E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.095 0.188 -9999.0 0.0 -0.441 32.0 32.0 KLHL20 -0.04 0.098 -9999.0 0.0 -0.196 35.0 35.0 CYFIP2 0.013 0.043 -9999.0 0.0 -0.381 2.0 2.0 Rac1/GDP -0.038 0.117 -9999.0 0.0 -0.244 28.0 28.0 ENAH -0.092 0.173 -9999.0 0.0 -0.406 33.0 33.0 AP1M1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.05 0.073 -9999.0 0.0 -0.245 13.0 13.0 ABI1/Sra1/Nap1 -0.05 0.061 -9999.0 0.0 -0.149 40.0 40.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.03 0.101 -9999.0 0.0 -0.199 32.0 32.0 RAPGEF1 -0.059 0.15 -9999.0 0.0 -0.351 30.0 30.0 CTNND1 0.008 0.06 -9999.0 0.0 -0.381 4.0 4.0 regulation of calcium-dependent cell-cell adhesion -0.068 0.167 -9999.0 0.0 -0.399 31.0 31.0 CRK -0.069 0.162 -9999.0 0.0 -0.374 32.0 32.0 E-cadherin/gamma catenin/alpha catenin -0.064 0.126 -9999.0 0.0 -0.244 43.0 43.0 alphaE/beta7 Integrin 0.011 0.056 -9999.0 0.0 -0.199 11.0 11.0 IQGAP1 0.015 0.03 -9999.0 0.0 -0.381 1.0 1.0 NCKAP1 -0.046 0.132 -9999.0 0.0 -0.313 33.0 33.0 Rap1/GTP/I-afadin 0.004 0.065 -9999.0 0.0 -0.186 9.0 9.0 DLG1 -0.06 0.162 -9999.0 0.0 -0.396 29.0 29.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.036 0.054 -9999.0 0.0 -0.188 11.0 11.0 MLLT4 -0.037 0.121 -9999.0 0.0 -0.298 30.0 30.0 ARF6/GTP/NME1/Tiam1 0.003 0.068 -9999.0 0.0 -0.186 12.0 12.0 PI3K -0.045 0.068 -9999.0 0.0 -0.242 11.0 11.0 ARF6 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.083 0.142 -9999.0 0.0 -0.239 71.0 71.0 TIAM1 -0.04 0.126 -9999.0 0.0 -0.31 30.0 30.0 E-cadherin(dimer)/Ca2+ -0.028 0.093 -9999.0 0.0 -0.179 34.0 34.0 AKT1 -0.023 0.042 -9999.0 0.0 -0.141 10.0 10.0 PIK3R1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.098 0.163 -9999.0 0.0 -0.319 59.0 59.0 RhoA/GDP -0.037 0.117 -9999.0 0.0 -0.243 28.0 28.0 actin cytoskeleton organization -0.028 0.073 -9999.0 0.0 -0.144 35.0 35.0 CDC42/GDP -0.037 0.117 -9999.0 0.0 -0.229 35.0 35.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.057 0.117 -9999.0 0.0 -0.226 46.0 46.0 ITGB7 0.005 0.066 -9999.0 0.0 -0.342 6.0 6.0 RAC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.03 0.1 -9999.0 0.0 -0.191 34.0 34.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.032 0.087 -9999.0 0.0 -0.18 31.0 31.0 mol:GDP -0.052 0.131 -9999.0 0.0 -0.267 36.0 36.0 CDC42/GTP/IQGAP1 0.022 0.018 -9999.0 0.0 -0.214 1.0 1.0 JUP -0.026 0.123 -9999.0 0.0 -0.375 19.0 19.0 p120 catenin/RhoA/GDP -0.038 0.12 -9999.0 0.0 -0.251 28.0 28.0 RAC1/GTP/IQGAP1 0.022 0.018 -9999.0 0.0 -0.214 1.0 1.0 PIP5K1C/AP1M1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.008 0.06 -9999.0 0.0 -0.381 4.0 4.0 positive regulation of S phase of mitotic cell cycle -0.027 0.068 -9999.0 0.0 -0.131 39.0 39.0 NME1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.084 0.166 -9999.0 0.0 -0.402 31.0 31.0 regulation of cell-cell adhesion -0.045 0.065 -9999.0 0.0 -0.211 14.0 14.0 WASF2 -0.024 0.033 -9999.0 0.0 -0.094 16.0 16.0 Rap1/GTP -0.033 0.103 -9999.0 0.0 -0.274 14.0 14.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.046 0.12 -9999.0 0.0 -0.212 46.0 46.0 CCND1 -0.033 0.082 -9999.0 0.0 -0.161 39.0 39.0 VAV2 -0.103 0.217 -9999.0 0.0 -0.457 40.0 40.0 RAP1/GDP -0.035 0.108 -9999.0 0.0 -0.279 14.0 14.0 adherens junction assembly -0.082 0.161 -9999.0 0.0 -0.39 31.0 31.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.039 0.114 -9999.0 0.0 -0.298 15.0 15.0 E-cadherin/beta catenin -0.052 0.111 -9999.0 0.0 -0.285 28.0 28.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.079 0.171 -9999.0 0.0 -0.396 33.0 33.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.096 0.131 -9999.0 0.0 -0.315 36.0 36.0 E-cadherin/beta catenin/alpha catenin -0.039 0.103 -9999.0 0.0 -0.214 31.0 31.0 ITGAE 0.009 0.047 -9999.0 0.0 -0.262 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.069 0.17 -9999.0 0.0 -0.408 31.0 31.0