Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.018 0.027 0.155 9.0 -0.083 14.0 23.0 IHH 0.038 0.021 0.126 8.0 -0.049 1.0 9.0 SHH Np/Cholesterol/GAS1 0.014 0.02 -9999.0 0.0 -0.041 37.0 37.0 LRPAP1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.013 0.02 0.041 37.0 -9999.0 0.0 37.0 SMO/beta Arrestin2 0.066 0.056 -9999.0 0.0 -9999.0 0.0 0.0 SMO 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 AKT1 0.003 0.083 -9999.0 0.0 -0.334 21.0 21.0 ARRB2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 STIL 0.024 0.085 0.17 125.0 -9999.0 0.0 125.0 DHH N/PTCH2 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.017 0.014 -9999.0 0.0 -0.065 1.0 1.0 PIK3CA 0.028 0.018 -9999.0 0.0 -0.063 17.0 17.0 DHH 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.015 0.024 0.156 7.0 -9999.0 0.0 7.0 determination of left/right symmetry 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 PIK3R1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.015 0.024 0.156 7.0 -9999.0 0.0 7.0 IHH N/Hhip 0.025 0.012 0.071 17.0 -9999.0 0.0 17.0 DHH N/Hhip -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 pancreas development -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.039 0.023 -9999.0 0.0 -0.05 16.0 16.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.021 0.03 -9999.0 0.0 -0.063 55.0 55.0 somite specification 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 SHH Np/Cholesterol/PTCH1 0.014 0.017 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH2 0.018 0.014 -9999.0 0.0 -0.031 4.0 4.0 SHH Np/Cholesterol/Megalin 0.018 0.014 -9999.0 0.0 -0.033 5.0 5.0 SHH -0.015 0.011 0.0 167.0 -9999.0 0.0 167.0 catabolic process 0.02 0.017 -9999.0 0.0 -0.076 1.0 1.0 SMO/Vitamin D3 0.016 0.032 0.18 14.0 -9999.0 0.0 14.0 SHH Np/Cholesterol/Hhip -0.011 0.007 0.0 163.0 -9999.0 0.0 163.0 LRP2 0.032 0.005 -9999.0 0.0 -0.063 1.0 1.0 receptor-mediated endocytosis 0.012 0.027 0.153 13.0 -9999.0 0.0 13.0 SHH Np/Cholesterol/BOC -0.011 0.007 0.0 163.0 -9999.0 0.0 163.0 SHH Np/Cholesterol/CDO 0.018 0.014 -9999.0 0.0 -0.031 4.0 4.0 mesenchymal cell differentiation 0.011 0.007 -9999.0 0.0 0.0 163.0 163.0 mol:Vitamin D3 0.041 0.096 0.19 146.0 -9999.0 0.0 146.0 IHH N/PTCH2 0.05 0.012 0.106 8.0 -0.036 1.0 9.0 CDON 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.036 0.021 -9999.0 0.0 -0.063 13.0 13.0 Megalin/LRPAP1 0.047 0.007 -9999.0 0.0 -0.05 1.0 1.0 PTCH2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.011 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.02 0.017 -9999.0 0.0 -0.076 1.0 1.0 HHIP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0