Lung Adenocarcinoma: Correlation between gene mutation status and selected clinical features
(primary solid tumor cohort)
(primary solid tumor cohort)
Maintained by TCGA GDAC Team
(Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Overview
Introduction
This pipeline computes the correlation between significantly recurrent gene mutations and selected clinical features.
Summary
Testing the association between mutation status of 184 genes and 14 clinical features across 172 patients, 9 significant findings detected with Q value < 0.25.
-
CNBD1 mutation correlated to 'HISTOLOGICAL.TYPE'.
-
LRRIQ3 mutation correlated to 'HISTOLOGICAL.TYPE'.
-
U2AF1 mutation correlated to 'HISTOLOGICAL.TYPE'.
-
GBA3 mutation correlated to 'HISTOLOGICAL.TYPE'.
-
OR2W5 mutation correlated to 'NUMBERPACKYEARSSMOKED'.
-
AKR1B10 mutation correlated to 'HISTOLOGICAL.TYPE'.
-
DACH1 mutation correlated to 'HISTOLOGICAL.TYPE'.
-
PYHIN1 mutation correlated to 'HISTOLOGICAL.TYPE'.
-
OR13G1 mutation correlated to 'HISTOLOGICAL.TYPE'.
Results
Overview of the results
Table 1. Get Full Table Overview of the association between mutation status of 184 genes and 14 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 9 significant findings detected.
|
Clinical Features |
Time to Death |
AGE | GENDER |
KARNOFSKY PERFORMANCE SCORE |
HISTOLOGICAL TYPE |
PATHOLOGY T |
PATHOLOGY N |
PATHOLOGICSPREAD(M) |
TUMOR STAGE |
RADIATIONS RADIATION REGIMENINDICATION |
NUMBERPACKYEARSSMOKED | TOBACCOSMOKINGHISTORYINDICATOR | YEAROFTOBACCOSMOKINGONSET |
COMPLETENESS OF RESECTION |
||
| nMutated (%) | nWild-Type | logrank test | t-test | Fisher's exact test | t-test | Chi-square test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | t-test | Fisher's exact test | t-test | Fisher's exact test | |
| CNBD1 | 10 (6%) | 162 |
0.73 (1.00) |
0.692 (1.00) |
0.111 (1.00) |
8.55e-05 (0.201) |
0.607 (1.00) |
0.754 (1.00) |
0.79 (1.00) |
0.947 (1.00) |
0.601 (1.00) |
0.785 (1.00) |
0.0243 (1.00) |
0.412 (1.00) |
1 (1.00) |
|
| LRRIQ3 | 10 (6%) | 162 |
0.597 (1.00) |
0.834 (1.00) |
0.755 (1.00) |
2.48e-05 (0.0586) |
0.568 (1.00) |
0.903 (1.00) |
1 (1.00) |
0.947 (1.00) |
0.601 (1.00) |
0.871 (1.00) |
0.893 (1.00) |
0.772 (1.00) |
1 (1.00) |
|
| U2AF1 | 6 (3%) | 166 |
0.401 (1.00) |
0.894 (1.00) |
0.22 (1.00) |
1.18e-08 (2.79e-05) |
0.856 (1.00) |
0.0572 (1.00) |
0.0949 (1.00) |
0.0979 (1.00) |
0.448 (1.00) |
0.71 (1.00) |
0.677 (1.00) |
0.265 (1.00) |
0.404 (1.00) |
|
| GBA3 | 8 (5%) | 164 |
0.426 (1.00) |
0.0276 (1.00) |
0.728 (1.00) |
1.34e-06 (0.00317) |
1 (1.00) |
0.0409 (1.00) |
1 (1.00) |
0.087 (1.00) |
1 (1.00) |
0.0798 (1.00) |
0.448 (1.00) |
0.379 (1.00) |
0.581 (1.00) |
|
| OR2W5 | 7 (4%) | 165 |
0.666 (1.00) |
0.227 (1.00) |
0.455 (1.00) |
0.303 (1.00) |
0.208 (1.00) |
0.881 (1.00) |
1 (1.00) |
1 (1.00) |
0.502 (1.00) |
2.56e-05 (0.0603) |
0.862 (1.00) |
1 (1.00) |
||
| AKR1B10 | 4 (2%) | 168 |
0.615 (1.00) |
0.00726 (1.00) |
1 (1.00) |
9.3e-06 (0.022) |
1 (1.00) |
0.783 (1.00) |
0.0113 (1.00) |
0.85 (1.00) |
0.326 (1.00) |
0.336 (1.00) |
0.612 (1.00) |
|||
| DACH1 | 11 (6%) | 161 |
0.499 (1.00) |
0.483 (1.00) |
0.349 (1.00) |
