rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(2), ACO2(2), FH(1), IDH1(131), IDH2(6) 2251788 142 138 9 0 126 5 0 11 0 0 1.11e-15 <1.00e-15 <1.01e-13 2 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(4), CDC25A(1), CDK2(1), CDK4(1), CHEK1(2), MYT1(2), RB1(4), TP53(113), WEE1(1) 4452968 129 91 79 9 49 14 17 27 19 3 6.69e-08 <1.00e-15 <1.01e-13 3 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MAX(4), SP3(2), TP53(113), WT1(1) 1784759 120 91 69 2 49 13 14 28 13 3 6.55e-15 <1.00e-15 <1.01e-13 4 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(3), ACO1(2), ACO2(2), ACSS1(1), ACSS2(3), FH(1), IDH1(131), IDH2(6) 3363648 149 140 16 0 128 6 0 13 2 0 2.33e-15 1.11e-15 1.01e-13 5 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(1), EGFR(10), IGF1R(3), POLR2A(3), PPP2CA(3), PRKCA(3), RB1(4), TEP1(5), TERF1(1), TP53(113), XRCC5(1) 7123118 147 99 95 6 54 16 19 36 18 4 8.82e-14 1.11e-15 1.01e-13 6 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(4), CCNA1(1), CCND1(1), CCNE2(1), CCNG2(1), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CDKN2C(1), CREB3L1(1), E2F1(1), E2F3(1), E2F5(1), GBA2(1), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(2), MDM2(2), MYT1(2), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), POLE(6), PRIM1(1), RB1(4), RBL1(2), RPA1(2), TNXB(9), TP53(113), WEE1(1) 19490078 178 96 128 22 61 20 24 44 26 3 4.78e-08 1.22e-15 1.01e-13 7 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), CCND1(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CFL1(1), E2F1(1), MDM2(2), PRB1(2), TP53(113) 2118324 126 89 76 7 49 14 17 28 15 3 2.42e-10 1.33e-15 1.01e-13 8 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(2), ACO2(2), FH(1), IDH1(131), IDH2(6), IDH3B(1), PC(1), PCK1(3), SUCLG2(1) 5210151 148 138 15 2 128 8 0 12 0 0 3.00e-15 1.44e-15 1.01e-13 9 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(2), AKT1(1), APAF1(1), ATM(4), BAX(1), BIRC2(1), CFLAR(1), CYCS(2), DFFA(1), FAS(1), IL1B(1), IL1R1(1), IL1RAP(1), IL3RA(2), IRAK2(1), IRAK3(4), IRAK4(1), MAP3K14(1), NFKB1(1), NFKB2(1), PIK3CA(15), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(13), PIK3R2(1), PIK3R3(1), PIK3R5(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKAR1A(1), RELA(1), RIPK1(1), TNFRSF10D(1), TP53(113) 21116382 186 109 129 28 57 27 27 42 30 3 5.36e-06 1.67e-15 1.01e-13 10 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(1), ATM(4), BAX(1), CCND1(1), CDK2(1), CDK4(1), E2F1(1), MDM2(2), RB1(4), TIMP3(2), TP53(113) 4580868 131 92 81 6 49 14 19 29 17 3 9.58e-11 1.67e-15 1.01e-13 11 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(2), G6PD(1), GCLC(1), GGT1(2), GPX4(1), GSTA4(1), GSTA5(3), GSTZ1(2), IDH1(131), IDH2(6), OPLAH(2) 5536370 152 139 19 10 130 8 2 12 0 0 2.22e-15 2.00e-15 1.01e-13 12 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(4), ATR(4), BRCA1(1), BRCA2(3), CHEK1(2), CHEK2(3), FANCA(2), FANCC(1), FANCD2(2), FANCE(2), HUS1(1), MRE11A(2), RAD1(2), RAD17(1), RAD50(2), RAD9A(1), TP53(113), TREX1(1) 11181052 147 90 97 10 55 22 17 33 17 3 4.19e-09 2.11e-15 1.01e-13 13 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(3), AKT1(1), ATM(4), BAX(1), CPB2(1), CSNK1A1(2), CSNK1D(1), MAPK8(1), MDM2(2), TP53(113) 5246010 129 90 79 9 50 14 16 31 15 3 5.10e-09 2.44e-15 1.01e-13 14 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(4), CDKN2A(2), E2F1(1), MDM2(2), PIK3CA(15), PIK3R1(13), POLR1A(4), POLR1B(2), RAC1(1), RB1(4), TBX2(1), TP53(113) 5128534 162 112 105 8 52 21 25 32 29 3 9.40e-13 3.00e-15 1.01e-13 15 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(4), ATR(4), CHEK1(2), CHEK2(3), TP53(113) 4056688 126 88 76 6 50 16 15 28 14 3 2.04e-08 3.00e-15 1.01e-13 16 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(1), CAT(2), GH1(1), GHR(2), IGF1R(3), PIK3CA(15), PIK3R1(13), SHC1(1), SOD2(1) 3369975 39 29 32 2 3 10 10 5 11 0 0.00115 3.00e-15 1.01e-13 17 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(3), IFNGR2(1), JAK2(3), NFKB1(1), RB1(4), RELA(1), TNFRSF1B(2), TP53(113), WT1(1) 4591340 129 92 79 10 50 13 15 29 19 3 1.16e-08 3.11e-15 1.01e-13 18 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(1), EIF4E(1), IGF1R(3), INPPL1(4), PIK3CA(15), PIK3R1(13), PPP2CA(3), PTEN(8), RPS6KB1(1) 4982344 49 35 42 5 4 11 10 9 15 0 0.00741 3.11e-15 1.01e-13 19 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(6), DAXX(2), PAX3(1), PML(2), RB1(4), SP100(3), TNFRSF1B(2), TP53(113) 4795174 133 92 83 6 50 14 16 33 17 3 1.29e-11 3.44e-15 1.01e-13 20 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(3), ACO1(2), ACO2(2), FH(1), IDH1(131), IDH2(6), IDH3B(1), OGDHL(1), PC(1), PCK1(3), SDHC(1), SUCLG2(1) 7553903 153 139 20 7 129 8 1 14 1 0 <1.00e-15 3.55e-15 1.01e-13 21 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(4), ATM(4), BRCA1(1), CHEK1(2), CHEK2(3), MAPK8(1), MDM2(2), MRE11A(2), NFKB1(1), RAD50(2), RBBP8(2), RELA(1), TP53(113) 7540336 138 89 88 13 52 19 17 32 15 3 2.59e-07 3.55e-15 1.01e-13 22 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(1), APAF1(1), ATM(4), BAX(1), CYCS(2), PRKCA(3), PTK2(1), STAT1(2), TLN1(2), TP53(113) 6925880 130 91 80 7 50 14 15 32 14 5 3.20e-10 3.77e-15 1.01e-13 23 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(1), ATM(4), ATR(4), BAI1(2), BAX(1), CCNB3(3), CCND1(1), CCNE2(1), CCNG2(1), CDK2(1), CDK4(1), CDKN2A(2), CHEK1(2), CHEK2(3), CYCS(2), DDB2(1), EI24(2), FAS(1), GTSE1(4), MDM2(2), MDM4(1), PPM1D(1), PTEN(8), RFWD2(3), SERPINE1(1), SESN1(1), SESN3(1), SFN(2), SIAH1(1), STEAP3(1), THBS1(1), TP53(113), TSC2(1), ZMAT3(3) 16489564 177 100 127 25 60 22 24 46 22 3 6.67e-07 4.00e-15 1.01e-13 24 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(2), G6PD(1), GCLC(1), GGT1(2), GPX4(1), GSTA4(1), GSTZ1(2), IDH1(131), IDH2(6) 4563041 147 139 14 9 128 6 2 11 0 0 7.33e-15 4.11e-15 1.01e-13 25 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 DNAJC3(2), MAP3K14(1), NFKB1(1), RELA(1), TP53(113) 2473275 118 88 68 6 47 14 14 26 14 3 2.92e-09 4.11e-15 1.01e-13 26 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(4), ATR(4), BRCA1(1), CDC25A(1), CDC34(1), CHEK1(2), CHEK2(3), EP300(3), MDM2(2), MYT1(2), PRKDC(8), RPS6KA1(2), TP53(113), WEE1(1), YWHAQ(1) 10577273 148 90 98 16 51 18 18 39 18 4 9.06e-07 4.44e-15 1.05e-13 27 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(4), ATM(4), ATR(4), CCNA1(1), CCND1(1), CDC25A(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), E2F1(1), RB1(4), SKP2(2), TGFB2(2), TGFB3(1), TP53(113) 7639657 143 91 93 8 54 16 19 32 19 3 5.66e-11 4.88e-15 1.11e-13 28 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BAX(1), BFAR(1), BTK(1), CAD(4), CASP8AP2(2), CD7(1), CSNK1A1(2), DAXX(2), DFFA(1), DIABLO(1), EGFR(10), EPHB2(1), FAF1(3), MAP3K1(2), MAP3K5(2), MAPK1(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MET(6), NFAT5(1), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(2), TP53(113), TPX2(2), TUFM(1) 18354569 174 96 122 15 62 22 21 41 25 3 2.84e-10 5.55e-15 1.22e-13 29 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(1), BAX(1), BCL2L11(1), BIRC2(1), CASP1(1), CASP4(1), CYCS(2), DFFA(1), FAS(1), HELLS(2), IRF1(4), IRF2(1), IRF4(1), IRF6(1), IRF7(2), MAP3K1(2), MAPK10(1), MDM2(2), NFKB1(1), NFKBIE(1), PLEKHG5(1), PRF1(1), RELA(1), RIPK1(1), TNFRSF1B(2), TNFRSF21(2), TP53(113), TRAF3(1) 14439633 150 89 100 17 61 18 16 33 19 3 7.40e-08 5.88e-15 1.25e-13 30 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(1), DUSP4(1), GCK(1), IL1R1(1), MAP2K5(1), MAP3K1(2), MAP3K11(1), MAP3K12(3), MAP3K13(1), MAP3K3(2), MAP3K4(1), MAP3K5(2), MAP3K9(2), MAPK10(1), MAPK7(3), MAPK8(1), MYEF2(2), NFATC3(2), NR2C2(1), PAPPA(3), SHC1(1), TP53(113), ZAK(1) 12722434 147 89 97 11 57 17 22 33 15 3 4.94e-10 6.11e-15 1.25e-13 31 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(1), BAX(1), BIRC2(1), CYCS(2), FAS(1), MAP3K1(2), MAP3K14(1), MAPK10(1), MDM2(2), NFKB1(1), PARP1(1), PRF1(1), RELA(1), RIPK1(1), TNFRSF1B(2), TP53(113) 9437684 132 90 82 11 51 14 16 31 17 3 4.89e-09 6.77e-15 1.35e-13 32 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(1), PIK3CA(15), PIK3R1(13), PLCB1(2), PLCG1(6), PRKCA(3), VAV1(3) 3248760 43 33 35 4 5 10 10 6 11 1 0.00837 1.22e-14 2.35e-13 33 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(1), BCAR1(1), CDKN1B(1), ITGB1(2), MAPK1(1), MAPK3(1), PIK3CA(15), PIK3R1(13), PTEN(8), PTK2(1), SHC1(1), SOS1(1) 4883826 46 34 39 5 5 9 9 7 15 1 0.0152 1.27e-14 2.36e-13 34 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(1), PIK3CA(15), PIK3R1(13), PLCG1(6), PRKCA(3), SHC1(1), SOS1(1) 3939946 40 32 32 3 4 9 10 4 12 1 0.00555 9.93e-14 1.80e-12 35 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(1), ELK1(3), INSR(3), IRS1(2), MAPK3(1), MAPK8(1), PIK3CA(15), PIK3R1(13), PTPN11(4), RAF1(1), RASA1(4), SHC1(1), SLC2A4(1), SOS1(1), SRF(2) 6451484 53 36 46 8 7 14 9 8 14 1 0.0170 7.03e-12 1.24e-10 36 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(1), ACTR3(1), ARPC1B(1), ARPC3(1), PAK1(1), PDGFRA(5), PIK3CA(15), PIK3R1(13), RAC1(1), WASL(1) 3399430 40 29 33 5 1 11 8 7 13 0 0.0464 1.05e-11 1.80e-10 37 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(1), EIF4A1(2), EIF4B(1), EIF4E(1), EIF4G1(2), EIF4G2(1), EIF4G3(4), PIK3CA(15), PIK3R1(13), PPP2CA(3), PTEN(8), RPS6KB1(1), TSC1(2), TSC2(1) 6990309 55 39 48 7 6 13 12 8 16 0 0.0111 1.35e-11 2.24e-10 38 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3D(1), CTLA4(1), HLA-DRA(2), ITK(1), PIK3CA(15), PIK3R1(13), PTPN11(4) 3243349 37 28 30 5 3 8 9 7 10 0 0.0645 1.76e-11 2.85e-10 39 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(1), EIF4A1(2), EIF4E(1), EIF4G1(2), EIF4G2(1), EIF4G3(4), GHR(2), IRS1(2), MAPK1(1), MAPK3(1), PABPC1(3), PIK3CA(15), PIK3R1(13), PRKCA(3), PTEN(8), RPS6KB1(1) 7125003 60 40 53 9 7 15 11 7 18 2 0.0229 6.25e-11 9.87e-10 40 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), EGF(2), EGFR(10), ELK1(3), MAP3K1(2), MAPK3(1), MAPK8(1), PIK3CA(15), PIK3R1(13), PLCG1(6), PRKCA(3), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SRF(2), STAT1(2), STAT3(1) 9486305 69 42 59 8 11 15 10 14 16 3 0.00188 6.77e-11 1.04e-09 41 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(1), JAK2(3), MAPK3(1), MPL(2), PIK3CA(15), PIK3R1(13), PLCG1(6), PRKCA(3), RAF1(1), RASA1(4), SHC1(1), SOS1(1), STAT1(2), STAT3(1), STAT5B(2) 7581094 56 37 48 5 7 10 10 10 16 3 0.00215 8.62e-11 1.30e-09 42 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(1), ELK1(3), MAPK3(1), MAPK8(1), NGFR(1), PIK3CA(15), PIK3R1(13), PLCG1(6), RAF1(1), SHC1(1), SOS1(1) 4830432 44 32 36 6 3 13 9 5 13 1 0.0210 1.75e-10 2.57e-09 43 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(1), CREB1(1), MAPK1(1), MAPK3(1), MAPK7(3), MEF2A(2), MEF2B(1), PIK3CA(15), PIK3R1(13), PLCG1(6), RPS6KA1(2), SHC1(1) 4788955 47 33 39 7 4 13 9 8 12 1 0.0267 2.22e-10 3.17e-09 44 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(1), GH1(1), GHR(2), NFKB1(1), PIK3CA(15), PIK3R1(13), PPP2CA(3), RELA(1) 3560449 37 27 30 5 4 8 9 6 10 0 0.0599 2.26e-10 3.17e-09 45 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(1), ELK1(3), IGF1R(3), IRS1(2), MAPK3(1), MAPK8(1), PIK3CA(15), PIK3R1(13), PTPN11(4), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SRF(2) 6276711 52 38 45 9 5 14 10 7 15 1 0.0364 3.35e-10 4.59e-09 46 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(1), GHR(2), INSR(3), IRS1(2), JAK2(3), MAPK1(1), MAPK3(1), PIK3CA(15), PIK3R1(13), PLCG1(6), PRKCA(3), RAF1(1), RPS6KA1(2), SHC1(1), SLC2A4(1), SOS1(1), SRF(2), STAT5B(2) 8363626 60 37 52 8 6 15 11 11 15 2 0.00584 1.29e-09 1.73e-08 47 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(1), AKT1(1), BAX(1), IGF1R(3), IL3RA(2), KIT(3), KITLG(2), PIK3CA(15), PIK3R1(13), PRKAR1A(1) 5548509 42 31 35 6 3 9 10 7 13 0 0.0289 2.09e-09 2.74e-08 48 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(1), CHRNB1(1), CHRNG(1), MUSK(4), PIK3CA(15), PIK3R1(13), PTK2(1) 4127348 36 27 29 5 3 7 9 6 11 0 0.0685 3.06e-09 3.93e-08 49 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CFL1(1), MAP3K1(2), MYL2(1), MYLK(3), NCF2(3), PAK1(1), PDGFRA(5), PIK3CA(15), PIK3R1(13), PLD1(3), RAC1(1), RALBP1(1), RPS6KB1(1), TRIO(4), VAV1(3), WASF1(1) 8845080 58 35 51 7 8 13 12 6 19 0 0.00232 4.38e-09 5.51e-08 50 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(1), CCND1(1), CDK2(1), CDK4(1), CDKN1B(1), E2F1(1), MAPK1(1), MAPK3(1), NFKB1(1), PAK1(1), PIK3CA(15), PIK3R1(13), RAC1(1), RAF1(1), RB1(4), RELA(1) 5117352 45 29 38 7 5 9 11 3 16 1 0.0443 1.03e-08 1.27e-07 51 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(1), IGF1R(3), IRS1(2), MAPK1(1), MAPK3(1), PIK3CA(15), PIK3R1(13), RAF1(1), SHC1(1), SOS1(1) 4803452 39 29 32 5 2 11 9 3 13 1 0.0229 2.88e-08 3.48e-07 52 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(1), CREB1(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), MAPK3(1), NFKB1(1), PIK3CA(15), PIK3R1(13), RB1(4), RELA(1) 4920143 43 30 36 7 7 9 9 3 14 1 0.0790 7.38e-08 8.75e-07 53 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(1), AXIN1(1), BTRC(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CCND1(1), CHD8(1), CREBBP(6), CSNK1A1(2), CSNK1A1L(2), CSNK1E(1), CSNK2A1(1), CTBP1(3), CUL1(1), CXXC4(1), DAAM1(1), DKK1(1), DKK2(2), DKK4(2), DVL2(1), DVL3(1), EP300(3), FZD1(1), FZD10(1), FZD4(1), FZD6(1), FZD7(1), FZD8(1), FZD9(1), LRP5(4), LRP6(4), MAPK10(1), MAPK8(1), NFAT5(1), NFATC1(1), NFATC2(3), NFATC3(2), NFATC4(2), NKD2(1), NLK(1), PLCB1(2), PLCB3(3), PLCB4(1), PORCN(4), PPP2CA(3), PPP2CB(1), PPP2R2A(2), PPP2R2C(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRICKLE1(1), PRICKLE2(3), PRKCA(3), RAC1(1), RAC2(1), ROCK1(2), ROCK2(2), RUVBL1(1), SENP2(2), SFRP1(1), SFRP4(1), SIAH1(1), SMAD2(3), SMAD3(1), SOX17(2), TBL1XR1(1), TCF7L2(2), TP53(113), VANGL1(1), VANGL2(1), WIF1(2), WNT11(4), WNT2(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(1), WNT8B(1), WNT9B(1) 40843639 243 107 193 44 85 35 29 63 27 4 5.47e-07 9.30e-08 1.08e-06 54 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(1), AKT1(1), ANXA1(2), GNAS(2), NFKB1(1), NOS3(5), NR3C1(2), PIK3CA(15), PIK3R1(13), RELA(1) 4513848 43 31 36 8 9 7 10 5 12 0 0.143 1.20e-07 1.37e-06 55 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(1), CRKL(1), JAK2(3), MAP3K1(2), MAPK3(1), MAPK8(1), PIK3CA(15), PIK3R1(13), RAF1(1), SOS1(1), STAT1(2), STAT5B(2) 7105038 43 27 36 5 5 9 8 6 13 2 0.0129 3.56e-07 3.99e-06 56 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), ELK1(3), MAP3K1(2), MAPK3(1), MAPK8(1), PDGFA(1), PDGFRA(5), PIK3CA(15), PIK3R1(13), PLCG1(6), PRKCA(3), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SRF(2), STAT1(2), STAT3(1) 8837934 63 41 55 11 9 15 10 9 17 3 0.0305 3.95e-07 4.35e-06 57 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(1), AKT1(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CREB1(1), GNAS(2), MAPK1(1), MAPK3(1), PIK3CA(15), PIK3R1(13), PRKAR1A(1), PRKCA(3), RAC1(1), RPS6KA1(2), SOS1(1) 7344992 47 31 40 6 5 10 9 6 15 2 0.0235 1.09e-06 1.18e-05 58 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 FURIN(1), NOTCH1(23) 2346584 24 16 21 2 5 3 1 6 7 2 0.0285 2.30e-06 2.44e-05 59 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 ITGB1(2), KLRC1(1), LAT(1), MAPK3(1), PAK1(1), PIK3CA(15), PIK3R1(13), RAC1(1), SYK(1), VAV1(3) 4720634 39 27 32 7 3 9 10 3 13 1 0.0888 5.69e-06 5.94e-05 60 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(1), DIAPH1(3), FYN(1), GSN(1), ITGA1(2), ITGB1(2), MAPK1(1), MAPK3(1), MYL2(1), MYLK(3), PIK3CA(15), PIK3R1(13), PTK2(1), RAF1(1), ROCK1(2), SHC1(1), TLN1(2) 9448341 51 31 44 8 8 10 11 9 12 1 0.0248 6.62e-06 6.80e-05 61 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(1), ELK1(3), H2AFX(1), MAPK3(1), NFKB1(1), PIK3CA(15), PIK3R1(13), RAC1(1), RAF1(1), RALA(1), RALBP1(1), RALGDS(2), RELA(1) 4817156 42 28 35 8 4 9 9 5 14 1 0.120 9.93e-06 0.000100 62 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(4), ANAPC10(1), ANAPC2(2), ANAPC5(2), ANAPC7(1), ATM(4), ATR(4), BUB1(3), BUB1B(1), BUB3(2), CCNA1(1), CCNB3(3), CCND1(1), CCNE2(1), CCNH(2), CDC14A(2), CDC14B(2), CDC16(1), CDC20(1), CDC23(2), CDC25A(1), CDC27(3), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CDKN2C(1), CHEK1(2), CHEK2(3), CREBBP(6), CUL1(1), DBF4(4), E2F1(1), E2F3(1), EP300(3), ESPL1(4), FZR1(2), HDAC2(4), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(2), MDM2(2), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), PKMYT1(1), PLK1(1), PRKDC(8), RB1(4), RBL1(2), RBL2(2), SFN(2), SKP2(2), SMAD2(3), SMAD3(1), SMC1A(1), SMC1B(4), TGFB2(2), TGFB3(1), TP53(113), WEE1(1), YWHAQ(1), YWHAZ(1) 34341123 247 103 196 44 68 41 35 64 34 5 8.39e-06 1.04e-05 0.000104 63 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), ELK1(3), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(3), NFATC3(2), NFATC4(2), PIK3CA(15), PIK3R1(13), PLA2G4A(2), PLCG1(6), PPP3CA(1), PPP3CC(1), RAF1(1), SHC1(1), SOS1(1), SYK(1), VAV1(3) 10887817 62 37 54 11 10 14 12 11 14 1 0.0270 3.33e-05 0.000325 64 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(4), ATM(4), BUB1(3), BUB1B(1), BUB3(2), CCNA1(1), CCNB3(3), CCNE2(1), CCNH(2), CDAN1(3), CDC14A(2), CDC14B(2), CDC20(1), CDC25A(1), CDH1(3), CDK2(1), CDK4(1), CDKN2A(2), CHEK1(2), CHEK2(3), DTX4(1), E2F1(1), E2F3(1), E2F5(1), EP300(3), ESPL1(4), HDAC2(4), HDAC3(1), HDAC4(1), HDAC5(1), HDAC6(3), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(2), MDM2(2), MPEG1(2), MPL(2), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), PLK1(1), PRKDC(8), PTPRA(4), RB1(4), RBL1(2), SKP2(2), TBC1D8(1), TP53(113), WEE1(1) 27766256 219 97 169 41 65 36 31 54 28 5 4.45e-05 3.49e-05 0.000335 65 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(1), AKT1(1), GNAI1(1), ITGAV(2), ITGB3(2), MAPK1(1), MAPK3(1), PDGFA(1), PDGFRA(5), PIK3CA(15), PIK3R1(13), PLCB1(2), PRKCA(3), PTK2(1), RAC1(1), SMPD2(1) 6951376 51 32 44 10 5 12 10 7 15 2 0.0730 3.53e-05 0.000335 66 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(1), APC(1), AR(2), BRAF(3), EGFR(10), GNA11(1), GNAI1(1), ITPR1(2), ITPR2(11), ITPR3(6), KCNJ3(1), KCNJ5(2), MAPK1(1), MAPK10(1), PHKA2(4), PIK3CA(15), PIK3CD(1), PIK3R1(13), PITX2(3), PTX3(1), RAF1(1) 13520815 81 41 72 13 13 15 18 20 15 0 0.00555 4.26e-05 0.000398 67 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(1), CABIN1(5), CAMK1G(1), HDAC5(1), IGF1R(3), INSR(3), MAPK7(3), MEF2A(2), MEF2B(1), NFATC1(1), NFATC2(3), PIK3CA(15), PIK3R1(13), PPP3CA(1), PPP3CC(1) 8786281 54 31 47 11 11 14 9 8 12 0 0.0496 5.51e-05 0.000507 68 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(1), ELK1(3), MAP2K2(1), NGFR(1), PIK3CA(15), PIK3CD(1), SHC1(1), SOS1(1) 4079395 24 17 19 4 3 7 5 5 4 0 0.0920 5.97e-05 0.000541 69 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(1), BTK(1), CDKN2A(2), FLOT1(1), FLOT2(1), ITPR1(2), ITPR2(11), ITPR3(6), PDK1(1), PHF11(1), PIK3CA(15), PITX2(3), PLCG2(6), PPP1R13B(1), PREX1(5), PTEN(8), PTPRC(3), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SAG(1), SYK(1), TEC(1), VAV1(3) 13997915 81 39 76 14 20 16 14 24 7 0 0.00400 9.88e-05 0.000882 70 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(6), EP300(3), FYN(1), JAK3(1), PIK3CA(15), PIK3R1(13), STAT5B(2) 7077552 41 26 34 8 4 8 8 11 10 0 0.189 0.000123 0.00108 71 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(3), CPEB1(3), EGFR(10), ERBB4(2), ETS1(3), ETV6(2), ETV7(1), FMN2(2), KRAS(1), MAPK1(1), MAPK3(1), NOTCH1(23), NOTCH2(9), NOTCH3(4), NOTCH4(8), PIWIL2(3), PIWIL3(1), RAF1(1), SOS1(1), SOS2(3), SPIRE1(1), SPIRE2(2) 13234318 85 41 80 16 19 17 10 22 13 4 0.0129 0.000131 0.00113 72 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(1), BPNT1(1), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(15), PIK3CD(1), PTEN(8), RBL2(2), SHC1(1), SOS1(1) 