Clinical Features Time to Death AGE GENDER KARNOFSKY.PERFORMANCE.SCORE RADIATIONS.RADIATION.REGIMENINDICATION nMutated (%) nWild-Type logrank test_P logrank test_Q t-test_P t-test_Q Fisher's exact test_P Fisher's exact test_Q t-test_P t-test_Q Fisher's exact test_P Fisher's exact test_Q PIK3R1 31 (12%) 238 0.74688 1 0.59601 1 0.43064 1 0.87241 1 0.55068 1 BRAF 4 (1%) 265 0.24222 1 0.19826 1 1 1 0.15793 1 0.12425 1 EGFR 72 (27%) 197 0.79095 1 0.48475 1 0.254 1 0.51153 1 0.66511 1 IDH1 13 (5%) 256 0.0020386 1 0.00024532 0.131 0.38607 1 0.06548 1 0.0051438 1 PTEN 85 (32%) 184 0.63156 1 0.19465 1 0.58832 1 0.98024 1 0.054162 1 TP53 77 (29%) 192 0.032065 1 0.1592 1 0.67431 1 0.006569 1 0.3224 1 PIK3CA 28 (10%) 241 0.57669 1 0.85361 1 0.83609 1 0.98008 1 0.53392 1 RB1 22 (8%) 247 0.10443 1 0.8222 1 0.81781 1 0.017908 1 0.49248 1 NF1 28 (10%) 241 0.8446 1 0.28886 1 1 1 0.17991 1 0.67658 1 SPTA1 26 (10%) 243 0.53328 1 0.17611 1 0.29032 1 0.46861 1 0.27861 1 KRTAP4-11 9 (3%) 260 0.62668 1 0.40628 1 0.72774 1 0.81805 1 0.72378 1 GABRA6 11 (4%) 258 0.91223 1 0.21992 1 1 1 0.60717 1 1 1 KEL 15 (6%) 254 0.51188 1 0.40388 1 0.41716 1 0.092517 1 0.40447 1 CDH18 11 (4%) 258 0.37891 1 0.52703 1 1 1 0.56724 1 0.52341 1 PRB2 5 (2%) 264 0.91811 1 0.16714 1 1 1 0.00042329 0.226 1 1 RPL5 7 (3%) 262 0.99406 1 0.78409 1 0.26149 1 0.55833 1 0.42734 1 SEMA3C 11 (4%) 258 0.054123 1 0.95905 1 0.75103 1 0.76986 1 0.20022 1 TPTE2 8 (3%) 261 0.25553 1 0.5852 1 1 1 0.023202 1 0.45607 1 ZNF844 6 (2%) 263 0.57941 1 0.82108 1 0.19487 1 0.87172 1 1 1 OR8K3 6 (2%) 263 0.69537 1 0.90433 1 0.42113 1 0.54421 1 0.66831 1 OR5AR1 6 (2%) 263 0.42623 1 0.0071001 1 0.67145 1 0.060456 1 0.42436 1 STAG2 12 (4%) 257 0.01478 1 0.94897 1 0.76261 1 0.09563 1 0.35302 1 SEMG1 8 (3%) 261 0.94082 1 0.1421 1 0.71462 1 0.32998 1 0.13238 1 CDC27 5 (2%) 264 0.20879 1 0.6895 1 0.35774 1 NA NA 1 1 PDGFRA 11 (4%) 258 0.59046 1 0.028158 1 1 1 0.71877 1 0.52341 1 ADAM29 9 (3%) 260 0.66803 1 0.055061 1 0.16192 1 0.82489 1 0.50199 1 SULT1B1 6 (2%) 263 0.077893 1 0.98444 1 1 1 0.82489 1 1 1 ABCC9 11 (4%) 258 0.96823 1 0.26713 1 0.21591 1 0.51962 1 0.52341 1 NLRP5 12 (4%) 257 0.33353 1 0.96434 1 0.5449 1 0.06548 1 1 1 LZTR1 10 (4%) 259 0.70466 1 0.28487 1 0.09892 1 0.76986 1 0.32617 1 CALCR 7 (3%) 262 0.029804 1 0.016196 1 1 1 0.71753 1 1 1 QKI 5 (2%) 264 0.91965 1 0.81291 1 1 1 0.52659 1 0.052052 1 ZPBP 5 (2%) 264 0.3505 1 0.99383 1 0.35774 1 0.87172 