Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Reelin signaling pathway	61.0	3424.0	56.0	-0.329	0.066	1000.0	-1000.0	-0.038	-1000.0
IL4-mediated signaling events	40.0	3722.0	91.0	-0.794	0.614	1000.0	-1000.0	-0.138	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	36.0	1944.0	54.0	-0.329	0.033	1000.0	-1000.0	-0.047	-1000.0
Syndecan-1-mediated signaling events	31.0	1061.0	34.0	-0.393	0.024	1000.0	-1000.0	-0.033	-1000.0
Glypican 1 network	31.0	1508.0	48.0	-0.199	0.045	1000.0	-1000.0	-0.028	-1000.0
Osteopontin-mediated events	28.0	1075.0	38.0	-0.188	0.035	1000.0	-1000.0	-0.044	-1000.0
TCGA08_retinoblastoma	28.0	227.0	8.0	-0.092	0.039	1000.0	-1000.0	-0.003	-1000.0
Ephrin A  reverse signaling	27.0	194.0	7.0	-0.035	0.019	1000.0	-1000.0	-0.011	-1000.0
TCGA08_p53	25.0	175.0	7.0	-0.07	0.031	1000.0	-1000.0	-0.005	-1000.0
Signaling events mediated by the Hedgehog family	24.0	1260.0	52.0	-0.105	0.092	1000.0	-1000.0	-0.033	-1000.0
Fc-epsilon receptor I signaling in mast cells	22.0	2173.0	97.0	-0.108	0.044	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	22.0	1727.0	78.0	-0.127	0.042	1000.0	-1000.0	-0.042	-1000.0
HIF-1-alpha transcription factor network	21.0	1630.0	76.0	-0.491	0.034	1000.0	-1000.0	-0.147	-1000.0
IL1-mediated signaling events	20.0	1263.0	62.0	-0.14	0.098	1000.0	-1000.0	-0.04	-1000.0
Endothelins	20.0	1982.0	96.0	-0.285	0.024	1000.0	-1000.0	-0.054	-1000.0
BCR signaling pathway	19.0	1909.0	99.0	-0.121	0.029	1000.0	-1000.0	-0.047	-1000.0
FOXA2 and FOXA3 transcription factor networks	18.0	856.0	46.0	-0.374	0.032	1000.0	-1000.0	-0.126	-1000.0
Syndecan-2-mediated signaling events	17.0	1198.0	69.0	-0.23	0.041	1000.0	-1000.0	-0.028	-1000.0
Calcium signaling in the CD4+ TCR pathway	17.0	530.0	31.0	-0.291	0.024	1000.0	-1000.0	-0.042	-1000.0
PDGFR-beta signaling pathway	17.0	1683.0	97.0	-0.118	0.075	1000.0	-1000.0	-0.049	-1000.0
p75(NTR)-mediated signaling	16.0	2023.0	125.0	-0.393	0.062	1000.0	-1000.0	-0.067	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	15.0	535.0	34.0	-0.02	0.035	1000.0	-1000.0	-0.026	-1000.0
BMP receptor signaling	15.0	1234.0	81.0	-0.064	0.044	1000.0	-1000.0	-0.045	-1000.0
Glypican 2 network	15.0	60.0	4.0	-0.006	0.01	1000.0	-1000.0	0.007	-1000.0
LPA receptor mediated events	15.0	1543.0	102.0	-0.147	0.03	1000.0	-1000.0	-0.045	-1000.0
Visual signal transduction: Rods	15.0	790.0	52.0	-0.094	0.023	1000.0	-1000.0	-0.03	-1000.0
Signaling events regulated by Ret tyrosine kinase	14.0	1187.0	82.0	-0.085	0.024	1000.0	-1000.0	-0.052	-1000.0
Canonical Wnt signaling pathway	14.0	729.0	51.0	-0.216	0.113	1000.0	-1000.0	-0.031	-1000.0
Wnt signaling	14.0	100.0	7.0	-0.07	0.021	1000.0	-1000.0	-0.014	-1000.0
amb2 Integrin signaling	13.0	1101.0	82.0	-0.068	0.038	1000.0	-1000.0	-0.029	-1000.0
HIF-2-alpha transcription factor network	13.0	566.0	43.0	-0.255	0.159	1000.0	-1000.0	-0.07	-1000.0
Effects of Botulinum toxin	13.0	347.0	26.0	-0.069	0.038	1000.0	-1000.0	-0.007	-1000.0