4.58e-05 (0.108) |
0.507 (1.00) |
1 (1.00) |
0.813 (1.00) |
1 (1.00) |
0.602 (1.00) |
0.0331 (1.00) |
0.295 (1.00) |
0.31 (1.00) |
0.273 (1.00) |
|
| PYHIN1 | 7 (4%) | 165 |
0.653 (1.00) |
0.572 (1.00) |
0.704 (1.00) |
9.21e-05 (0.217) |
0.356 (1.00) |
0.339 (1.00) |
0.493 (1.00) |
0.255 (1.00) |
1 (1.00) |
0.405 (1.00) |
0.248 (1.00) |
0.775 (1.00) |
1 (1.00) |
|
| OR13G1 | 9 (5%) | 163 |
0.247 (1.00) |
0.213 (1.00) |
1 (1.00) |
1.08e-05 (0.0254) |
1 (1.00) |
0.14 (1.00) |
1 (1.00) |
0.205 (1.00) |
1 (1.00) |
0.25 (1.00) |
0.396 (1.00) |
0.879 (1.00) |
0.756 (1.00) |
|
| CDKN2A | 8 (5%) | 164 |
0.689 (1.00) |
0.117 (1.00) |
0.728 (1.00) |
1 (1.00) |
0.878 (1.00) |
0.764 (1.00) |
0.726 (1.00) |
1 (1.00) |
1 (1.00) |
0.5 (1.00) |
0.392 (1.00) |
0.0411 (1.00) |
1 (1.00) |
|
| EGFR | 22 (13%) | 150 |
0.0143 (1.00) |
0.149 (1.00) |
0.176 (1.00) |
0.708 (1.00) |
0.731 (1.00) |
0.467 (1.00) |
0.581 (1.00) |
0.296 (1.00) |
0.697 (1.00) |
0.719 (1.00) |
0.00101 (1.00) |
0.168 (1.00) |
0.48 (1.00) |
|
| KRAS | 47 (27%) | 125 |
0.323 (1.00) |
0.955 (1.00) |
0.493 (1.00) |
0.428 (1.00) |
0.907 (1.00) |
0.0834 (1.00) |
0.406 (1.00) |
1 (1.00) |
0.938 (1.00) |
1 (1.00) |
0.676 (1.00) |
0.0886 (1.00) |
0.779 (1.00) |
0.407 (1.00) |
| STK11 | 20 (12%) | 152 |
0.404 (1.00) |
0.6 (1.00) |
0.0941 (1.00) |
0.979 (1.00) |
0.595 (1.00) |
0.851 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.621 (1.00) |
0.97 (1.00) |
0.403 (1.00) |
1 (1.00) |
|
| TP53 | 87 (51%) | 85 |
0.721 (1.00) |
0.0626 (1.00) |
0.225 (1.00) |
0.74 (1.00) |
0.216 (1.00) |
0.637 (1.00) |
0.871 (1.00) |
0.825 (1.00) |
0.977 (1.00) |
1 (1.00) |
0.531 (1.00) |
0.00415 (1.00) |
0.396 (1.00) |
0.836 (1.00) |
| KEAP1 | 32 (19%) | 140 |
0.59 (1.00) |
0.784 (1.00) |
1 (1.00) |
0.128 (1.00) |
0.244 (1.00) |
0.52 (1.00) |
1 (1.00) |
0.193 (1.00) |
0.922 (1.00) |
0.503 (1.00) |
0.131 (1.00) |
0.396 (1.00) |
0.216 (1.00) |
1 (1.00) |
| NAV3 | 35 (20%) | 137 |
0.872 (1.00) |
0.736 (1.00) |
0.261 (1.00) |
0.548 (1.00) |
0.774 (1.00) |
0.313 (1.00) |
0.466 (1.00) |
0.69 (1.00) |
0.948 (1.00) |
1 (1.00) |
0.376 (1.00) |
0.0204 (1.00) |
0.181 (1.00) |
0.549 (1.00) |
| MAGEC1 | 23 (13%) | 149 |
0.99 (1.00) |
0.569 (1.00) |
0.826 (1.00) |
0.776 (1.00) |
0.233 (1.00) |
0.0607 (1.00) |
0.0847 (1.00) |
0.103 (1.00) |
0.699 (1.00) |
0.702 (1.00) |
0.0232 (1.00) |
0.681 (1.00) |
0.745 (1.00) |
|
| CDH10 | 34 (20%) | 138 |
0.0594 (1.00) |
0.584 (1.00) |
0.57 (1.00) |
0.737 (1.00) |
0.0451 (1.00) |
0.127 (1.00) |
0.139 (1.00) |
0.0497 (1.00) |
1 (1.00) |
0.236 (1.00) |
0.0254 (1.00) |
0.416 (1.00) |
1 (1.00) |
|
| MUC7 | 15 (9%) | 157 |
0.229 (1.00) |
0.39 (1.00) |
0.0313 (1.00) |
0.742 (1.00) |
0.495 (1.00) |
0.762 (1.00) |
0.534 (1.00) |
0.945 (1.00) |
1 (1.00) |
0.623 (1.00) |
0.0362 (1.00) |
0.346 (1.00) |
0.604 (1.00) |
|
| TMTC1 | 22 (13%) | 150 |
0.322 (1.00) |
0.297 (1.00) |
0.0695 (1.00) |
0.132 (1.00) |
0.135 (1.00) |
0.778 (1.00) |
0.29 (1.00) |
0.378 (1.00) |
1 (1.00) |
0.759 (1.00) |
0.0407 (1.00) |
0.355 (1.00) |
0.0973 (1.00) |
|
| OR4C16 | 14 (8%) | 158 |
0.879 (1.00) |
0.521 (1.00) |
0.578 (1.00) |
0.00461 (1.00) |
0.868 (1.00) |
0.385 (1.00) |
