Clinical Features	CN_CNMF		METHLYATION_CNMF		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Chi-square test_P	Chi-square test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
NRAS	15 (8%)	182	0.01452	1	0.57099	1	0.64501	1	0.53908	1	0.93773	1	0.87847	1
WT1	12 (6%)	185	0.58063	1	2.1894e-06	0.000282	0.081654	1	1	1	0.66565	1	0.51645	1
RUNX1	18 (9%)	179	0.38101	1	0.010983	1	0.0015186	0.178	0.092601	1	0.006489	0.746	5.0959e-05	0.00632
DNMT3A	51 (26%)	146	0.9778	1	3.0298e-05	0.00382	0.012187	1	0.19478	1	5.7055e-05	0.00702	5.4511e-06	0.000698
FLT3	56 (28%)	141	0.016356	1	4.5179e-05	0.00565	1.8625e-07	2.42e-05	0.02093	1	0.00028481	0.0345	1.2791e-05	0.00162
IDH1	19 (10%)	178	0.96802	1	7.0448e-09	9.3e-07	0.42274	1	0.26799	1	0.30652	1	0.23613	1
IDH2	20 (10%)	177	0.26856	1	1.311e-09	1.76e-07	0.72548	1	1	1	0.89602	1	0.89533	1
NPM1	54 (27%)	143	0.00093496	0.11	3.1057e-18	4.25e-16	1.7916e-13	2.44e-11	0.0064878	0.746	2.169e-20	2.99e-18	1.7893e-21	2.49e-19
U2AF1	8 (4%)	189	0.77591	1	0.24029	1	0.23192	1	0.42592	1	0.17562	1	0.17133	1
TP53	15 (8%)	182	1.5192e-10	2.05e-08	2.813e-09	3.74e-07	0.00068675	0.0817	0.062529	1	0.00066802	0.0802	0.00014405	0.0176
KRAS	8 (4%)	189	0.53312	1	0.92542	1	0.32561	1	0.22546	1	0.099573	1	0.063045	1
PTPN11	9 (5%)	188	0.48466	1	0.90321	1	0.047552	1	1	1	0.1759	1	0.44718	1
TET2	17 (9%)	180	0.46353	1	0.53428	1	0.25558	1	0.77566	1	0.51212	1	0.42808	1
KIT	8 (4%)	189	0.88529	1	0.0077858	0.88	0.32561	1	0.68817	1	0.11508	1	0.1133	1
PHF6	6 (3%)	191	0.31722	1	0.39614	1	0.72884	1	0.16967	1	0.5148	1	0.14769	1
SMC1A	7 (4%)	190	0.82596	1	0.35921	1	0.37017	1	0.042958	1	0.15312	1	0.10634	1
SMC3	7 (4%)	190	0.76995	1	0.56393	1	0.55181	1	0.42592	1	0.42639	1	0.47968	1
RAD21	5 (3%)	192	0.75693	1	0.54314	1	0.60751	1	1	1	0.37341	1	0.28673	1
STAG2	6 (3%)	191	0.77591	1	0.034415	1	0.13219	1	0.16967	1	0.85166	1	0.22174	1
FAM5C	5 (3%)	192	1.1546e-07	1.51e-05	0.61092	1	0.72884	1	0.66487	1	1	1	1	1
EZH2	3 (2%)	194	0.0061446	0.713	NA	NA	0.2606	1	1	1	0.22246	1	0.2289	1
ASXL1	5 (3%)	192	0.75693	1	0.18719	1	0.2606	1	0.55162	1	0.22246	1	0.2289	1
PHACTR1	3 (2%)	194	NA	NA	0.42401	1	NA	NA	1	1	0.22246	1	0.2289	1
DIS3	3 (2%)	194	0.5529	1	NA	NA	NA	NA	1	1	0.088997	1	0.095763	1