Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.071 0.243 -9999.0 0.0 -0.673 19.0 19.0 IHH -0.063 0.21 -9999.0 0.0 -0.683 19.0 19.0 SHH Np/Cholesterol/GAS1 -0.079 0.165 -9999.0 0.0 -0.38 37.0 37.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.079 0.164 0.378 37.0 -9999.0 0.0 37.0 SMO/beta Arrestin2 -0.065 0.234 -9999.0 0.0 -0.637 19.0 19.0 SMO -0.075 0.248 -9999.0 0.0 -0.592 27.0 27.0 AKT1 -0.011 0.102 -9999.0 0.0 -0.314 7.0 7.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.072 0.196 -9999.0 0.0 -0.507 31.0 31.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.073 0.242 -9999.0 0.0 -0.58 27.0 27.0 STIL -0.036 0.178 -9999.0 0.0 -0.587 12.0 12.0 DHH N/PTCH2 -0.076 0.206 -9999.0 0.0 -0.468 37.0 37.0 DHH N/PTCH1 -0.078 0.21 -9999.0 0.0 -0.487 24.0 24.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.053 0.188 -9999.0 0.0 -0.582 21.0 21.0 PTHLH -0.099 0.311 -9999.0 0.0 -0.913 19.0 19.0 determination of left/right symmetry -0.073 0.242 -9999.0 0.0 -0.58 27.0 27.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.098 0.307 -9999.0 0.0 -0.9 19.0 19.0 IHH N/Hhip -0.142 0.246 -9999.0 0.0 -0.474 62.0 62.0 DHH N/Hhip -0.135 0.23 -9999.0 0.0 -0.44 64.0 64.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.073 0.242 -9999.0 0.0 -0.58 27.0 27.0 pancreas development -0.134 0.251 -9999.0 0.0 -0.546 50.0 50.0 HHAT 0.005 0.066 -9999.0 0.0 -0.635 2.0 2.0 PI3K 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.132 0.25 -9999.0 0.0 -0.543 50.0 50.0 somite specification -0.073 0.242 -9999.0 0.0 -0.58 27.0 27.0 SHH Np/Cholesterol/PTCH1 -0.045 0.188 -9999.0 0.0 -0.602 13.0 13.0 SHH Np/Cholesterol/PTCH2 -0.035 0.131 -9999.0 0.0 -0.369 22.0 22.0 SHH Np/Cholesterol/Megalin -0.021 0.103 -9999.0 0.0 -0.408 9.0 9.0 SHH -0.004 0.105 -9999.0 0.0 -0.449 10.0 10.0 catabolic process -0.052 0.191 -9999.0 0.0 -0.44 27.0 27.0 SMO/Vitamin D3 -0.06 0.223 -9999.0 0.0 -0.65 17.0 17.0 SHH Np/Cholesterol/Hhip -0.08 0.17 -9999.0 0.0 -0.386 38.0 38.0 LRP2 -0.022 0.106 -9999.0 0.0 -0.416 13.0 13.0 receptor-mediated endocytosis -0.059 0.213 -9999.0 0.0 -0.619 17.0 17.0 SHH Np/Cholesterol/BOC -0.044 0.137 -9999.0 0.0 -0.376 21.0 21.0 SHH Np/Cholesterol/CDO -0.008 0.102 -9999.0 0.0 -0.377 12.0 12.0 mesenchymal cell differentiation 0.08 0.168 0.383 38.0 -9999.0 0.0 38.0 mol:Vitamin D3 -0.043 0.19 -9999.0 0.0 -0.606 13.0 13.0 IHH N/PTCH2 -0.079 0.205 -9999.0 0.0 -0.466 38.0 38.0 CDON -0.007 0.1 -9999.0 0.0 -0.509 7.0 7.0 IHH N/PTCH1 -0.052 0.193 -9999.0 0.0 -0.445 27.0 27.0 Megalin/LRPAP1 -0.006 0.075 -9999.0 0.0 -0.284 13.0 13.0 PTCH2 -0.054 0.183 -9999.0 0.0 -0.539 23.0 23.0 SHH Np/Cholesterol -0.018 0.079 -9999.0 0.0 -0.367 9.0 9.0 PTCH1 -0.052 0.192 -9999.0 0.0 -0.442 27.0 27.0 HHIP -0.134 0.251 -9999.0 0.0 -0.547 50.0 50.0