5155177 33 24 28 6 2 9 5 9 7 1 0.115 0.000189 0.00162 73 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CD3D(1), ELK1(3), FYN(1), LAT(1), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(3), NFATC3(2), NFATC4(2), NFKB1(1), PIK3CA(15), PIK3R1(13), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(3), PTPN7(1), RAC1(1), RAF1(1), RASA1(4), RELA(1), SHC1(1), SOS1(1), VAV1(3), ZAP70(2) 12090025 73 38 65 14 17 15 11 12 16 2 0.0215 0.000195 0.00165 74 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 CRKL(1), DOCK1(1), ELK1(3), HGF(3), ITGA1(2), ITGB1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(1), MET(6), PAK1(1), PIK3CA(15), PIK3R1(13), PTEN(8), PTK2(1), PTPN11(4), RAF1(1), RASA1(4), SOS1(1), STAT3(1) 11163102 71 43 64 16 12 13 12 14 19 1 0.0805 0.000283 0.00236 75 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(1), BTK(1), FYN(1), GAB2(1), INPP5D(2), KRAS(1), LAT(1), MAP2K2(1), MAP2K3(2), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(1), NRAS(1), PDK1(1), PIK3CA(15), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(13), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(2), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(6), PRKCA(3), RAC1(1), RAC2(1), RAF1(1), SOS1(1), SOS2(3), SYK(1), VAV1(3), VAV2(1), VAV3(2) 18258149 95 48 87 18 22 23 18 13 17 2 0.00347 0.000342 0.00281 76 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(2), APOA1(1), CD36(3), CITED2(1), CREBBP(6), EHHADH(1), EP300(3), HSD17B4(2), LPL(2), MAPK1(1), MAPK3(1), ME1(1), NCOA1(1), NCOR1(8), NCOR2(3), NR1H3(4), NRIP1(1), PDGFA(1), PIK3CA(15), PIK3R1(13), PPARA(2), PRKAR1A(1), PRKCA(3), PTGS2(1), RB1(4), RELA(1), RXRA(1), STAT5B(2) 15992446 85 43 77 18 10 18 14 21 19 3 0.0616 0.000518 0.00419 77 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(1), ARHGEF1(1), F2(2), GNAI1(1), PIK3CA(15), PIK3R1(13), PLCB1(2), PRKCA(3), ROCK1(2) 6536433 40 28 33 8 4 9 10 4 12 1 0.122 0.000612 0.00489 78 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(1), BRD4(1), CDKN2A(2), FLOT1(1), FLOT2(1), INPPL1(4), IRS1(2), IRS2(1), IRS4(4), LNPEP(1), MAPK1(1), MAPK3(1), PARD3(1), PARD6A(1), PDK1(1), PIK3CA(15), PIK3CD(1), PIK3R1(13), PPYR1(2), PTEN(8), RAF1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SFN(2), SHC1(1), SLC2A4(1), SORBS1(1), SOS1(1), SOS2(3), YWHAQ(1), YWHAZ(1) 15052942 81 41 74 16 10 18 14 19 19 1 0.0346 0.000843 0.00666 79 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 AGT(2), AKT1(1), CALR(2), CAMK1G(1), CAMK4(1), CREBBP(6), CSNK1A1(2), F2(2), MAPK1(1), MAPK3(1), MAPK8(1), MYH2(8), NFATC1(1), NFATC2(3), NFATC3(2), NFATC4(2), PIK3CA(15), PIK3R1(13), PPP3CA(1), PPP3CC(1), PRKAR1A(1), RAF1(1), RPS6KB1(1) 12825101 69 34 62 14 14 15 10 16 13 1 0.0268 0.000958 0.00747 80 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(1), ACTR3(1), AKT1(1), ARHGAP4(1), ARHGEF11(2), BTK(1), CFL1(1), GDI1(2), INPPL1(4), ITPR1(2), ITPR2(11), ITPR3(6), MYLK(3), MYLK2(1), PAK1(1), PAK3(3), PAK6(2), PAK7(2), PDK1(1), PIK3CA(15), PIK3CD(1), PIK3CG(4), PIK3R1(13), PITX2(3), PPP1R13B(1), PTEN(8), ROCK1(2), ROCK2(2), RPS4X(1), SAG(1), WASF1(1), WASL(1) 17750963 99 45 92 17 19 21 20 23 16 0 0.00255 0.00130 0.00997 81 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(2), EGFR(10), ERBB3(2), NRG1(2) 2608526 16 11 14 1 6 2 0 6 2 0 0.0685 0.00167 0.0127 82 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CSF1R(3), EGF(2), EGFR(10), MET(6), PDGFRA(5), PRKCA(3), SH3GLB1(3), SH3KBP1(3) 4915868 35 16 33 6 10 5 3 11 5 1 0.0485 0.00187 0.0140 83 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(4) 512292 4 4 4 0 2 1 0 0 1 0 0.316 0.00194 0.0144 84 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(1), KDR(4), KRAS(1), MAP2K2(1), MAPK1(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(1), NFAT5(1), NFATC1(1), NFATC2(3), NFATC3(2), NFATC4(2), NOS3(5), NRAS(1), PIK3CA(15), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(13), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(2), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(6), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(3), PTGS2(1), PTK2(1), RAC1(1), RAC2(1), RAF1(1), SH2D2A(1), SHC2(1), VEGFA(2) 18186795 102 49 94 23 27 20 22 14 17 2 0.0143 0.00262 0.0192 85 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT1(1), BTK(1), CDKN2A(2), IARS(1), INPP5D(2), PDK1(1), PIK3CA(15), PPP1R13B(1), PTEN(8), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SFN(2), SHC1(1), SOS1(1), SOS2(3), TEC(1), YWHAQ(1), YWHAZ(1) 9103745 49 28 44 10 6 10 9 15 9 0 0.110 0.00362 0.0262 86 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(1), BRAF(3), CREB1(1), CREBBP(6), CRKL(1), EGR1(1), EGR3(1), ELK1(3), FRS2(1), MAP1B(6), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), OPN1LW(1), PIK3C2G(1), PIK3CA(15), PIK3CD(1), PIK3R1(13), PTPN11(4), RPS6KA3(2), SHC1(1), TH(1) 12974893 72 35 65 16 11 15 13 19 13 1 0.0512 0.00450 0.0322 87 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), PIK3CA(15), PIK3CD(1), PIK3R1(13), TRAF3(1), TRAF5(1) 8476988 47 27 40 10 8 11 9 6 12 1 0.0930 0.00496 0.0351 88 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(1), CISH(1), IARS(1), IL13RA1(1), INPP5D(2), JAK2(3), JAK3(1), PI3(1), PIK3CA(15), PPP1R13B(1), RPS6KB1(1), SERPINA4(1), SHC1(1), SOS1(1), SOS2(3), STAT6(3), TYK2(5) 9344752 42 23 37 4 8 7 8 11 8 0 0.00516 0.00629 0.0440 89 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(7), GABRA3(1), GABRA4(3), GABRA5(1), GABRA6(3) 1995807 15 9 15 4 3 4 1 5 2 0 0.365 0.00699 0.0484 90 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDK2(1), CDKN1B(1), CUL1(1), E2F1(1), RB1(4), SKP2(2), UBE2M(1) 2167354 11 8 11 1 1 1 4 1 4 0 0.172 0.00816 0.0558 91 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), CDC34(1), CDK2(1), CUL1(1), E2F1(1), RB1(4), SKP2(2) 2161111 11 8 11 1 1 1 4 1 4 0 0.190 0.0101 0.0685 92 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP4B(2), INPP5B(2), INPPL1(4), IPMK(1), ISYNA1(2), ITGB1BP3(1), ITPK1(2), MINPP1(1), OCRL(4), PI4KA(4), PI4KB(1), PIK3C3(2), PIK3CA(15), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIP4K2A(1), PIP4K2B(1), PIP4K2C(1), PIP5K1C(1), PLCB1(2), PLCB3(3), PLCB4(1), PLCD1(1), PLCD3(2), PLCE1(5), PLCG1(6), PLCG2(6), PLCZ1(3), PTEN(8), SYNJ1(4), SYNJ2(5) 18805664 97 41 91 19 18 22 13 29 15 0 0.00879 0.0131 0.0875 93 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGF(2), EGFR(10), HGS(2), TF(1), TFRC(1) 3246149 18 12 16 2 5 4 1 7 1 0 0.0720 0.0139 0.0923 94 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(1), CFLAR(1), CRKL(1), E2F1(1), IRS1(2), JAK3(1), MAPK1(1), MAPK3(1), PIK3CA(15), PIK3R1(13), RAF1(1), RPS6KB1(1), SHC1(1), SOS1(1), STAT5B(2), SYK(1) 9141616 44 29 37 9 3 11 9 7 13 1 0.116 0.0146 0.0950 95 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(1), AXIN1(1), BTRC(1), FZD1(1), NOTCH1(23) 5408217 27 16 24 5 5 4 1 7 8 2 0.231 0.0147 0.0950 96 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(2), CPS1(4), GLS(1), GLUD1(3), GOT1(2) 1974792 12 6 12 2 1 2 0 5 4 0 0.440 0.0285 0.183 97 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(3), FADS2(2), PLA2G2D(1), PLA2G3(3), PLA2G4A(2), PLA2G5(1), PLA2G6(2) 2562807 16 7 16 2 3 4 2 5 2 0 0.109 0.0310 0.197 98 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(1), BLNK(2), BTK(1), CD81(1), CR2(3), CSK(1), FLOT1(1), FLOT2(1), INPP5D(2), ITPR1(2), ITPR2(11), ITPR3(6), MAPK1(1), MAPK3(1), NFATC1(1), NFATC2(3), PDK1(1), PIK3CA(15), PIK3CD(1), PIK3R1(13), PLCG2(6), PPP1R13B(1), PPP3CA(1), PPP3CC(1), PTPRC(3), RAF1(1), SHC1(1), SOS1(1), SOS2(3), SYK(1), VAV1(3) 18707005 90 44 83 21 21 18 17 18 15 1 0.0352 0.0329 0.207 99 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(1), APC(1), AXIN1(1), CCND1(1), FZD1(1), GJA1(4), GNAI1(1), LBP(1), NFKB1(1), PIK3CA(15), PIK3R1(13), PPP2CA(3), RELA(1) 7766506 44 29 37 11 6 10 9 7 12 0 0.285 0.0356 0.222 100 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), ME1(1), PC(1), PDHA1(2), SLC25A1(1) 2347660 8 7 8 0 1 2 0 3 2 0 0.0677 0.0408 0.251 101 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(2), EGFR(10), MAP3K1(2), NCOR2(3), RXRA(1) 4371597 18 12 16 3 5 4 0 7 2 0 0.162 0.0483 0.295 102 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(1), CDK2(1), CDKN1B(1), CDKN2A(2), CREB1(1), ERBB4(2), INPPL1(4), IRS1(2), IRS2(1), IRS4(4), MET(6), NOLC1(1), PAK1(1), PAK3(3), PAK6(2), PAK7(2), PARD3(1), PARD6A(1), PDK1(1), PIK3CA(15), PIK3CD(1), PPP1R13B(1), PREX1(5), PTEN(8), PTK2(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SFN(2), SHC1(1), SLC2A4(1), SOS1(1), SOS2(3), TSC1(2), TSC2(1), YWHAQ(1), YWHAZ(1) 19531834 88 36 83 20 15 18 16 24 15 0 0.0286 0.0512 0.309 103 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 EGF(2), EGFR(10), MAPK1(1), MAPK3(1), PTPRB(5), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SPRY1(1), SPRY4(1) 6316457 28 16 26 5 7 3 2 9 6 1 0.157 0.0538 0.320 104 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(2), DCN(1), FMOD(1), LUM(2) 917147 6 5 6 2 1 1 0 4 0 0 0.690 0.0540 0.320 105 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), NAT1(1), NAT2(2), XDH(7) 2013925 11 6 11 0 3 1 0 5 2 0 0.0516 0.0546 0.321 106 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(3), PDHA1(2), PDHA2(4) 1756754 11 6 11 1 2 5 1 1 2 0 0.0483 0.0580 0.337 107 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(2), ALG6(3), CCKBR(3), CELSR1(7), CELSR2(9), CELSR3(9), CHRM3(2), EMR2(2), EMR3(1), FSHR(1), GHRHR(2), GNRHR(2), GPR116(5), GPR132(3), GPR133(1), GPR143(3), GPR61(2), GPR77(1), GPR84(2), GRM1(4), GRPR(2), LPHN2(4), LPHN3(3), LTB4R2(1), NTSR1(2), OR8G2(1), P2RY13(1), PTGFR(5), SMO(2), SSTR2(1), TAAR5(1), TSHR(4) 16821897 91 31 91 26 31 20 10 21 9 0 0.0343 0.0623 0.359 108 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(4), AKT1(1), ARAF(1), AREG(2), BRAF(3), CAMK2A(1), CAMK2D(1), CAMK2G(2), CBLB(1), CBLC(1), CDKN1B(1), CRKL(1), EGF(2), EGFR(10), ELK1(3), ERBB3(2), ERBB4(2), KRAS(1), MAP2K2(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), NRAS(1), NRG1(2), PAK1(1), PAK3(3), PAK6(2), PAK7(2), PIK3CA(15), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(13), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(6), PRKCA(3), PTK2(1), RAF1(1), RPS6KB1(1), RPS6KB2(2), SHC1(1), SHC2(1), SHC4(1), SOS1(1), SOS2(3), STAT5B(2) 26026145 121 53 111 20 29 23 17 26 24 2 0.000456 0.0631 0.360 109 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(3), ENPP1(1), ENPP3(2), NADSYN1(3), NNMT(1), NNT(3), NT5C(2), NT5E(1), NT5M(1) 3681460 17 8 17 0 1 6 3 5 2 0 0.00419 0.0721 0.407 110 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 AGT(2), AGTR2(1), EDNRB(1), EGF(2), EGFR(10), NFKB1(1), PLCG1(6), PRKCA(3), RELA(1) 5192964 27 14 24 7 7 5 2 10 2 1 0.291 0.0782 0.438 111 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CDC34(1), CDK2(1), CUL1(1), E2F1(1), FBXW7(1), RB1(4) 2086855 9 6 9 1 1 1 2 1 4 0 0.326 0.0824 0.457 112 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT3(1), AGPS(2), ENPP2(2), ENPP6(1), PAFAH1B1(4), PAFAH1B3(1), PAFAH2(2), PLA2G2D(1), PLA2G3(3), PLA2G4A(2), PLA2G5(1), PLA2G6(2), PLD1(3), PPAP2A(2), PPAP2C(1) 5858875 28 12 28 6 3 6 5 11 3 0 0.187 0.0842 0.463 113 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(1), BRAF(3), CAB39(1), EIF4B(1), MAPK1(1), MAPK3(1), PIK3CA(15), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(13), PIK3R2(1), PIK3R3(1), PIK3R5(1), PRKAA1(2), PRKAA2(2), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), RPS6KB2(2), TSC1(2), TSC2(1), ULK2(5), VEGFA(2), VEGFB(1), VEGFC(2) 13443080 71 33 64 16 14 13 16 13 14 1 0.0650 0.0897 0.489 114 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACPP(1), ENPP1(1), ENPP3(2), FLAD1(2), TYR(3) 2447265 9 6 9 1 1 1 1 4 2 0 0.300 0.0949 0.513 115 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(1), IRS1(2), IRS2(1), JAK3(1), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(15), PIK3CD(1), PIK3R1(13), PPP1R13B(1), RAF1(1), SHC1(1), SOS1(1), SOS2(3), STAT6(3) 9211578 47 30 40 11 5 11 10 8 12 1 0.193 0.104 0.555 116 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(1), ADH1C(2), ADH6(3), ADH7(1), ADHFE1(2) 1430280 10 5 10 3 1 0 2 7 0 0 0.615 0.122 0.649 117 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B4(1), FLT1(3), FLT4(3), KDR(4), NOS3(5), PIK3CA(15), PIK3R1(13), PLCG1(6), PRKCA(3), PTK2(1), SHC1(1) 8609437 55 36 47 15 10 12 14 6 12 1 0.247 0.150 0.789 118 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 NR1H3(4), RXRA(1) 1374555 5 4 4 1 2 1 2 0 0 0 0.372 0.168 0.877 119 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 RB1(4), SP3(2) 1686070 6 4 6 0 1 0 1 1 3 0 0.248 0.176 0.907 120 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLUD1(3), GLUD2(1) 1150076 5 4 5 2 0 2 0 2 1 0 0.734 0.178 0.907 121 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(1), COQ5(1), COQ6(1), NDUFB11(1) 1015591 4 3 4 0 0 2 0 2 0 0 0.310 0.178 0.907 122 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACPP(1), ENPP1(1), ENPP3(2), FLAD1(2), MTMR1(1), MTMR2(2), MTMR6(1), TYR(3) 3799763 13 7 13 2 1 3 1 5 3 0 0.294 0.181 0.916 123 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA3(2), LTB4R(2), P2RY1(1), P2RY2(3), P2RY6(2) 1506365 10 4 10 4 5 2 1 2 0 0 0.526 0.186 0.933 124 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), ENO1(2), GPI(2), HK1(3), PFKL(2), PGAM1(1), PKLR(1), TPI1(1) 2342936 13 6 13 0 5 5 0 2 1 0 0.00330 0.196 0.974 125 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(2), ICAM1(2), ITGA4(2), ITGB1(2), ITGB2(1), SELE(4) 3068611 13 9 12 4 6 4 2 1 0 0 0.340 0.206 1.000 126 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), TAT(1) 667470 3 2 3 1 1 0 1 1 0 0 0.728 0.233 1.000 127 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(10), CPT1A(1), LEPR(1), PRKAA1(2), PRKAA2(2), PRKAG1(1), PRKAG2(1) 3668621 18 6 17 1 3 2 2 9 2 0 0.0428 0.241 1.000 128 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(2), PLCD1(1), PRKCA(3) 1249246 6 3 6 1 2 0 1 2 0 1 0.393 0.241 1.000 129 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), IDI1(1), SQLE(1) 800485 3 2 3 0 0 0 3 0 0 0 0.337 0.246 1.000 130 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GAPDHS(1), GCK(1), GOT1(2), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PC(1), PCK1(3), PDHA1(2), PDHA2(4), PFKL(2), PGAM1(1), PGAM2(1), PKLR(1), TNFAIP1(2), TPI1(1) 10750999 42 17 42 1 15 14 3 8 2 0 1.09e-06 0.264 1.000 131 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(1), COL4A2(2), COL4A4(3), COL4A5(3), COL4A6(5), F2(2), F5(7), F8(12), F9(1), FGA(4), KLKB1(5), PROS1(1), SERPING1(1) 11244833 47 22 47 11 11 12 9 8 6 1 0.0585 0.269 1.000 132 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(2), ATP6AP1(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), CCL5(1), CSK(1), EGFR(10), F11R(1), GIT1(1), JAM2(3), JAM3(2), MAP3K14(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK8(1), MET(6), NFKB1(1), NFKB2(1), NOD1(1), PAK1(1), PLCG1(6), PLCG2(6), PTPN11(4), PTPRZ1(7), RAC1(1), RELA(1), TCIRG1(1), TJP1(3) 17791414 77 30 74 16 20 15 9 19 13 1 0.0158 0.288 1.000 133 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GGT1(2), SHMT1(1) 1051067 4 3 4 1 2 1 1 0 0 0 0.431 0.290 1.000 134 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 GSTZ1(2), HGD(3) 563959 5 2 5 1 2 0 0 1 2 0 0.563 0.290 1.000 135 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(10), ACYP1(1), ADH5(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), LDHB(1), ME1(1), ME3(1), PC(1), PCK1(3), PDHA1(2), PDHA2(4), PKLR(1) 9369026 36 17 35 5 11 10 4 8 3 0 0.00878 0.291 1.000 136 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 FUT8(3), ST3GAL1(1), ST3GAL4(1) 1979414 5 4 5 1 2 2 0 0 1 0 0.395 0.297 1.000 137 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(3), ACAD9(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), DHRS2(2), DHRS3(1), DHRS7(1), ESCO2(2), MYST3(1), MYST4(8), PNPLA3(1), SH3GLB1(3) 6315999 34 11 33 7 7 4 3 15 5 0 0.261 0.297 1.000 138 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH7A1(1), CYP2C19(4), DHRS2(2), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(1), ESCO2(2), MYST3(1), MYST4(8), PNPLA3(1), SH3GLB1(3) 7804515 37 13 36 7 15 6 3 6 7 0 0.0704 0.299 1.000 139 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(1), HLA-DRA(2), IFNB1(1), IL12B(2), IL15(2), IL6(1), PDGFA(1), TGFB2(2), TGFB3(1) 3319913 13 8 13 2 3 0 3 6 1 0 0.292 0.300 1.000 140 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(1), HLA-DRA(2) 600316 3 2 3 1 0 0 0 3 0 0 0.771 0.302 1.000 141 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), PTGS1(2), PTGS2(1) 1352343 4 3 4 0 1 0 0 2 1 0 0.502 0.306 1.000 142 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), HTR2C(1), PLCB1(2), TUB(2) 1810166 6 4 6 2 2 1 0 2 1 0 0.574 0.311 1.000 143 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(2), AMY2B(2), ENPP1(1), ENPP3(2), G6PC(3), GAA(5), GANAB(2), GBE1(1), GCK(1), GPI(2), GUSB(2), GYS1(1), HK1(3), HK2(2), HK3(1), MGAM(3), PYGB(1), PYGL(3), PYGM(1), SI(6), UCHL3(1), UGDH(1), UGT1A1(1), UGT1A5(2), UGT1A7(1), UGT1A8(1), UGT2B15(1), UGT2B4(2), UXS1(1) 14420559 55 26 55 12 15 11 9 14 6 0 0.0318 0.311 1.000 144 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(1), BLNK(2), BTK(1), CSK(1), EPHB2(1), MAP2K2(1), MAPK1(1), NFAT5(1), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), PI3(1), PIK3CA(15), PIK3CD(1), PIK3R1(13), PLCG2(6), PPP1R13B(1), RAF1(1), SERPINA4(1), SHC1(1), SOS1(1), SOS2(3), SYK(1), VAV1(3) 13309040 61 34 54 16 17 11 11 9 13 0 0.174 0.313 1.000 145 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK2(3), JAK3(1), MAPK1(1), MAPK3(1), STAT3(1), TYK2(5) 2978100 12 5 12 3 3 1 0 5 2 1 0.506 0.314 1.000 146 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCL5(1), HLA-DRA(2) 770676 4 2 4 1 0 0 0 3 1 0 0.674 0.317 1.000 147 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(2), CRY1(2), CSNK1E(1), PER1(3) 2157879 8 4 8 0 2 2 1 1 2 0 0.124 0.324 1.000 148 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(3) 534452 3 2 3 0 1 1 0 1 0 0 0.365 0.335 1.000 149 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(2), ECHS1(2), HSD17B4(2), MECR(1), PPT2(2) 2142874 9 5 9 3 3 2 0 2 2 0 0.648 0.339 1.000 150 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT2(2), FUT5(2), FUT6(2) 1270984 6 3 6 2 3 1 0 1 1 0 0.633 0.342 1.000 151 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CSNK1D(1), GRM1(4), PLCB1(2), PPP2CA(3), PPP3CA(1), PRKAR1A(1) 4059311 12 7 12 3 1 1 0 8 2 0 0.724 0.356 1.000 152 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), JAK2(3), TYK2(5) 2658785 9 5 9 2 3 0 1 3 2 0 0.486 0.357 1.000 153 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), JAK2(3), TYK2(5) 2658785 9 5 9 2 3 0 1 3 2 0 0.486 0.357 1.000 154 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), IDI1(1), SQLE(1) 1073929 3 2 3 0 0 0 3 0 0 0 0.328 0.359 1.000 155 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), GOT1(2), TAT(1), TYR(3) 1192087 7 4 7 3 2 0 1 4 0 0 0.824 0.361 1.000 156 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 TGDS(1), UGDH(1), UXS1(1) 971990 3 2 3 1 0 1 2 0 0 0 0.624 0.366 1.000 157 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(3), FDFT1(1), HMGCS1(1), IDI1(1), MVD(2), NSDHL(2), SQLE(1) 3340169 12 5 12 4 5 1 3 3 0 0 0.464 0.378 1.000 158 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(1), CCND1(1), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CDKN2C(1), E2F1(1), RB1(4), RBL1(2) 4063427 18 8 18 4 4 2 5 3 4 0 0.278 0.379 1.000 159 