1 (1.00) |
0.165 (1.00) |
1 (1.00) |
0.511 (1.00) |
0.51 (1.00) |
0.885 (1.00) |
0.708 (1.00) |
|
| ZNF676 | 16 (9%) | 156 |
0.967 (1.00) |
0.196 (1.00) |
1 (1.00) |
0.42 (1.00) |
0.825 (1.00) |
0.71 (1.00) |
0.761 (1.00) |
0.528 (1.00) |
1 (1.00) |
0.568 (1.00) |
0.0592 (1.00) |
0.67 (1.00) |
0.398 (1.00) |
|
| EPHA6 | 22 (13%) | 150 |
0.653 (1.00) |
0.666 (1.00) |
0.108 (1.00) |
0.953 (1.00) |
0.374 (1.00) |
0.307 (1.00) |
0.607 (1.00) |
0.253 (1.00) |
0.712 (1.00) |
1 (1.00) |
0.254 (1.00) |
0.414 (1.00) |
0.714 (1.00) |
0.381 (1.00) |
| RIMS2 | 32 (19%) | 140 |
0.703 (1.00) |
0.716 (1.00) |
0.239 (1.00) |
0.953 (1.00) |
0.815 (1.00) |
0.546 (1.00) |
0.895 (1.00) |
0.661 (1.00) |
0.943 (1.00) |
1 (1.00) |
0.394 (1.00) |
0.852 (1.00) |
0.0367 (1.00) |
0.38 (1.00) |
| OR2L3 | 13 (8%) | 159 |
0.927 (1.00) |
0.867 (1.00) |
0.0229 (1.00) |
0.725 (1.00) |
0.744 (1.00) |
0.119 (1.00) |
0.475 (1.00) |
0.96 (1.00) |
0.613 (1.00) |
0.278 (1.00) |
0.102 (1.00) |
0.343 (1.00) |
0.448 (1.00) |
|
| ELTD1 | 15 (9%) | 157 |
0.0881 (1.00) |
0.0391 (1.00) |
0.788 (1.00) |
0.143 (1.00) |
0.033 (1.00) |
0.127 (1.00) |
0.534 (1.00) |
0.0665 (1.00) |
1 (1.00) |
0.909 (1.00) |
0.321 (1.00) |
0.648 (1.00) |
0.424 (1.00) |
|
| CD5L | 12 (7%) | 160 |
0.949 (1.00) |
0.928 (1.00) |
0.229 (1.00) |
0.653 (1.00) |
0.119 (1.00) |
0.922 (1.00) |
1 (1.00) |
0.668 (1.00) |
0.309 (1.00) |
0.722 (1.00) |
0.824 (1.00) |
0.914 (1.00) |
0.756 (1.00) |
|
| REG1B | 13 (8%) | 159 |
0.493 (1.00) |
0.0662 (1.00) |
1 (1.00) |
0.129 (1.00) |
0.714 (1.00) |
0.537 (1.00) |
0.264 (1.00) |
0.392 (1.00) |
0.394 (1.00) |
0.106 (1.00) |
0.82 (1.00) |
0.156 (1.00) |
0.141 (1.00) |
0.833 (1.00) |
| REG3A | 14 (8%) | 158 |
0.591 (1.00) |
0.722 (1.00) |
0.414 (1.00) |
0.0283 (1.00) |
0.649 (1.00) |
0.729 (1.00) |
1 (1.00) |
1 (1.00) |
0.368 (1.00) |
0.934 (1.00) |
0.264 (1.00) |
0.907 (1.00) |
0.473 (1.00) |
|
| OR2T4 | 13 (8%) | 159 |
0.00886 (1.00) |
0.238 (1.00) |
0.576 (1.00) |
0.978 (1.00) |
0.0822 (1.00) |
0.605 (1.00) |
1 (1.00) |
0.593 (1.00) |
1 (1.00) |
0.427 (1.00) |
0.647 (1.00) |
0.0383 (1.00) |
1 (1.00) |
|
| GABRB3 | 11 (6%) | 161 |
0.255 (1.00) |
0.992 (1.00) |
0.349 (1.00) |
0.659 (1.00) |
0.611 (1.00) |
0.64 (1.00) |
0.11 (1.00) |
0.0746 (1.00) |
1 (1.00) |
0.187 (1.00) |
0.328 (1.00) |
0.393 (1.00) |
0.819 (1.00) |
|
| TRIM58 | 8 (5%) | 164 |
0.746 (1.00) |
0.369 (1.00) |
0.728 (1.00) |
0.934 (1.00) |
0.591 (1.00) |
0.693 (1.00) |
0.557 (1.00) |
0.758 (1.00) |
1 (1.00) |
0.259 (1.00) |
0.439 (1.00) |
1 (1.00) |
||
| BAGE2 | 9 (5%) | 163 |
0.429 (1.00) |
0.527 (1.00) |
0.734 (1.00) |
0.0389 (1.00) |
0.165 (1.00) |
0.585 (1.00) |
0.465 (1.00) |
0.497 (1.00) |
0.594 (1.00) |
0.751 (1.00) |
0.236 (1.00) |
1 (1.00) |
||
| OR4A5 | 12 (7%) | 160 |
0.0375 (1.00) |
0.831 (1.00) |
0.0393 (1.00) |
0.694 (1.00) |
0.94 (1.00) |
0.0467 (1.00) |
0.226 (1.00) |
0.0762 (1.00) |
1 (1.00) |
0.584 (1.00) |
0.0535 (1.00) |
0.63 (1.00) |
0.756 (1.00) |
|
| BRAF | 15 (9%) | 157 |
0.965 (1.00) |
0.5 (1.00) |
0.287 (1.00) |
0.996 (1.00) |
0.183 (1.00) |
0.659 (1.00) |
0.233 (1.00) |
0.499 (1.00) |
0.634 (1.00) |
0.732 (1.00) |
0.252 (1.00) |
