Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.089 0.298 -9999.0 0.0 -0.734 28.0 28.0 IHH -0.008 0.072 -9999.0 0.0 -0.511 2.0 2.0 SHH Np/Cholesterol/GAS1 -0.101 0.176 -9999.0 0.0 -0.435 38.0 38.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.1 0.174 0.432 38.0 -9999.0 0.0 38.0 SMO/beta Arrestin2 -0.029 0.178 -9999.0 0.0 -0.69 7.0 7.0 SMO -0.039 0.189 -9999.0 0.0 -0.596 12.0 12.0 AKT1 0.005 0.093 -9999.0 0.0 -0.425 3.0 3.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.003 0.081 -9999.0 0.0 -0.584 4.0 4.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.038 0.185 -9999.0 0.0 -0.584 12.0 12.0 STIL -0.089 0.237 -9999.0 0.0 -0.61 25.0 25.0 DHH N/PTCH2 -0.064 0.158 -9999.0 0.0 -0.44 32.0 32.0 DHH N/PTCH1 -0.064 0.202 -9999.0 0.0 -0.501 25.0 25.0 PIK3CA 0.011 0.046 -9999.0 0.0 -0.673 1.0 1.0 DHH -0.052 0.191 -9999.0 0.0 -0.591 24.0 24.0 PTHLH -0.108 0.365 -9999.0 0.0 -0.983 27.0 27.0 determination of left/right symmetry -0.038 0.185 -9999.0 0.0 -0.584 12.0 12.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.106 0.358 -9999.0 0.0 -0.966 27.0 27.0 IHH N/Hhip -0.137 0.238 -9999.0 0.0 -0.491 66.0 66.0 DHH N/Hhip -0.174 0.238 -9999.0 0.0 -0.468 82.0 82.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.038 0.185 -9999.0 0.0 -0.584 12.0 12.0 pancreas development -0.168 0.286 -9999.0 0.0 -0.604 65.0 65.0 HHAT -0.004 0.108 -9999.0 0.0 -0.643 6.0 6.0 PI3K -0.002 0.033 -9999.0 0.0 -0.497 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.022 0.135 -9999.0 0.0 -0.519 15.0 15.0 somite specification -0.038 0.185 -9999.0 0.0 -0.584 12.0 12.0 SHH Np/Cholesterol/PTCH1 -0.092 0.238 -9999.0 0.0 -0.573 29.0 29.0 SHH Np/Cholesterol/PTCH2 -0.095 0.176 -9999.0 0.0 -0.426 39.0 39.0 SHH Np/Cholesterol/Megalin -0.185 0.238 -9999.0 0.0 -0.493 64.0 64.0 SHH -0.087 0.214 -9999.0 0.0 -0.469 50.0 50.0 catabolic process -0.037 0.181 -9999.0 0.0 -0.583 11.0 11.0 SMO/Vitamin D3 -0.083 0.239 -9999.0 0.0 -0.616 23.0 23.0 SHH Np/Cholesterol/Hhip -0.18 0.236 -9999.0 0.0 -0.409 97.0 97.0 LRP2 -0.179 0.285 -9999.0 0.0 -0.585 71.0 71.0 receptor-mediated endocytosis -0.177 0.237 -9999.0 0.0 -0.624 37.0 37.0 SHH Np/Cholesterol/BOC -0.088 0.164 -9999.0 0.0 -0.416 36.0 36.0 SHH Np/Cholesterol/CDO -0.1 0.179 -9999.0 0.0 -0.38 58.0 58.0 mesenchymal cell differentiation 0.179 0.234 0.406 97.0 -9999.0 0.0 97.0 mol:Vitamin D3 -0.09 0.239 -9999.0 0.0 -0.572 29.0 29.0 IHH N/PTCH2 -0.008 0.113 -9999.0 0.0 -0.526 9.0 9.0 CDON -0.019 0.144 -9999.0 0.0 -0.641 11.0 11.0 IHH N/PTCH1 -0.037 0.182 -9999.0 0.0 -0.587 11.0 11.0 Megalin/LRPAP1 -0.136 0.202 -9999.0 0.0 -0.422 71.0 71.0 PTCH2 -0.01 0.125 -9999.0 0.0 -0.651 8.0 8.0 SHH Np/Cholesterol -0.084 0.162 -9999.0 0.0 -0.37 50.0 50.0 PTCH1 -0.037 0.182 -9999.0 0.0 -0.585 11.0 11.0 HHIP -0.169 0.286 -9999.0 0.0 -0.605 65.0 65.0