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT3(1), AGPS(2), CDS2(2), CHAT(3), CHKB(1), DGKB(2), DGKD(2), DGKG(1), DGKH(3), DGKQ(1), GNPAT(1), LGALS13(2), PAFAH1B1(4), PAFAH2(2), PCYT1B(1), PLA2G3(3), PLA2G4A(2), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(6), PPAP2A(2), PPAP2C(1) 12629496 53 24 52 12 18 12 5 11 7 0 0.0573 0.385 1.000 160 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(1), DPYD(3), DPYS(1), ENPP1(1), ENPP3(2), PANK2(1), PANK4(2) 3520713 11 6 11 3 2 1 0 5 3 0 0.728 0.388 1.000 161 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4B(2), INPPL1(4), OCRL(4), PIK3C2A(3), PIK3C2G(1), PIK3CA(15), PIK3CB(1), PIK3CG(4), PLCB1(2), PLCB3(3), PLCB4(1), PLCD1(1), PLCG1(6), PLCG2(6) 11348640 53 29 47 13 8 13 10 14 8 0 0.169 0.393 1.000 162 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), GLS(1), GLUD1(3), OAT(1) 1395744 7 4 7 3 1 1 0 4 1 0 0.766 0.399 1.000 163 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GGT1(2), SHMT1(1) 1389356 3 3 3 1 1 1 1 0 0 0 0.568 0.402 1.000 164 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(10), ACACB(5), ACSS1(1), ACSS2(3), ACYP1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH7A1(1), LDHB(1), ME1(1), ME3(1), PC(1), PCK1(3), PDHA1(2), PDHA2(4), PKLR(1) 11856448 44 20 43 7 15 11 5 9 4 0 0.00748 0.406 1.000 165 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 GAD1(2), GGT1(2) 1453357 4 3 4 0 1 1 1 1 0 0 0.245 0.414 1.000 166 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR2(1), JAK2(3), STAT1(2) 2074691 6 3 6 3 1 0 0 2 2 1 0.842 0.415 1.000 167 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(4), ACTR2(1), ACTR3(1), AKT1(1), ARHGEF6(3), BCAR1(1), BRAF(3), CDKN2A(2), DOCK1(1), EPHB2(1), FYN(1), GRB7(3), GRLF1(3), ITGA1(2), ITGA10(2), ITGA11(2), ITGA2(4), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), MAP3K11(1), MAPK1(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MRAS(1), MYLK(3), MYLK2(1), PAK1(1), PAK3(3), PAK6(2), PAK7(2), PIK3CA(15), PIK3CB(1), PKLR(1), PLCG1(6), PLCG2(6), PTEN(8), PTK2(1), RAF1(1), RALA(1), ROCK1(2), ROCK2(2), SHC1(1), SOS1(1), SOS2(3), TLN1(2), TLN2(3), WAS(2) 30933449 124 44 118 21 30 21 18 36 19 0 0.000517 0.416 1.000 168 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CFL1(1), CFLAR(1) 981816 2 2 2 0 0 0 0 1 1 0 0.516 0.417 1.000 169 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(2), PRKAR1A(1), PRKCA(3) 2402625 8 5 8 2 1 0 1 4 1 1 0.713 0.418 1.000 170 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(2), ECHS1(2), EHHADH(1) 1221447 5 2 5 2 2 1 1 0 1 0 0.598 0.421 1.000 171 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(2), F2(2), FGA(4), PLAT(1), PLAU(1), PLG(3), SERPINE1(1) 3393022 15 7 15 3 7 3 1 2 2 0 0.153 0.422 1.000 172 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD4(1), FYN(1), HLA-DRA(2), PTPRC(3), ZAP70(2) 2286267 10 4 10 1 2 3 0 5 0 0 0.161 0.429 1.000 173 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(2) 1211022 4 4 4 2 2 0 0 1 1 0 0.865 0.435 1.000 174 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD3D(1), CD4(1), IL12B(2), IL12RB1(1), IL12RB2(1), JAK2(3), STAT4(2), TYK2(5) 3723957 16 6 16 5 6 2 1 5 2 0 0.483 0.436 1.000 175 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(3), PDXK(1) 1228156 4 2 4 2 0 2 0 2 0 0 0.818 0.439 1.000 176 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH7A1(1) 3359876 21 8 21 5 8 1 3 9 0 0 0.220 0.441 1.000 177 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(3), HK2(2), HK3(1), ISYNA1(2), TGDS(1) 2954375 10 5 10 1 3 4 2 1 0 0 0.0759 0.448 1.000 178 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG2(1), ASL(2), CKM(1), CKMT1A(1), CKMT2(1), CPS1(4), GLUD1(3), OAT(1), ODC1(2), SMS(1) 4435019 18 6 18 4 3 4 0 6 5 0 0.336 0.453 1.000 179 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(3), C9orf95(1), ENPP1(1), ENPP3(2), NADSYN1(3), NMNAT3(1), NNMT(1), NNT(3), NT5C(2), NT5C1B(1), NT5E(1), NT5M(1) 5441723 20 8 20 3 1 8 4 5 2 0 0.0777 0.457 1.000 180 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(2), DHRS2(2), DHRS3(1), DHRS7(1), PON1(1), PON3(1) 2272571 8 4 7 2 5 0 0 1 2 0 0.457 0.463 1.000 181 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IL12B(2) 758918 3 2 3 1 0 1 1 1 0 0 0.687 0.464 1.000 182 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(1), ACADM(1), ECHS1(2) 1368141 4 2 4 1 1 2 0 1 0 0 0.558 0.464 1.000 183 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(2), ICAM1(2), ITGA4(2), ITGAM(1), ITGB1(2), ITGB2(1), SELE(4), SELP(2) 4042001 16 10 15 6 6 4 3 3 0 0 0.519 0.467 1.000 184 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(1), LARS(3), PDHA1(2), PDHA2(4) 2545713 10 5 10 2 2 2 2 2 2 0 0.363 0.467 1.000 185 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 IL6(1), LPL(2) 1349171 3 3 3 0 0 0 0 3 0 0 0.585 0.475 1.000 186 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(2), EGFR(10), ELK1(3), MAP2K2(1), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), MEF2A(2), MEF2B(1), PAK1(1), PRKCA(3), PTK2(1), RAC1(1), RAF1(1), SHC1(1), SOS1(1) 8474829 33 12 31 8 6 8 1 12 4 2 0.165 0.477 1.000 187 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(1), CREBBP(6), DFFA(1), HMGB2(1), PRF1(1), SET(1) 2669697 11 4 11 3 3 1 2 4 1 0 0.443 0.478 1.000 188 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 TGDS(1), UGDH(1), UGP2(1), UXS1(1) 1238280 4 2 4 1 0 1 2 1 0 0 0.552 0.484 1.000 189 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 JAK2(3), JAK3(1), STAT1(2), STAT3(1), STAT5B(2), TYK2(5) 4656478 14 6 14 4 3 0 0 8 2 1 0.599 0.486 1.000 190 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(2), ALOX15(1), CYP1A2(1), CYP2C19(4), CYP2C8(1), CYP3A7(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(2), PLA2G5(1), PLA2G6(2) 6040435 19 12 19 5 5 5 2 3 4 0 0.380 0.493 1.000 191 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10B(2), ALG12(1), ALG13(3), ALG3(1), ALG5(2), ALG6(3), DAD1(1), DHDDS(2), DPAGT1(1), DPM1(2), FUT8(3), GANAB(2), MAN1A1(2), MAN1A2(1), MAN1C1(1), MAN2A1(4), MGAT1(2), MGAT2(2), MGAT3(2), RPN2(1), ST6GAL1(1), STT3B(1) 10709224 40 15 40 9 7 10 7 6 10 0 0.125 0.502 1.000 192 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(2), C1QB(1), C1R(2), C1S(2), C2(2), C3(8), C5(4), C6(1), C7(3) 4426151 25 8 25 8 7 3 2 9 4 0 0.452 0.502 1.000 193 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ADC(2), ALDH4A1(2), ALDH5A1(1), CAD(4), CPS1(4), EARS2(1), EPRS(2), GAD1(2), GCLC(1), GFPT1(1), GFPT2(3), GLS(1), GLUD1(3), GLUD2(1), GLUL(1), GNPNAT1(1), GOT1(2), NADSYN1(3), PPAT(2), QARS(1) 9986284 38 15 38 9 6 8 4 13 7 0 0.178 0.503 1.000 194 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(2), ADRA1B(2), ADRB2(1), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(3), DRD3(1), DRD5(1), HRH1(1), HTR1A(1), HTR1B(1), HTR1D(1), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(1), HTR5A(3), HTR7(1) 6445032 27 12 27 7 8 5 3 6 5 0 0.106 0.508 1.000 195 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 289186 1 1 1 1 0 1 0 0 0 0 0.899 0.508 1.000 196 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH6(3), ADH7(1), ADHFE1(2), AKR1A1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GCK(1), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PDHA1(2), PDHA2(4), PGAM1(1), PKLR(1), TPI1(1) 12362961 53 21 53 9 19 12 6 14 2 0 0.00358 0.512 1.000 197 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH6(3), ADH7(1), ADHFE1(2), AKR1A1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GCK(1), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PDHA1(2), PDHA2(4), PGAM1(1), PKLR(1), TPI1(1) 12362961 53 21 53 9 19 12 6 14 2 0 0.00358 0.512 1.000 198 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(2), NR3C1(2), PPARG(1), RXRA(1) 1469943 7 6 7 4 1 1 1 4 0 0 0.814 0.514 1.000 199 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), XYLT1(1), XYLT2(1) 1641684 3 3 3 0 0 1 0 2 0 0 0.357 0.519 1.000 200 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), XYLT1(1), XYLT2(1) 1641684 3 3 3 0 0 1 0 2 0 0 0.357 0.519 1.000 201 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ECHS1(2), EHHADH(1) 3075282 13 6 13 5 7 3 1 1 1 0 0.412 0.522 1.000 202 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(1), CSNK2A1(1), ELK1(3), IL6(1), IL6ST(2), JAK2(3), JAK3(1), MAPK3(1), PTPN11(4), RAF1(1), SHC1(1), SOS1(1), SRF(2), STAT3(1) 6041677 23 13 23 7 3 6 1 8 4 1 0.388 0.524 1.000 203 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(3), HK2(2), HK3(1), TGDS(1) 2591222 8 4 8 1 3 3 2 0 0 0 0.139 0.526 1.000 204 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(2), C1QB(1), C1R(2), C1S(2), C2(2), C3(8), C5(4), C6(1), C7(3), MBL2(2) 5383502 27 10 27 9 7 3 3 9 5 0 0.495 0.526 1.000 205 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(2), C1QA(2), C1QB(1), C1R(2), C1S(2), C2(2), C3(8), C3AR1(2), C4BPA(2), C4BPB(1), C5(4), C6(1), C7(3), C8B(2), CD46(2), CD55(1), CFD(1), CFH(5), CPB2(1), CR1(2), CR2(3), F13A1(2), F2(2), F5(7), F7(1), F8(12), F9(1), FGA(4), KLKB1(5), KNG1(1), MBL2(2), PLAT(1), PLAU(1), PLG(3), PROS1(1), SERPIND1(1), SERPINE1(1), SERPINF2(1), SERPING1(1), VWF(4) 22891668 100 36 100 24 27 18 13 29 13 0 0.0177 0.531 1.000 206 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(2), ICAM1(2), ITGAM(1), ITGB2(1), SELE(4) 2630211 10 7 9 4 5 4 1 0 0 0 0.471 0.531 1.000 207 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH4A1(2), ALDH5A1(1), CAD(4), CPS1(4), EPRS(2), GAD1(2), GCLC(1), GFPT1(1), GLS(1), GLUD1(3), GLUL(1), GOT1(2), NADSYN1(3), PPAT(2), QARS(1) 8390462 30 11 30 7 6 6 3 10 5 0 0.196 0.532 1.000 208 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(2), DHRS3(1), DHRS7(1), ESCO2(2), MYST3(1), MYST4(8), PNPLA3(1), SH3GLB1(3) 4180224 19 5 18 2 5 3 1 5 5 0 0.127 0.534 1.000 209 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(2), ECHS1(2), EHHADH(1), HSD17B4(2), SIRT7(1) 2995649 8 4 8 3 2 1 1 2 2 0 0.702 0.556 1.000 210 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2) 2023699 10 5 10 3 6 2 1 1 0 0 0.317 0.559 1.000 211 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2) 2023699 10 5 10 3 6 2 1 1 0 0 0.317 0.559 1.000 212 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP9(1), RECK(2), TIMP3(2), TIMP4(1) 1901951 6 3 6 1 1 2 2 0 1 0 0.336 0.561 1.000 213 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(1), AGT(2), AGTR2(1), KNG1(1), NOS3(5), REN(1) 2507712 11 6 11 4 5 1 1 2 2 0 0.662 0.570 1.000 214 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), ANKRD1(1), DUSP14(1), EIF4E(1), IL1R1(1), NR4A3(1) 2717527 7 5 7 2 1 1 2 1 2 0 0.571 0.578 1.000 215 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG5(3), ATG7(3), IFNA21(2), IFNA7(1), IFNA8(1), PIK3C3(2), PIK3R4(2), PRKAA1(2), PRKAA2(2), ULK2(5) 5332067 23 6 23 2 4 3 5 7 4 0 0.0234 0.580 1.000 216 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 COASY(1), DPYD(3), DPYS(1), ENPP1(1), ENPP3(2), ILVBL(3), PANK2(1), PANK4(2), VNN1(1) 4368741 15 8 15 3 3 2 0 7 3 0 0.452 0.582 1.000 217 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), ELK1(3), EPOR(1), JAK2(3), MAPK3(1), MAPK8(1), PLCG1(6), RAF1(1), SHC1(1), SOS1(1), STAT5B(2) 5431092 21 11 20 6 3 6 1 6 4 1 0.326 0.582 1.000 218 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(1), PARK2(1), SNCA(1), SNCAIP(1) 1628759 4 3 4 2 3 0 0 1 0 0 0.719 0.584 1.000 219 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCND1(1), CCNE2(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), E2F1(1), PRB1(2) 2252663 11 7 11 3 3 1 4 2 1 0 0.372 0.610 1.000 220 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), LPO(3), MPO(2), PRDX1(1), TPO(3), TYR(3) 2438274 14 6 14 4 5 4 0 4 1 0 0.240 0.612 1.000 221 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1), CHRNA1(2) 823872 3 3 3 2 1 0 0 1 1 0 0.802 0.613 1.000 222 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(2), DPAGT1(1), DPM1(2), FUT8(3), MAN1A1(2), MGAT1(2), MGAT2(2), MGAT3(2), RPN2(1), ST6GAL1(1) 5016477 19 7 19 5 4 5 3 2 5 0 0.294 0.615 1.000 223 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(2), F5(7), F7(1), FGA(4), PROS1(1) 4150522 15 10 15 5 4 2 4 4 1 0 0.506 0.617 1.000 224 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(2), CR2(3), HLA-DRA(2), ICAM1(2), ITGB2(1), PTPRC(3) 3845819 13 8 13 3 4 4 0 4 1 0 0.263 0.620 1.000 225 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(1), BRAF(3), EGFR(10), EPHB2(1), ITPR1(2), ITPR2(11), ITPR3(6), KCNJ3(1), KCNJ5(2), MAPK1(1), PI3(1), PIK3CB(1), PITX2(3), PLCB1(2), PLCB3(3), PLCB4(1), RAF1(1), SHC1(1), SOS1(1), SOS2(3), STAT3(1) 14814351 56 20 54 10 12 8 10 21 5 0 0.0242 0.624 1.000 226 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1), GRIA2(2) 950945 3 2 3 0 1 0 0 2 0 0 0.423 0.628 1.000 227 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F2(2), F5(7), F7(1), F8(12), F9(1), FGA(4), LPA(5), PLAT(1), PLAU(1), PLG(3), SERPINE1(1), SERPINF2(1), VWF(4) 8920861 43 14 43 7 11 6 6 14 6 0 0.0212 0.629 1.000 228 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(1), MTMR2(2), MTMR6(1), NFS1(3), THTPA(2) 1626055 9 2 9 2 1 3 0 4 1 0 0.514 0.631 1.000 229 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(1), ADCY4(1), CACNA1A(1), CACNA1B(7), GNAS(2), GRM4(2), ITPR3(6), KCNB1(3), PDE1A(1), SCNN1B(2), TAS1R2(3), TAS2R1(2), TAS2R10(2), TAS2R13(1), TAS2R16(2), TAS2R3(1), TAS2R4(1), TAS2R41(2), TAS2R42(1), TAS2R46(1), TAS2R5(1), TAS2R9(4), TRPM5(1) 14332996 48 21 48 9 12 10 3 15 8 0 0.0370 0.634 1.000 230 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR2(1), IFNB1(1), STAT1(2), TYK2(5) 2734691 9 4 9 3 2 0 1 4 1 1 0.670 0.635 1.000 231 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACPP(1), ALPP(1), CYP3A7(1), DHRS2(2), DHRS3(1), DHRS7(1), PON1(1), PON3(1) 4535255 9 6 8 1 5 0 0 1 3 0 0.139 0.640 1.000 232 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 GALNT12(2), GALNT13(1), GALNT14(2), GALNT2(2), GALNT4(1), GALNT5(2), GALNT6(2), GALNT8(1), GALNT9(2), GALNTL1(2), GALNTL4(2), GALNTL5(1), GCNT4(2), OGT(5), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(4) 8166767 33 12 33 9 10 8 1 11 3 0 0.282 0.642 1.000 233 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB27A(1), RAB3A(1), RAB9A(1) 1073996 3 2 3 0 2 1 0 0 0 0 0.267 0.643 1.000 234 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BAX(1), BCL2L11(1), CASP8AP2(2), CES1(1) 2727629 6 3 6 0 1 2 0 1 2 0 0.181 0.644 1.000 235 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 MARCKS(1), NFATC1(1), NFATC2(3), NFATC3(2), NFATC4(2), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(3), SP3(2) 5285626 22 9 21 6 7 3 3 5 3 1 0.327 0.647 1.000 236 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(10), ACACB(5), ACADM(1), ACSS1(1), ACSS2(3), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH6A1(2), ALDH7A1(1), ECHS1(2), EHHADH(1), HIBCH(1), LDHB(1), MLYCD(3), MUT(1), PCCB(2), SUCLG2(1) 10047719 44 14 43 10 14 13 4 10 3 0 0.0574 0.649 1.000 237 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 CRADD(1), DFFA(1), LMNA(2), LMNB2(1), MAP3K1(2), MAPK8(1), PAK1(1), PRKDC(8), RB1(4), RIPK1(1), SPTAN1(1) 9771524 23 12 23 5 4 3 4 5 6 1 0.243 0.651 1.000 238 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(3), CTH(1), GGT1(2), MARS(4), MARS2(1), SCLY(1) 3131151 12 4 12 0 3 5 1 3 0 0 0.0102 0.653 1.000 239 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(3), NDUFS1(2), NDUFV1(2), NDUFV2(1) 1763994 8 3 8 3 0 0 1 4 3 0 0.791 0.654 1.000 240 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1) 986874 1 1 1 1 0 1 0 0 0 0 0.876 0.655 1.000 241 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ADSL(3), AGXT(2), AGXT2(1), ASL(2), ASNS(2), ASPA(1), CAD(4), CRAT(1), GAD1(2), GOT1(2), PC(1) 6592305 22 8 22 2 6 6 0 7 3 0 0.0206 0.657 1.000 242 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(10), ACADL(1), ACADM(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH6A1(2), ECHS1(2), EHHADH(1), LDHB(1), MLYCD(3), MUT(1), PCCB(2), SUCLG2(1) 8377043 35 11 34 8 10 12 2 9 2 0 0.104 0.662 1.000 243 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GLB1(1), GUSB(2), HGSNAT(2), HPSE(2), HPSE2(1), HYAL1(1), IDS(1), LCT(5), NAGLU(2), SPAM1(1) 5181514 18 7 18 5 7 1 4 4 2 0 0.423 0.665 1.000 244 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BLNK(2), ELK1(3), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8IP3(3), PAPPA(3), RAC1(1), RPS6KA1(2), RPS6KA3(2), SHC1(1), SOS1(1), SYK(1), VAV1(3), VAV2(1), VAV3(2) 8107258 29 10 29 7 5 7 2 11 3 1 0.165 0.665 1.000 245 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CFLAR(1), DAXX(2), DFFA(1), FAF1(3), LMNA(2), LMNB2(1), MAP3K1(2), MAPK8(1), PAK1(1), PRKDC(8), PTPN13(1), RB1(4), SPTAN1(1) 10279196 28 11 28 5 4 5 4 8 6 1 0.128 0.669 1.000 246 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(6), PRKCA(3) 1702287 12 8 11 6 5 2 2 1 1 1 0.770 0.670 1.000 247 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(1), FBP1(1), FBP2(2), G6PD(1), GPI(2), H6PD(3), PFKL(2), PRPS1L1(1), PRPS2(3), RBKS(1), TALDO1(2), TKT(2), TKTL2(1) 6140397 22 10 22 6 12 6 0 3 1 0 0.118 0.675 1.000 248 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH5A1(1), ECHS1(2), EHHADH(1), GAD1(2), OXCT1(1), PDHA1(2), PDHA2(4) 6531634 24 10 24 5 9 7 2 4 2 0 0.0656 0.677 1.000 249 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 FBP2(2), G6PC(3), GAA(5), GANAB(2), GCK(1), GLA(1), GLB1(1), HK1(3), HK2(2), HK3(1), LCT(5), MGAM(3) 8247538 29 13 29 6 16 4 2 6 1 0 0.0810 0.677 1.000 250 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDFT1(1), IDI1(1), MVD(2), NQO2(1), SQLE(1) 2798634 9 3 9 4 3 1 3 1 1 0 0.585 0.679 1.000 251 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 NFKB1(1), NOX1(1), RELA(1), XDH(7) 2515891 10 3 10 4 2 2 0 5 1 0 0.673 0.685 1.000 252 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), ADSL(3), AGXT(2), AGXT2(1), ASL(2), ASNS(2), ASPA(1), CAD(4), CRAT(1), DARS2(1), GAD1(2), GOT1(2), NARS2(1), PC(1), PDHA1(2), PDHA2(4) 9569056 30 12 30 2 7 8 2 8 5 0 0.00267 0.687 1.000 253 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), JAK2(3), PTPRU(2), STAT1(2) 2894171 8 4 8 4 2 0 0 2 3 1 0.777 0.688 1.000 254 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(3), ABCB11(1), ABCB4(4), ABCC1(4), ABCC3(6) 3630972 18 6 18 4 4 2 3 7 2 0 0.263 0.692 1.000 255 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 FLT3(2), IL6(1), IL9(1), KITLG(2), TGFB2(2), TGFB3(1) 2055566 9 3 9 1 2 1 1 4 1 0 0.191 0.693 1.000 256 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(5), CAPNS1(1), CAPNS2(1), EP300(3), HDAC2(4), NFATC1(1), NFATC2(3), PPP3CA(1), PPP3CC(1), PRKCA(3) 6166547 23 7 23 7 6 3 3 5 5 1 0.512 0.699 1.000 257 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT3(1), CHPF(1), CHST11(1), CHST13(1), CHST3(2), CHSY1(1), DSE(1), XYLT1(1), XYLT2(1) 3501058 10 6 10 2 3 1 0 6 0 0 0.350 0.704 1.000 258 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SRP68(2), SRP72(3), SRPR(2) 1911291 7 2 7 1 2 0 1 2 2 0 0.485 0.709 1.000 259 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(8), C5(4), C6(1), C7(3) 3181031 16 6 16 6 4 2 2 4 4 0 0.575 0.720 1.000 260 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTR2(1), ACTR3(1), ARPC1B(1), ARPC3(1), RAC1(1), WASF1(1), WASL(1) 2058806 7 2 7 1 0 2 1 4 0 0 0.365 0.722 1.000 261 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(3), CBS(3), CTH(1), MUT(1) 1240484 8 2 8 0 2 5 0 1 0 0 0.0469 0.723 1.000 262 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(1), CES1(1) 1526027 2 2 2 1 1 1 0 0 0 0 0.735 0.726 1.000 263 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), LCT(5), PYGL(3), PYGM(1), TPI1(1), TREH(1) 3394034 14 6 14 5 4 4 2 2 2 0 0.467 0.729 1.000 264 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(3) 779599 3 1 3 2 0 1 0 1 1 0 0.837 0.729 1.000 265 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 