E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.071 0.183 -9999.0 0.0 -0.434 30.0 30.0 KLHL20 -0.022 0.098 0.168 1.0 -0.214 22.0 23.0 CYFIP2 0.026 0.041 -9999.0 0.0 -0.337 2.0 2.0 Rac1/GDP -0.04 0.116 -9999.0 0.0 -0.252 26.0 26.0 ENAH -0.063 0.173 -9999.0 0.0 -0.418 28.0 28.0 AP1M1 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.02 0.094 -9999.0 0.0 -0.232 13.0 13.0 ABI1/Sra1/Nap1 -0.038 0.06 -9999.0 0.0 -0.161 26.0 26.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.027 0.096 -9999.0 0.0 -0.177 28.0 28.0 RAPGEF1 -0.065 0.147 -9999.0 0.0 -0.352 29.0 29.0 CTNND1 0.024 0.049 -9999.0 0.0 -0.337 3.0 3.0 regulation of calcium-dependent cell-cell adhesion -0.052 0.169 -9999.0 0.0 -0.393 30.0 30.0 CRK -0.064 0.156 -9999.0 0.0 -0.385 27.0 27.0 E-cadherin/gamma catenin/alpha catenin -0.014 0.123 -9999.0 0.0 -0.222 40.0 40.0 alphaE/beta7 Integrin 0.036 0.044 -9999.0 0.0 -0.228 4.0 4.0 IQGAP1 0.029 0.029 -9999.0 0.0 -0.337 1.0 1.0 NCKAP1 -0.001 0.099 -9999.0 0.0 -0.337 13.0 13.0 Rap1/GTP/I-afadin 0.044 0.055 -9999.0 0.0 -0.178 9.0 9.0 DLG1 -0.053 0.16 -9999.0 0.0 -0.397 27.0 27.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.063 -9999.0 0.0 -0.175 13.0 13.0 MLLT4 0.008 0.083 -9999.0 0.0 -0.337 9.0 9.0 ARF6/GTP/NME1/Tiam1 0.038 0.061 -9999.0 0.0 -0.178 11.0 11.0 PI3K -0.032 0.082 -9999.0 0.0 -0.224 13.0 13.0 ARF6 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.028 0.131 -9999.0 0.0 -0.267 36.0 36.0 TIAM1 0.003 0.091 -9999.0 0.0 -0.337 11.0 11.0 E-cadherin(dimer)/Ca2+ 0.018 0.096 -9999.0 0.0 -0.175 31.0 31.0 AKT1 -0.026 0.049 -9999.0 0.0 -0.147 9.0 9.0 PIK3R1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.033 0.132 -9999.0 0.0 -0.337 26.0 26.0 RhoA/GDP -0.041 0.118 -9999.0 0.0 -0.25 27.0 27.0 actin cytoskeleton organization -0.013 0.076 0.153 3.0 -0.158 21.0 24.0 CDC42/GDP -0.042 0.119 0.269 1.0 -0.251 27.0 28.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.04 0.109 -9999.0 0.0 -0.213 43.0 43.0 ITGB7 0.023 0.057 -9999.0 0.0 -0.337 4.0 4.0 RAC1 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.02 0.103 -9999.0 0.0 -0.187 31.0 31.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.01 0.085 -9999.0 0.0 -0.172 28.0 28.0 mol:GDP -0.06 0.125 -9999.0 0.0 -0.279 31.0 31.0 CDC42/GTP/IQGAP1 0.04 0.021 -9999.0 0.0 -0.195 1.0 1.0 JUP -0.008 0.111 -9999.0 0.0 -0.337 17.0 17.0 p120 catenin/RhoA/GDP -0.037 0.123 -9999.0 0.0 -0.259 26.0 26.0 RAC1/GTP/IQGAP1 0.036 0.022 -9999.0 0.0 -0.169 1.0 1.0 PIP5K1C/AP1M1 0.044 0.014 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.057 -9999.0 0.0 -0.337 4.0 4.0 positive regulation of S phase of mitotic cell cycle -0.013 0.052 -9999.0 0.0 -0.136 14.0 14.0 NME1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.063 0.166 -9999.0 0.0 -0.399 29.0 29.0 regulation of cell-cell adhesion -0.024 0.079 -9999.0 0.0 -0.169 28.0 28.0 WASF2 -0.01 0.042 0.082 1.0 -0.094 18.0 19.0 Rap1/GTP -0.023 0.104 0.175 2.0 -0.257 13.0 15.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.01 0.123 -9999.0 0.0 -0.191 41.0 41.0 CCND1 -0.016 0.063 -9999.0 0.0 -0.167 14.0 14.0 VAV2 -0.092 0.218 -9999.0 0.0 -0.55 21.0 21.0 RAP1/GDP -0.028 0.11 -9999.0 0.0 -0.288 10.0 10.0 adherens junction assembly -0.062 0.161 -9999.0 0.0 -0.387 29.0 29.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.002 0.11 -9999.0 0.0 -0.188 39.0 39.0 E-cadherin/beta catenin -0.027 0.102 -9999.0 0.0 -0.274 24.0 24.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.07 0.167 -9999.0 0.0 -0.396 30.0 30.0 PIK3CA 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.063 0.131 -9999.0 0.0 -0.333 24.0 24.0 E-cadherin/beta catenin/alpha catenin 0.01 0.1 -9999.0 0.0 -0.205 28.0 28.0 ITGAE 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.053 0.172 -9999.0 0.0 -0.406 29.0 29.0