E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.019 0.028 -9999.0 0.0 -0.279 2.0 2.0 KLHL20 0.033 0.055 0.141 1.0 -0.213 3.0 4.0 CYFIP2 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.068 0.073 0.186 22.0 -9999.0 0.0 22.0 ENAH 0.019 0.028 -9999.0 0.0 -0.279 2.0 2.0 AP1M1 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.016 0.018 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.005 0.021 -9999.0 0.0 -0.159 2.0 2.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.03 -9999.0 0.0 -9999.0 0.0 0.0 RAPGEF1 0.056 0.079 0.286 2.0 -0.28 1.0 3.0 CTNND1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.026 0.029 -9999.0 0.0 -0.286 2.0 2.0 CRK 0.056 0.077 0.177 66.0 -0.298 1.0 67.0 E-cadherin/gamma catenin/alpha catenin 0.046 0.01 -9999.0 0.0 -9999.0 0.0 0.0 alphaE/beta7 Integrin 0.027 0.029 -9999.0 0.0 -0.154 5.0 5.0 IQGAP1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.044 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.019 0.028 -9999.0 0.0 -0.279 2.0 2.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.004 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.023 0.063 -9999.0 0.0 -0.24 7.0 7.0 PI3K 0.007 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.054 0.012 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.025 0.044 0.091 73.0 -9999.0 0.0 73.0 PIK3R1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.078 0.075 0.188 25.0 -9999.0 0.0 25.0 actin cytoskeleton organization 0.038 0.054 0.168 14.0 -0.169 2.0 16.0 CDC42/GDP 0.073 0.073 0.189 20.0 -9999.0 0.0 20.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.017 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ITGB7 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.058 0.013 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.041 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.071 0.081 0.19 26.0 -9999.0 0.0 26.0 CDC42/GTP/IQGAP1 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.086 0.073 0.197 21.0 -9999.0 0.0 21.0 RAC1/GTP/IQGAP1 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.035 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.03 0.043 0.127 14.0 -0.142 5.0 19.0 NME1 0.013 0.076 0.308 2.0 -0.4 7.0 9.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.018 0.028 -9999.0 0.0 -0.279 2.0 2.0 regulation of cell-cell adhesion 0.011 0.013 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.016 0.023 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.073 0.067 0.163 83.0 -9999.0 0.0 83.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.057 0.033 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 0.035 0.051 0.145 14.0 -0.173 5.0 19.0 VAV2 0.079 0.095 -9999.0 0.0 -0.5 2.0 2.0 RAP1/GDP 0.083 0.074 0.192 27.0 -9999.0 0.0 27.0 adherens junction assembly 0.018 0.027 -9999.0 0.0 -0.272 2.0 2.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.045 0.031 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin 0.012 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.012 0.024 -9999.0 0.0 -0.313 1.0 1.0 PIK3CA 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP 0.001 0.051 -9999.0 0.0 -0.34 3.0 3.0 E-cadherin/beta catenin/alpha catenin 0.047 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.02 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.026 0.03 -9999.0 0.0 -0.291 2.0 2.0