GUSB(2), UCHL3(1), UGDH(1), UGT1A1(1), UGT1A5(2), UGT1A7(1), UGT1A8(1), UGT2B15(1), UGT2B4(2) 4449211 12 6 12 4 2 1 3 5 1 0 0.520 0.738 1.000 266 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 DFFA(1), HMGB2(1), TOP2A(4), TOP2B(1) 2235127 7 2 7 3 3 1 2 0 1 0 0.682 0.739 1.000 267 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH1B(1), ADH1C(2), ADH6(3), ADH7(1), ADHFE1(2), AGPAT3(1), AKR1A1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), CEL(1), DGKB(2), DGKD(2), DGKG(1), DGKH(3), DGKQ(1), GLA(1), GLB1(1), LCT(5), LIPC(1), LIPG(2), LPL(2), PNLIP(1), PNLIPRP1(2), PPAP2A(2), PPAP2C(1) 12197412 51 17 51 13 19 6 8 15 3 0 0.0812 0.745 1.000 268 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACOT11(1), ACYP1(1), DHRS2(2), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(1), ESCO2(2), GCDH(1), ITGB1BP3(1), MYST3(1), MYST4(8), PNPLA3(1), SH3GLB1(3) 6553952 26 6 25 6 7 5 2 6 6 0 0.300 0.749 1.000 269 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 ABP1(1), CES1(1), CES7(1), ESCO2(2), LIPA(2), MYST3(1), MYST4(8), PLA1A(2), PNPLA3(1), SH3GLB1(3) 6404771 22 6 22 4 3 4 2 6 7 0 0.246 0.751 1.000 270 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2), TPI1(1) 416594 3 1 3 0 0 3 0 0 0 0 0.291 0.752 1.000 271 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 CREB1(1), DAXX(2), ELK1(3), MAP3K1(2), MAP3K5(2), MAP3K9(2), MAPKAPK2(1), MAX(4), MEF2A(2), MEF2B(1), PLA2G4A(2), RAC1(1), RIPK1(1), SHC1(1), STAT1(2), TGFB2(2), TGFB3(1), TGFBR1(1) 9255072 31 14 30 7 8 5 5 10 2 1 0.188 0.754 1.000 272 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(2), PRKCA(3) 2275265 5 2 5 0 1 1 1 1 0 1 0.170 0.759 1.000 273 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNB1(1), PTPRU(2), STAT1(2), TYK2(5) 3161279 10 5 10 4 2 0 1 3 3 1 0.741 0.763 1.000 274 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(1), BAX(1), BIRC2(1), CYCS(2), DFFA(1), DIABLO(1) 3394428 7 3 7 1 1 2 0 3 1 0 0.323 0.763 1.000 275 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT2(2), GALNT4(1), GALNT6(2), GALNT8(1), GALNT9(2), ST3GAL1(1), ST3GAL4(1), WBSCR17(4) 3656381 14 5 14 4 7 3 0 3 1 0 0.352 0.766 1.000 276 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS1(1), CPO(1), HBA2(1), UROS(1) 1988626 6 2 6 1 3 0 1 2 0 0 0.394 0.766 1.000 277 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), LPO(3), MPO(2), TPO(3) 2112073 10 5 10 4 5 4 0 1 0 0 0.394 0.768 1.000 278 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(1), GNAS(2), PRKAR1A(1) 1644533 4 4 4 2 0 0 0 2 2 0 0.879 0.771 1.000 279 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CD4(1), HLA-DRA(2), IL1B(1), IL5RA(1), IL6(1) 1351721 7 3 7 2 0 0 0 7 0 0 0.710 0.772 1.000 280 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1) 2074900 6 2 6 3 1 3 0 0 1 1 0.521 0.775 1.000 281 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(3), ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1A1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH7A1(1), ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(3), G6PC2(1), GALM(1), GAPDHS(1), GCK(1), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PDHA1(2), PDHA2(4), PFKL(2), PGAM1(1), PGAM2(1), PKLR(1), TPI1(1) 14727558 64 23 64 8 23 13 7 18 3 0 0.000140 0.775 1.000 282 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(1), MAPK1(1), MAPK8(1), PRKCA(3) 2228718 6 2 6 1 1 2 1 0 1 1 0.221 0.778 1.000 283 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(1), CSK(1), PRKCA(3), PTPRA(4) 2334231 9 2 9 3 3 2 2 1 0 1 0.499 0.793 1.000 284 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BFAR(1), BRAF(3), CREB1(1), MAPK1(1), RAF1(1), SNX13(1) 2833832 8 3 8 2 1 1 2 2 2 0 0.412 0.794 1.000 285 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREB1(1), CREBBP(6), EP300(3), NCOA3(1), PRKAR1A(1), RXRA(1) 5224792 13 5 13 4 2 2 0 7 2 0 0.588 0.794 1.000 286 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 IL3RA(2), JAK2(3), MAPK3(1), RAF1(1), SHC1(1), SOS1(1), STAT5B(2) 4469261 11 5 11 4 2 0 0 5 3 1 0.656 0.795 1.000 287 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 GAD1(2), HDC(2), TH(1), TPH1(2) 1527083 7 3 7 2 4 2 0 1 0 0 0.349 0.796 1.000 288 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(1), ENO3(1), FARS2(1), GOT1(2), PAH(1), TAT(1), YARS(1) 2104226 10 3 10 3 5 1 1 2 1 0 0.548 0.799 1.000 289 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 IL1B(1), MST1(3), MST1R(1) 1656562 5 2 5 2 1 2 0 2 0 0 0.614 0.800 1.000 290 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B10(2), ALDOB(1), FBP1(1), FBP2(2), FPGT(1), GMDS(1), GMPPA(1), HK1(3), HK2(2), HK3(1), MTMR1(1), MTMR2(2), MTMR6(1), PFKFB1(3), PFKFB2(1), PFKFB3(2), PFKL(2), PGM2(5), SORD(1), TPI1(1), TSTA3(1) 9417439 35 13 35 7 15 9 2 5 4 0 0.0343 0.801 1.000 291 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(2), CP(3), EPRS(2), GUSB(2), HCCS(3), UGT1A1(1), UGT1A5(2), UGT1A7(1), UGT1A8(1), UGT2B15(1), UGT2B4(2), UROS(1) 6928561 23 11 23 5 6 1 7 8 1 0 0.176 0.803 1.000 292 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(1), GFPT1(1), GNE(1), GNPDA1(2), HK1(3), HK2(2), HK3(1) 4294251 12 5 12 3 3 4 3 2 0 0 0.272 0.803 1.000 293 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(1), GNAS(2), PPP2CA(3), PRKAA1(2), PRKAA2(2), PRKAG1(1), PRKAG2(1), PRKAR1A(1) 3856093 13 5 13 4 2 0 0 8 3 0 0.741 0.806 1.000 294 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), ACSM1(3), AKR1B10(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH5A1(1), ALDH7A1(1), BDH1(1), BDH2(1), ECHS1(2), EHHADH(1), GAD1(2), HMGCS1(1), HMGCS2(2), HSD17B4(2), ILVBL(3), OXCT1(1), PDHA1(2), PDHA2(4), PLA1A(2) 10263621 41 14 41 8 14 9 4 10 4 0 0.0345 0.809 1.000 295 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), ESR2(3), PDE1A(1), PDE1B(2), PLCB1(2) 2813391 9 7 9 4 2 3 0 2 2 0 0.705 0.810 1.000 296 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1) 460210 1 1 1 0 1 0 0 0 0 0 0.724 0.815 1.000 297 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(1), FBP1(1), FBP2(2), GOT1(2), ME1(1), ME3(1), PKLR(1), TKT(2), TPI1(1) 4559912 12 5 12 2 5 2 1 3 1 0 0.213 0.818 1.000 298 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(2), CHAT(3), DDC(1), GAD1(2), HDC(2), PAH(1), TH(1), TPH1(2) 3627828 15 6 15 6 6 5 0 2 2 0 0.482 0.819 1.000 299 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2E1(3), GTF2F1(2), GTF2H1(1), GTF2IRD1(2), TAF1(6), TAF2(1), TAF4(2), TAF4B(3), TAF5L(2), TAF6L(1), TAF7L(1), TAF9(2), TAF9B(1), TBPL1(1) 9112142 28 9 28 5 5 9 2 9 3 0 0.0765 0.821 1.000 300 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD3D(1), ICAM1(2), ITGB2(1), PTPRC(3) 2724084 7 5 7 4 2 4 0 1 0 0 0.697 0.822 1.000 301 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD4(1), IL6(1), IL9(1) 1507600 3 2 3 1 0 0 0 3 0 0 0.803 0.825 1.000 302 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD3D(1), CD4(1), ICAM1(2), ITGB2(1), PTPRC(3) 2856604 8 5 8 4 2 4 0 2 0 0 0.660 0.827 1.000 303 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD3D(1), CD4(1), IL6(1), KITLG(2) 1563792 5 2 5 1 0 1 1 3 0 0 0.522 0.827 1.000 304 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 RIPK1(1), TNFRSF1B(2) 2111235 3 2 3 2 1 0 0 0 2 0 0.883 0.828 1.000 305 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH3A1(2), AOX1(3), DDC(1), ECH1(1), ESCO2(2), GOT1(2), GSTZ1(2), HGD(3), HPD(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), MYST3(1), MYST4(8), PNPLA3(1), PRMT2(2), PRMT5(1), PRMT6(1), SH3GLB1(3), TAT(1), TH(1), TPO(3), TYR(3), TYRP1(2) 15040701 66 18 66 19 18 9 7 24 8 0 0.235 0.828 1.000 306 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(4), CDC25A(1), CHEK1(2), MYT1(2), WEE1(1) 3484462 10 3 10 7 2 2 1 2 3 0 0.948 0.829 1.000 307 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPP(1), GGH(1) 1638445 2 2 2 1 1 1 0 0 0 0 0.756 0.831 1.000 308 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), SHMT1(1) 3819631 7 3 7 2 2 4 0 0 0 1 0.421 0.839 1.000 309 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), SHMT1(1) 3819631 7 3 7 2 2 4 0 0 0 1 0.421 0.839 1.000 310 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), SHMT1(1) 3819631 7 3 7 2 2 4 0 0 0 1 0.421 0.839 1.000 311 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH7A1(1), UGDH(1) 2159100 11 4 11 2 7 2 1 1 0 0 0.144 0.841 1.000 312 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(2), AGTR2(1), CMA1(2), COL4A1(1), COL4A2(2), COL4A4(3), COL4A5(3), COL4A6(5), REN(1) 6390283 23 9 23 8 6 9 1 3 3 1 0.475 0.841 1.000 313 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), BTK(1), ELK1(3), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(3), NFATC3(2), NFATC4(2), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(3), RAC1(1), RAF1(1), SHC1(1), SOS1(1), SYK(1), VAV1(3) 9660138 37 13 36 10 11 7 4 8 5 2 0.173 0.844 1.000 314 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(2), AGTR2(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), F2(2), FYN(1), GNA11(1), GNAI1(1), JAK2(3), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(1), MYLK(3), PLCG1(6), PRKCA(3), RAF1(1), SHC1(1), SOS1(1), STAT1(2), STAT3(1) 10544638 37 14 36 9 11 7 3 7 6 3 0.119 0.846 1.000 315 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(5), FYN(1), ITGA1(2), ITGB1(2), L1CAM(4), SELP(2) 3997230 16 5 16 6 5 3 2 6 0 0 0.564 0.848 1.000 316 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(1), AR(2), ESR1(1), ESR2(3), ESRRA(2), HNF4A(1), NPM1(2), NR1D1(1), NR1D2(1), NR1H2(1), NR1H3(4), NR1I2(1), NR2C2(1), NR2E1(1), NR2F2(1), NR3C1(2), NR4A1(1), NR4A2(1), NR5A1(1), PGR(2), PPARA(2), PPARG(1), ROR1(2), RXRA(1), RXRG(3), VDR(1) 10596318 40 12 39 8 14 7 6 9 4 0 0.0350 0.848 1.000 317 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(2), ACOX3(3), FADS2(2), FASN(1), SCD(1) 3618350 9 5 9 9 2 1 0 4 2 0 0.983 0.849 1.000 318 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CHEK1(2), WEE1(1) 1743856 4 2 4 3 1 1 1 0 1 0 0.951 0.849 1.000 319 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(1), ADRB2(1), CFTR(1), GNAS(2), PRKAR1A(1), SLC9A3R1(1) 3281770 7 6 7 3 2 1 0 2 2 0 0.762 0.856 1.000 320 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP1(1), RANBP2(3) 2131893 4 2 4 0 1 1 1 1 0 0 0.253 0.862 1.000 321 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(1), AXIN1(1), BTRC(1), CCND1(1), CREBBP(6), CSNK1A1(2), CSNK1D(1), CSNK2A1(1), CTBP1(3), FZD1(1), NLK(1), PPP2CA(3), WIF1(2) 7423826 24 6 24 5 5 4 2 10 3 0 0.171 0.862 1.000 322 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), CYCS(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), NFKB1(1), NSMAF(1), RAF1(1), RELA(1), RIPK1(1) 5188590 13 6 13 7 3 3 0 3 3 1 0.802 0.867 1.000 323 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOB(1), FBP1(1), FBP2(2), FPGT(1), GCK(1), GMDS(1), GMPPA(1), HK1(3), HK2(2), HK3(1), PFKFB1(3), PFKFB3(2), SORD(1), TPI1(1) 6059197 21 8 21 4 8 8 1 3 1 0 0.0363 0.868 1.000 324 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(3), ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP7A(5), ATP7B(2), COX7A1(1), COX7B(1), NDUFA10(3), NDUFS1(2), NDUFV1(2), NDUFV2(1), SHMT1(1), UQCRC1(2), UQCRH(2) 9673456 31 9 31 5 5 6 2 12 5 1 0.0607 0.870 1.000 325 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), FDXR(1), SHMT1(1) 4064361 8 3 8 2 3 4 0 0 0 1 0.341 0.872 1.000 326 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(1), FHL5(1), FSHR(1), GNAS(2), XPO1(1) 2397803 6 5 6 3 0 1 1 2 2 0 0.869 0.873 1.000 327 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(2), CDC25A(1), SHH(1), XPO1(1) 2199005 5 3 5 3 1 4 0 0 0 0 0.752 0.874 1.000 328 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 HLA-DRA(2), IFNGR2(1), IL12B(2), IL12RB1(1), IL12RB2(1) 3212911 7 5 7 4 1 1 1 3 1 0 0.861 0.875 1.000 329 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(1), ACTR3(1), AKT1(1), ITPR1(2), ITPR2(11), ITPR3(6), MAPK1(1), MAPK3(1), PAK1(1), PDE3A(1), PI3(1), PIK3C2G(1), PIK3CA(15), PIK3CD(1), PIK3R1(13), RPS4X(1), SGCB(1) 12331029 59 32 52 18 8 11 14 13 12 1 0.455 0.877 1.000 330 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSD(1), ARSE(2), GALC(3), GLA(1), GLB1(1), LCT(5), NEU1(1), NEU2(1), NEU3(1), PPAP2A(2), PPAP2C(1), SMPD2(1), SPTLC1(2), SPTLC2(1), UGCG(2) 6108796 26 9 25 4 9 3 1 10 3 0 0.0813 0.877 1.000 331 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 IARS(1), IARS2(1), ILVBL(3), LARS(3), PDHA1(2), PDHA2(4), VARS(3), VARS2(1) 4704863 18 6 18 4 4 4 2 6 2 0 0.298 0.878 1.000 332 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(1), FBP1(1), FBP2(2), GOT1(2), ME1(1), ME3(1), PKLR(1), TKT(2), TKTL2(1), TPI1(1) 5098757 13 6 13 2 5 2 1 4 1 0 0.184 0.878 1.000 333 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GLB1(1), GUSB(2), IDS(1), LCT(5), NAGLU(2) 3633589 11 4 11 4 6 1 2 2 0 0 0.556 0.879 1.000 334 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 HSD11B1(1) 1749794 1 1 1 1 1 0 0 0 0 0 0.848 0.884 1.000 335 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B10(2), G6PC(3), G6PC2(1), GAA(5), GANC(3), GCK(1), GLA(1), GLB1(1), HK1(3), HK2(2), HK3(1), LCT(5), MGAM(3), PFKL(2), UGP2(1) 9781866 34 12 34 8 18 4 2 8 2 0 0.122 0.894 1.000 336 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK2(3), JAK3(1), PIAS1(1), PIAS3(1), PTPRU(2), SOAT1(1) 3474120 10 7 10 6 2 0 0 5 3 0 0.916 0.894 1.000 337 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3D(1), CD4(1), CREBBP(6), CSK(1), GNAS(2), HLA-DRA(2), PRKAR1A(1), PTPRC(3), ZAP70(2) 5780082 20 8 20 5 3 4 0 11 2 0 0.383 0.896 1.000 338 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3D(1), CD4(1), CREBBP(6), CSK(1), GNAS(2), HLA-DRA(2), PRKAR1A(1), PTPRC(3), ZAP70(2) 5780082 20 8 20 5 3 4 0 11 2 0 0.383 0.896 1.000 339 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(2), EPX(2), LPO(3), MPO(2), MTHFR(6), SHMT1(1), TPO(3) 2936502 20 6 20 5 8 6 1 4 1 0 0.116 0.898 1.000 340 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(6), EP300(3), LPL(2), NCOA1(1), PPARG(1), RXRA(1) 4671403 14 6 14 5 2 3 0 9 0 0 0.660 0.898 1.000 341 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST11(1), CHST13(1), SULT2A1(2), SUOX(1) 2314118 6 2 6 3 0 1 0 5 0 0 0.852 0.900 1.000 342 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(1), ADRB2(1), GNAS(2), PLCE1(5), PRKAR1A(1), RAP2B(1) 3706109 11 6 11 4 3 3 1 2 2 0 0.572 0.900 1.000 343 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(6), CTBP1(3), DTX2(1), DTX3L(1), DTX4(1), DVL2(1), DVL3(1), EP300(3), HDAC2(4), JAG1(2), LFNG(1), MAML1(1), MAML2(1), MAML3(3), NCOR2(3), NCSTN(3), NOTCH1(23), NOTCH2(9), NOTCH3(4), NOTCH4(8), NUMBL(2), RBPJ(2), RBPJL(1), SNW1(1) 17462266 85 36 82 27 21 13 5 23 20 3 0.378 0.901 1.000 344 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), IL12B(2), IL12RB1(1), IL12RB2(1), JAK2(3), MAPK8(1), STAT4(2), TYK2(5) 4724616 16 6 16 6 6 3 1 4 2 0 0.598 0.901 1.000 345 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), ATP6V0C(1), CAT(2), EPX(2), LPO(3), MPO(2), PRDX1(1), SHMT1(1), TPO(3) 2985802 16 5 16 5 7 6 0 2 1 0 0.184 0.904 1.000 346 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 HSD17B2(1), HSD17B4(2) 2051881 3 3 3 3 1 0 0 1 1 0 0.964 0.906 1.000 347 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS2(2), DHRS3(1), DHRS7(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1) 3802421 15 3 14 3 6 2 1 5 1 0 0.176 0.907 1.000 348 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), MRPS7(2), RPL10L(1), RPL13A(1), RPL18A(1), RPL29(1), RPL32(1), RPL37A(1), RPL6(1), RPL7(2), RPS11(1), RPS12(1), RPS18(1), RPS3(1) 5689362 16 5 16 2 7 1 3 3 2 0 0.196 0.909 1.000 349 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(10), ACACB(5), FASN(1), MCAT(1), OXSM(1) 3996503 18 10 17 7 4 4 2 6 2 0 0.564 0.911 1.000 350 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CBS(3), CTH(1), GGT1(2), LCMT1(2), LCMT2(1), MARS(4), MARS2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), SCLY(1) 6311265 23 5 23 3 5 7 2 8 1 0 0.0273 0.911 1.000 351 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AGK(1), AGPAT3(1), AKR1A1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH7A1(1), CEL(1), DAK(1), DGKB(2), DGKD(2), DGKG(1), DGKH(3), DGKQ(1), GK2(2), GLA(1), GLB1(1), LCT(5), LIPA(2), LIPC(1), LIPG(2), LPL(2), MGLL(1), PNLIP(1), PNLIPRP1(2), PNPLA3(1), PPAP2A(2), PPAP2C(1) 14857547 60 17 60 14 21 6 10 19 4 0 0.0497 0.912 1.000 352 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(1), SEC22B(1), SNAP29(1), STX11(1), TSNARE1(3), USE1(1), VAMP4(1), VAMP8(1), VTI1A(1) 4225242 11 6 11 7 3 3 1 1 3 0 0.874 0.914 1.000 353 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(1), APC(1), DLG4(3), EPHB2(1), GNAI1(1), ITPR1(2), ITPR2(11), ITPR3(6), KCNJ3(1), KCNJ5(2), MAPK1(1), PITX2(3), PTX3(1), RAC1(1), RYR1(8) 11571277 43 13 43 11 13 8 8 11 3 0 0.135 0.916 1.000 354 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), GOT1(2), PAH(1), TAT(1), YARS(1) 2202828 6 3 6 3 2 1 1 1 1 0 0.832 0.917 1.000 355 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), PLCB1(2), PRKCA(3), RELA(1) 2083741 7 4 7 5 2 0 1 3 0 1 0.919 0.918 1.000 356 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABP1(1), ACADM(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH7A1(1), CNDP1(1), DPYD(3), DPYS(1), ECHS1(2), EHHADH(1), GAD1(2), HIBCH(1), MLYCD(3), SMS(1), SRM(1) 6827874 28 7 28 9 11 7 2 6 2 0 0.291 0.920 1.000 357 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(1), ACE2(3), AGT(2), AGTR2(1), ANPEP(2), CMA1(2), CTSG(1), ENPEP(3), LNPEP(1), MME(2), REN(1), THOP1(3) 5362376 22 8 22 4 7 5 1 6 3 0 0.103 0.920 1.000 358 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(1), GNAI1(1), GNAS(2), MAPK1(1), MAPK3(1), MYT1(2), PRKAR1A(1), RPS6KA1(2) 5165468 11 7 11 8 0 1 0 4 5 1 0.973 0.922 1.000 359 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(5), PRKAG1(1) 2549551 6 2 6 1 1 0 0 4 1 0 0.487 0.922 1.000 360 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(3), BAIAP2(2), CASP1(1), INSR(3), MAGI1(2), MAGI2(3), RERE(4), WWP1(3) 6056611 21 7 21 5 9 6 1 4 1 0 0.190 0.923 1.000 361 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 CBS(3), CTH(1), DNMT1(3), DNMT3A(2), DNMT3B(4), MARS(4), MARS2(1), MTR(2) 4406403 20 4 20 7 5 5 0 8 1 1 0.448 0.924 1.000 362 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 OXCT1(1) 857854 1 1 1 0 0 1 0 0 0 0 0.723 0.924 1.000 363 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), MAPK3(1), POLR2A(3), PRKAR1A(1) 3250936 6 3 6 2 1 0 0 3 1 1 0.653 0.925 1.000 364 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(2), CA1(1), CA5A(1), CPS1(4), CTH(1), GLS(1), GLUD1(3), GLUL(1), HAL(1) 4809963 15 9 15 6 2 5 1 4 3 0 0.661 0.925 1.000 365 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(1), ARSE(2), B4GALT6(1), DEGS1(2), DEGS2(1), GALC(3), GLA(1), GLB1(1), LCT(5), NEU1(1), NEU2(1), NEU3(1), PPAP2A(2), PPAP2C(1), SGMS2(2), SGPP1(1), SGPP2(1), SMPD2(1), SMPD3(2), SPTLC1(2), SPTLC2(1), UGCG(2) 8996015 36 11 35 6 12 4 2 15 3 0 0.0453 0.925 1.000 366 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(8), C5(4), C6(1), C7(3), ICAM1(2), IL6(1), ITGA4(2), ITGB1(2), ITGB2(1), SELP(2), SELPLG(1), VCAM1(1) 6280860 28 13 28 10 7 5 4 8 4 0 0.467 0.928 1.000 367 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 GUSB(2), UGDH(1), UGP2(1), UGT1A1(1), UGT1A5(2), UGT1A7(1), UGT1A8(1), UGT2A1(3), UGT2A3(3), UGT2B10(3), UGT2B15(1), UGT2B4(2) 6906920 21 9 21 7 3 2 6 9 1 0 0.515 0.928 1.000 368 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(1), JAK2(3), JAK3(1), PIAS3(1), PTPRU(2), STAT3(1) 3861111 10 7 10 4 2 0 0 5 3 0 0.750 0.928 1.000 369 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(1), MAPK8(1), PLCG1(6), PRKCA(3) 3482144 11 8 10 5 2 3 3 1 1 1 0.632 0.930 1.000 370 