0.491 (1.00) |
0.797 (1.00) |
|
| OR2L8 | 12 (7%) | 160 |
0.166 (1.00) |
0.418 (1.00) |
0.229 (1.00) |
0.996 (1.00) |
0.471 (1.00) |
0.172 (1.00) |
1 (1.00) |
0.399 (1.00) |
0.606 (1.00) |
0.682 (1.00) |
0.822 (1.00) |
0.324 (1.00) |
0.848 (1.00) |
|
| CRIPAK | 11 (6%) | 161 |
0.0496 (1.00) |
0.29 (1.00) |
0.349 (1.00) |
0.00809 (1.00) |
0.448 (1.00) |
1 (1.00) |
0.528 (1.00) |
0.84 (1.00) |
0.602 (1.00) |
0.566 (1.00) |
0.585 (1.00) |
0.636 (1.00) |
1 (1.00) |
|
| PABPC3 | 9 (5%) | 163 |
0.0778 (1.00) |
0.413 (1.00) |
0.51 (1.00) |
0.976 (1.00) |
0.839 (1.00) |
0.585 (1.00) |
0.115 (1.00) |
0.0482 (1.00) |
0.594 (1.00) |
0.587 (1.00) |
0.116 (1.00) |
0.354 (1.00) |
0.291 (1.00) |
|
| ZNF804A | 30 (17%) | 142 |
0.0284 (1.00) |
0.504 (1.00) |
0.841 (1.00) |
0.705 (1.00) |
0.678 (1.00) |
0.263 (1.00) |
0.527 (1.00) |
0.339 (1.00) |
0.118 (1.00) |
0.486 (1.00) |
0.848 (1.00) |
0.00705 (1.00) |
0.622 (1.00) |
0.426 (1.00) |
| C18ORF34 | 19 (11%) | 153 |
0.987 (1.00) |
0.359 (1.00) |
0.628 (1.00) |
0.705 (1.00) |
0.61 (1.00) |
0.533 (1.00) |
0.167 (1.00) |
0.266 (1.00) |
0.654 (1.00) |
0.691 (1.00) |
0.297 (1.00) |
0.378 (1.00) |
0.452 (1.00) |
0.566 (1.00) |
| SERPINB4 | 10 (6%) | 162 |
0.074 (1.00) |
0.694 (1.00) |
1 (1.00) |
0.606 (1.00) |
0.799 (1.00) |
0.0961 (1.00) |
1 (1.00) |
0.253 (1.00) |
1 (1.00) |
0.301 (1.00) |
0.396 (1.00) |
0.489 (1.00) |
0.551 (1.00) |
|
| OR2T34 | 10 (6%) | 162 |
0.805 (1.00) |
0.187 (1.00) |
0.755 (1.00) |
0.999 (1.00) |
0.461 (1.00) |
0.585 (1.00) |
0.505 (1.00) |
0.745 (1.00) |
1 (1.00) |
0.416 (1.00) |
0.0302 (1.00) |
0.204 (1.00) |
0.433 (1.00) |
|
| ZNF492 | 8 (5%) | 164 |
0.6 (1.00) |
0.942 (1.00) |
0.728 (1.00) |
0.998 (1.00) |
0.737 (1.00) |
0.288 (1.00) |
0.414 (1.00) |
0.234 (1.00) |
0.163 (1.00) |
0.0949 (1.00) |
0.43 (1.00) |
0.393 (1.00) |
0.581 (1.00) |
|
| OR4C15 | 13 (8%) | 159 |
0.429 (1.00) |
0.732 (1.00) |
0.576 (1.00) |
0.0122 (1.00) |
0.209 (1.00) |
0.3 (1.00) |
0.475 (1.00) |
0.458 (1.00) |
0.613 (1.00) |
0.146 (1.00) |
0.51 (1.00) |
0.342 (1.00) |
1 (1.00) |
|
| TBX22 | 12 (7%) | 160 |
0.99 (1.00) |
0.549 (1.00) |
0.388 (1.00) |
0.0209 (1.00) |
0.142 (1.00) |
0.922 (1.00) |
1 (1.00) |
0.668 (1.00) |
0.606 (1.00) |
0.232 (1.00) |
0.841 (1.00) |
0.769 (1.00) |
0.797 (1.00) |
|
| FERD3L | 7 (4%) | 165 |
0.0116 (1.00) |
0.166 (1.00) |
1 (1.00) |
1 (1.00) |
0.272 (1.00) |
1 (1.00) |
1 (1.00) |
0.844 (1.00) |
0.129 (1.00) |
0.696 (1.00) |
0.594 (1.00) |
0.881 (1.00) |
0.298 (1.00) |
|
| LRRTM4 | 18 (10%) | 154 |
0.265 (1.00) |
0.907 (1.00) |
0.0238 (1.00) |
0.0651 (1.00) |
0.907 (1.00) |
0.79 (1.00) |
1 (1.00) |
0.635 (1.00) |
0.381 (1.00) |
0.064 (1.00) |
0.0618 (1.00) |
0.562 (1.00) |
0.465 (1.00) |
|
| OR5W2 | 9 (5%) | 163 |
0.483 (1.00) |
0.633 (1.00) |
0.51 (1.00) |
0.53 (1.00) |
0.407 (1.00) |
1 (1.00) |
1 (1.00) |
0.838 (1.00) |
0.594 (1.00) |
0.863 (1.00) |
0.893 (1.00) |
0.115 (1.00) |
1 (1.00) |
|
| RIT1 | 8 (5%) | 164 |
0.765 (1.00) |
0.303 (1.00) |
1 (1.00) |
0.971 (1.00) |
0.382 (1.00) |
0.161 (1.00) |
0.188 (1.00) |
0.194 (1.00) |
0.55 (1.00) |
0.401 (1.00) |
0.708 (1.00) |
0.287 (1.00) |
0.0218 (1.00) |
|
| OR5D14 | 13 (8%) | 159 |