1 0.34674 1 PSPH 5 (2%) 264 0.20674 1 0.37395 1 0.65581 1 0.93178 1 0.66059 1 UGT2A3 6 (2%) 263 0.96948 1 0.84127 1 1 1 0.87172 1 0.094477 1 WNT2 5 (2%) 264 0.3604 1 0.24445 1 0.060636 1 0.68528 1 1 1 OR5D18 6 (2%) 263 0.17355 1 0.71627 1 0.67145 1 0.17943 1 1 1 OR5W2 5 (2%) 264 0.39409 1 0.07632 1 1 1 0.00042367 0.226 0.16624 1 ABCB1 10 (4%) 259 0.49844 1 0.11014 1 0.17735 1 0.4555 1 0.32617 1 COL1A2 10 (4%) 259 0.75144 1 0.1075 1 1 1 0.98305 1 0.32617 1 ATRX 15 (6%) 254 0.045042 1 0.00057593 0.305 0.41716 1 0.0429 1 0.094464 1 C1ORF150 3 (1%) 266 0.6699 1 0.093603 1 1 1 0.23958 1 1 1 LRRC55 6 (2%) 263 0.016467 1 0.51765 1 0.67145 1 0.045138 1 1 1 DCAF12L2 8 (3%) 261 0.53584 1 0.6909 1 0.26495 1 0.71329 1 1 1 LRFN5 7 (3%) 262 0.028188 1 0.41216 1 0.26149 1 0.3308 1 0.0081706 1 LUM 4 (1%) 265 0.089074 1 0.84516 1 1 1 0.75211 1 0.61315 1 MMP13 6 (2%) 263 0.60798 1 0.15698 1 1 1 0.025781 1 0.094477 1 HEATR7B2 11 (4%) 258 0.88511 1 0.061418 1 0.75103 1 0.97929 1 0.20022 1 UGT2B28 6 (2%) 263 0.77403 1 0.82795 1 0.42113 1 0.80389 1 1 1 OR5D13 5 (2%) 264 0.46062 1 0.42713 1 0.65581 1 NA NA 0.66059 1 ZNF99 6 (2%) 263 0.75196 1 0.75863 1 0.42113 1 0.82407 1 1 1 SLC5A7 6 (2%) 263 0.12783 1 0.67501 1 0.42113 1 0.32998 1 1 1 SEMA3E 7 (3%) 262 0.3965 1 0.66114 1 1 1 0.54421 1 0.10013 1 TCHH 16 (6%) 253 0.35085 1 0.33662 1 0.42672 1 0.47169 1 0.1878 1 SLC26A3 6 (2%) 263 0.49709 1 0.34522 1 0.42113 1 0.54421 1 0.66831 1 GABRB2 6 (2%) 263 0.27375 1 0.030843 1 0.19487 1 0.3717 1 0.1878 1 CFHR4 5 (2%) 264 0.37054 1 0.99639 1 0.35774 1 0.97695 1 1 1 IL18RAP 5 (2%) 264 0.7782 1 0.19537 1 0.35774 1 0.29431 1 0.66059 1 OGDH 3 (1%) 266 0.2452 1 0.31739 1 1 1 0.29687 1 1 1 PCDH11X 8 (3%) 261 0.098217 1 0.16137 1 0.46788 1 0.023705 1 0.13238 1 SPRYD5 6 (2%) 263 0.79963 1 0.82108 1 0.67145 1 0.54421 1 1 1 TGFA 4 (1%) 265 0.90711 1 0.37841 1 0.13884 1 NA NA 1 1 OR5P2 4 (1%) 265 0.2652 1 0.12034 1 0.30004 1 0.00042329 0.226 0.61315 1 UGT2B4 5 (2%) 264 0.34792 1 0.65591 1 0.65581 1 0.13837 1 0.34674 1 FOXR2 5 (2%) 264 0.20208 1 0.95739 1 1 1 0.87172 1 1 1 PSG8 6 (2%) 263 0.27732 1 0.47855 1 0.19487 1 0.86455 1 0.42436 1 CNTNAP2 12 (4%) 257 0.81832 1 0.14337 1 0.36387 1 0.1574 1 1 1 PIK3C2G 9 (3%) 260 0.12412 1 0.41104 1 0.29347 1 0.54421 1 0.28453 1 SCN9A 11 (4%) 258 0.029944 1 0.26023 1 0.75103 1 0.25452 1 0.20022 1 GABRA1 5 (2%) 264 0.78808 1 0.91311 1 0.65581 1 0.23958 1 1 1 DYNC1I1 7 (3%) 262 0.099687 1 