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(1), BLNK(2), BTK(1), CD81(1), CR2(3), INPP5D(2), KRAS(1), LILRB3(1), NFAT5(1), NFATC1(1), NFATC2(3), NFATC3(2), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIE(1), NRAS(1), PIK3CA(15), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(13), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG2(6), PPP3CA(1), PPP3CC(1), PPP3R2(1), RAC1(1), RAC2(1), RASGRP3(1), SYK(1), VAV1(3), VAV2(1), VAV3(2) 18794819 81 38 74 25 23 17 12 14 15 0 0.216 0.932 1.000 371 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(2), FH(1), IDH2(6), IDH3B(1), PC(1), PDHA1(2), PDHA2(4), PDK1(1), PDK3(2), PDK4(1), PDP2(1), SDHC(1), SUCLG2(1) 7175311 24 12 20 8 4 8 3 8 1 0 0.359 0.933 1.000 372 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(1), CXCR4(1), GNAI1(1), MAPK1(1), MAPK3(1), NFKB1(1), PIK3C2G(1), PIK3CA(15), PIK3R1(13), PLCG1(6), PRKCA(3), PTK2(1), RAF1(1), RELA(1) 6995301 47 34 39 15 6 10 11 5 13 2 0.517 0.933 1.000 373 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 CD3D(1), ICAM1(2), ITGB2(1), PRF1(1) 2211913 5 3 5 3 3 2 0 0 0 0 0.709 0.934 1.000 374 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CMAS(1), GFPT1(1), GFPT2(3), GNE(1), GNPDA1(2), GNPNAT1(1), HK1(3), HK2(2), HK3(1), MTMR1(1), MTMR2(2), MTMR6(1) 7266218 20 8 20 6 3 7 3 4 3 0 0.371 0.941 1.000 375 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(6), EP300(3), ESR1(1), MAPK1(1), MAPK3(1), PELP1(1) 3729659 13 2 13 4 4 2 0 6 0 1 0.513 0.942 1.000 376 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PCYT1B(1), PRMT2(2), PRMT5(1), PRMT6(1) 3559971 12 2 12 3 3 2 1 5 1 0 0.353 0.944 1.000 377 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(4), MAP2(3), PPP2CA(3), PRKAG1(1) 4600173 11 3 11 2 2 2 0 6 1 0 0.365 0.944 1.000 378 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(1), CRKL(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), PAK1(1), PLCG1(6), PRKCA(3), RAC1(1), RAF1(1), SHC1(1), SOS1(1) 7205399 24 11 23 7 7 7 2 2 4 2 0.211 0.945 1.000 379 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), BIRC2(1), CASP1(1), CASP4(1), CYCS(2), DFFA(1), LMNA(2), LMNB2(1), PRF1(1) 4879301 11 4 11 2 2 4 1 3 1 0 0.240 0.945 1.000 380 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CFL1(1), GNAS(2), MAPK1(1), MAPK3(1), MYL2(1), NOX1(1), PIK3C2G(1), PLCB1(2), PRKCA(3), PTK2(1), RAF1(1), ROCK2(2) 6343489 18 10 18 9 2 2 1 7 4 2 0.893 0.946 1.000 381 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(1), CASP1(1), CYCS(2), PRF1(1) 3255327 6 3 6 2 1 3 0 2 0 0 0.574 0.946 1.000 382 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTR2(1), ACTR3(1), AKT1(1), CFL1(1), FLNA(8), FLNC(6), FSCN1(2), FSCN2(1), GDI1(2), MYH2(8), MYLK(3), MYLK2(1), PAK1(1), PAK3(3), PAK6(2), PAK7(2), ROCK1(2), ROCK2(2), RPS4X(1), WASF1(1), WASL(1) 12095686 50 13 50 15 19 8 5 14 4 0 0.134 0.950 1.000 383 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CTH(1), GOT1(2), LDHB(1), SULT1B1(2), SULT1C2(3) 3173932 9 2 9 1 1 3 0 3 2 0 0.262 0.954 1.000 384 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(1), CD44(2), FCGR3A(1), IL1B(1), SPN(1), TGFB2(2), TNFRSF1B(2), TNFRSF8(1), TNFSF8(1) 3304687 12 4 12 4 4 3 1 2 2 0 0.421 0.954 1.000 385 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(2), CRY1(2), CSNK1D(1), CSNK1E(1), NPAS2(1), NR1D1(1), PER1(3), PER2(3), PER3(1) 4316911 15 5 15 6 2 4 1 6 2 0 0.767 0.955 1.000 386 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(2), CA1(1), CA13(1), CA5A(1), CPS1(4), CTH(1), GLS(1), GLUD1(3), GLUD2(1), GLUL(1), HAL(1) 5378062 17 10 17 7 2 6 1 5 3 0 0.677 0.956 1.000 387 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 MAPK1(1), MAPK3(1), NFKB1(1), PLCB1(2), PRKCA(3), RAF1(1), RELA(1) 3922328 10 5 10 6 2 1 1 3 1 2 0.815 0.957 1.000 388 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(3), E2F1(1), ETS1(3), HDAC2(4), HDAC5(1), NCOR2(3), RBL1(2), RBL2(2), SIN3A(1), SIN3B(1) 6566513 21 7 21 9 5 4 1 5 6 0 0.748 0.959 1.000 389 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(1), POLR2G(1) 3406230 9 4 9 3 4 2 1 2 0 0 0.498 0.960 1.000 390 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), UBE2M(1) 2663757 2 2 2 7 0 0 1 0 1 0 1.000 0.961 1.000 391 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(2), AGPAT3(1), CDS2(2), CHAT(3), CHKB(1), DGKB(2), DGKD(2), DGKG(1), DGKH(3), DGKQ(1), ESCO2(2), ETNK2(2), GNPAT(1), MYST3(1), MYST4(8), PCYT1B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(2), PLA2G5(1), PLA2G6(2), PLD1(3), PNPLA3(1), PPAP2A(2), PPAP2C(1), PTDSS1(1), SH3GLB1(3) 16508940 53 14 53 14 12 14 5 12 10 0 0.160 0.961 1.000 392 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 CBS(3), CTH(1), DNMT1(3), DNMT3A(2), DNMT3B(4), MARS(4), MARS2(1), MTFMT(1), MTR(2), SRM(1), TAT(1) 5248109 23 5 23 9 5 5 1 10 1 1 0.575 0.963 1.000 393 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(2), ACO2(2), HYI(1), MTHFD1(2), MTHFD1L(1) 3238687 8 3 8 3 3 4 0 1 0 0 0.527 0.963 1.000 394 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA2(2), ACADM(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH6A1(2), ALDH7A1(1), AOX1(3), BCKDHA(1), DBT(1), ECHS1(2), EHHADH(1), HIBADH(1), HIBCH(1), HMGCS1(1), HMGCS2(2), HSD17B4(2), MCCC2(5), MUT(1), OXCT1(1), PCCB(2) 10883635 39 12 38 11 15 12 2 7 3 0 0.197 0.963 1.000 395 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTB(1), ARHGEF2(2), CDH1(3), CLDN1(1), CTTN(1), EZR(1), FYN(1), HCLS1(1), ITGB1(2), NCL(1), OCLN(1), PRKCA(3), ROCK1(2), ROCK2(2), TUBA1A(1), TUBA3C(3), TUBA3D(1), TUBB(1), TUBB2C(2), TUBB3(3), TUBB4(1), TUBB4Q(2), TUBB6(2), WAS(2), WASL(1), YWHAQ(1), YWHAZ(1) 13263173 47 15 47 15 14 6 11 12 3 1 0.267 0.966 1.000 396 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTB(1), ARHGEF2(2), CDH1(3), CLDN1(1), CTTN(1), EZR(1), FYN(1), HCLS1(1), ITGB1(2), NCL(1), OCLN(1), PRKCA(3), ROCK1(2), ROCK2(2), TUBA1A(1), TUBA3C(3), TUBA3D(1), TUBB(1), TUBB2C(2), TUBB3(3), TUBB4(1), TUBB4Q(2), TUBB6(2), WAS(2), WASL(1), YWHAQ(1), YWHAZ(1) 13263173 47 15 47 15 14 6 11 12 3 1 0.267 0.966 1.000 397 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(1), PSMB2(1), PSMB4(1), PSMC3(1), PSMD1(1), PSMD11(1), PSMD2(1) 4054126 10 2 10 3 2 3 1 3 1 0 0.524 0.967 1.000 398 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(1), ADC(2), ALDH18A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH7A1(1), ARG2(1), ASL(2), CPS1(4), ODC1(2), SMS(1), SRM(1) 7460315 25 10 25 9 8 4 2 6 5 0 0.545 0.967 1.000 399 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(2), ACO2(2), HYI(1), MTHFD1(2), MTHFD1L(1) 3391967 8 3 8 3 3 4 0 1 0 0 0.520 0.968 1.000 400 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CEBPB(1), CLOCK(2), CRY1(2), EIF4G2(1), ETV6(2), HERPUD1(1), IDI1(1), NCKAP1(2), NCOA4(2), NR1D2(1), PER1(3), PER2(3), PPP1R3C(1), PPP2CB(1), PSMA4(1), PURA(1), SF3A3(1), TOB1(1), TUBB3(3), UGP2(1), ZFR(1) 9232226 32 9 32 7 5 9 6 8 4 0 0.152 0.969 1.000 401 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CDS2(2), DGKB(2), DGKD(2), DGKG(1), DGKH(3), DGKQ(1), INPP4B(2), INPP5B(2), INPP5D(2), INPPL1(4), ITGB1BP3(1), ITPK1(2), ITPR1(2), ITPR2(11), ITPR3(6), OCRL(4), PI4KA(4), PI4KB(1), PIK3C2A(3), PIK3C2G(1), PIK3C3(2), PIK3CA(15), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(13), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(1), PIP4K2C(1), PIP5K1C(1), PLCB1(2), PLCB3(3), PLCB4(1), PLCD1(1), PLCD3(2), PLCE1(5), PLCG1(6), PLCG2(6), PLCZ1(3), PRKCA(3), PTEN(8), SYNJ1(4), SYNJ2(5) 31533707 148 59 140 35 34 30 23 34 26 1 0.0169 0.969 1.000 402 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOB(1), TPI1(1) 991249 4 1 4 0 0 4 0 0 0 0 0.151 0.970 1.000 403 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(1), ATP6V0C(1), GART(3), MTHFD1(2), MTHFD1L(1), MTHFR(6), MTHFS(1), MTR(2), SHMT1(1) 4527836 18 3 18 7 5 6 2 3 1 1 0.472 0.971 1.000 404 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 EPOR(1), JAK2(3), NFKB1(1), RELA(1), SOD2(1) 3202495 7 2 7 5 2 1 0 3 1 0 0.916 0.973 1.000 405 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(2), GLB1(1), LCT(5), SLC33A1(2), ST3GAL1(1), ST6GALNAC3(1), ST8SIA5(2) 4167520 14 5 14 7 8 1 1 1 3 0 0.867 0.973 1.000 406 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH3A1(2), AOX1(3), DDC(1), GOT1(2), GSTZ1(2), HGD(3), HPD(1), TAT(1), TH(1), TPO(3), TYR(3) 8024580 36 13 36 13 14 3 4 13 2 0 0.471 0.973 1.000 407 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ESR1(1), GREB1(4), MTA3(2) 2756329 7 2 7 1 4 0 1 2 0 0 0.264 0.974 1.000 408 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), EPRS(2), FARS2(1), GARS(2), HARS(1), IARS(1), LARS(3), MARS(4), MARS2(1), QARS(1), RARS(2), WARS2(2), YARS(1) 8120828 22 6 22 6 5 6 1 8 2 0 0.421 0.975 1.000 409 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), IL10RB(1), IL6(1), STAT1(2), STAT3(1) 3079525 7 3 7 4 2 0 0 4 0 1 0.865 0.975 1.000 410 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(10), ELK1(3), GNAS(2), IGF1R(3), ITGB1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), PDGFRA(5), PPP2CA(3), PTPRR(3), RAF1(1), RPS6KA1(2), SHC1(1), SOS1(1), STAT3(1) 8346986 41 22 39 13 6 8 3 15 8 1 0.531 0.975 1.000 411 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IRS1(2), JAK3(1), RPS6KB1(1), SHC1(1), STAT6(3) 3744900 9 5 9 4 2 2 0 4 1 0 0.725 0.976 1.000 412 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(2), CD33(1), CD7(1), IFNB1(1), IL12B(2), TLR7(3), TLR9(1) 4696548 11 5 10 9 1 2 2 4 2 0 0.978 0.977 1.000 413 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(1), COL4A2(2), COL4A4(3), COL4A5(3), COL4A6(5), SLC23A2(3), SLC2A1(1), SLC2A3(2) 6342400 20 8 20 8 6 7 1 2 3 1 0.522 0.978 1.000 414 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACPP(1), ALPP(1), CYP1A2(1), CYP2B6(1), CYP2C19(4), CYP2C8(1), CYP3A7(1), CYP4B1(1), CYP51A1(1), PON1(1) 7366823 13 10 13 6 4 1 1 3 4 0 0.776 0.979 1.000 415 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(2), ACADL(1), ACADM(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH6A1(2), AOX1(3), BCKDHA(1), ECHS1(2), EHHADH(1), HIBADH(1), MCCC2(5), MUT(1), OXCT1(1), PCCB(2) 9114169 33 10 32 11 12 13 1 5 2 0 0.310 0.979 1.000 416 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(4), ASH2L(1), CTCFL(2), DOT1L(2), EHMT1(3), EHMT2(2), EZH1(3), EZH2(1), HCFC1(2), HSF4(1), JMJD6(1), KDM6A(2), MLL(7), MLL2(8), MLL3(12), MLL4(6), MLL5(2), NSD1(2), OGT(5), PAXIP1(1), PPP1CB(1), PRDM2(2), PRDM7(2), PRDM9(6), PRMT5(1), PRMT6(1), SATB1(1), SETD1A(1), SETD2(6), SETD7(2), SETD8(1), SETDB1(1), SETDB2(1), SETMAR(2), STK38(1), SUV39H1(1), SUV420H1(2), WHSC1L1(3) 29919606 102 33 102 27 27 19 14 31 11 0 0.102 0.979 1.000 417 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(1), PIGA(2), PIGC(1), PIGG(1), PIGN(1), PIGO(3), PIGQ(4), PIGS(1), PIGT(1), PIGW(1), PIGZ(1) 6040046 18 3 18 4 8 3 3 4 0 0 0.138 0.980 1.000 418 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT7(1), CHST4(1), FUT8(3), ST3GAL1(1), ST3GAL4(1) 3130856 7 5 7 5 3 3 0 0 1 0 0.843 0.980 1.000 419 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTR2(1), ACTR3(1), ARPC1B(1), ARPC3(1), NCKAP1(2), RAC1(1), WASF1(1), WASF3(2), WASL(1) 3870465 11 3 11 4 2 3 1 5 0 0 0.607 0.983 1.000 420 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(2), AMY2B(2), ASCC3(2), ATP13A2(1), DDX19A(2), DDX23(2), DDX4(3), DDX41(1), DDX47(1), DDX52(1), DDX54(2), DDX55(1), DDX56(2), DHX58(1), ENPP1(1), ENPP3(2), EP400(2), ERCC2(1), ERCC3(1), G6PC(3), G6PC2(1), GAA(5), GANC(3), GBE1(1), GCK(1), GPI(2), GUSB(2), GYS1(1), HK1(3), HK2(2), HK3(1), IFIH1(1), LYZL1(1), MGAM(3), MOV10L1(1), PYGB(1), PYGL(3), PYGM(1), RAD54B(2), RAD54L(2), SETX(3), SI(6), SKIV2L2(2), SMARCA2(1), SMARCA5(1), TREH(1), UGDH(1), UGP2(1), UGT1A1(1), UGT1A5(2), UGT1A7(1), UGT1A8(1), UGT2A1(3), UGT2A3(3), UGT2B10(3), UGT2B15(1), UGT2B4(2), UXS1(1) 31293030 104 34 104 26 28 19 18 30 9 0 0.0364 0.985 1.000 421 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(2), GNAI1(1), ITGA1(2), ITGB1(2), MAPK1(1), MAPK3(1), PLA2G4A(2), PLCB1(2), PRKCA(3), PTGS1(2), PTK2(1), RAF1(1), SYK(1) 6165755 21 12 21 9 2 3 4 8 2 2 0.750 0.985 1.000 422 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABP1(1), ACADL(1), ACADM(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), CNDP1(1), DPYD(3), DPYS(1), ECHS1(2), EHHADH(1), GAD1(2), MLYCD(3), SMS(1) 7349466 27 8 27 10 10 8 1 6 2 0 0.416 0.987 1.000 423 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2E1(3), GTF2F1(2), HDAC3(1), NCOA1(1), NCOA3(1), NCOR2(3), POLR2A(3), RXRA(1) 6312341 16 8 16 7 3 4 0 6 3 0 0.723 0.987 1.000 424 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(1), FBP1(1), FBP2(2), G6PD(1), GPI(2), H6PD(3), PRPS1L1(1), PRPS2(3), RBKS(1), TALDO1(2), TKT(2) 5160031 19 8 19 8 10 6 0 2 1 0 0.374 0.987 1.000 425 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(4), CES1(1), CES2(1), UGT1A1(1), UGT1A5(2), UGT1A7(1), UGT1A8(1) 5779383 11 4 11 4 3 2 2 3 1 0 0.519 0.989 1.000 426 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT3(1), B3GNT4(2), B3GNT5(2), FUT2(2), FUT5(2), FUT6(2), ST3GAL6(1) 4057933 12 5 12 6 5 1 1 4 1 0 0.854 0.989 1.000 427 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 ANPEP(2), CD1A(2), CD1B(3), CD1E(3), CD33(1), CD36(3), CD3D(1), CD4(1), CD44(2), CD55(1), CD7(1), CR1(2), CR2(3), CSF1R(3), CSF2RA(3), CSF3R(1), EPOR(1), FCGR1A(1), FLT3(2), GP5(1), GP9(1), HLA-DRA(2), HLA-DRB5(1), IL1B(1), IL1R1(1), IL1R2(2), IL3RA(2), IL5RA(1), IL6(1), ITGA1(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGAM(1), ITGB3(2), KIT(3), KITLG(2), MME(2), MS4A1(2), TFRC(1), TPO(3) 20582271 78 22 78 21 18 20 8 24 8 0 0.0495 0.990 1.000 428 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ATP6V0C(1), DOT1L(2), ECHS1(2), EHHADH(1), EHMT1(3), EHMT2(2), GCDH(1), PLOD1(2), PLOD2(1), PLOD3(1), SHMT1(1), TMLHE(1) 9363054 30 7 30 10 15 7 3 3 2 0 0.182 0.991 1.000 429 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(1), ACADM(1), ACADVL(1), ACSL1(1), ACSL3(2), ACSL4(1), CPT1A(1), CPT2(1), DCI(1), EHHADH(1), SCP2(1), SLC25A20(1) 4260661 13 3 13 4 1 4 1 4 3 0 0.552 0.992 1.000 430 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(2), ACAD8(3), ACAD9(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1B10(2), AKR1D1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH7A1(1), CEL(1), CYP27A1(1), CYP7A1(1), LIPA(2), SLC27A5(3), SOAT1(1), SOAT2(1), SRD5A1(1) 7991908 41 13 41 15 14 5 4 16 2 0 0.555 0.993 1.000 431 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(1), ARAF(1), ATF4(1), BRAF(3), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CREBBP(6), EP300(3), GRIA1(2), GRIA2(2), GRIN2A(1), GRIN2B(4), GRIN2C(2), GRIN2D(3), GRM1(4), GRM5(2), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(2), PLCB3(3), PLCB4(1), PPP1CB(1), PPP1R12A(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(3), RAF1(1), RAPGEF3(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2) 25189966 86 29 86 26 18 11 12 31 12 2 0.235 0.993 1.000 432 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AP2A1(1), BIN1(2), EPS15(1), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ1(4), SYNJ2(5) 5422244 16 3 16 5 5 1 2 3 5 0 0.487 0.994 1.000 433 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC2(1), DFFA(1), PRF1(1), SCAP(1), SREBF1(2), SREBF2(1) 4618381 8 3 8 4 2 3 1 2 0 0 0.713 0.995 1.000 434 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), ELK1(3), JAK3(1), MAPK3(1), MAPK8(1), RAF1(1), SHC1(1), SOS1(1), STAT5B(2), SYK(1) 5897901 13 8 13 6 1 3 1 5 2 1 0.703 0.995 1.000 435 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(1), CDH1(3), CREBBP(6), EP300(3), MAPK3(1), SKIL(2), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2) 6491533 22 4 22 4 4 4 1 12 0 1 0.189 0.995 1.000 436 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 IKBKAP(1), MAP3K1(2), MAP3K14(1), NFKB1(1), RELA(1), RIPK1(1), TANK(1), TNFAIP3(1), TNFRSF1B(2), TRAF3(1) 5680514 12 5 12 7 6 1 1 1 3 0 0.828 0.995 1.000 437 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 MAP3K1(2), MAP3K5(2), MAP4K5(1), MAPK8(1), NFKB1(1), RELA(1), TNFRSF9(2) 4902714 10 6 10 5 4 2 2 1 1 0 0.754 0.996 1.000 438 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(2) 1763680 2 1 2 0 0 0 1 1 0 0 0.545 0.996 1.000 439 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(2), ADH1A(1), ADH1B(1), ADH1C(2), ADH6(3), ADH7(1), ADHFE1(2), AKR1D1(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), CEL(1), CYP27A1(1), CYP7A1(1), SOAT2(1), SRD5A1(1) 5869287 28 11 28 11 11 4 3 10 0 0 0.535 0.996 1.000 440 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(1), FTCD(1), GART(3), MTFMT(1), MTHFD1(2), MTHFD1L(1), MTHFR(6), MTHFS(1), MTR(2), SHMT1(1) 4791168 19 4 19 9 5 6 2 4 1 1 0.658 0.997 1.000 441 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR4(1), CCR7(1), CD4(1), CXCR4(1), IFNGR2(1), IL12B(2), IL12RB1(1), IL12RB2(1), TGFB2(2), TGFB3(1) 5053617 12 7 12 8 3 2 3 3 1 0 0.880 0.997 1.000 442 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ADCY3(2), ADCY9(3), ARF1(1), ARF6(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ERO1L(1), GNAS(2), PLCG1(6), PLCG2(6), PRKCA(3), SEC61A1(1) 9339115 34 18 33 11 16 7 3 4 3 1 0.313 0.997 1.000 443 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CRADD(1), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAPK8(1), NFKB1(1), RELA(1), RIPK1(1), TANK(1) 6095916 11 6 11 8 5 3 0 1 2 0 0.929 0.997 1.000 444 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 CYCS(2), SDHC(1), UQCRC1(2) 1671556 5 2 5 2 0 1 1 3 0 0 0.730 0.997 1.000 445 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(1), GOT1(2), LDHB(1) 1731894 4 1 4 1 1 2 0 1 0 0 0.531 0.997 1.000 446 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 BDH1(1), BDH2(1), HMGCS1(1), HMGCS2(2), OXCT1(1) 1810436 6 1 6 0 1 3 0 2 0 0 0.144 0.997 1.000 447 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BIRC2(1), CFLAR(1), CYCS(2), DFFA(1), GAS2(1), LMNA(2), MAP3K14(1), NFKB1(1), RELA(1), RIPK1(1), SPTAN1(1) 8431111 14 5 14 7 3 3 1 4 3 0 0.804 0.998 1.000 448 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1D1(1), ARSD(1), ARSE(2), CYP11B1(1), HSD11B1(1), HSD17B2(1), SRD5A1(1), SULT2A1(2), UGT1A1(1), UGT1A5(2), UGT1A7(1), UGT1A8(1), UGT2B15(1), UGT2B4(2) 6913457 18 10 18 8 7 1 4 5 1 0 0.597 0.998 1.000 449 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(1), ARHGEF1(1), MYL2(1), MYLK(3), PLCB1(2), PRKCA(3), ROCK1(2) 5220106 13 5 13 6 5 1 3 2 1 1 0.670 0.998 1.000 450 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(3), APOA1(1), APOA4(2), APOE(1), CETP(1), CYP7A1(1), LIPC(1), LPL(2), LRP1(15), SOAT1(1) 6915559 28 12 28 10 10 6 1 9 2 0 0.451 0.998 1.000 451 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(1), ARF1(1), BTK(1), EEA1(2), GRASP(1), PFKL(2), PLCG1(6), RAC1(1), RPS6KB1(1), VAV2(1) 6291696 18 8 17 9 6 7 1 2 2 0 0.709 0.999 1.000 452 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 DAXX(2), EGF(2), EGFR(10), ETS1(3), HOXA7(1), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAP3K5(2), MAPK1(1), MAPK13(1), MAPK3(1), MAPK8(1), NFKB1(1), PPP2CA(3), PRKCA(3), PRKCH(2), PRKCQ(2), RAF1(1), RELA(1), RIPK1(1), TNFRSF1B(2) 12405192 45 19 43 15 13 9 4 11 6 2 0.276 0.999 1.000 453 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACYP1(1), ECHS1(2), EHHADH(1), GCDH(1) 1971948 5 2 5 3 1 2 0 1 1 0 0.814 0.999 1.000 454 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS1(1), UROS(1) 1923677 4 1 4 1 2 0 0 2 0 0 0.640 0.999 1.000 455 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(2), ECHS1(2), EHHADH(1) 2113311 5 3 5 5 2 2 0 0 1 0 0.958 0.999 1.000 456 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(1), CFLAR(1), MAP3K3(2), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), NR2C2(1), RALBP1(1), RIPK1(1), TNFAIP3(1), TNFRSF1B(2) 