0.399 (1.00) |
0.356 (1.00) |
1 (1.00) |
0.0049 (1.00) |
0.399 (1.00) |
0.729 (1.00) |
0.392 (1.00) |
0.872 (1.00) |
0.346 (1.00) |
0.0494 (1.00) |
0.0141 (1.00) |
0.424 (1.00) |
||
| OR8H2 | 11 (6%) | 161 |
0.662 (1.00) |
0.949 (1.00) |
0.349 (1.00) |
0.36 (1.00) |
0.245 (1.00) |
0.393 (1.00) |
0.528 (1.00) |
0.874 (1.00) |
0.272 (1.00) |
0.271 (1.00) |
0.0725 (1.00) |
0.572 (1.00) |
0.797 (1.00) |
|
| NRG3 | 13 (8%) | 159 |
0.909 (1.00) |
0.658 (1.00) |
0.576 (1.00) |
0.371 (1.00) |
0.261 (1.00) |
0.729 (1.00) |
0.392 (1.00) |
0.693 (1.00) |
0.346 (1.00) |
0.32 (1.00) |
0.321 (1.00) |
0.806 (1.00) |
0.506 (1.00) |
|
| HEATR7B2 | 20 (12%) | 152 |
0.776 (1.00) |
0.711 (1.00) |
1 (1.00) |
0.359 (1.00) |
0.518 (1.00) |
0.167 (1.00) |
0.791 (1.00) |
0.6 (1.00) |
0.222 (1.00) |
0.0943 (1.00) |
0.067 (1.00) |
0.895 (1.00) |
0.247 (1.00) |
|
| ZNF268 | 5 (3%) | 167 |
0.278 (1.00) |
0.507 (1.00) |
0.181 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.35 (1.00) |
0.249 (1.00) |
1 (1.00) |
0.244 (1.00) |
0.862 (1.00) |
0.437 (1.00) |
0.5 (1.00) |
|
| OR5I1 | 11 (6%) | 161 |
0.666 (1.00) |
0.872 (1.00) |
0.115 (1.00) |
0.36 (1.00) |
0.0118 (1.00) |
0.262 (1.00) |
1 (1.00) |
0.176 (1.00) |
1 (1.00) |
0.0981 (1.00) |
0.714 (1.00) |
0.93 (1.00) |
0.366 (1.00) |
|
| KCNT2 | 17 (10%) | 155 |
0.0574 (1.00) |
0.526 (1.00) |
0.127 (1.00) |
0.195 (1.00) |
0.735 (1.00) |
0.576 (1.00) |
0.0988 (1.00) |
0.238 (1.00) |
1 (1.00) |
0.653 (1.00) |
0.14 (1.00) |
0.669 (1.00) |
0.143 (1.00) |
|
| HGF | 16 (9%) | 156 |
0.311 (1.00) |
0.321 (1.00) |
0.0671 (1.00) |
0.233 (1.00) |
0.961 (1.00) |
0.0342 (1.00) |
0.761 (1.00) |
0.234 (1.00) |
1 (1.00) |
0.124 (1.00) |
0.321 (1.00) |
0.8 (1.00) |
0.214 (1.00) |
|
| THEMIS | 10 (6%) | 162 |
0.0493 (1.00) |
0.995 (1.00) |
0.516 (1.00) |
0.999 (1.00) |
0.4 (1.00) |
0.441 (1.00) |
0.383 (1.00) |
0.274 (1.00) |
0.601 (1.00) |
0.812 (1.00) |
0.937 (1.00) |
0.753 (1.00) |
0.797 (1.00) |
|
| IL1RAPL1 | 11 (6%) | 161 |
0.738 (1.00) |
0.446 (1.00) |
0.229 (1.00) |
0.973 (1.00) |
0.876 (1.00) |
0.478 (1.00) |
0.66 (1.00) |
0.333 (1.00) |
0.602 (1.00) |
0.998 (1.00) |
0.449 (1.00) |
0.216 (1.00) |
1 (1.00) |
|
| ADAMTS2 | 14 (8%) | 158 |
0.78 (1.00) |
0.933 (1.00) |
0.414 (1.00) |
0.915 (1.00) |
0.441 (1.00) |
0.673 (1.00) |
0.503 (1.00) |
0.913 (1.00) |
1 (1.00) |
0.485 (1.00) |
0.353 (1.00) |
0.783 (1.00) |
0.819 (1.00) |
|
| SPANXN2 | 7 (4%) | 165 |
0.396 (1.00) |
0.696 (1.00) |
0.704 (1.00) |
0.439 (1.00) |
0.529 (1.00) |
0.24 (1.00) |
0.726 (1.00) |
0.844 (1.00) |
1 (1.00) |
0.678 (1.00) |
0.827 (1.00) |
0.914 (1.00) |
0.708 (1.00) |
|
| CPXCR1 | 10 (6%) | 162 |
0.117 (1.00) |
0.293 (1.00) |
0.111 (1.00) |
0.999 (1.00) |
0.496 (1.00) |
0.441 (1.00) |
0.79 (1.00) |
0.654 (1.00) |
1 (1.00) |
0.255 (1.00) |
0.53 (1.00) |
0.271 (1.00) |
0.756 (1.00) |
|
| TBX15 | 11 (6%) | 161 |
0.557 (1.00) |
0.697 (1.00) |
0.756 (1.00) |
0.0642 (1.00) |
0.0279 (1.00) |
0.699 (1.00) |
0.297 (1.00) |
0.446 (1.00) |
1 (1.00) |
0.425 (1.00) |
0.971 (1.00) |
0.871 (1.00) |
0.651 (1.00) |
|
| WDR49 | 9 (5%) | 163 |
0.94 (1.00) |
0.672 (1.00) |
0.51 (1.00) |
0.471 (1.00) |
0.596 (1.00) |
