63253 1 5.7847e-09 6.85e-06 ESR1 11 (7%) 144 0.43915 1 0.94398 1 1 1 0.38144 1 0.029593 1 0.51432 1 0.40074 1 0.55503 1 0.65086 1 0.057456 1 FAM5C 10 (6%) 145 0.012244 1 0.8452 1 0.2096 1 0.19524 1 0.14745 1 0.12468 1 0.39959 1 0.12651 1 0.63877 1 5.211e-08 6.13e-05 MIER3 10 (6%) 145 0.46317 1 0.73904 1 0.53368 1 1 1 0.55544 1 0.20237 1 0.39959 1 0.38157 1 0.65086 1 0.0023194 1 NLRP5 10 (6%) 145 0.63965 1 0.7941 1 0.74565 1 0.63402 1 0.55544 1 0.28292 1 1 1 0.41354 1 0.44423 1 0.42005 1 OR6T1 6 (4%) 149 0.50248 1 0.00012243 0.142 0.68133 1 1 1 0.68885 1 0.62392 1 0.54756 1 0.14779 1 0.53476 1 0.64572 1 PCDH10 14 (9%) 141 0.21794 1 0.3267 1 0.10064 1 0.23865 1 0.4681 1 0.63039 1 0.72166 1 0.50206 1 1 1 0.44738 1 PCDHB5 12 (8%) 143 0.048225 1 0.83061 1 0.078833 1 1 1 0.20415 1 0.49859 1 1 1 0.041491 1 0.46297 1 0.0064533 1 TRPC6 8 (5%) 147 0.28341 1 0.18722 1 1 1 0.61285 1 0.45846 1 0.52268 1 0.62142 1 0.15337 1 0.63253 1 0.86962 1 RHOA 4 (3%) 151 NA NA 0.91786 1 1 1 0.40506 1 0.741 1 0.12517 1 0.46857 1 0.55196 1 0.4566 1 0.63953 1 SYNE1 37 (24%) 118 0.77325 1 0.11312 1 0.57614 1 0.035028 1 0.59093 1 0.1568 1 0.54422 1 0.28272 1 0.74053 1 0.015422 1 CYTL1 4 (3%) 151 NA NA 0.24809 1 1 1 1 1 0.04828 1 0.48327 1 1 1 0.4009 1 1 1 6.0225e-09 7.12e-06 CHRM2 8 (5%) 147 0.32316 1 0.778 1 0.49473 1 0.61285 1 0.0061144 1 1 1 0.13053 1 0.018656 1 0.16383 1 0.93928 1 GALNT14 9 (6%) 146 0.51666 1 0.99592 1 0.74565 1 0.63402 1 0.010342 1 0.22352 1 0.39959 1 0.020307 1 0.65086 1 0.33899 1 LRRIQ3 7 (5%) 148 0.58239 1 0.49457 1 0.063328 1 1 1 0.31255 1 0.64504 1 1 1 0.9034 1 0.60214 1 0.59034 1 NAALAD2 11 (7%) 144 0.88394 1 0.54381 1 0.13026 1 0.015605 1 0.0055137 1 0.13884 1 1 1 0.28592 1 1 1 3.3351e-05 0.039 PCDH11X 11 (7%) 144 0.012848 1 0.56135 1 1 1 0.38144 1 0.18331 1 0.23074 1 0.40074 1 0.24839 1 0.44423 1 0.069371 1 TFAP2D 5 (3%) 150 NA NA 0.028093 1 0.20962 1 0.58183 1 0.78417 1 1 1 1 1 0.55886 1 1 1 0.86975 1 TNR 15 (10%) 140 0.44445 1 0.49265 1 0.5884 1 0.46517 1 0.16331 1 0.0083537 1 0.72166 1 0.01459 1 1 1 1.3913e-06 0.00163 CNTNAP4 10 (6%) 145 0.35328 1 0.93639 1 1 1 0.19524 1 0.16984 1 0.14093 1 0.39959 1 0.020307 1 0.65086 1 0.75202 1 DOCK2 16 (10%) 139 0.92239 1 0.38178 1 1 1 0.25921 1 0.16183 1 0.21207 1 0.21733 1 0.09624 1 0.35657 1 0.086964 1