6851378 14 3 14 6 8 1 1 1 3 0 0.661 0.999 1.000 457 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT2(1), B3GALT5(1), B3GNT5(2), FUT2(2), ST3GAL4(1) 1810209 7 2 7 2 4 0 0 2 1 0 0.562 0.999 1.000 458 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN2(6), ACTN3(1), CAPNS1(1), CAPNS2(1), ITGA1(2), ITGB1(2), ITGB3(2), PTK2(1), RAC1(1), SPTAN1(1), TLN1(2) 7214878 20 5 20 9 5 3 4 6 2 0 0.720 0.999 1.000 459 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(3), ATP4A(3), ATP5B(1), ATP5G2(1), ATP6AP1(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), COX15(1), COX17(1), COX7A1(1), COX7B(1), COX7B2(1), NDUFA10(3), NDUFA9(3), NDUFB11(1), NDUFS1(2), NDUFS3(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), SDHC(1), TCIRG1(1), UQCRC1(2), UQCRH(2) 14110039 44 13 44 14 10 10 3 14 6 1 0.391 0.999 1.000 460 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(1), CREB1(1), EPHB2(1), MAPK1(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3) 7222280 11 3 11 5 1 3 1 3 3 0 0.691 0.999 1.000 461 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1G(1), HDAC9(1), MEF2A(2), MEF2B(1) 1946598 5 1 5 3 1 2 0 2 0 0 0.837 0.999 1.000 462 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 EGR3(1), MAP3K1(2), NFATC1(1), NFATC2(3), NFKB1(1), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKAR1A(1), RELA(1) 7070487 18 9 17 9 6 2 1 7 2 0 0.867 0.999 1.000 463 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), BCAR1(1), CAPN10(3), CAPN11(2), CAPN3(3), CAPN5(2), CAPN6(1), CAPN7(1), CAPN9(3), CAPNS1(1), CSK(1), DOCK1(1), FYN(1), ITGA10(2), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAD(1), ITGAE(3), ITGAM(1), ITGAV(2), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), MAP2K2(1), MAP2K3(2), MAPK10(1), MAPK12(2), MAPK4(1), MAPK7(3), MYLK2(1), PAK1(1), PAK3(3), PAK6(2), PIK3R2(1), PTK2(1), RAC1(1), RAC2(1), RAPGEF1(3), ROCK1(2), ROCK2(2), SDCCAG8(1), SHC1(1), SORBS1(1), SOS1(1), TLN1(2), TNS1(2), VAV2(1), VAV3(2), VCL(1) 33893029 103 28 103 25 34 17 12 30 10 0 0.0215 0.999 1.000 464 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GALT2(1), B3GALT5(1), B3GNT3(1), B3GNT4(2), B3GNT5(2), B4GALNT1(2), B4GALT6(1), FUT2(2), FUT5(2), FUT6(2), PIGA(2), PIGC(1), PIGG(1), PIGN(1), PIGO(3), PIGQ(4), PIGS(1), PIGT(1), PIGZ(1), ST3GAL1(1), ST3GAL4(1), ST3GAL6(1), ST6GALNAC3(1), ST8SIA5(2), UGCG(2) 12247944 39 9 39 13 16 6 3 10 4 0 0.387 0.999 1.000 465 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), SHC1(1), SOS1(1) 2235981 3 2 3 2 0 0 0 1 2 0 0.854 1.000 1.000 466 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(1), PSMB2(1), PSMB4(1), PSMB8(1) 2214188 7 1 7 1 2 1 1 3 0 0 0.328 1.000 1.000 467 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 CALR(2), CANX(1), CD4(1), CIITA(1), CREB1(1), CTSB(1), HLA-DMA(1), HLA-DMB(3), HLA-DPB1(1), HLA-DQA2(2), HLA-DRA(2), HLA-DRB5(1), HLA-E(1), HLA-F(1), HSP90AB1(1), IFI30(1), IFNA21(2), IFNA7(1), IFNA8(1), KIR2DL1(1), KLRC1(1), LGMN(1), RFX5(1), RFXANK(1) 11643722 30 11 30 10 6 5 4 10 5 0 0.447 1.000 1.000 468 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(2), CKM(1), EIF4E(1), FBL(1), LDHB(1), NCL(1) 2252066 7 1 7 2 2 2 1 1 1 0 0.402 1.000 1.000 469 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP4(2), BMP5(3), BMP6(1), BTRC(1), CSNK1A1(2), CSNK1A1L(2), CSNK1D(1), CSNK1E(1), CSNK1G1(1), CSNK1G2(1), GLI1(2), GLI2(1), GLI3(2), HHIP(1), LRP2(8), PTCH1(3), SHH(1), SMO(2), SUFU(1), WNT11(4), WNT2(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(1), WNT8B(1), WNT9B(1), ZIC2(2) 15355194 50 16 50 16 19 10 7 11 3 0 0.213 1.000 1.000 470 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IL12B(2), IL15(2), IL16(5), IL6(1), IL9(1) 2509788 12 7 12 5 1 0 3 6 2 0 0.817 1.000 1.000 471 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(2), ADRBK2(2), CAMK2A(1), CAMK2D(1), CAMK2G(2), CLCA1(2), CLCA2(2), CNGA3(1), CNGB1(1), GNAL(1), PDE1C(5), PRKG1(1) 7716697 21 4 21 6 11 4 1 3 2 0 0.229 1.000 1.000 472 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(1), CABIN1(5), CAMK4(1), CEBPB(1), CNR1(1), CREBBP(6), CSNK2A1(1), CTLA4(1), EGR3(1), EP300(3), FCGR3A(1), GATA3(1), GRLF1(3), IFNB1(1), IL1B(1), IL6(1), ITK(1), KPNA5(2), MAPK8(1), MEF2A(2), MEF2B(1), MYF5(4), NFAT5(1), NFATC1(1), NFATC2(3), NFATC3(2), NFATC4(2), NFKB2(1), NFKBIE(1), NUP214(2), P2RX7(1), PAK1(1), PPP3CC(1), PTPRC(3), RELA(1), RPL13A(1), SFN(2), SLA(2), SP3(2), TRPV6(3), VAV1(3), VAV2(1), VAV3(2) 22980874 76 18 76 25 16 23 4 24 9 0 0.225 1.000 1.000 473 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(3), APC(1), AXIN1(1), BMP10(1), BMP4(2), BMP5(3), CHRD(1), FZD1(1), MYL2(1), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2) 9172856 20 5 20 4 8 4 2 5 1 0 0.126 1.000 1.000 474 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), CYSLTR2(1), GPR161(1), GPR171(1), GPR34(1), GPR75(1), GPR81(1) 2479465 7 2 7 8 0 1 2 2 2 0 0.982 1.000 1.000 475 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3D(1), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), TOB1(1), TOB2(1) 2669583 9 3 9 2 2 3 1 3 0 0 0.318 1.000 1.000 476 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ACTR3(1), ARHGAP4(1), ARHGAP5(1), ARHGEF1(1), ARHGEF11(2), ARPC1B(1), ARPC3(1), BAIAP2(2), CFL1(1), DIAPH1(3), GSN(1), MYL2(1), MYLK(3), OPHN1(1), ROCK1(2), TLN1(2), VCL(1) 11455131 26 9 26 9 8 4 2 10 2 0 0.483 1.000 1.000 477 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(4), CANT1(3), CTPS2(1), DCTD(1), DHODH(2), DPYD(3), DPYS(1), ENTPD1(1), NT5C(2), NT5E(1), NT5M(1), POLB(1), POLD2(2), POLE(6), POLG(1), POLL(1), POLQ(1), POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(1), POLR2G(1), RRM1(3), TK2(3), UCK1(2), UMPS(1), UPP1(1) 14472369 51 16 51 16 13 11 5 18 4 0 0.333 1.000 1.000 478 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(3), ACVR1B(2), ACVR2A(1), ACVRL1(2), AMHR2(1), BMP4(2), BMP5(3), BMP6(1), CHRD(1), CREBBP(6), CUL1(1), DCN(1), E2F5(1), EP300(3), GDF5(1), GDF6(1), INHBA(1), INHBB(1), INHBE(1), LTBP1(4), MAPK1(1), MAPK3(1), NODAL(1), PITX2(3), PPP2CA(3), PPP2CB(1), PPP2R2A(2), PPP2R2C(2), RBL1(2), RBL2(2), ROCK1(2), ROCK2(2), RPS6KB1(1), RPS6KB2(2), SMAD1(3), SMAD2(3), SMAD3(1), SMAD5(1), SMAD7(2), SMAD9(2), SMURF1(1), SMURF2(1), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), THBS1(1), THBS2(4), THBS3(2), THBS4(3) 24983081 92 21 92 29 28 15 12 31 5 1 0.162 1.000 1.000 479 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(1), ALDH1A3(3), ALDH3A1(2), DDC(1), EPX(2), ESCO2(2), GOT1(2), HPD(1), LPO(3), MPO(2), MYST3(1), MYST4(8), PNPLA3(1), SH3GLB1(3), TAT(1), TPO(3) 8646825 36 12 36 13 13 8 3 7 5 0 0.473 1.000 1.000 480 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), DARS2(1), EARS2(1), EPRS(2), FARS2(1), GARS(2), HARS(1), HARS2(1), IARS(1), IARS2(1), LARS(3), MARS(4), MARS2(1), MTFMT(1), NARS2(1), PARS2(1), QARS(1), RARS(2), RARS2(4), SARS2(1), TARS2(1), VARS(3), VARS2(1), WARS2(2), YARS(1) 13723053 39 8 39 11 7 9 4 15 4 0 0.357 1.000 1.000 481 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 AKT1(1), CHRM1(1), CHRNA1(2), FLT1(3), FLT4(3), KDR(4), NOS3(5), PDE3A(1), PRKAR1A(1), PRKG1(1), RYR2(10), SLC7A1(1), TNNI1(1) 10245480 34 16 34 13 11 6 7 8 2 0 0.458 1.000 1.000 482 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 APAF1(1), CYCS(2), DAXX(2), FAS(1), MAPKAPK2(1), MAPKAPK3(1) 2866132 8 2 8 3 0 2 2 4 0 0 0.673 1.000 1.000 483 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA1(7), GABRA3(1), GABRA4(3), GABRA5(1), GABRA6(3), GPHN(1), NSF(2) 3022341 18 9 18 8 3 7 1 5 2 0 0.684 1.000 1.000 484 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1G(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CAMKK1(1), CAMKK2(1), CREB1(1) 2930702 9 2 9 3 4 3 0 0 2 0 0.412 1.000 1.000 485 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPP(1), ASCC3(2), ATP13A2(1), DDX19A(2), DDX23(2), DDX4(3), DDX41(1), DDX47(1), DDX52(1), DDX54(2), DDX55(1), DDX56(2), DHX58(1), EP400(2), ERCC2(1), ERCC3(1), GGH(1), IFIH1(1), MOV10L1(1), QDPR(1), RAD54B(2), RAD54L(2), SETX(3), SKIV2L2(2), SMARCA2(1), SMARCA5(1) 15847004 39 9 39 12 12 8 5 10 4 0 0.367 1.000 1.000 486 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), MBTPS1(1), MBTPS2(2), SCAP(1), SREBF1(2), SREBF2(1) 3028718 8 2 8 3 0 2 2 4 0 0 0.632 1.000 1.000 487 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(1), CREB1(1), ELK1(3), GNAI1(1), GNAS(2), MAPK3(1), NFATC1(1), NFATC2(3), NFATC3(2), NFATC4(2), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKCA(3), RAF1(1), RPS6KA3(2) 8796574 32 13 31 12 7 4 4 8 7 2 0.605 1.000 1.000 488 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(1), PSMB2(1), PSMB4(1), PSMC3(1), RPN2(1) 3273972 8 2 8 4 2 2 1 2 1 0 0.813 1.000 1.000 489 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(1), CNR2(2), DNMT1(3), MTNR1A(1), PTGER4(1), PTGFR(5), TBXA2R(1) 2817166 14 3 14 9 4 1 0 8 1 0 0.924 1.000 1.000 490 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(3), IMPDH1(2), POLB(1), POLG(1), PRPS2(3), RRM1(3), SRM(1) 3138019 14 4 14 6 4 4 2 3 1 0 0.620 1.000 1.000 491 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), CAD(4), CANT1(3), CTPS2(1), DCTD(1), DHODH(2), DPYD(3), DPYS(1), ENTPD1(1), ENTPD6(1), ENTPD8(1), NT5C(2), NT5C1B(1), NT5E(1), NT5M(1), POLA1(2), POLD2(2), POLD3(2), POLE(6), POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(1), POLR2G(1), POLR3A(5), POLR3B(2), PRIM1(1), PRIM2(2), RRM1(3), TK2(3), TXNRD2(1), UCK1(2), UMPS(1), UPP1(1), UPP2(2), UPRT(2) 20478217 75 26 75 24 17 12 8 28 10 0 0.357 1.000 1.000 492 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CD3D(1), CSK(1), CTLA4(1), EPHB2(1), FBXW7(1), ITK(1), LAT(1), MAPK1(1), NFAT5(1), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), PAK1(1), PAK3(3), PAK6(2), PAK7(2), PLCG1(6), PTPRC(3), RAF1(1), RASGRP2(1), RASGRP3(1), SOS1(1), SOS2(3), VAV1(3), ZAP70(2) 14068306 42 11 41 13 14 10 3 9 6 0 0.282 1.000 1.000 493 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 APAF1(1), BIRC2(1), CFLAR(1), CRADD(1), CYCS(2), DAXX(2), DFFA(1), GSN(1), LMNA(2), LMNB2(1), MAP3K1(2), MAP3K14(1), MAP3K5(2), MAPK8(1), MDM2(2), NFKB1(1), NUMA1(6), PRKDC(8), PTK2(1), RASA1(4), RB1(4), RELA(1), RIPK1(1), SPTAN1(1), TNFRSF1B(2) 17458010 50 21 50 16 12 7 8 14 8 1 0.426 1.000 1.000 494 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(1), EEF1D(2), EEF2(1), EEF2K(1), EIF1AX(2), EIF2AK3(2), EIF2B4(1), EIF4A1(2), EIF4E(1), EIF4G1(2), EIF4G3(4), GSPT2(4), KIAA0664(4), PABPC1(3), PABPC3(1), PAIP1(1) 11079766 32 20 32 11 9 5 4 8 6 0 0.556 1.000 1.000 495 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAP3K14(1), MAPK8(1), NFKB1(1), RELA(1), TNFRSF13B(1), TNFRSF17(1), TRAF3(1), TRAF5(1) 3676412 8 2 8 5 2 3 1 1 1 0 0.814 1.000 1.000 496 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15(1), ALOX5AP(1), GGT1(2), LTA4H(2), PLA2G6(2), PTGS1(2), PTGS2(1) 3812598 11 4 11 6 1 5 2 2 1 0 0.767 1.000 1.000 497 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGEF2(2), COPA(2), GBF1(2), GPLD1(1) 4105036 8 3 8 4 2 2 1 2 1 0 0.768 1.000 1.000 498 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(1), CREB1(1), EP300(3), NOS3(5) 4298343 10 3 10 6 5 0 2 2 1 0 0.849 1.000 1.000 499 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 IKBKAP(1), MAP3K1(2), MAP3K14(1), NFKB1(1), RELA(1), TNFAIP3(1), TRAF3(1) 4592022 8 3 8 8 5 0 1 1 1 0 0.976 1.000 1.000 500 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA3(2), ADRA1A(2), ADRA1B(2), ADRB2(1), AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(3), C3AR1(2), CCBP2(1), CCKBR(3), CCR10(1), CCR4(1), CCR6(1), CCR7(1), CCR9(1), CHML(2), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(3), CMKLR1(1), CNR1(1), CNR2(2), CX3CR1(1), CXCR4(1), DRD3(1), DRD5(1), EDNRB(1), FPR1(1), FSHR(1), GALR1(1), GNB2L1(1), GPR174(1), GPR37(1), GPR4(1), GPR50(2), GPR6(1), GPR63(1), GPR77(1), GPR83(2), GPR85(2), GPR87(1), GRPR(2), HCRTR2(2), HRH1(1), HTR1A(1), HTR1B(1), HTR1D(1), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(1), HTR5A(3), HTR7(1), LTB4R(2), MC3R(1), MC4R(3), MC5R(1), MLNR(1), MTNR1A(1), NMBR(2), NMUR1(3), NMUR2(2), NPY1R(3), NTSR1(2), OPN1SW(1), OPN3(1), OPRL1(1), OPRM1(1), OR10A5(2), OR11A1(1), OR1C1(3), OR1F1(1), OR5V1(2), OR7C1(1), P2RY1(1), P2RY12(1), P2RY13(1), P2RY2(3), P2RY6(2), PPYR1(2), PTGER4(1), PTGFR(5), SSTR2(1), SSTR3(2), SSTR4(3), SUCNR1(1), TBXA2R(1), TRHR(2) 30633809 138 45 138 43 43 23 17 42 13 0 0.0300 1.000 1.000 501 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(1), ACADM(1), ACOX1(2), ACOX2(2), ACOX3(3), ACSL1(1), ACSL3(2), ACSL4(1), ACSL6(1), ANGPTL4(1), APOA1(1), AQP7(1), CD36(3), CPT1A(1), CPT1C(1), CPT2(1), CYP27A1(1), CYP7A1(1), EHHADH(1), FABP7(1), FADS2(2), GK2(2), HMGCS2(2), LPL(2), ME1(1), NR1H3(4), PCK1(3), PPARA(2), PPARG(1), RXRA(1), RXRG(3), SCD(1), SCP2(1), SLC27A1(2), SLC27A5(3), SORBS1(1), UBC(3) 16539002 61 20 60 22 14 15 8 20 4 0 0.382 1.000 1.000 502 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1G(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(1), ESRRA(2), HDAC5(1), MEF2A(2), MEF2B(1), PPARA(2), PPP3CA(1), PPP3CC(1), SLC2A4(1) 5117355 17 3 17 6 5 6 0 3 3 0 0.456 1.000 1.000 503 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(2), CLK3(3), CLK4(1), COL2A1(4), CPSF1(1), CPSF3(1), CSTF1(1), CSTF2(1), CSTF3(2), DHX16(2), DHX38(2), DHX8(7), DHX9(2), DICER1(1), FUS(2), LOC440563(2), METTL3(2), NCBP1(1), NONO(1), PAPOLA(5), POLR2A(3), PRPF4(1), PRPF4B(2), PRPF8(6), PSKH1(1), PTBP1(1), RNGTT(1), SF3A3(1), SF3B1(4), SF4(1), SFRS14(1), SFRS2(1), SFRS4(1), SFRS5(2), SFRS7(1), SFRS8(3), SFRS9(1), SNRPA(1), SNRPB2(1), SNRPD3(1), SNRPE(1), SNURF(1), SPOP(2), SRPK1(1), SRPK2(1), SRRM1(2), SUPT5H(2), U2AF1(2), U2AF2(1), XRN2(2) 26731183 92 29 91 25 31 16 7 22 16 0 0.264 1.000 1.000 504 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(1), POLR2G(1), POLR3A(5), POLR3B(2) 5939612 20 6 20 9 7 2 2 7 2 0 0.716 1.000 1.000 505 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(1), CD36(3), CD44(2), CHAD(1), COL11A1(5), COL11A2(4), COL1A1(2), COL1A2(6), COL2A1(4), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(3), COL4A6(5), COL5A1(3), COL5A2(2), COL5A3(1), COL6A1(1), COL6A3(9), COL6A6(2), FN1(2), FNDC1(2), FNDC3A(3), FNDC5(1), GP5(1), GP9(1), HSPG2(7), IBSP(1), ITGA1(2), ITGA10(2), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAV(2), ITGB1(2), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), LAMA1(7), LAMA2(4), LAMA3(7), LAMA4(1), LAMA5(8), LAMB1(2), LAMB2(1), LAMB4(4), LAMC1(3), LAMC2(3), LAMC3(1), RELN(6), SDC1(1), SDC3(1), SPP1(1), SV2A(2), SV2B(2), SV2C(1), THBS1(1), THBS2(4), THBS3(2), THBS4(3), TNC(3), TNN(6), TNR(4), TNXB(9), VWF(4) 56576422 206 56 206 57 62 55 22 52 14 1 0.00398 1.000 1.000 506 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(1), BRAF(3), CD244(1), FAS(1), FCGR3A(1), FCGR3B(1), FYN(1), HLA-E(1), ICAM1(2), ICAM2(1), IFNA21(2), IFNA7(1), IFNA8(1), IFNAR2(1), IFNB1(1), IFNGR2(1), ITGB2(1), KIR2DL1(1), KLRC1(1), KRAS(1), LAT(1), MAP2K2(1), MAPK1(1), MAPK3(1), MICA(3), NCR2(1), NFAT5(1), NFATC1(1), NFATC2(3), NFATC3(2), NFATC4(2), NRAS(1), PAK1(1), PIK3CA(15), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(13), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(6), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRF1(1), PRKCA(3), PTPN11(4), RAC1(1), RAC2(1), RAF1(1), SHC1(1), SHC2(1), SHC4(1), SOS1(1), SOS2(3), SYK(1), TNFRSF10D(1), ULBP1(1), ULBP3(2), VAV1(3), VAV2(1), VAV3(2), ZAP70(2) 28631680 126 57 118 37 29 23 23 24 25 2 0.107 1.000 1.000 507 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(2), AKT1(1), ARRB1(2), ATF4(1), BDNF(1), BRAF(3), CACNA1A(1), CACNA1B(7), CACNA1D(5), CACNA1E(4), CACNA1F(3), CACNA1G(5), CACNA1H(3), CACNA1I(2), CACNA1S(6), CACNA2D1(2), CACNA2D3(1), CACNA2D4(2), CACNB2(3), CACNG1(3), CACNG2(1), CACNG3(1), CACNG7(3), CRKL(1), DAXX(2), DUSP14(1), DUSP16(1), DUSP4(1), DUSP5(1), DUSP7(1), DUSP9(2), EGF(2), EGFR(10), ELK1(3), FAS(1), FGF13(1), FGF16(1), FGF5(2), FGF6(1), FGF7(1), FGFR1(1), FGFR2(2), FGFR3(1), FGFR4(2), FLNA(8), FLNB(7), FLNC(6), IL1B(1), IL1R1(1), IL1R2(2), KRAS(1), MAP2K2(1), MAP2K3(2), MAP2K5(1), MAP3K1(2), MAP3K12(3), MAP3K13(1), MAP3K14(1), MAP3K3(2), MAP3K4(1), MAP3K5(2), MAP3K8(2), MAP4K3(1), MAP4K4(2), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK7(3), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPKAPK2(1), MAPKAPK3(1), MAX(4), MRAS(1), NF1(14), NFATC2(3), NFATC4(2), NFKB1(1), NFKB2(1), NLK(1), NR4A1(1), NRAS(1), PAK1(1), PDGFA(1), PDGFRA(5), PLA2G2D(1), PLA2G3(3), PLA2G4A(2), PLA2G5(1), PLA2G6(2), PPM1A(1), PPM1B(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(3), PTPN5(1), PTPN7(1), PTPRR(3), RAC1(1), RAC2(1), RAF1(1), RAPGEF2(3), RASA1(4), RASA2(2), RASGRF1(2), RASGRF2(2), RASGRP2(1), RASGRP3(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RRAS(1), SOS1(1), SOS2(3), SRF(2), STK3(2), TAOK2(3), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), TP53(113), ZAK(1) 72214122 379 122 326 104 124 66 44 87 47 11 0.000306 1.000 1.000 508 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTB(1), ACTN2(6), ACTN3(1), ACTN4(1), ACVR1B(2), BAIAP2(2), CDH1(3), CREBBP(6), CSNK2A1(1), CTNNA2(2), CTNNA3(1), EGFR(10), EP300(3), FARP2(1), FER(1), FGFR1(1), FYN(1), IGF1R(3), INSR(3), IQGAP1(9), LMO7(4), MAPK1(1), MAPK3(1), MET(6), MLLT4(3), NLK(1), PARD3(1), PTPRB(5), PTPRF(3), PTPRJ(2), PTPRM(4), PVRL1(1), PVRL4(2), RAC1(1), RAC2(1), SMAD2(3), SMAD3(1), SORBS1(1), SSX2IP(1), TCF7L2(2), TGFBR1(1), TGFBR2(2), TJP1(3), VCL(1), WAS(2), WASF1(1), WASF3(2), WASL(1), YES1(2) 30316490 117 39 115 33 31 20 11 39 15 1 0.0711 1.000 1.000 509 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(1), ACTN2(6), ACTN3(1), ACTN4(1), AKT1(1), ARHGAP5(1), BCAR1(1), BIRC2(1), BRAF(3), CCND1(1), CHAD(1), COL11A1(5), COL11A2(4), COL1A1(2), COL1A2(6), COL2A1(4), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(3), COL4A6(5), COL5A1(3), COL5A2(2), COL5A3(1), COL6A1(1), COL6A3(9), COL6A6(2), CRKL(1), DIAPH1(3), DOCK1(1), EGF(2), EGFR(10), ELK1(3), FARP2(1), FLNA(8), FLNB(7), FLNC(6), FLT1(3), FN1(2), FYN(1), GRLF1(3), HGF(3), IBSP(1), IGF1R(3), ITGA1(2), ITGA10(2), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAV(2), ITGB1(2), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), KDR(4), LAMA1(7), LAMA2(4), LAMA3(7), LAMA4(1), LAMA5(8), LAMB1(2), LAMB2(1), LAMB4(4), LAMC1(3), LAMC2(3), LAMC3(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), MET(6), MYL2(1), MYLK(3), MYLK2(1), PAK1(1), PAK3(3), PAK6(2), PAK7(2), PARVA(1), PARVB(1), PDGFA(1), PDGFC(1), PDGFD(1), PDGFRA(5), PIK3CA(15), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(13), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP5K1C(1), PPP1CB(1), PPP1R12A(1), PRKCA(3), PTEN(8), PTK2(1), RAC1(1), RAC2(1), RAF1(1), RAPGEF1(3), RELN(6), ROCK1(2), ROCK2(2), SHC1(1), SHC2(1), SHC4(1), SOS1(1), SOS2(3), SPP1(1), THBS1(1), THBS2(4), THBS3(2), THBS4(3), TLN1(2), TLN2(3), TNC(3), TNN(6), TNR(4), TNXB(9), VAV1(3), VAV2(1), VAV3(2), VCL(1), VEGFA(2), VEGFB(1), VEGFC(2), VWF(4) 93836606 373 99 364 103 98 84 48 91 49 3 0.000560 1.000 1.000 510 