Nongenotropic Androgen signaling	13.0	686.0	52.0	-0.122	0.057	1000.0	-1000.0	-0.026	-1000.0
Noncanonical Wnt signaling pathway	12.0	325.0	26.0	-0.07	0.023	1000.0	-1000.0	-0.035	-1000.0
Presenilin action in Notch and Wnt signaling	12.0	754.0	61.0	-0.216	0.107	1000.0	-1000.0	-0.034	-1000.0
TCR signaling in naïve CD8+ T cells	12.0	1206.0	93.0	-0.031	0.034	1000.0	-1000.0	-0.044	-1000.0
EGFR-dependent Endothelin signaling events	12.0	259.0	21.0	-0.037	0.034	1000.0	-1000.0	-0.038	-1000.0
Plasma membrane estrogen receptor signaling	12.0	1090.0	86.0	-0.279	0.07	1000.0	-1000.0	-0.047	-1000.0
VEGFR1 specific signals	12.0	726.0	56.0	-0.003	0.088	1000.0	-1000.0	-0.044	-1000.0
Angiopoietin receptor Tie2-mediated signaling	12.0	1081.0	88.0	-0.118	0.056	1000.0	-1000.0	-0.07	-1000.0
Caspase cascade in apoptosis	11.0	866.0	74.0	-0.129	0.081	1000.0	-1000.0	-0.029	-1000.0
Visual signal transduction: Cones	11.0	427.0	38.0	-0.087	0.039	1000.0	-1000.0	-0.015	-1000.0
PLK1 signaling events	11.0	936.0	85.0	-0.009	0.052	1000.0	-1000.0	-0.023	-1000.0
EPHB forward signaling	11.0	1006.0	85.0	-0.037	0.077	1000.0	-1000.0	-0.058	-1000.0
IL23-mediated signaling events	11.0	669.0	60.0	-0.316	0.034	1000.0	-1000.0	-0.12	-1000.0
Ras signaling in the CD4+ TCR pathway	11.0	199.0	17.0	-0.054	0.044	1000.0	-1000.0	-0.021	-1000.0
Glucocorticoid receptor regulatory network	10.0	1150.0	114.0	-0.283	0.191	1000.0	-1000.0	-0.051	-1000.0
Syndecan-4-mediated signaling events	10.0	725.0	67.0	-0.292	0.05	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by PRL	10.0	358.0	34.0	-0.08	0.081	1000.0	-1000.0	-0.037	-1000.0
JNK signaling in the CD4+ TCR pathway	9.0	159.0	17.0	-0.119	0.046	1000.0	-1000.0	-0.027	-1000.0
Nectin adhesion pathway	9.0	620.0	63.0	-0.377	0.066	1000.0	-1000.0	-0.037	-1000.0
Ephrin B reverse signaling	9.0	441.0	48.0	-0.03	0.028	1000.0	-1000.0	-0.024	-1000.0
Syndecan-3-mediated signaling events	8.0	310.0	35.0	-0.23	0.062	1000.0	-1000.0	-0.028	-1000.0
Integrins in angiogenesis	8.0	692.0	84.0	-0.187	0.056	1000.0	-1000.0	-0.037	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	8.0	548.0	68.0	-0.291	0.038	1000.0	-1000.0	-0.082	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	8.0	965.0	120.0	-0.087	0.079	1000.0	-1000.0	-0.047	-1000.0
Coregulation of Androgen receptor activity	7.0	563.0	76.0	-0.217	0.062	1000.0	-1000.0	-0.025	-1000.0
Thromboxane A2 receptor signaling	7.0	745.0	105.0	-0.092	0.058	1000.0	-1000.0	-0.051	-1000.0
Arf6 signaling events	7.0	453.0	62.0	-0.042	0.05	1000.0	-1000.0	-0.035	-1000.0
Ceramide signaling pathway	7.0	536.0	76.0	-0.028	0.062	1000.0	-1000.0	-0.035	-1000.0
S1P1 pathway	7.0	287.0	36.0	-0.087	0.024	1000.0	-1000.0	-0.047	-1000.0
Signaling mediated by p38-gamma and p38-delta	7.0	110.0	15.0	-0.072	0.024	1000.0	-1000.0	-0.029	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	7.0	245.0	33.0	-0.089	0.058	1000.0	-1000.0	-0.026	-1000.0