0.721 (1.00) |
0.115 (1.00) |
0.188 (1.00) |
0.199 (1.00) |
0.706 (1.00) |
0.379 (1.00) |
0.875 (1.00) |
0.65 (1.00) |
|
| PCK1 | 10 (6%) | 162 |
0.099 (1.00) |
0.319 (1.00) |
1 (1.00) |
0.999 (1.00) |
0.147 (1.00) |
0.613 (1.00) |
0.0859 (1.00) |
0.0406 (1.00) |
1 (1.00) |
0.483 (1.00) |
0.749 (1.00) |
0.00122 (1.00) |
0.148 (1.00) |
|
| CXORF59 | 8 (5%) | 164 |
0.174 (1.00) |
0.417 (1.00) |
0.728 (1.00) |
0.156 (1.00) |
0.663 (1.00) |
0.535 (1.00) |
1 (1.00) |
0.808 (1.00) |
1 (1.00) |
0.57 (1.00) |
0.036 (1.00) |
0.954 (1.00) |
0.177 (1.00) |
|
| ZIC4 | 13 (8%) | 159 |
0.243 (1.00) |
0.648 (1.00) |
0.0229 (1.00) |
0.725 (1.00) |
0.24 (1.00) |
1 (1.00) |
0.168 (1.00) |
0.26 (1.00) |
1 (1.00) |
0.84 (1.00) |
0.295 (1.00) |
0.0163 (1.00) |
0.473 (1.00) |
|
| OR52E4 | 6 (3%) | 166 |
0.794 (1.00) |
0.148 (1.00) |
0.0952 (1.00) |
0.982 (1.00) |
0.419 (1.00) |
0.85 (1.00) |
1 (1.00) |
0.808 (1.00) |
1 (1.00) |
0.58 (1.00) |
0.489 (1.00) |
1 (1.00) |
||
| LRRIQ1 | 21 (12%) | 151 |
0.463 (1.00) |
0.953 (1.00) |
0.249 (1.00) |
0.805 (1.00) |
0.897 (1.00) |
0.596 (1.00) |
0.72 (1.00) |
0.861 (1.00) |
0.696 (1.00) |
0.507 (1.00) |
0.344 (1.00) |
0.647 (1.00) |
0.628 (1.00) |
|
| ASTN2 | 14 (8%) | 158 |
0.751 (1.00) |
0.753 (1.00) |
1 (1.00) |
0.000227 (0.534) |
0.441 (1.00) |
0.928 (1.00) |
0.246 (1.00) |
0.443 (1.00) |
0.368 (1.00) |
0.801 (1.00) |
0.189 (1.00) |
0.888 (1.00) |
0.559 (1.00) |
|
| FAM71B | 14 (8%) | 158 |
0.571 (1.00) |
0.831 (1.00) |
0.578 (1.00) |
0.203 (1.00) |
0.211 (1.00) |
0.928 (1.00) |
0.503 (1.00) |
0.913 (1.00) |
0.368 (1.00) |
0.497 (1.00) |
0.696 (1.00) |
0.114 (1.00) |
0.797 (1.00) |
|
| EPHB1 | 18 (10%) | 154 |
0.245 (1.00) |
0.27 (1.00) |
0.805 (1.00) |
0.316 (1.00) |
0.563 (1.00) |
1 (1.00) |
0.883 (1.00) |
0.894 (1.00) |
0.225 (1.00) |
0.468 (1.00) |
0.257 (1.00) |
0.833 (1.00) |
0.876 (1.00) |
|
| OR8H3 | 11 (6%) | 161 |
0.69 (1.00) |
0.861 (1.00) |
0.349 (1.00) |
0.178 (1.00) |
0.00719 (1.00) |
0.699 (1.00) |
0.528 (1.00) |
0.5 (1.00) |
1 (1.00) |
0.442 (1.00) |
0.628 (1.00) |
0.889 (1.00) |
0.273 (1.00) |
|
| RPL10L | 6 (3%) | 166 |
0.661 (1.00) |
0.87 (1.00) |
0.688 (1.00) |
0.00302 (1.00) |
0.479 (1.00) |
0.26 (1.00) |
0.424 (1.00) |
0.175 (1.00) |
0.448 (1.00) |
0.862 (1.00) |
0.0968 (1.00) |
0.331 (1.00) |
0.581 (1.00) |
|
| OR4S2 | 6 (3%) | 166 |
0.482 (1.00) |
0.348 (1.00) |
1 (1.00) |
0.883 (1.00) |
0.621 (1.00) |
1 (1.00) |
0.424 (1.00) |
0.175 (1.00) |
1 (1.00) |
0.189 (1.00) |
0.461 (1.00) |
0.183 (1.00) |
||
| PJA1 | 8 (5%) | 164 |
0.181 (1.00) |
0.365 (1.00) |
0.728 (1.00) |
0.231 (1.00) |
0.451 (1.00) |
0.693 (1.00) |
0.745 (1.00) |
0.758 (1.00) |
1 (1.00) |
0.646 (1.00) |
0.81 (1.00) |
0.808 (1.00) |
0.708 (1.00) |
|
| INHBA | 9 (5%) | 163 |
0.585 (1.00) |
0.128 (1.00) |
0.51 (1.00) |
0.471 (1.00) |
0.407 (1.00) |
0.0441 (1.00) |
0.767 (1.00) |
0.0994 (1.00) |
0.199 (1.00) |
0.863 (1.00) |
0.101 (1.00) |
0.419 (1.00) |
1 (1.00) |
|
| RBM10 | 12 (7%) | 160 |
0.892 (1.00) |
0.176 (1.00) |
0.0676 (1.00) |
0.996 (1.00) |
0.00496 (1.00) |
0.12 (1.00) |
1 (1.00) |
0.668 (1.00) |
0.606 (1.00) |
0.698 (1.00) |
0.0716 (1.00) |
0.139 (1.00) |