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(2), ACTN2(6), ACTN3(1), ACTN4(1), APC(1), ARAF(1), ARHGEF1(1), ARHGEF12(1), ARHGEF4(3), ARHGEF6(3), ARPC1B(1), ARPC3(1), BAIAP2(2), BCAR1(1), BRAF(3), CFL1(1), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(3), CRKL(1), CSK(1), CYFIP2(5), DIAPH1(3), DIAPH2(1), DIAPH3(2), DOCK1(1), EGF(2), EGFR(10), EZR(1), F2(2), FGD3(1), FGF13(1), FGF16(1), FGF5(2), FGF6(1), FGF7(1), FGFR1(1), FGFR2(2), FGFR3(1), FGFR4(2), FN1(2), GIT1(1), GRLF1(3), GSN(1), IQGAP1(9), IQGAP2(3), IQGAP3(1), ITGA1(2), ITGA10(2), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAD(1), ITGAE(3), ITGAM(1), ITGAV(2), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), KRAS(1), MAP2K2(1), MAPK1(1), MAPK3(1), MRAS(1), MYH10(4), MYH14(3), MYL2(1), MYLK(3), MYLK2(1), NCKAP1(2), NCKAP1L(3), NRAS(1), PAK1(1), PAK3(3), PAK6(2), PAK7(2), PDGFA(1), PDGFRA(5), PIK3CA(15), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(13), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(1), PIP4K2C(1), PIP5K1C(1), PPP1CB(1), PPP1R12A(1), PTK2(1), RAC1(1), RAC2(1), RAF1(1), RDX(5), ROCK1(2), ROCK2(2), RRAS(1), SCIN(2), SOS1(1), SOS2(3), SSH2(1), SSH3(1), TIAM1(3), TIAM2(3), TMSL3(1), VAV1(3), VAV2(1), VAV3(2), VCL(1), WAS(2), WASF1(1), WASL(1) 69871752 262 82 253 75 61 54 38 68 39 2 0.0150 1.000 1.000 511 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(1), ADCY7(1), ADCY9(3), ADRA1A(2), ADRA1B(2), ADRB2(1), ATP2A2(3), ATP2A3(1), ATP2B2(2), ATP2B3(6), AVPR1A(2), AVPR1B(1), CACNA1A(1), CACNA1B(7), CACNA1D(5), CACNA1E(4), CACNA1F(3), CACNA1G(5), CACNA1H(3), CACNA1I(2), CACNA1S(6), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CCKBR(3), CHRM1(1), CHRM3(2), CHRM5(3), CHRNA7(1), CYSLTR1(1), CYSLTR2(1), EDNRB(1), EGFR(10), ERBB3(2), ERBB4(2), GNA11(1), GNA14(1), GNAL(1), GNAS(2), GRIN2A(1), GRIN2C(2), GRIN2D(3), GRM1(4), GRM5(2), GRPR(2), HRH1(1), HTR2A(1), HTR2B(1), HTR2C(1), HTR5A(3), HTR7(1), ITPR1(2), ITPR2(11), ITPR3(6), LTB4R2(1), MYLK(3), MYLK2(1), NOS1(1), NOS3(5), NTSR1(2), P2RX1(1), P2RX2(1), P2RX3(1), P2RX4(2), P2RX7(1), PDE1A(1), PDE1B(2), PDE1C(5), PDGFRA(5), PHKA1(2), PHKA2(4), PHKG1(1), PLCB1(2), PLCB3(3), PLCB4(1), PLCD1(1), PLCD3(2), PLCE1(5), PLCG1(6), PLCG2(6), PLCZ1(3), PPID(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(3), PTGER3(1), PTGFR(5), RYR1(8), RYR2(10), RYR3(5), SLC25A5(1), SLC25A6(1), SLC8A2(2), SLC8A3(1), TACR2(1), TBXA2R(1), TNNC1(1), TRHR(2), TRPC1(1), VDAC2(1), VDAC3(2) 67984165 263 78 260 92 85 50 30 62 35 1 0.112 1.000 1.000 512 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(3), ADORA3(2), ADRA1A(2), ADRA1B(2), ADRB2(1), AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(3), C3AR1(2), CALCR(1), CCKBR(3), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(3), CNR1(1), CNR2(2), CTSG(1), CYSLTR1(1), CYSLTR2(1), DRD3(1), DRD5(1), EDNRB(1), F2(2), FPR1(1), FSHR(1), GABBR1(2), GABRA1(7), GABRA3(1), GABRA4(3), GABRA5(1), GABRA6(3), GABRB1(4), GABRB2(2), GABRB3(2), GABRD(2), GABRE(3), GABRG1(5), GABRG2(2), GABRG3(1), GABRP(1), GABRQ(1), GABRR1(2), GALR1(1), GH1(1), GHR(2), GHRHR(2), GIPR(2), GLP2R(1), GLRA1(1), GLRB(2), GNRHR(2), GPR50(2), GPR63(1), GPR83(2), GRIA1(2), GRIA2(2), GRIA3(5), GRIA4(2), GRID1(1), GRID2(3), GRIK1(3), GRIK2(1), GRIK3(1), GRIK4(4), GRIK5(2), GRIN2A(1), GRIN2B(4), GRIN2C(2), GRIN2D(3), GRIN3A(2), GRM1(4), GRM2(4), GRM3(4), GRM4(2), GRM5(2), GRM6(2), GRM7(2), GRM8(1), GRPR(2), HCRTR2(2), HRH1(1), HTR1A(1), HTR1B(1), HTR1D(1), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(1), HTR5A(3), HTR7(1), LEPR(1), LTB4R(2), LTB4R2(1), MC3R(1), MC4R(3), MC5R(1), MCHR1(1), MCHR2(1), MLNR(1), MTNR1A(1), NMBR(2), NMUR1(3), NMUR2(2), NPBWR1(1), NPBWR2(1), NPY1R(3), NR3C1(2), NTSR1(2), OPRL1(1), OPRM1(1), P2RX1(1), P2RX2(1), P2RX3(1), P2RX4(2), P2RX7(1), P2RY1(1), P2RY13(1), P2RY2(3), P2RY4(1), P2RY6(2), P2RY8(2), PARD3(1), PPYR1(2), PRLR(1), PRSS1(1), PRSS3(1), PTGER3(1), PTGER4(1), PTGFR(5), PTH2R(1), RXFP1(2), RXFP2(1), SSTR2(1), SSTR3(2), SSTR4(3), TAAR5(1), TAAR6(1), TACR2(1), TBXA2R(1), TRHR(2), TSHR(4), UTS2R(1), VIPR1(1) 55928611 262 75 262 80 76 55 31 75 25 0 0.00518 1.000 1.000 513 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(1), CHAD(1), COL11A1(5), COL11A2(4), COL17A1(2), COL1A1(2), COL1A2(6), COL2A1(4), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(3), COL4A6(5), COL5A1(3), COL5A2(2), COL5A3(1), COL6A1(1), COL6A3(9), COL6A6(2), DSC1(2), DSC2(1), DSC3(2), DSG1(2), DSG2(2), DSG3(1), DSG4(1), FN1(2), GJA1(4), GJA10(1), GJA3(1), GJA4(1), GJA8(2), GJB2(1), GJB6(1), GJD4(1), IBSP(1), INA(1), ITGA6(3), ITGB4(2), KRT1(1), KRT12(1), KRT14(1), KRT15(1), KRT16(2), KRT17(2), KRT2(1), KRT20(2), KRT24(1), KRT25(1), KRT27(1), KRT28(2), KRT3(3), KRT31(1), KRT33A(4), KRT33B(2), KRT34(1), KRT35(3), KRT36(2), KRT37(1), KRT39(2), KRT5(4), KRT6B(2), KRT6C(3), KRT7(1), KRT71(2), KRT73(1), KRT75(2), KRT76(1), KRT77(1), KRT78(1), KRT8(3), KRT84(1), KRT86(2), KRT9(1), LAMA1(7), LAMA2(4), LAMA3(7), LAMA4(1), LAMA5(8), LAMB1(2), LAMB2(1), LAMB4(4), LAMC1(3), LAMC2(3), LAMC3(1), LMNA(2), LMNB2(1), NES(3), PRPH(1), RELN(6), SPP1(1), THBS1(1), THBS2(4), THBS3(2), THBS4(3), TNC(3), TNN(6), TNR(4), TNXB(9), VIM(2), VWF(4) 62836576 241 74 240 81 84 59 22 57 18 1 0.0591 1.000 1.000 514 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(1), ACTN2(6), ACTN3(1), ACTN4(1), AKT1(1), ASH1L(4), CASK(1), CDK4(1), CLDN1(1), CLDN16(1), CLDN19(2), CLDN2(1), CLDN22(1), CLDN7(1), CLDN8(1), CRB3(2), CSNK2A1(1), CTNNA2(2), CTNNA3(1), CTTN(1), EPB41L1(1), EPB41L2(2), EPB41L3(2), EXOC3(1), EXOC4(1), F11R(1), GNAI1(1), HCLS1(1), INADL(4), JAM2(3), JAM3(2), KRAS(1), LLGL1(3), LLGL2(1), MAGI1(2), MAGI2(3), MAGI3(5), MLLT4(3), MPDZ(4), MRAS(1), MYH1(5), MYH10(4), MYH11(2), MYH13(3), MYH14(3), MYH15(4), MYH2(8), MYH3(5), MYH4(4), MYH6(2), MYH7(5), MYH7B(4), MYH8(5), MYL2(1), NRAS(1), OCLN(1), PARD3(1), PARD6A(1), PPM1J(2), PPP2CA(3), PPP2CB(1), PPP2R2A(2), PPP2R2C(2), PPP2R3A(2), PPP2R4(1), PRKCA(3), PRKCH(2), PRKCI(1), PRKCQ(2), PTEN(8), RAB3B(1), RRAS(1), SPTAN1(1), SYMPK(2), TJAP1(1), TJP1(3), TJP2(1), TJP3(1), YES1(2), ZAK(1) 48946201 175 61 175 64 55 29 25 48 17 1 0.342 1.000 1.000 515 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(10), ACACB(5), AKT1(1), ARAF(1), BRAF(3), CBLB(1), CBLC(1), CRKL(1), ELK1(3), EXOC7(1), FASN(1), FBP1(1), FBP2(2), FLOT1(1), FLOT2(1), G6PC(3), G6PC2(1), GCK(1), GYS1(1), INPP5D(2), INSR(3), IRS1(2), IRS2(1), IRS4(4), KRAS(1), LIPE(1), MAP2K2(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), NRAS(1), PCK1(3), PDE3A(1), PFKL(2), PHKA1(2), PHKA2(4), PHKG1(1), PIK3CA(15), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(13), PIK3R2(1), PIK3R3(1), PIK3R5(1), PKLR(1), PPP1CB(1), PPP1R3A(1), PPP1R3C(1), PRKAA1(2), PRKAA2(2), PRKAG1(1), PRKAG2(1), PRKAR1A(1), PRKCI(1), PTPRF(3), PYGB(1), PYGL(3), PYGM(1), RAF1(1), RAPGEF1(3), RPS6KB1(1), RPS6KB2(2), SHC1(1), SHC2(1), SHC4(1), SLC2A4(1), SOCS4(1), SORBS1(1), SOS1(1), SOS2(3), SREBF1(2), TSC1(2), TSC2(1) 40498379 151 58 143 47 33 31 20 40 25 2 0.146 1.000 1.000 516 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN2(6), ACTN3(1), ACTN4(1), ARHGAP5(1), BCAR1(1), CDH5(2), CLDN1(1), CLDN16(1), CLDN19(2), CLDN2(1), CLDN22(1), CLDN7(1), CLDN8(1), CTNNA2(2), CTNNA3(1), CXCR4(1), CYBB(1), ESAM(1), EZR(1), F11R(1), GNAI1(1), GRLF1(3), ICAM1(2), ITGA4(2), ITGAM(1), ITGB1(2), ITGB2(1), ITK(1), JAM2(3), JAM3(2), MAPK12(2), MAPK13(1), MLLT4(3), MMP9(1), MYL2(1), NCF1(1), NCF2(3), NOX1(1), NOX3(1), OCLN(1), PIK3CA(15), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(13), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(6), PRKCA(3), PTK2(1), PTPN11(4), RAC1(1), RAC2(1), RAPGEF3(1), RAPGEF4(2), ROCK1(2), ROCK2(2), SIPA1(2), TXK(1), VAV1(3), VAV2(1), VAV3(2), VCAM1(1), VCL(1) 31410945 138 53 130 47 38 29 20 30 20 1 0.232 1.000 1.000 517 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(3), ACVR1B(2), ACVR2A(1), AMHR2(1), CCL11(1), CCL26(2), CCL27(1), CCL5(1), CCR4(1), CCR6(1), CCR7(1), CCR9(1), CD40(1), CD40LG(2), CD70(1), CLCF1(1), CNTF(1), CNTFR(2), CSF1R(3), CSF2RA(3), CSF3R(1), CX3CR1(1), CXCL9(1), CXCR4(1), EDAR(3), EGF(2), EGFR(10), EPOR(1), FAS(1), FLT1(3), FLT3(2), FLT4(3), GDF5(1), GH1(1), GHR(2), HGF(3), IFNA21(2), IFNA7(1), IFNA8(1), IFNAR2(1), IFNB1(1), IFNGR2(1), IFNK(1), IFNW1(1), IL10RB(1), IL12B(2), IL12RB1(1), IL12RB2(1), IL13RA1(1), IL15(2), IL17B(1), IL18RAP(1), IL1B(1), IL1R1(1), IL1R2(2), IL1RAP(1), IL20RA(2), IL23A(1), IL23R(4), IL25(2), IL26(1), IL3RA(2), IL5RA(1), IL6(1), IL6ST(2), IL9(1), INHBA(1), INHBB(1), INHBE(1), KDR(4), KIT(3), KITLG(2), LEPR(1), LTBR(2), MET(6), MPL(2), NGFR(1), OSMR(2), PDGFC(1), PDGFRA(5), PRLR(1), RELT(2), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), TNFRSF10D(1), TNFRSF11A(2), TNFRSF12A(1), TNFRSF13B(1), TNFRSF17(1), TNFRSF1B(2), TNFRSF21(2), TNFRSF8(1), TNFRSF9(2), TNFSF14(1), TNFSF15(3), TNFSF8(1), TPO(3), VEGFA(2), VEGFB(1), VEGFC(2), XCL1(1) 44690551 175 52 173 60 46 40 27 40 22 0 0.102 1.000 1.000 518 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(4), ABLIM1(2), ABLIM2(2), ABLIM3(1), ARHGEF12(1), CFL1(1), CXCR4(1), DCC(5), EFNA1(1), EFNA3(1), EFNA5(1), EFNB1(1), EFNB3(1), EPHA2(2), EPHA3(3), EPHA4(5), EPHA5(2), EPHA6(1), EPHA7(4), EPHA8(2), EPHB2(1), EPHB3(1), EPHB4(1), EPHB6(2), FES(2), FYN(1), GNAI1(1), ITGB1(2), KRAS(1), L1CAM(4), LRRC4C(4), MAPK1(1), MAPK3(1), MET(6), NFAT5(1), NFATC1(1), NFATC2(3), NFATC3(2), NFATC4(2), NGEF(3), NRAS(1), NRP1(3), NTNG1(1), PAK1(1), PAK3(3), PAK6(2), PAK7(2), PLXNA1(7), PLXNA2(3), PLXNA3(4), PLXNB1(4), PLXNB2(3), PLXNB3(3), PLXNC1(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTK2(1), RAC1(1), RAC2(1), RASA1(4), RGS3(4), RHOD(1), RND1(1), ROBO1(2), ROBO2(5), ROBO3(1), ROCK1(2), ROCK2(2), SEMA3A(3), SEMA3C(1), SEMA3D(2), SEMA3E(4), SEMA3F(1), SEMA4B(1), SEMA4D(2), SEMA4F(2), SEMA4G(1), SEMA6A(2), SEMA6B(2), SEMA6C(1), SEMA6D(2), SEMA7A(2), SLIT1(4), SLIT2(3), SLIT3(1), SRGAP1(2), SRGAP2(3), SRGAP3(1), UNC5A(1), UNC5B(1), UNC5C(1) 49898974 190 49 190 66 54 39 26 55 15 1 0.136 1.000 1.000 519 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(1), CBLB(1), CBLC(1), CCND1(1), CISH(1), CLCF1(1), CNTF(1), CNTFR(2), CREBBP(6), CSF2RA(3), CSF3R(1), EP300(3), EPOR(1), GH1(1), GHR(2), IFNA21(2), IFNA7(1), IFNA8(1), IFNAR2(1), IFNB1(1), IFNGR2(1), IFNK(1), IFNW1(1), IL10RB(1), IL12B(2), IL12RB1(1), IL12RB2(1), IL13RA1(1), IL15(2), IL20RA(2), IL23A(1), IL23R(4), IL26(1), IL3RA(2), IL5RA(1), IL6(1), IL6ST(2), IL9(1), IRF9(2), JAK2(3), JAK3(1), LEPR(1), MPL(2), OSMR(2), PIAS1(1), PIAS3(1), PIAS4(1), PIK3CA(15), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(13), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIM1(2), PRLR(1), PTPN11(4), SOCS4(1), SOS1(1), SOS2(3), SPRED1(1), SPRED2(2), SPRY1(1), SPRY4(1), STAM2(1), STAT1(2), STAT3(1), STAT4(2), STAT5B(2), STAT6(3), TPO(3), TYK2(5) 36705706 145 48 138 44 29 25 26 44 20 1 0.201 1.000 1.000 520 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(1), ADCY5(1), ADCY7(1), ADCY9(3), ADRA1A(2), ADRA1B(2), ADRB2(1), ANXA6(2), ARRB1(2), ATP1B2(1), ATP2A2(3), ATP2A3(1), ATP2B2(2), ATP2B3(6), CACNA1A(1), CACNA1B(7), CACNA1D(5), CACNA1E(4), CACNA1S(6), CALR(2), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CASQ1(2), CASQ2(2), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(3), GJA1(4), GJA4(1), GJB2(1), GJB6(1), GNA11(1), GNAO1(1), GNB5(1), GRK4(3), GRK5(4), ITPR1(2), ITPR2(11), ITPR3(6), KCNB1(3), KCNJ3(1), KCNJ5(2), MIB1(1), PLCB3(3), PRKAR1A(1), PRKCA(3), PRKCH(2), PRKCQ(2), RGS11(1), RGS14(1), RGS18(1), RGS19(1), RGS3(4), RGS6(1), RGS7(3), RGS9(2), RYR1(8), RYR2(10), RYR3(5), SFN(2), SLC8A3(1), YWHAQ(1) 47423623 170 46 170 67 59 33 20 41 16 1 0.378 1.000 1.000 521 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(1), CCL5(1), CD40(1), CXCL9(1), IFNA21(2), IFNA7(1), IFNA8(1), IFNAR2(1), IFNB1(1), IKBKE(3), IL12B(2), IL1B(1), IL6(1), IRAK4(1), IRF7(2), LBP(1), MAP2K2(1), MAP2K3(2), MAP3K8(2), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(1), NFKB1(1), NFKB2(1), PIK3CA(15), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(13), PIK3R2(1), PIK3R3(1), PIK3R5(1), RAC1(1), RELA(1), RIPK1(1), SPP1(1), STAT1(2), TBK1(2), TICAM1(1), TLR1(1), TLR3(5), TLR6(1), TLR7(3), TLR9(1), TRAF3(1) 22672343 93 45 85 33 18 22 19 17 15 2 0.392 1.000 1.000 522 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(1), ADCY5(1), ADCY7(1), ADCY9(3), ADSL(3), AK5(1), AK7(3), ALLC(2), AMPD1(2), AMPD2(3), AMPD3(1), CANT1(3), ENPP1(1), ENPP3(2), ENTPD1(1), ENTPD6(1), ENTPD8(1), GART(3), GMPR(1), GMPR2(2), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), IMPDH1(2), NPR1(1), NPR2(2), NT5C(2), NT5C1B(1), NT5E(1), NT5M(1), PAICS(1), PDE10A(1), PDE11A(4), PDE1A(1), PDE1C(5), PDE4A(1), PDE4C(1), PDE4D(3), PDE5A(1), PDE7A(1), PDE7B(1), PDE8A(4), PDE9A(1), PFAS(4), PKLR(1), POLA1(2), POLD2(2), POLD3(2), POLE(6), POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(1), POLR2G(1), POLR3A(5), POLR3B(2), PPAT(2), PRIM1(1), PRIM2(2), PRPS1L1(1), PRPS2(3), RRM1(3), XDH(7) 41307440 141 44 140 48 44 28 15 39 15 0 0.174 1.000 1.000 523 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(1), ADCY5(1), ADCY7(1), ADCY9(3), CSNK1D(1), EGF(2), EGFR(10), GJA1(4), GNA11(1), GNAI1(1), GNAS(2), GRM1(4), GRM5(2), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), HTR2A(1), HTR2B(1), HTR2C(1), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAP2K5(1), MAPK1(1), MAPK3(1), MAPK7(3), NPR1(1), NPR2(2), NRAS(1), PDGFA(1), PDGFC(1), PDGFD(1), PDGFRA(5), PLCB1(2), PLCB3(3), PLCB4(1), PRKCA(3), PRKG1(1), RAF1(1), SOS1(1), SOS2(3), TJP1(3), TUBA1A(1), TUBA3C(3), TUBA3D(1), TUBB(1), TUBB2C(2), TUBB3(3), TUBB4(1), TUBB4Q(2), TUBB6(2) 33423559 122 44 120 44 35 21 17 28 19 2 0.370 1.000 1.000 524 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(1), CADM1(2), CD226(1), CD274(1), CD276(1), CD4(1), CD40(1), CD40LG(2), CDH1(3), CDH2(2), CDH3(1), CDH4(2), CDH5(2), CLDN1(1), CLDN16(1), CLDN19(2), CLDN2(1), CLDN22(1), CLDN7(1), CLDN8(1), CNTN1(1), CNTNAP1(4), CNTNAP2(3), CTLA4(1), ESAM(1), F11R(1), GLG1(1), HLA-DMA(1), HLA-DMB(3), HLA-DPB1(1), HLA-DQA2(2), HLA-DRA(2), HLA-DRB5(1), HLA-E(1), HLA-F(1), ICAM1(2), ICAM2(1), ITGA4(2), ITGA6(3), ITGA8(3), ITGAM(1), ITGAV(2), ITGB1(2), ITGB2(1), ITGB7(4), JAM2(3), JAM3(2), L1CAM(4), MPZ(1), NCAM1(1), NEGR1(2), NEO1(4), NFASC(1), NLGN1(2), NLGN2(2), NLGN3(2), NRCAM(3), NRXN1(4), NRXN3(2), OCLN(1), PDCD1LG2(1), PTPRC(3), PTPRF(3), PTPRM(4), PVR(2), PVRL1(1), SDC1(1), SDC3(1), SELE(4), SELP(2), SELPLG(1), SIGLEC1(2), SPN(1), VCAM1(1), VCAN(5) 37322375 139 43 138 46 40 40 10 38 11 0 0.0607 1.000 1.000 525 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(3), ACVR1B(2), ACVRL1(2), AKT1(1), BUB1(3), CDS2(2), CLK1(2), CLK4(1), CSNK2A1(1), DGKB(2), DGKD(2), DGKG(1), DGKH(3), DGKQ(1), INPP4B(2), INPPL1(4), NEK3(1), OCRL(4), PIK3C2A(3), PIK3C2G(1), PIK3CA(15), PIK3CB(1), PIK3CG(4), PIM2(1), PLCB1(2), PLCB3(3), PLCB4(1), PLCD1(1), PLCG1(6), PLCG2(6), PLK3(1), PRKAR1A(1), PRKCA(3), PRKCH(2), PRKCQ(2), PRKG1(1), RAF1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), TGFBR1(1), VRK1(3) 28529972 103 43 97 37 22 22 16 24 17 2 0.481 1.000 1.000 526 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA2(1), ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(1), ADCY5(1), ADCY7(1), ADCY9(3), ARRB1(2), ATF4(1), ATF5(1), ATP2A2(3), ATP2A3(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CNN2(1), CORIN(1), GABPA(2), GABPB2(1), GBA2(1), GJA1(4), GNB5(1), GRK4(3), GRK5(4), GUCY1A3(1), IGFBP2(2), IL1B(1), IL6(1), ITPR1(2), ITPR2(11), ITPR3(6), MIB1(1), MYL2(1), MYLK2(1), NFKB1(1), NOS1(1), NOS3(5), PDE4D(3), PLCB3(3), PLCD1(1), PLCG1(6), PLCG2(6), PRKAR1A(1), PRKCA(3), PRKCH(2), PRKCQ(2), RGS11(1), RGS14(1), RGS18(1), RGS19(1), RGS3(4), RGS6(1), RGS7(3), RGS9(2), RLN1(1), RYR1(8), RYR2(10), RYR3(5), SFN(2), TNXB(9), YWHAQ(1) 43751975 154 42 153 63 54 25 19 41 14 1 0.526 1.000 1.000 527 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(1), CBLB(1), CBLC(1), CD3D(1), CD4(1), CD40LG(2), CDK4(1), CTLA4(1), FYN(1), ITK(1), KRAS(1), LAT(1), MAP3K14(1), MAP3K8(2), NFAT5(1), NFATC1(1), NFATC2(3), NFATC3(2), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIE(1), NRAS(1), PAK1(1), PAK3(3), PAK6(2), PAK7(2), PDK1(1), PIK3CA(15), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(13), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCQ(2), PTPRC(3), SOS1(1), SOS2(3), TEC(1), VAV1(3), VAV2(1), VAV3(2), ZAP70(2) 25650123 102 41 94 32 23 22 15 21 21 0 0.257 1.000 1.000 528 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(1), ADCY5(1), ADCY7(1), ADCY9(3), ATF4(1), CACNA1D(5), CACNA1F(3), CACNA1S(6), CAMK2A(1), CAMK2D(1), CAMK2G(2), EGFR(10), ELK1(3), GNA11(1), GNAS(2), GNRHR(2), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAP3K3(2), MAP3K4(1), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK7(3), MAPK8(1), NRAS(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(2), PLA2G5(1), PLA2G6(2), PLCB1(2), PLCB3(3), PLCB4(1), PLD1(3), PRKCA(3), RAF1(1), SOS1(1), SOS2(3) 32189753 114 40 112 37 37 22 14 25 14 2 0.128 1.000 1.000 529 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(1), BRAF(3), C7orf16(1), CACNA1A(1), GNA11(1), GNAI1(1), GNAO1(1), GNAS(2), GRIA1(2), GRIA2(2), GRIA3(5), GRID2(3), GRM1(4), GRM5(2), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), IGF1R(3), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAPK1(1), MAPK3(1), NOS1(1), NOS3(5), NPR1(1), NPR2(2), NRAS(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(2), PLA2G5(1), PLA2G6(2), PLCB1(2), PLCB3(3), PLCB4(1), PPP2CA(3), PPP2CB(1), PPP2R2A(2), PPP2R2C(2), PRKCA(3), PRKG1(1), RAF1(1), RYR1(8) 27866021 108 38 108 37 25 20 19 27 15 2 0.350 1.000 1.000 530 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA2(1), ACTN2(6), ACTN3(1), ACTN4(1), DMD(6), FAM48A(1), MYBPC1(2), MYBPC2(2), MYH3(5), MYH6(2), MYH7(5), MYH8(5), MYL1(1), MYL2(1), MYOM1(1), NEB(16), TNNI1(1), TNNT1(1), TNNT3(1), TPM1(5), TPM3(2), TPM4(1), TTN(67), VIM(2) 34406543 136 38 136 44 37 30 16 44 8 1 0.194 1.000 1.000 531 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 ALG10B(2), ALG12(1), ALG13(3), ALG3(1), ALG6(3), B3GNT7(1), CHPF(1), CHST11(1), CHST13(1), CHST3(2), CHST4(1), CHSY1(1), DAD1(1), DPAGT1(1), EXT1(2), EXT2(1), EXTL1(2), EXTL3(1), FUT8(3), GALNT12(2), GALNT13(1), GALNT14(2), GALNT2(2), GALNT4(1), GALNT5(2), GALNT6(2), GALNT8(1), GALNT9(2), GALNTL1(2), GALNTL4(2), GALNTL5(1), GANAB(2), GCNT4(2), HS6ST2(3), MAN1A1(2), MAN1A2(1), MAN1C1(1), MAN2A1(4), MGAT1(2), MGAT2(2), MGAT3(2), NDST1(1), NDST2(2), NDST3(2), NDST4(1), OGT(5), RPN2(1), ST3GAL1(1), ST3GAL4(1), ST6GAL1(1), ST6GALNAC1(1), STT3B(1), WBSCR17(4), XYLT1(1), XYLT2(1) 27777034 93 31 93 30 30 18 9 24 12 0 0.264 1.000 1.000 532 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(1), ADCY5(1), ADCY7(1), ADSL(3), AK5(1), ALLC(2), AMPD1(2), AMPD2(3), AMPD3(1), ATP5B(1), ATP5G2(1), CANT1(3), ENPP1(1), ENPP3(2), ENTPD1(1), GART(3), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), IMPDH1(2), NPR1(1), NPR2(2), NT5C(2), NT5E(1), NT5M(1), PAICS(1), PDE1A(1), PDE4A(1), PDE4C(1), PDE4D(3), PDE5A(1), PDE6B(3), PDE6C(5), PDE7B(1), PDE8A(4), PDE9A(1), PFAS(4), PKLR(1), POLB(1), POLD2(2), POLE(6), POLG(1), POLL(1), POLQ(1), POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(1), POLR2G(1), PPAT(2), PRPS1L1(1), PRPS2(3), RRM1(3) 32402862 107 31 107 47 37 25 12 26 7 0 0.666 1.000 1.000 533 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(1), ADCY5(1), ADCY7(1), ADCY9(3), CAMK2A(1), CAMK2D(1), CAMK2G(2), CREB1(1), CREB3L1(1), CREB3L2(1), CREBBP(6), DVL2(1), DVL3(1), EDNRB(1), EP300(3), FZD1(1), FZD10(1), FZD4(1), FZD6(1), FZD7(1), FZD8(1), FZD9(1), GNAI1(1), GNAO1(1), GNAS(2), KIT(3), KITLG(2), KRAS(1), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(2), PLCB3(3), PLCB4(1), PRKCA(3), RAF1(1), TCF7L2(2), TYR(3), TYRP1(2), WNT11(4), WNT2(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(1), WNT8B(1), WNT9B(1) 27471574 81 27 81 34 27 10 7 25 10 2 0.604 1.000 1.000 534 