Aurora B signaling	7.0	482.0	67.0	-0.397	0.087	1000.0	-1000.0	-0.033	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	6.0	553.0	85.0	-0.038	0.041	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by PTP1B	6.0	500.0	76.0	-0.199	0.04	1000.0	-1000.0	-0.036	-1000.0
S1P5 pathway	6.0	106.0	17.0	-0.073	0.063	1000.0	-1000.0	-0.013	-1000.0
Signaling mediated by p38-alpha and p38-beta	6.0	275.0	44.0	-0.014	0.028	1000.0	-1000.0	-0.031	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	468.0	76.0	-0.005	0.086	1000.0	-1000.0	-0.051	-1000.0
IGF1 pathway	6.0	343.0	57.0	-0.029	0.046	1000.0	-1000.0	-0.037	-1000.0
S1P3 pathway	6.0	288.0	42.0	-0.072	0.041	1000.0	-1000.0	-0.035	-1000.0
S1P4 pathway	6.0	162.0	25.0	-0.073	0.039	1000.0	-1000.0	-0.02	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	701.0	136.0	-0.155	0.058	1000.0	-1000.0	-0.044	-1000.0
FAS signaling pathway (CD95)	5.0	250.0	47.0	-0.019	0.035	1000.0	-1000.0	-0.032	-1000.0
Retinoic acid receptors-mediated signaling	5.0	333.0	58.0	-0.149	0.044	1000.0	-1000.0	-0.052	-1000.0
Regulation of p38-alpha and p38-beta	5.0	287.0	54.0	-0.047	0.047	1000.0	-1000.0	-0.043	-1000.0
ErbB2/ErbB3 signaling events	4.0	302.0	65.0	-0.034	0.034	1000.0	-1000.0	-0.05	-1000.0
Sphingosine 1-phosphate (S1P) pathway	4.0	128.0	28.0	-0.071	0.032	1000.0	-1000.0	-0.021	-1000.0
PLK2 and PLK4 events	4.0	14.0	3.0	0.002	0.023	1000.0	-1000.0	-0.014	-1000.0
Cellular roles of Anthrax toxin	4.0	179.0	39.0	-0.035	0.025	1000.0	-1000.0	-0.015	-1000.0
Insulin-mediated glucose transport	4.0	136.0	32.0	-0.136	0.04	1000.0	-1000.0	-0.029	-1000.0
PDGFR-alpha signaling pathway	4.0	182.0	44.0	-0.009	0.055	1000.0	-1000.0	-0.038	-1000.0
IFN-gamma pathway	4.0	301.0	68.0	-0.045	0.034	1000.0	-1000.0	-0.048	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	309.0	68.0	-0.054	0.066	1000.0	-1000.0	-0.034	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	344.0	83.0	-0.149	0.054	1000.0	-1000.0	-0.038	-1000.0
Class I PI3K signaling events	4.0	341.0	73.0	-0.032	0.043	1000.0	-1000.0	-0.038	-1000.0
Arf6 trafficking events	4.0	287.0	71.0	-0.042	0.043	1000.0	-1000.0	-0.03	-1000.0
FOXM1 transcription factor network	4.0	231.0	51.0	-0.091	0.044	1000.0	-1000.0	-0.15	-1000.0
Regulation of Androgen receptor activity	4.0	339.0	70.0	-0.259	0.055	1000.0	-1000.0	-0.042	-1000.0
IL12-mediated signaling events	3.0	331.0	87.0	-0.082	0.052	1000.0	-1000.0	-0.088	-1000.0
ErbB4 signaling events	3.0	209.0	69.0	-0.181	0.081	1000.0	-1000.0	-0.044	-1000.0
EPO signaling pathway	3.0	202.0	55.0	0.011	0.065	1000.0	-1000.0	-0.038	-1000.0
mTOR signaling pathway	3.0	160.0	53.0	-0.065	0.032	1000.0	-1000.0	-0.034	-1000.0
ceramide signaling pathway	3.0	164.0	49.0	-0.0	0.039	1000.0	-1000.0	-0.038	-1000.0
Atypical NF-kappaB pathway	3.0	107.0	31.0	-0.0	0.053	1000.0	-1000.0	-0.02	-1000.0
IL27-mediated signaling events	3.0	173.0	51.0	-0.058	0.043	1000.0	-1000.0	-0.056	-1000.0
IL6-mediated signaling events	3.0	280.0	75.0	-0.02	0.073	1000.0	-1000.0	-0.067	-1000.0
Regulation of Telomerase	3.0	387.0	102.0	-0.162	0.057	1000.0	-1000.0	-0.057	-1000.0
