Clinical Features	MRNA_CNMF		MRNA_CHIERARCHICAL		CN_CNMF		METHLYATION_CNMF		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
IDH1	131 (77%)	39	0.17886	1	0.27157	1	4.1526e-11	8.31e-09	1.3003e-25	2.72e-23	1.1599e-16	2.38e-14	0.063951	1	0.14781	1	0.074082	1
IDH2	6 (4%)	164	NA	NA	NA	NA	0.23968	1	0.33069	1	0.1334	1	0.0073426	1	0.043583	1	0.78668	1
TP53	88 (52%)	82	0.13558	1	0.18832	1	8.2872e-19	1.72e-16	4.1618e-34	8.74e-32	5.9115e-12	1.19e-09	1.645e-10	3.26e-08	2.4636e-05	0.00456	0.3766	1
PIK3CA	15 (9%)	155	NA	NA	NA	NA	0.00048089	0.087	8.1228e-05	0.0149	0.036155	1	0.21539	1	0.57303	1	0.30509	1
ATRX	73 (43%)	97	0.04212	1	0.027051	1	1.4388e-10	2.86e-08	4.0304e-23	8.38e-21	1.7629e-12	3.58e-10	5.042e-07	9.68e-05	1.3239e-05	0.00248	0.4647	1
CIC	35 (21%)	135	0.076376	1	0.11751	1	6.0848e-15	1.24e-12	6.4599e-18	1.33e-15	4.6842e-10	9.23e-08	5.8055e-12	1.17e-09	2.7232e-07	5.28e-05	0.15009	1
FUBP1	19 (11%)	151	0.086154	1	0.091923	1	3.2991e-08	6.47e-06	1.6045e-07	3.13e-05	3.3565e-05	0.00618	1.5986e-05	0.00297	0.00026783	0.0487	0.92225	1
PIK3R1	12 (7%)	158	NA	NA	NA	NA	0.033082	1	0.45416	1	0.78021	1	0.91507	1	0.86668	1	0.78997	1
NOTCH1	16 (9%)	154	0.50154	1	0.46346	1	0.0006708	0.119	0.0005602	0.101	0.018768	1	0.00062978	0.113	0.006748	1	0.042957	1
ZNF844	5 (3%)	165	NA	NA	NA	NA	0.45145	1	1	1	0.37598	1	0.71069	1	0.41443	1	0.38225	1
IL32	4 (2%)	166	NA	NA	NA	NA	0.12824	1	0.092231	1	0.23296	1	1	1	0.82644	1	0.23855	1
PTEN	8 (5%)	162	NA	NA	NA	NA	5.5134e-06	0.00104	1.4208e-06	0.000271	3.3355e-07	6.44e-05	0.022723	1	0.0044805	0.78	0.23531	1
TIMD4	6 (4%)	164	NA	NA	NA	NA	0.44696	1	0.65313	1	0.69939	1	0.73691	1	0.5581	1	1	1
CREBZF	4 (2%)	166	NA	NA	NA	NA	0.17667	1	0.41575	1	0.34719	1	0.059438	1	0.31344	1	0.052705	1
ZNF57	6 (4%)	164	NA	NA	NA	NA	0.1344	1	0.20961	1	0.095927	1	0.072485	1	0.029668	1	0.27199	1
ARID1A	11 (6%)	159	NA	NA	NA	NA	0.64567	1	0.7141	1	0.30369	1	0.24981	1	0.30716	1	0.26498	1
NF1	11 (6%)	159	NA	NA	NA	NA	0.048944	1	0.00074176	0.131	0.0012339	0.216	0.30617	1	0.28955	1	0.7625	1
TCF12	6 (4%)	164	NA	NA	NA	NA	1	1	0.56369	1	0.87102	1	0.3219	1	0.34047	1	0.36576	1
NOX4	5 (3%)	165	NA	NA	NA	NA	0.14094	1	0.80199	1	0.58878	1	0.24846	1	0.62293	1	0.21883	1
EGFR	8 (5%)	162	NA	NA	NA	NA	5.5134e-06	0.00104	1.6333e-06	0.00031	0.0012123	0.213	0.38175	1	0.068828	1	1	1
ZBTB20	7 (4%)	163	NA	NA	NA	NA	0.38556	1	0.22676	1	0.62561	1	1	1	0.95134	1	0.41633	1
MUC7	5 (3%)	165	NA	NA	NA	NA	0.17392	1	0.2462	1	0.32336	1	0.57747	1	0.92344	1	0.38225	1
ZNF845	6 (4%)	164	NA	NA	NA	NA	0.28482	1	0.90869	1	0.69939	1	0.55167	1	0.83575	1	0.087171	1
ANKRD30A	7 (4%)	163	NA	NA	NA	NA	0.61508	1	0.24276	1	0.47307	1	0.86942	1	0.18959	1	0.15134	1
SPDYE5	4 (2%)	166	NA	NA	NA	NA	0.059813	1	0.028348	1	0.061579	1	0.29495	1	0.069345	1	0.32935	1
SCAF1	4 (2%)	166	NA	NA	NA	NA	1	1	0.8704	1	0.456	1	0.39434	1	0.11788	1	1	1
PRDM9	5 (3%)	165	NA	NA	NA	NA	0.84517	1	0.34295	1	0.63967	1	0.71069	1	0.19612	1	0.56164	1
PRAMEF11	5 (3%)	165	NA	NA	NA	NA	0.84517	1	0.52144	1	0.29275	1	0.46423	1	0.41443	1	0.023134	1
ZCCHC12	3 (2%)	167	NA	NA	NA	NA	0.062754	1	0.10764	1	0.55643	1	0.15188	1	0.50533	1	0.14698	1
ZNF91	5 (3%)	165	NA	NA	NA	NA	0.36887	1	0.0070221	1	0.36878	1	0.38832	1	1	1	1	1
C3ORF35	3 (2%)	167	NA	NA	NA	NA	1	1	0.79423	1	0.56609	1	0.58081	1	0.77376	1	0.14698	1
RPTN	5 (3%)	165	NA	NA	NA	NA	0.24821	1	0.10557	1	0.54865	1	0.82318	1	0.80861	1	0.56164	1
DDX5	5 (3%)	165	NA	NA	NA	NA	1	1	0.80199	1	0.43712	1	0.10798	1	0.41443	1	0.21883	1