0.42922 1 1 1 0.085287 1 0.69807 1 PODXL 3 (1%) 266 0.35547 1 0.224 1 0.30076 1 0.12565 1 0.55389 1 HCN1 10 (4%) 259 0.17892 1 0.83655 1 1 1 0.15793 1 0.10254 1 POTEF 5 (2%) 264 0.96933 1 0.70202 1 1 1 NA NA 1 1 CXORF22 8 (3%) 261 0.90251 1 0.5481 1 0.14503 1 0.45483 1 0.268 1 AFM 6 (2%) 263 0.27735 1 0.40688 1 0.67145 1 0.37812 1 1 1 KRTAP20-2 3 (1%) 266 0.51942 1 0.33779 1 1 1 NA NA 0.55389 1 OTC 3 (1%) 266 0.1232 1 0.76448 1 0.30076 1 NA NA 0.28022 1 TRAT1 4 (1%) 265 0.14069 1 0.47125 1 1 1 NA NA 0.61315 1 KLK6 3 (1%) 266 0.24141 1 0.22104 1 0.30076 1 NA NA 0.55389 1 OR4D5 4 (1%) 265 0.65424 1 0.084262 1 0.30004 1 0.83734 1 0.12425 1 GPX5 3 (1%) 266 0.35641 1 0.23207 1 1 1 NA NA 0.55389 1 KRTAP4-7 3 (1%) 266 0.45901 1 0.31734 1 0.55599 1 NA NA 0.28022 1 CDH9 8 (3%) 261 0.53445 1 0.57913 1 0.46788 1 0.48246 1 1 1 CDHR3 3 (1%) 266 0.26379 1 0.55264 1 1 1 0.29431 1 0.55389 1 OR4P4 4 (1%) 265 0.95223 1 0.36372 1 1 1 NA NA 1 1 OR52M1 4 (1%) 265 0.96884 1 0.4652 1 1 1 0.75223 1 1 1 KLF17 5 (2%) 264 0.0026162 1 0.30637 1 0.16222 1 0.46941 1 1 1 OR8J3 4 (1%) 265 0.38375 1 0.57305 1 0.62387 1 0.64359 1 0.30121 1 AP3S1 3 (1%) 266 0.23864 1 0.34814 1 0.55599 1 0.23958 1 0.55389 1 ST6GAL2 5 (2%) 264 0.88375 1 0.3421 1 0.060636 1 0.085762 1 0.66059 1 CD3EAP 3 (1%) 266 0.8567 1 0.668 1 1 1 0.73754 1 1 1 F9 4 (1%) 265 0.023292 1 0.54142 1 0.62387 1 NA NA 1 1 DPP10 7 (3%) 262 0.58491 1 0.44194 1 0.26149 1 0.23997 1 1 1 TCN1 4 (1%) 265 0.90728 1 0.32151 1 0.62387 1 NA NA 0.12425 1 TRPV6 7 (3%) 262 0.82218 1 0.072494 1 0.70793 1 0.82489 1 0.10013 1 PAN3 6 (2%) 263 0.28901 1 0.46184 1 1 1 0.77695 1 0.66831 1 CDKN2C 3 (1%) 266 0.73298 1 0.55949 1 0.55599 1 NA NA 1 1 AZGP1 4 (1%) 265 0.64319 1 0.82184 1 1 1 NA NA 1 1 DRD5 7 (3%) 262 0.62955 1 0.24133 1 1 1 0.29431 1 1 1 FGA 6 (2%) 263 0.92698 1 0.36908 1 0.089334 1 0.3717 1 0.66831 1 FGG 5 (2%) 264 0.40958 1 0.074046 1 0.35774 1 0.29431 1 0.66059 1 OR10G8 4 (1%) 265 0.87664 1 0.26213 1 0.62387 1 0.87172 1 0.61315 1 PCMTD1 3 (1%) 266 0.87361 1 0.67197 1 0.55599 1 0.55599 1 0.55389 1 PROKR2 6 (2%) 263 0.46028 1 0.02052 1 1 1 0.99186 1 0.66831 1 SHB 3 (1%) 266 0.9776 1 0.62105 1 0.30076 1 0.00042367 0.226 0.55389 1 CYP3A5 5 (2%) 264 0.34937 1 0.71499 1 0.35774 1 0.37812 1 1 1 FRMD7 6 (2%) 263 0.71635 1 0.58253 1 1 1 0.90788 1 1 1 KCNB2 5 (2%) 264 0.35721 1 0.66604 1 0.35774 1 NA NA 0.052052 1 KDR 7 (3%) 262 0.35203 1 0.77458 1 0.4281 1 0.87721 1 0.42734 1