Canonical NF-kappaB pathway	2.0	92.0	39.0	-0.025	0.052	1000.0	-1000.0	-0.029	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	10.0	5.0	0.023	0.033	1000.0	-1000.0	0.006	-1000.0
Aurora A signaling	2.0	159.0	60.0	-0.019	0.067	1000.0	-1000.0	-0.02	-1000.0
Arf6 downstream pathway	2.0	120.0	43.0	-0.025	0.039	1000.0	-1000.0	-0.023	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	152.0	52.0	-0.095	0.054	1000.0	-1000.0	-0.05	-1000.0
FoxO family signaling	2.0	176.0	64.0	-0.062	0.08	1000.0	-1000.0	-0.069	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	97.0	45.0	0.0	0.066	1000.0	-1000.0	-0.051	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	293.0	125.0	-0.008	0.088	1000.0	-1000.0	-0.049	-1000.0
TCGA08_rtk_signaling	2.0	56.0	26.0	-0.021	0.047	1000.0	-1000.0	-0.015	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	149.0	74.0	-0.049	0.054	1000.0	-1000.0	-0.059	-1000.0
Rapid glucocorticoid signaling	2.0	49.0	20.0	-0.015	0.026	1000.0	-1000.0	-0.003	-1000.0
p38 MAPK signaling pathway	2.0	100.0	44.0	-0.002	0.052	1000.0	-1000.0	-0.028	-1000.0
Arf1 pathway	2.0	109.0	54.0	-0.001	0.044	1000.0	-1000.0	-0.016	-1000.0
LPA4-mediated signaling events	1.0	18.0	12.0	-0.013	0.006	1000.0	-1000.0	-0.019	-1000.0
BARD1 signaling events	1.0	105.0	57.0	-0.047	0.062	1000.0	-1000.0	-0.031	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	118.0	65.0	-0.069	0.044	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by HDAC Class III	1.0	69.0	40.0	-0.043	0.045	1000.0	-1000.0	-0.017	-1000.0
TRAIL signaling pathway	1.0	91.0	48.0	-0.018	0.051	1000.0	-1000.0	-0.033	-1000.0
IL2 signaling events mediated by PI3K	1.0	113.0	58.0	-0.021	0.041	1000.0	-1000.0	-0.044	-1000.0
IL2 signaling events mediated by STAT5	1.0	35.0	22.0	-0.003	0.039	1000.0	-1000.0	-0.039	-1000.0
Insulin Pathway	1.0	108.0	74.0	-0.008	0.073	1000.0	-1000.0	-0.041	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	7.0	23.0	0.012	0.038	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by HDAC Class II	0.0	40.0	75.0	-0.017	0.064	1000.0	-1000.0	-0.027	-1000.0
Circadian rhythm pathway	0.0	7.0	22.0	-0.007	0.054	1000.0	-1000.0	-0.032	-1000.0
Aurora C signaling	0.0	2.0	7.0	-0.0	0.036	1000.0	-1000.0	-0.012	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	36.0	37.0	-0.041	0.058	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by HDAC Class I	0.0	61.0	104.0	-0.046	0.056	1000.0	-1000.0	-0.029	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	22.0	36.0	-0.049	0.05	1000.0	-1000.0	-0.038	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	4.0	27.0	0.0	0.049	1000.0	-1000.0	-0.03	-1000.0
E-cadherin signaling in keratinocytes	0.0	20.0	43.0	-0.043	0.076	1000.0	-1000.0	-0.034	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.023	0.024	1000.0	-1000.0	-0.008	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.023	0.046	1000.0	-1000.0	0.006	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.066	1000.0	-1000.0	0.0	-1000.0
Total	1185	71165	7203	-13.9094814989	7.24416125523	131000	-131000	-5.06062359505	-131000