Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.053 0.192 -9999.0 0.0 -0.598 17.0 17.0 IHH -0.039 0.173 -9999.0 0.0 -0.523 20.0 20.0 SHH Np/Cholesterol/GAS1 -0.039 0.117 0.17 1.0 -0.288 31.0 32.0 LRPAP1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.039 0.116 0.286 31.0 -0.168 1.0 32.0 SMO/beta Arrestin2 -0.057 0.201 -9999.0 0.0 -0.495 25.0 25.0 SMO -0.064 0.205 -9999.0 0.0 -0.519 25.0 25.0 AKT1 -0.026 0.132 -9999.0 0.0 -0.485 6.0 6.0 ARRB2 0.022 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.028 0.138 -9999.0 0.0 -0.305 31.0 31.0 ADRBK1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.065 0.203 -9999.0 0.0 -0.504 26.0 26.0 STIL -0.03 0.145 -9999.0 0.0 -0.445 13.0 13.0 DHH N/PTCH2 -0.027 0.151 -9999.0 0.0 -0.396 24.0 24.0 DHH N/PTCH1 -0.048 0.169 -9999.0 0.0 -0.326 43.0 43.0 PIK3CA 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.023 0.146 -9999.0 0.0 -0.416 21.0 21.0 PTHLH -0.079 0.26 -9999.0 0.0 -0.777 19.0 19.0 determination of left/right symmetry -0.065 0.203 -9999.0 0.0 -0.504 26.0 26.0 PIK3R1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.078 0.257 -9999.0 0.0 -0.767 19.0 19.0 IHH N/Hhip -0.083 0.191 -9999.0 0.0 -0.399 45.0 45.0 DHH N/Hhip -0.074 0.177 -9999.0 0.0 -0.376 44.0 44.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.065 0.203 -9999.0 0.0 -0.504 26.0 26.0 pancreas development -0.072 0.187 -9999.0 0.0 -0.369 47.0 47.0 HHAT 0.019 0.053 -9999.0 0.0 -0.493 2.0 2.0 PI3K 0.036 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.072 0.185 -9999.0 0.0 -0.354 49.0 49.0 somite specification -0.065 0.203 -9999.0 0.0 -0.504 26.0 26.0 SHH Np/Cholesterol/PTCH1 -0.035 0.145 -9999.0 0.0 -0.362 24.0 24.0 SHH Np/Cholesterol/PTCH2 -0.011 0.089 -9999.0 0.0 -0.279 17.0 17.0 SHH Np/Cholesterol/Megalin 0.001 0.07 -9999.0 0.0 -0.291 9.0 9.0 SHH -0.004 0.075 -9999.0 0.0 -0.358 8.0 8.0 catabolic process -0.037 0.152 -9999.0 0.0 -0.346 33.0 33.0 SMO/Vitamin D3 -0.048 0.182 -9999.0 0.0 -0.449 25.0 25.0 SHH Np/Cholesterol/Hhip -0.045 0.123 -9999.0 0.0 -0.289 35.0 35.0 LRP2 0.009 0.048 -9999.0 0.0 -0.169 13.0 13.0 receptor-mediated endocytosis -0.052 0.173 -9999.0 0.0 -0.552 14.0 14.0 SHH Np/Cholesterol/BOC -0.018 0.1 0.17 1.0 -0.287 20.0 21.0 SHH Np/Cholesterol/CDO 0.003 0.075 -9999.0 0.0 -0.28 12.0 12.0 mesenchymal cell differentiation 0.045 0.122 0.287 35.0 -9999.0 0.0 35.0 mol:Vitamin D3 -0.026 0.155 -9999.0 0.0 -0.415 17.0 17.0 IHH N/PTCH2 -0.033 0.154 -9999.0 0.0 -0.383 27.0 27.0 CDON 0.013 0.07 -9999.0 0.0 -0.493 3.0 3.0 IHH N/PTCH1 -0.032 0.156 -9999.0 0.0 -0.349 33.0 33.0 Megalin/LRPAP1 0.024 0.037 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 -0.012 0.121 -9999.0 0.0 -0.331 20.0 20.0 SHH Np/Cholesterol 0.0 0.061 -9999.0 0.0 -0.272 9.0 9.0 PTCH1 -0.038 0.153 -9999.0 0.0 -0.347 33.0 33.0 HHIP -0.072 0.187 -9999.0 0.0 -0.369 47.0 47.0