Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.015 0.082 -9999.0 0.0 -0.377 8.0 8.0 IHH 0.026 0.035 -9999.0 0.0 -0.386 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.093 0.13 0.178 1.0 -0.236 101.0 102.0 LRPAP1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.092 0.129 0.235 101.0 -0.176 1.0 102.0 SMO/beta Arrestin2 0.0 0.072 -9999.0 0.0 -0.398 2.0 2.0 SMO -0.009 0.067 -9999.0 0.0 -0.366 3.0 3.0 AKT1 -0.004 0.093 -9999.0 0.0 -0.351 11.0 11.0 ARRB2 0.02 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.02 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.009 0.067 -9999.0 0.0 -0.362 3.0 3.0 STIL -0.062 0.11 0.187 6.0 -0.317 4.0 10.0 DHH N/PTCH2 0.029 0.037 -9999.0 0.0 -0.218 5.0 5.0 DHH N/PTCH1 0.029 0.06 -9999.0 0.0 -0.298 4.0 4.0 PIK3CA 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.021 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.011 0.1 -9999.0 0.0 -0.718 3.0 3.0 determination of left/right symmetry -0.009 0.067 -9999.0 0.0 -0.362 3.0 3.0 PIK3R1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.011 0.1 -9999.0 0.0 -0.71 3.0 3.0 IHH N/Hhip -0.004 0.092 -9999.0 0.0 -0.204 40.0 40.0 DHH N/Hhip -0.001 0.079 -9999.0 0.0 -0.179 39.0 39.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.009 0.067 -9999.0 0.0 -0.362 3.0 3.0 pancreas development 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.015 0.047 -9999.0 0.0 -0.4 3.0 3.0 somite specification -0.009 0.067 -9999.0 0.0 -0.362 3.0 3.0 SHH Np/Cholesterol/PTCH1 -0.063 0.113 0.184 3.0 -0.309 5.0 8.0 SHH Np/Cholesterol/PTCH2 -0.074 0.119 0.178 3.0 -0.214 100.0 103.0 SHH Np/Cholesterol/Megalin -0.088 0.133 0.175 3.0 -0.231 107.0 110.0 SHH -0.105 0.15 0.261 3.0 -0.283 98.0 101.0 catabolic process 0.019 0.061 -9999.0 0.0 -0.333 4.0 4.0 SMO/Vitamin D3 -0.054 0.11 0.195 6.0 -0.3 6.0 12.0 SHH Np/Cholesterol/Hhip -0.091 0.125 0.178 3.0 -0.228 99.0 102.0 LRP2 -0.025 0.111 -9999.0 0.0 -0.4 19.0 19.0 receptor-mediated endocytosis -0.061 0.104 -9999.0 0.0 -0.304 7.0 7.0 SHH Np/Cholesterol/BOC -0.089 0.124 0.178 3.0 -0.226 98.0 101.0 SHH Np/Cholesterol/CDO -0.074 0.119 0.178 3.0 -0.214 98.0 101.0 mesenchymal cell differentiation 0.091 0.124 0.226 99.0 -0.176 3.0 102.0 mol:Vitamin D3 -0.06 0.117 0.199 6.0 -0.31 5.0 11.0 IHH N/PTCH2 0.027 0.048 -9999.0 0.0 -0.256 4.0 4.0 CDON 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.027 0.064 -9999.0 0.0 -0.335 4.0 4.0 Megalin/LRPAP1 0.006 0.085 -9999.0 0.0 -0.282 19.0 19.0 PTCH2 0.019 0.039 -9999.0 0.0 -0.4 2.0 2.0 SHH Np/Cholesterol -0.079 0.111 -9999.0 0.0 -0.213 98.0 98.0 PTCH1 0.019 0.062 -9999.0 0.0 -0.334 4.0 4.0 HHIP 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0