0.604 (1.00) |
|
| MARCH11 | 8 (5%) | 164 |
0.717 (1.00) |
0.479 (1.00) |
1 (1.00) |
0.0653 (1.00) |
0.00266 (1.00) |
0.792 (1.00) |
1 (1.00) |
0.42 (1.00) |
1 (1.00) |
0.61 (1.00) |
0.28 (1.00) |
0.8 (1.00) |
0.325 (1.00) |
|
| OR14I1 | 6 (3%) | 166 |
0.175 (1.00) |
0.647 (1.00) |
0.415 (1.00) |
0.194 (1.00) |
0.145 (1.00) |
0.467 (1.00) |
1 (1.00) |
0.673 (1.00) |
1 (1.00) |
0.851 (1.00) |
0.883 (1.00) |
0.215 (1.00) |
1 (1.00) |
|
| PTH | 3 (2%) | 169 |
0.0103 (1.00) |
0.807 (1.00) |
1 (1.00) |
1 (1.00) |
0.179 (1.00) |
1 (1.00) |
0.651 (1.00) |
1 (1.00) |
0.878 (1.00) |
0.344 (1.00) |
0.841 (1.00) |
1 (1.00) |
||
| FLI1 | 6 (3%) | 166 |
0.306 (1.00) |
0.568 (1.00) |
0.688 (1.00) |
1 (1.00) |
0.215 (1.00) |
0.622 (1.00) |
1 (1.00) |
0.571 (1.00) |
0.448 (1.00) |
0.828 (1.00) |
1 (1.00) |
0.765 (1.00) |
0.367 (1.00) |
|
| GPR174 | 6 (3%) | 166 |
0.326 (1.00) |
0.0533 (1.00) |
0.22 (1.00) |
0.00302 (1.00) |
1 (1.00) |
0.467 (1.00) |
0.306 (1.00) |
1 (1.00) |
1 (1.00) |
0.142 (1.00) |
0.424 (1.00) |
0.137 (1.00) |
||
| KRTAP19-6 | 4 (2%) | 168 |
0.148 (1.00) |
0.0534 (1.00) |
0.334 (1.00) |
0.0241 (1.00) |
0.601 (1.00) |
0.815 (1.00) |
1 (1.00) |
0.719 (1.00) |
1 (1.00) |
0.0381 (1.00) |
0.398 (1.00) |
0.501 (1.00) |
0.5 (1.00) |
|
| MAGEB18 | 5 (3%) | 167 |
0.494 (1.00) |
0.219 (1.00) |
0.063 (1.00) |
0.989 (1.00) |
1 (1.00) |
0.152 (1.00) |
0.644 (1.00) |
0.699 (1.00) |
0.39 (1.00) |
0.983 (1.00) |
0.201 (1.00) |
0.283 (1.00) |
||
| NHEDC1 | 9 (5%) | 163 |
0.141 (1.00) |
0.0899 (1.00) |
0.734 (1.00) |
0.000678 (1.00) |
0.439 (1.00) |
0.299 (1.00) |
0.465 (1.00) |
0.577 (1.00) |
1 (1.00) |
0.0323 (1.00) |
0.749 (1.00) |
0.859 (1.00) |
1 (1.00) |
|
| OR2T27 | 8 (5%) | 164 |
0.352 (1.00) |
0.665 (1.00) |
0.728 (1.00) |
0.997 (1.00) |
0.814 (1.00) |
0.693 (1.00) |
1 (1.00) |
0.758 (1.00) |
1 (1.00) |
0.442 (1.00) |
0.195 (1.00) |
0.092 (1.00) |
1 (1.00) |
|
| SYT4 | 11 (6%) | 161 |
0.346 (1.00) |
0.977 (1.00) |
1 (1.00) |
0.955 (1.00) |
0.548 (1.00) |
0.278 (1.00) |
0.913 (1.00) |
0.334 (1.00) |
0.446 (1.00) |
1 (1.00) |
0.295 (1.00) |
0.506 (1.00) |
0.698 (1.00) |
0.224 (1.00) |
| ZSWIM2 | 13 (8%) | 159 |
0.102 (1.00) |
0.331 (1.00) |
0.386 (1.00) |
0.994 (1.00) |
0.261 (1.00) |
0.514 (1.00) |
1 (1.00) |
0.872 (1.00) |
0.106 (1.00) |
0.912 (1.00) |
0.943 (1.00) |
0.826 (1.00) |
0.797 (1.00) |
|
| MYL10 | 5 (3%) | 167 |
0.657 (1.00) |
0.423 (1.00) |
1 (1.00) |
0.934 (1.00) |
0.0226 (1.00) |
0.172 (1.00) |
1 (1.00) |
0.219 (1.00) |
0.39 (1.00) |
0.202 (1.00) |
0.201 (1.00) |
0.26 (1.00) |
||
| KRTAP15-1 | 5 (3%) | 167 |
0.532 (1.00) |
0.392 (1.00) |
0.662 (1.00) |
0.934 (1.00) |
0.0484 (1.00) |
0.599 (1.00) |
1 (1.00) |
0.87 (1.00) |
1 (1.00) |
0.63 (1.00) |
0.393 (1.00) |
1 (1.00) |
||
| NTNG1 | 11 (6%) | 161 |
0.255 (1.00) |
0.432 (1.00) |
0.551 (1.00) |
0.664 (1.00) |
0.399 (1.00) |
0.152 (1.00) |
1 (1.00) |
0.564 (1.00) |
0.602 (1.00) |
0.541 (1.00) |
0.328 (1.00) |
0.325 (1.00) |
1 (1.00) |
|
| OR2M7 | 9 (5%) | 163 |
0.462 (1.00) |
0.676 (1.00) |
1 (1.00) |
1 (1.00) |
0.233 (1.00) |
0.239 (1.00) |
0.767 (1.00) |
0.0994 (1.00) |
0.594 (1.00) |
0.162 (1.00) |
0.299 (1.00) |
0.724 (1.00) |
