Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.038 0.141 -9999.0 0.0 -0.358 10.0 10.0 IHH -0.085 0.271 -9999.0 0.0 -0.679 13.0 13.0 SHH Np/Cholesterol/GAS1 -0.002 0.084 -9999.0 0.0 -0.394 3.0 3.0 LRPAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.002 0.084 0.391 3.0 -9999.0 0.0 3.0 SMO/beta Arrestin2 -0.033 0.186 -9999.0 0.0 -0.446 10.0 10.0 SMO -0.053 0.175 -9999.0 0.0 -0.464 10.0 10.0 AKT1 -0.034 0.158 -9999.0 0.0 -0.799 2.0 2.0 ARRB2 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.052 0.172 -9999.0 0.0 -0.457 10.0 10.0 STIL -0.034 0.134 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH2 0.023 0.087 -9999.0 0.0 -0.497 2.0 2.0 DHH N/PTCH1 -0.042 0.158 -9999.0 0.0 -0.358 15.0 15.0 PIK3CA 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.002 0.109 -9999.0 0.0 -0.654 2.0 2.0 PTHLH -0.054 0.171 -9999.0 0.0 -0.439 11.0 11.0 determination of left/right symmetry -0.052 0.172 -9999.0 0.0 -0.457 10.0 10.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.054 0.17 -9999.0 0.0 -0.436 11.0 11.0 IHH N/Hhip -0.078 0.217 -9999.0 0.0 -0.466 18.0 18.0 DHH N/Hhip -0.014 0.154 -9999.0 0.0 -0.497 7.0 7.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.052 0.172 -9999.0 0.0 -0.457 10.0 10.0 pancreas development -0.02 0.168 -9999.0 0.0 -0.653 5.0 5.0 HHAT 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.002 0.132 -9999.0 0.0 -0.654 3.0 3.0 somite specification -0.052 0.172 -9999.0 0.0 -0.457 10.0 10.0 SHH Np/Cholesterol/PTCH1 -0.038 0.124 -9999.0 0.0 -0.321 10.0 10.0 SHH Np/Cholesterol/PTCH2 0.013 0.049 -9999.0 0.0 -0.399 1.0 1.0 SHH Np/Cholesterol/Megalin -0.043 0.147 -9999.0 0.0 -0.399 11.0 11.0 SHH -0.02 0.056 -9999.0 0.0 -0.498 1.0 1.0 catabolic process -0.045 0.157 -9999.0 0.0 -0.389 13.0 13.0 SMO/Vitamin D3 -0.046 0.152 -9999.0 0.0 -0.415 8.0 8.0 SHH Np/Cholesterol/Hhip -0.014 0.106 -9999.0 0.0 -0.399 5.0 5.0 LRP2 -0.063 0.23 -9999.0 0.0 -0.654 10.0 10.0 receptor-mediated endocytosis -0.085 0.207 -9999.0 0.0 -0.655 6.0 6.0 SHH Np/Cholesterol/BOC 0.013 0.049 -9999.0 0.0 -0.399 1.0 1.0 SHH Np/Cholesterol/CDO 0.013 0.05 -9999.0 0.0 -0.399 1.0 1.0 mesenchymal cell differentiation 0.014 0.106 0.396 5.0 -9999.0 0.0 5.0 mol:Vitamin D3 -0.009 0.154 0.359 1.0 -0.327 9.0 10.0 IHH N/PTCH2 -0.04 0.182 -9999.0 0.0 -0.438 13.0 13.0 CDON 0.029 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.038 0.162 -9999.0 0.0 -0.393 13.0 13.0 Megalin/LRPAP1 -0.032 0.181 -9999.0 0.0 -0.495 10.0 10.0 PTCH2 0.026 0.012 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.005 0.046 -9999.0 0.0 -0.394 1.0 1.0 PTCH1 -0.046 0.157 -9999.0 0.0 -0.39 13.0 13.0 HHIP -0.02 0.168 -9999.0 0.0 -0.654 5.0 5.0