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(1), ADCY5(1), ADCY7(1), ADCY9(3), AKAP11(1), AKAP12(1), AKAP3(1), AKAP4(3), AKAP5(1), AKAP6(7), AKAP7(1), AKAP8(2), AKAP9(4), ARHGEF1(1), GNA11(1), GNA14(1), GNAL(1), GNAO1(1), GNB5(1), ITPR1(2), KCNJ3(1), KRAS(1), NRAS(1), PDE1A(1), PDE1B(2), PDE1C(5), PDE4A(1), PDE4C(1), PDE4D(3), PDE7A(1), PDE7B(1), PDE8A(4), PLCB3(3), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKCA(3), PRKCH(2), PRKCI(1), PRKCQ(2), RRAS(1) 29597366 78 25 78 43 25 14 6 22 10 1 0.944 1.000 1.000 535 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(5), ACSL1(1), ACSL3(2), ACSL4(1), ACSL6(1), ADIPOR1(1), ADIPOR2(3), AKT1(1), CAMKK1(1), CAMKK2(1), CD36(3), CPT1A(1), CPT1C(1), CPT2(1), G6PC(3), G6PC2(1), IRS1(2), IRS2(1), IRS4(4), JAK2(3), JAK3(1), LEPR(1), MAPK10(1), MAPK8(1), NFKB1(1), NFKB2(1), NFKBIE(1), NPY(1), PCK1(3), PPARA(2), PRKAA1(2), PRKAA2(2), PRKAG1(1), PRKAG2(1), PRKCQ(2), PTPN11(4), RELA(1), RXRA(1), RXRG(3), SLC2A1(1), SLC2A4(1), STAT3(1), TNFRSF1B(2), TYK2(5) 20970236 77 23 77 31 20 16 5 26 10 0 0.604 1.000 1.000 536 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 BRAF(3), CREB1(1), DAXX(2), ELK1(3), MAP2K2(1), MAP2K3(2), MAP2K5(1), MAP3K1(2), MAP3K11(1), MAP3K12(3), MAP3K13(1), MAP3K14(1), MAP3K3(2), MAP3K4(1), MAP3K5(2), MAP3K8(2), MAP3K9(2), MAP4K3(1), MAP4K4(2), MAP4K5(1), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK4(1), MAPK7(3), MAPK8(1), MAPKAPK2(1), MAPKAPK3(1), MAX(4), MEF2A(2), MEF2B(1), NFKB1(1), PAK1(1), RAC1(1), RAF1(1), RELA(1), RIPK1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), RPS6KB2(2), SHC1(1), STAT1(2), TGFB2(2), TGFB3(1), TGFBR1(1) 24027530 76 23 75 31 22 12 12 20 8 2 0.623 1.000 1.000 537 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(3), C3AR1(2), CCKBR(3), CCR10(1), CCR4(1), CCR6(1), CCR7(1), CX3CR1(1), CXCR4(1), EDNRB(1), FPR1(1), FSHR(1), GALR1(1), GNB2L1(1), GNRHR(2), GPR77(1), GRPR(2), MC3R(1), MC4R(3), MC5R(1), NMBR(2), NPY1R(3), NTSR1(2), OPRL1(1), OPRM1(1), PPYR1(2), SSTR2(1), SSTR3(2), SSTR4(3), TACR2(1), TRHR(2), TSHR(4) 13212298 57 23 57 25 18 10 10 16 3 0 0.524 1.000 1.000 538 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1C2(1), AKR1C3(1), ALDH1A3(3), ALDH3A1(2), CYP1A2(1), CYP1B1(1), CYP2B6(1), CYP2C19(4), CYP2C8(1), CYP3A7(1), EPHX1(3), GSTA4(1), GSTA5(3), GSTZ1(2), UGT1A1(1), UGT1A5(2), UGT1A7(1), UGT1A8(1), UGT2A1(3), UGT2A3(3), UGT2B10(3), UGT2B15(1), UGT2B4(2) 14484324 53 22 53 20 13 7 10 19 4 0 0.581 1.000 1.000 539 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(3), ABCA12(3), ABCA13(8), ABCA2(3), ABCA3(2), ABCA4(3), ABCA5(2), ABCA6(5), ABCA7(2), ABCA8(3), ABCA9(2), ABCB1(3), ABCB11(1), ABCB4(4), ABCB5(3), ABCB7(2), ABCB8(1), ABCB9(1), ABCC1(4), ABCC10(6), ABCC11(3), ABCC12(4), ABCC3(6), ABCC4(2), ABCC5(3), ABCC6(1), ABCC8(4), ABCC9(3), ABCD1(2), ABCG1(1), ABCG4(1), ABCG5(3), ABCG8(3), CFTR(1) 29840899 98 21 98 36 26 18 14 29 10 1 0.392 1.000 1.000 540 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX12B(2), ALOX15(1), CBR3(1), CYP2B6(1), CYP2C19(4), CYP2C8(1), CYP2U1(1), CYP4F3(3), EPHX2(2), GGT1(2), GPX4(1), LTA4H(2), PLA2G2D(1), PLA2G3(3), PLA2G4A(2), PLA2G5(1), PLA2G6(2), PTGES2(1), PTGS1(2), PTGS2(1) 9835135 35 20 35 13 8 8 5 9 5 0 0.512 1.000 1.000 541 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ABP1(1), ACMSD(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), AOX1(3), CAT(2), CYP1A2(1), CYP2B6(1), CYP2C19(4), CYP2C8(1), CYP3A7(1), CYP4B1(1), CYP51A1(1), DDC(1), ECHS1(2), EHHADH(1), GCDH(1), KMO(2), TDO2(1), TPH1(2), WARS2(2) 13911064 40 17 40 16 15 10 2 8 5 0 0.589 1.000 1.000 542 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX15(1), CBR3(1), CYP4F3(3), EPX(2), GGT1(2), LPO(3), LTA4H(2), MPO(2), PLA2G3(3), PLA2G4A(2), PLA2G5(1), PLA2G6(2), PRDX1(1), PTGES2(1), PTGS1(2), PTGS2(1), TPO(3) 7053379 33 16 33 12 9 10 3 6 5 0 0.304 1.000 1.000 543 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH4A1(2), ARG2(1), ASL(2), CKM(1), CKMT1A(1), CKMT2(1), CPS1(4), GLUD1(3), GOT1(2), NOS1(1), NOS3(5), OAT(1), ODC1(2), P4HA1(1), RARS(2), SMS(1) 11192112 41 15 41 19 16 9 2 10 4 0 0.732 1.000 1.000 544 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(2), ACADL(1), ACADM(1), ACADVL(1), ACOX1(2), ACOX3(3), ACSL1(1), ACSL3(2), ACSL4(1), ACSL6(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH7A1(1), CPT1A(1), CPT1C(1), CPT2(1), DCI(1), ECHS1(2), EHHADH(1), GCDH(1), HSD17B4(2) 12391968 46 15 46 18 14 8 5 14 5 0 0.599 1.000 1.000 545 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1D1(1), ARSD(1), ARSE(2), CYP11B1(1), HSD11B1(1), HSD17B2(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), SRD5A1(1), SULT2A1(2), UGT1A1(1), UGT1A5(2), UGT1A7(1), UGT1A8(1), UGT2A1(3), UGT2A3(3), UGT2B10(3), UGT2B15(1), UGT2B4(2) 12705924 38 14 38 15 10 4 8 14 2 0 0.541 1.000 1.000 546 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(2), ARG2(1), ASL(2), CKM(1), CKMT1A(1), CKMT2(1), CPS1(4), EPRS(2), GLUD1(3), GLUD2(1), GOT1(2), LAP3(1), NOS1(1), NOS3(5), OAT(1), P4HA1(1), PARS2(1), RARS(2), RARS2(4) 9091985 36 14 36 16 10 8 2 12 4 0 0.762 1.000 1.000 547 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AANAT(1), ABP1(1), ACMSD(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH7A1(1), AOX1(3), CAT(2), CYP1A2(1), CYP1B1(1), DDC(1), ECHS1(2), EHHADH(1), GCDH(1), HSD17B4(2), KMO(2), LCMT1(2), LCMT2(1), LNX1(2), METTL2B(3), METTL6(1), NFX1(1), OGDHL(1), PRMT2(2), PRMT5(1), PRMT6(1), TDO2(1), TPH1(2), TPH2(1), WARS2(2) 15329291 50 14 50 21 19 10 3 12 6 0 0.611 1.000 1.000 548 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(2), ALAS1(1), BLVRA(2), COX15(1), CP(3), EARS2(1), EPRS(2), FTH1(2), GUSB(2), HCCS(3), MMAB(1), UGT1A1(1), UGT1A5(2), UGT1A7(1), UGT1A8(1), UGT2A1(3), UGT2A3(3), UGT2B10(3), UGT2B15(1), UGT2B4(2), UROS(1) 10681696 38 14 38 13 10 4 10 13 1 0 0.434 1.000 1.000 549 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(1), AGXT(2), AGXT2(1), ALAS1(1), ATP6V0C(1), CBS(3), CHKB(1), CTH(1), GARS(2), GCAT(1), GLDC(2), PLCG1(6), PLCG2(6), SARDH(1), SHMT1(1) 10651750 30 13 29 13 13 11 1 4 1 0 0.502 1.000 1.000 550 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPNS1(1), CAPNS2(1), EGF(2), EGFR(10), ITGA1(2), ITGB1(2), MAPK1(1), MAPK3(1), MYL2(1), MYLK(3), PRKAR1A(1), PTK2(1), TLN1(2) 8262059 28 13 26 12 7 3 4 11 2 1 0.775 1.000 1.000 551 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), ARHGEF11(2), DLG4(3), LPA(5), MAP3K1(2), MAP3K5(2), MAPK8(1), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), PDK1(1), PHKA2(4), PI3(1), PIK3CB(1), PLD1(3), PLD3(1), PTK2(1), RDX(5), ROCK1(2), ROCK2(2), SERPINA4(1), SRF(2), TBXA2R(1) 12396510 45 13 45 15 12 8 6 14 5 0 0.418 1.000 1.000 552 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), ANKRD6(2), APC(1), AXIN1(1), CSNK1A1(2), DACT1(2), DKK1(1), DKK2(2), DKK4(2), LRP1(15), NKD2(1), PTPRA(4), SENP2(2), SFRP1(1), WIF1(2) 10186161 39 13 39 15 12 8 3 12 4 0 0.636 1.000 1.000 553 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2D(1), CAMK2G(2), ITPR1(2), ITPR2(11), ITPR3(6), NFAT5(1), PDE6B(3), PDE6C(5), SLC6A13(2), TF(1) 9066188 35 13 35 14 13 7 6 7 2 0 0.492 1.000 1.000 554 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH7A1(1), AMDHD1(2), ASPA(1), CNDP1(1), DDC(1), FTCD(1), HAL(1), HARS(1), HARS2(1), HDC(2), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), PRPS2(3) 10028600 36 12 36 16 17 8 2 8 1 0 0.527 1.000 1.000 555 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(1), CCND1(1), CREBBP(6), EP300(3), ERCC3(1), ESR1(1), GRIP1(1), GTF2E1(3), GTF2F1(2), HDAC2(4), HDAC3(1), HDAC4(1), HDAC5(1), HDAC6(3), NCOR2(3), NRIP1(1), PELP1(1), POLR2A(3) 11666491 37 11 37 15 9 5 2 14 7 0 0.778 1.000 1.000 556 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1G(1), ELK1(3), FPR1(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), MAPK3(1), NCF1(1), NCF2(3), NFATC1(1), NFATC2(3), NFATC3(2), NFATC4(2), NFKB1(1), PAK1(1), PIK3C2G(1), PLCB1(2), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(1), RELA(1) 9680849 34 11 34 18 13 6 1 8 5 1 0.844 1.000 1.000 557 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(1), GABBR1(2), GPRC5D(1), GRM1(4), GRM2(4), GRM3(4), GRM4(2), GRM5(2), GRM7(2), GRM8(1) 5309182 23 11 23 11 7 4 2 7 3 0 0.800 1.000 1.000 558 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(3), GRIN2A(1), GRIN2B(4), GRIN2C(2), GRIN2D(3), NOS1(1), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKCA(3) 6451892 20 11 20 10 6 3 2 6 2 1 0.738 1.000 1.000 559 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(1), AXIN1(1), CCND1(1), CSNK1E(1), DVL2(1), DVL3(1), FZD1(1), FZD10(1), FZD6(1), FZD7(1), FZD8(1), FZD9(1), MAPK10(1), PAFAH1B1(4), PLAU(1), PRKCA(3), PRKCH(2), PRKCI(1), PRKCQ(2), RAC1(1), SFRP4(1), WNT11(4), WNT2(2), WNT2B(1), WNT5B(1), WNT7A(1) 15145292 37 11 37 17 13 4 7 7 5 1 0.667 1.000 1.000 560 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(3), CALCR(1), ELTD1(1), EMR1(1), EMR2(2), GHRHR(2), GIPR(2), GLP2R(1), GPR64(2), LPHN1(1), LPHN2(4), LPHN3(3), VIPR1(1) 6751492 24 10 24 12 5 5 4 10 0 0 0.860 1.000 1.000 561 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ASPA(1), CNDP1(1), DDC(1), HAL(1), HARS(1), HDC(2), PRPS2(3) 6186631 21 10 21 11 13 5 1 2 0 0 0.676 1.000 1.000 562 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), GLB1(1), GUSB(2), HGSNAT(2), HPSE(2), HPSE2(1), HYAL1(1), IDS(1), LCT(5), MAN2B1(1), MAN2B2(1), MAN2C1(1), NAGLU(2), NEU1(1), NEU2(1), NEU3(1), SPAM1(1) 8696585 25 10 25 13 8 3 4 8 2 0 0.874 1.000 1.000 563 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(4), CDK4(1), CDKN1B(1), CEBPB(1), DMC1(2), EGR1(1), ESR2(3), FSHR(1), GJA4(1), MLH1(3), MSH5(1), NCOR1(8), NR5A1(1), NRIP1(1), PGR(2), PRLR(1), VDR(1), ZP2(1) 8859828 34 10 34 12 9 7 2 10 5 1 0.578 1.000 1.000 564 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(5), FAU(1), IL6ST(2), MRPL19(2), RPL10(3), RPL13A(1), RPL15(1), RPL18A(1), RPL29(1), RPL32(1), RPL36(1), RPL5(1), RPL6(1), RPL7(2), RPL7A(1), RPS11(1), RPS12(1), RPS18(1), RPS3(1), RPS4X(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), RPS6KB2(2), SLC36A2(1), TBC1D10C(1), UBC(3) 13231612 43 10 43 16 13 7 5 13 5 0 0.672 1.000 1.000 565 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT1(1), ITPR1(2), ITPR2(11), ITPR3(6), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), PDK1(1), PHKA2(4), PIK3CB(1), PITX2(3), PLD1(3), PLD3(1) 11334038 38 10 38 18 12 7 7 10 2 0 0.721 1.000 1.000 566 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AKR1B10(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(2), ALDH7A1(1), DOT1L(2), ECHS1(2), EHHADH(1), EHMT1(3), EHMT2(2), GCDH(1), HSD17B4(2), NSD1(2), OGDHL(1), PIPOX(1), PLOD1(2), PLOD2(1), PLOD3(1), SETD1A(1), SETD7(2), SETDB1(1), SHMT1(1), SUV39H1(1), TMLHE(1) 14685286 40 9 40 19 19 7 2 7 5 0 0.707 1.000 1.000 567 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC10(1), ANAPC2(2), ANAPC5(2), ANAPC7(1), BTRC(1), CDC16(1), CDC20(1), CDC23(2), CDC27(3), CUL1(1), CUL2(3), CUL3(1), FBXW7(1), FZR1(2), SKP2(2), SMURF1(1), SMURF2(1), UBE2D4(2), WWP1(3) 10182292 31 9 30 15 6 5 4 11 5 0 0.905 1.000 1.000 568 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(1), ALDH1A3(3), ALDH3A1(2), DDC(1), EPX(2), GOT1(2), HPD(1), LPO(3), MPO(2), PRDX1(1), TAT(1), TPO(3) 5559847 22 9 22 11 12 5 2 2 1 0 0.576 1.000 1.000 569 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(3), EPHB2(1), F2(2), MAP2K5(1), MAPK1(1), MAPK7(3), MAPK8(1), MYEF2(2), PLD1(3), PLD3(1), PTK2(1), RAF1(1), RASAL1(2), TEC(1), VAV1(3) 6929405 27 9 27 10 6 8 1 10 2 0 0.514 1.000 1.000 570 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BAX(1), CASP1(1), CASP4(1), CD40(1), CD40LG(2), CRADD(1), CYCS(2), DAXX(2), DFFA(1), FAS(1), IKBKE(3), NFKB1(1), NGFR(1), NR3C1(2), PTPN13(1), RIPK1(1), SFRS2IP(2), TFG(1), TNFRSF1B(2), TRAF3(1) 10978077 29 8 29 15 9 5 1 8 6 0 0.855 1.000 1.000 571 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(2), C1QB(1), C1R(2), C1S(2), C2(2), C3(8), C5(4), C6(1), C7(3), C8B(2) 5260684 27 8 27 11 7 5 2 9 4 0 0.621 1.000 1.000 572 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNB1(1), IL1B(1), IL1R1(1), IL1RAP(1), IL6(1), IRAK2(1), IRAK3(4), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAPK8(1), NFKB1(1), RELA(1), TGFB2(2), TGFB3(1) 7486817 21 8 21 10 6 4 4 5 2 0 0.771 1.000 1.000 573 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(2), ANXA2(1), ANXA3(1), ANXA6(2), EDNRB(1), HSD11B1(1), PLA2G4A(2), PTGER4(1), PTGFR(5), PTGS1(2), PTGS2(1), SCGB1A1(2) 5219067 21 8 21 10 6 3 2 7 3 0 0.825 1.000 1.000 574 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), CREB1(1), EEF2K(1), EIF4E(1), ELK1(3), IL1R1(1), MAP2K3(2), MAP3K4(1), MAP3K5(2), MAPK1(1), MAPK12(2), MAPK13(1), MAPKAPK2(1), MYEF2(2), NFKB1(1), NR2C2(1), SRF(2) 8417416 24 8 24 12 8 4 5 5 2 0 0.781 1.000 1.000 575 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 ELK1(3), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAPK8(1), NFKB1(1), PPARA(2), RELA(1), TLR10(3), TLR3(5), TLR6(1), TLR7(3), TLR9(1) 9229266 26 8 25 15 6 6 5 7 2 0 0.915 1.000 1.000 576 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(1), EXTL1(2), EXTL3(1), HS6ST2(3), NDST1(1), NDST2(2), NDST3(2), NDST4(1) 5212119 15 7 15 7 9 1 1 4 0 0 0.739 1.000 1.000 577 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(2), POLB(1), POLD2(2), POLD3(2), POLE(6), POLG(1), POLH(1), POLI(3), POLK(1), POLL(1), POLM(2), POLQ(1), PRIM1(1), PRIM2(2), REV1(1), REV3L(2) 10232580 29 7 29 11 3 5 4 12 5 0 0.785 1.000 1.000 578 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN2(6), ACTN3(1), BCAR1(1), CAPNS1(1), CAPNS2(1), CRKL(1), CSK(1), FYN(1), ITGA1(2), ITGB1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(1), PTK2(1), RAF1(1), ROCK1(2), SHC1(1), SOS1(1), TLN1(2), VCL(1) 11912829 30 7 30 14 10 5 4 8 2 1 0.740 1.000 1.000 579 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(2), FH(1), IDH2(6) 2378271 9 7 5 5 2 4 0 3 0 0 0.744 1.000 1.000 580 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), ERCC3(1), GTF2E1(3), GTF2H1(1), POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(1), POLR2G(1), POLR3B(2), POLR3D(1), TAF9(2) 8865278 25 7 25 15 9 4 1 9 2 0 0.922 1.000 1.000 581 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), GLB1(1), LCT(5), MAN2B1(1), MAN2B2(1), MAN2C1(1), NEU1(1), NEU2(1), NEU3(1) 5137557 13 6 13 11 5 2 1 5 0 0 0.981 1.000 1.000 582 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), GLB1(1), LCT(5), MAN2C1(1), NEU1(1), NEU2(1), NEU3(1) 4165203 11 6 11 5 4 2 1 4 0 0 0.759 1.000 1.000 583 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(1), AXIN1(1), CREBBP(6), EP300(3), FZD1(1), LDB1(2), PITX2(3), TRRAP(5) 8377753 22 6 22 12 7 4 1 10 0 0 0.850 1.000 1.000 584 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(3), CREB1(1), DUSP4(1), DUSP9(2), EEF2K(1), EIF4E(1), MAP2K2(1), MAP3K8(2), MAPK1(1), MAPK3(1), NFKB1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), SHC1(1), SOS1(1), SOS2(3), TRAF3(1) 7465931 27 6 27 11 8 3 5 8 2 1 0.605 1.000 1.000 585 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDK2(1), DIAPH2(1), GMNN(1), MCM10(3), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(2), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), POLD2(2), POLD3(2), POLE(6), PRIM1(1), RFC4(2), RPA1(2), UBC(3) 12816029 38 5 38 17 6 6 6 15 5 0 0.784 1.000 1.000 586 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), CYP51A1(1), DHCR24(2), DHCR7(3), FDFT1(1), IDI1(1), MVD(2), NSDHL(2), SQLE(1) 4874022 14 5 14 8 6 1 4 3 0 0 0.864 1.000 1.000 587 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(1), AGXT(2), AGXT2(1), AKR1B10(2), ALAS1(1), CBS(3), CHKB(1), CTH(1), GARS(2), GCAT(1), GLDC(2), PHGDH(1), PIPOX(1), SARDH(1), SARS2(1), SHMT1(1), TARS2(1) 10808452 23 5 23 13 9 9 1 3 1 0 0.808 1.000 1.000 588 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IL1R1(1), MAP3K1(2), MAP3K14(1), NFKB1(1), RELA(1), RIPK1(1), TNFAIP3(1), TNFRSF1B(2) 6149332 10 5 10 12 5 0 1 1 3 0 0.998 1.000 1.000 589 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(6), EP300(3), IL1B(1), MAP2K3(2), MAP3K14(1), NFKB1(1), NR3C1(2), RELA(1), TGFBR1(1), TGFBR2(2) 7510800 20 5 20 12 4 3 2 10 1 0 0.941 1.000 1.000 590 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN2(6), ACTN3(1), BCAR1(1), CSK(1), CTNNA2(2), PTK2(1), VCL(1) 4845658 13 4 13 6 6 3 0 4 0 0 0.642 1.000 1.000 591 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(1), MAF(2), MAP2K3(2), NFATC1(1), NFATC2(3), PRKAR1A(1) 3064849 10 4 10 6 5 1 0 4 0 0 0.818 1.000 1.000 592 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(2), EIF2AK4(2) 2921000 4 3 4 4 1 1 1 1 0 0 0.954 1.000 1.000 593 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 FYN(1), RELN(6), VLDLR(1) 3548153 8 3 8 8 2 4 0 2 0 0 0.975 1.000 1.000 594 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(6), EP300(3), HDAC3(1), NFKB1(1), RELA(1), RIPK1(1), TNFRSF1B(2) 5648698 15 3 15 11 4 1 0 8 2 0 0.980 1.000 1.000 595 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(1), GLI2(1), GLI3(2), PRKAR1A(1), SHH(1), SMO(2), SUFU(1) 4197851 9 3 9 5 1 5 0 3 0 0 0.722 1.000 1.000 596 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(1), HLA-DRA(2) 1006444 3 2 3 3 0 0 0 3 0 0 0.960 1.000 1.000 597 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(1), CYP11B1(1), HSD11B1(1) 2330903 3 2 3 3 1 0 1 1 0 0 0.922 1.000 1.000 598 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(1), ST3GAL4(1) 1432630 2 2 2 3 2 0 0 0 0 0 0.969 1.000 1.000 599 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT2(2), GLA(1), ST3GAL1(1), ST3GAL4(1) 2554847 5 2 5 5 3 0 0 2 0 0 0.978 1.000 1.000 600 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(1), CYP11B1(1), HSD11B1(1) 2330903 3 2 3 3 1 0 1 1 0 0 0.922 1.000 1.000 601 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 APOBEC1(1), APOBEC3F(1), APOBEC3G(1) 1852597 3 2 3 5 2 0 0 1 0 0 0.993 1.000 1.000 602 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CAPNS1(1), CAPNS2(1), CSNK1A1(2), CSNK1D(1), PPP2CA(3) 2346980 9 2 9 5 2 0 3 4 0 0 0.871 1.000 1.000 603 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNAR2(1), IFNB1(1), MAPK8(1), NFKB1(1), RELA(1), TNFRSF11A(2) 2804730 7 2 7 6 1 1 1 4 0 0 0.957 1.000 1.000 604 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(2) 1593342 2 2 2 2 1 0 1 0 0 0 0.935 1.000 1.000 605 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(3), FYN(1), THBS1(1) 1868139 5 2 5 4 2 2 1 0 0 0 0.840 1.000 1.000 606 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT2(2) 1537179 2 1 2 3 1 0 0 1 0 0 0.989 1.000 1.000 607 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD2(2), POLE(6), POLG(1), POLL(1), POLQ(1) 4196072 12 1 12 7 1 2 2 7 0 0 0.901 1.000 1.000 608 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALT5(1), FUT2(2), GLA(1), ST3GAL1(1) 2712035 5 1 5 6 3 0 0 2 0 0 0.990 1.000 1.000 609 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), SULT2A1(2), SUOX(1) 1547534 4 1 4 3 0 1 0 3 0 0 0.935 1.000 1.000 610 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD3D(1), CD4(1) 813701 2 1 2 2 0 1 0 1 0 0 0.903 1.000 1.000 611 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 1197079 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 612 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 182982 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 613 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 128840 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 614 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 388016 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 433630 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 1535398 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000