Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.145 0.126 -9999.0 0.0 -0.568 1.0 1.0 IHH -0.035 0.054 -9999.0 0.0 -0.368 1.0 1.0 SHH Np/Cholesterol/GAS1 0.004 0.069 -9999.0 0.0 -0.212 26.0 26.0 LRPAP1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.004 0.068 0.211 26.0 -9999.0 0.0 26.0 SMO/beta Arrestin2 -0.072 0.107 -9999.0 0.0 -0.417 8.0 8.0 SMO -0.077 0.105 -9999.0 0.0 -0.427 10.0 10.0 AKT1 -0.038 0.106 -9999.0 0.0 -0.464 11.0 11.0 ARRB2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.021 0.152 -9999.0 0.0 -0.512 26.0 26.0 ADRBK1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.075 0.106 -9999.0 0.0 -0.421 10.0 10.0 STIL -0.078 0.089 -9999.0 0.0 -0.351 2.0 2.0 DHH N/PTCH2 0.023 0.083 -9999.0 0.0 -0.345 14.0 14.0 DHH N/PTCH1 -0.081 0.09 -9999.0 0.0 -0.385 3.0 3.0 PIK3CA 0.021 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.015 0.071 -9999.0 0.0 -0.47 6.0 6.0 PTHLH -0.202 0.16 -9999.0 0.0 -0.504 11.0 11.0 determination of left/right symmetry -0.075 0.106 -9999.0 0.0 -0.421 10.0 10.0 PIK3R1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.201 0.16 -9999.0 0.0 -0.501 11.0 11.0 IHH N/Hhip -0.033 0.088 -9999.0 0.0 -0.324 20.0 20.0 DHH N/Hhip 0.01 0.095 -9999.0 0.0 -0.294 26.0 26.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.075 0.106 -9999.0 0.0 -0.421 10.0 10.0 pancreas development -0.008 0.105 -9999.0 0.0 -0.394 20.0 20.0 HHAT 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.029 0.02 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.022 0.056 -9999.0 0.0 -0.449 4.0 4.0 somite specification -0.075 0.106 -9999.0 0.0 -0.421 10.0 10.0 SHH Np/Cholesterol/PTCH1 -0.084 0.085 -9999.0 0.0 -0.33 6.0 6.0 SHH Np/Cholesterol/PTCH2 0.0 0.08 -9999.0 0.0 -0.238 28.0 28.0 SHH Np/Cholesterol/Megalin -0.005 0.08 -9999.0 0.0 -0.225 30.0 30.0 SHH -0.017 0.075 -9999.0 0.0 -0.272 23.0 23.0 catabolic process -0.092 0.087 -9999.0 0.0 -9999.0 0.0 0.0 SMO/Vitamin D3 -0.076 0.098 -9999.0 0.0 -0.384 5.0 5.0 SHH Np/Cholesterol/Hhip -0.011 0.091 -9999.0 0.0 -0.249 33.0 33.0 LRP2 0.002 0.088 -9999.0 0.0 -0.387 14.0 14.0 receptor-mediated endocytosis -0.077 0.096 -9999.0 0.0 -0.404 3.0 3.0 SHH Np/Cholesterol/BOC -0.018 0.101 -9999.0 0.0 -0.257 43.0 43.0 SHH Np/Cholesterol/CDO 0.002 0.071 -9999.0 0.0 -0.219 26.0 26.0 mesenchymal cell differentiation 0.011 0.091 0.247 33.0 -9999.0 0.0 33.0 mol:Vitamin D3 -0.079 0.096 0.372 1.0 -0.349 3.0 4.0 IHH N/PTCH2 -0.02 0.075 -9999.0 0.0 -0.402 8.0 8.0 CDON 0.019 0.062 -9999.0 0.0 -0.512 4.0 4.0 IHH N/PTCH1 -0.09 0.09 -9999.0 0.0 -9999.0 0.0 0.0 Megalin/LRPAP1 0.024 0.065 -9999.0 0.0 -0.264 14.0 14.0 PTCH2 0.015 0.083 -9999.0 0.0 -0.482 8.0 8.0 SHH Np/Cholesterol -0.001 0.059 -9999.0 0.0 -0.204 23.0 23.0 PTCH1 -0.092 0.087 -9999.0 0.0 -9999.0 0.0 0.0 HHIP -0.008 0.105 -9999.0 0.0 -0.395 20.0 20.0