Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.004 0.089 -9999.0 0.0 -0.252 20.0 20.0 epithelial cell differentiation 0.056 0.063 -9999.0 0.0 -0.266 5.0 5.0 CYFIP2 0.029 0.052 -9999.0 0.0 -0.506 2.0 2.0 ENAH -0.015 0.06 0.282 1.0 -9999.0 0.0 1.0 EGFR 0.021 0.073 -9999.0 0.0 -0.506 4.0 4.0 EPHA2 0.016 0.074 -9999.0 0.0 -0.317 10.0 10.0 MYO6 0.009 0.051 -9999.0 0.0 -0.257 5.0 5.0 CTNNB1 0.026 0.053 -9999.0 0.0 -0.317 5.0 5.0 ABI1/Sra1/Nap1 0.063 0.042 -9999.0 0.0 -0.313 2.0 2.0 AQP5 0.007 0.055 -9999.0 0.0 -0.374 1.0 1.0 CTNND1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.011 0.053 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.003 0.068 -9999.0 0.0 -9999.0 0.0 0.0 EGF -0.09 0.209 -9999.0 0.0 -0.425 58.0 58.0 NCKAP1 0.033 0.024 -9999.0 0.0 -0.317 1.0 1.0 AQP3 0.008 0.052 -9999.0 0.0 -9999.0 0.0 0.0 cortical microtubule organization 0.056 0.063 -9999.0 0.0 -0.266 5.0 5.0 GO:0000145 -0.012 0.047 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.063 0.065 -9999.0 0.0 -0.269 5.0 5.0 MLLT4 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.023 0.054 -9999.0 0.0 -0.35 2.0 2.0 ARF6 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.063 0.06 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.004 0.043 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.032 0.024 -9999.0 0.0 -0.317 1.0 1.0 ZYX 0.008 0.051 -9999.0 0.0 -0.257 5.0 5.0 ARF6/GTP 0.064 0.063 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.021 0.081 -9999.0 0.0 -0.506 5.0 5.0 EGFR/EGFR/EGF/EGF -0.024 0.129 -9999.0 0.0 -0.382 3.0 3.0 RhoA/GDP 0.058 0.062 -9999.0 0.0 -0.254 5.0 5.0 actin cytoskeleton organization 0.0 0.047 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.275 0.267 -9999.0 0.0 -0.506 123.0 123.0 DIAPH1 0.057 0.108 -9999.0 0.0 -0.684 2.0 2.0 Wnt receptor signaling pathway -0.056 0.063 0.266 5.0 -9999.0 0.0 5.0 RHOA 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.024 0.055 -9999.0 0.0 -0.352 2.0 2.0 CTNNA1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.0 0.048 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.012 0.049 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 0.038 0.079 -9999.0 0.0 -0.319 5.0 5.0 SEC6/SEC8 0.007 0.047 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.003 0.069 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET -0.036 0.11 -9999.0 0.0 -0.346 3.0 3.0 HGF 0.029 0.034 -9999.0 0.0 -0.317 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.004 0.089 -9999.0 0.0 -0.254 20.0 20.0 actin cable formation 0.013 0.084 0.338 5.0 -0.307 1.0 6.0 KIAA1543 -0.012 0.048 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 0.006 0.057 -9999.0 0.0 -0.265 7.0 7.0 NCK1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.011 0.052 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.048 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.056 0.063 -9999.0 0.0 -0.266 5.0 5.0 EXOC4 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.01 0.048 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.011 0.054 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 -0.009 0.146 -9999.0 0.0 -0.506 17.0 17.0 ABI1 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.01 0.071 0.303 3.0 -9999.0 0.0 3.0 adherens junction assembly 0.007 0.061 0.285 3.0 -9999.0 0.0 3.0 IGF-1R heterotetramer/IGF1 -0.124 0.159 -9999.0 0.0 -0.444 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.047 0.022 -9999.0 0.0 -0.218 1.0 1.0 MET -0.11 0.171 -9999.0 0.0 -0.317 87.0 87.0 PLEKHA7 0.011 0.054 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.06 0.059 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.003 0.067 0.331 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization 0.004 0.089 -9999.0 0.0 -0.252 20.0 20.0 regulation of cell-cell adhesion 0.0 0.047 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.004 0.089 -9999.0 0.0 -0.254 20.0 20.0