1 (1.00) |
|
| SATB2 | 15 (9%) | 157 |
0.444 (1.00) |
0.647 (1.00) |
1 (1.00) |
0.185 (1.00) |
0.204 (1.00) |
0.865 (1.00) |
0.872 (1.00) |
0.87 (1.00) |
0.634 (1.00) |
0.0673 (1.00) |
0.369 (1.00) |
0.831 (1.00) |
0.368 (1.00) |
|
| OR5F1 | 12 (7%) | 160 |
0.182 (1.00) |
0.283 (1.00) |
1 (1.00) |
0.978 (1.00) |
0.756 (1.00) |
0.172 (1.00) |
0.451 (1.00) |
0.525 (1.00) |
1 (1.00) |
0.837 (1.00) |
0.124 (1.00) |
0.428 (1.00) |
0.473 (1.00) |
|
| CMKLR1 | 7 (4%) | 165 |
0.147 (1.00) |
0.169 (1.00) |
0.704 (1.00) |
0.439 (1.00) |
0.26 (1.00) |
0.24 (1.00) |
1 (1.00) |
0.548 (1.00) |
0.502 (1.00) |
0.424 (1.00) |
0.827 (1.00) |
0.0554 (1.00) |
||
| OR10K2 | 9 (5%) | 163 |
0.515 (1.00) |
0.00113 (1.00) |
0.51 (1.00) |
0.291 (1.00) |
0.0646 (1.00) |
0.458 (1.00) |
0.465 (1.00) |
0.548 (1.00) |
0.199 (1.00) |
0.0901 (1.00) |
0.013 (1.00) |
0.581 (1.00) |
||
| ADAMTS16 | 22 (13%) | 150 |
0.369 (1.00) |
0.607 (1.00) |
0.252 (1.00) |
0.953 (1.00) |
0.876 (1.00) |
0.657 (1.00) |
0.612 (1.00) |
0.191 (1.00) |
0.324 (1.00) |
1 (1.00) |
0.0128 (1.00) |
0.53 (1.00) |
0.212 (1.00) |
0.418 (1.00) |
| ARHGAP36 | 13 (8%) | 159 |
0.935 (1.00) |
0.977 (1.00) |
0.576 (1.00) |
0.697 (1.00) |
0.419 (1.00) |
0.64 (1.00) |
0.475 (1.00) |
0.429 (1.00) |
0.346 (1.00) |
0.346 (1.00) |
0.227 (1.00) |
0.521 (1.00) |
0.323 (1.00) |
|
| FABP12 | 3 (2%) | 169 |
0.594 (1.00) |
1 (1.00) |
0.461 (1.00) |
0.397 (1.00) |
1 (1.00) |
0.651 (1.00) |
1 (1.00) |
1 (1.00) |
||||||
| C7 | 14 (8%) | 158 |
0.142 (1.00) |
0.863 (1.00) |
0.0539 (1.00) |
0.997 (1.00) |
0.188 (1.00) |
0.446 (1.00) |
0.738 (1.00) |
0.717 (1.00) |
0.368 (1.00) |
0.619 (1.00) |
0.233 (1.00) |
0.932 (1.00) |
1 (1.00) |
|
| PI15 | 7 (4%) | 165 |
0.263 (1.00) |
0.68 (1.00) |
1 (1.00) |
0.303 (1.00) |
0.481 (1.00) |
0.881 (1.00) |
0.493 (1.00) |
0.774 (1.00) |
1 (1.00) |
0.167 (1.00) |
0.572 (1.00) |
0.564 (1.00) |
1 (1.00) |
|
| NRXN1 | 25 (15%) | 147 |
0.208 (1.00) |
0.852 (1.00) |
0.287 (1.00) |
0.953 (1.00) |
0.397 (1.00) |
0.317 (1.00) |
0.485 (1.00) |
0.905 (1.00) |
0.729 (1.00) |
0.133 (1.00) |
0.222 (1.00) |
0.0703 (1.00) |
0.741 (1.00) |
0.828 (1.00) |
| OR5D16 | 7 (4%) | 165 |
0.688 (1.00) |
0.886 (1.00) |
0.25 (1.00) |
0.994 (1.00) |
0.233 (1.00) |
0.506 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.872 (1.00) |
0.275 (1.00) |
0.968 (1.00) |
1 (1.00) |
|
| LIPI | 7 (4%) | 165 |
0.0963 (1.00) |
0.867 (1.00) |
1 (1.00) |
0.999 (1.00) |
1 (1.00) |
0.325 (1.00) |
1 (1.00) |
0.317 (1.00) |
0.502 (1.00) |
0.36 (1.00) |
0.0728 (1.00) |
0.617 (1.00) |
1 (1.00) |
|
| SEMA3A | 10 (6%) | 162 |
0.364 (1.00) |
0.305 (1.00) |
0.516 (1.00) |
0.121 (1.00) |
0.174 (1.00) |
0.291 (1.00) |
0.79 (1.00) |
0.295 (1.00) |
0.601 (1.00) |
0.622 (1.00) |
0.254 (1.00) |
0.48 (1.00) |
1 (1.00) |
|
| C1ORF49 | 6 (3%) | 166 |
0.761 (1.00) |
0.757 (1.00) |
0.415 (1.00) |
0.255 (1.00) |
0.194 (1.00) |
0.363 (1.00) |
0.733 (1.00) |
0.306 (1.00) |
0.87 (1.00) |
1 (1.00) |
0.104 (1.00) |
0.167 (1.00) |
0.952 (1.00) |
0.298 (1.00) |
| SLC35F1 | 9 (5%) | 163 |
0.507 (1.00) |
0.364 (1.00) |
0.0122 (1.00) |
0.381 (1.00) |
0.596 (1.00) |
0.101 (1.00) |
1 (1.00) |
0.793 (1.00) |
1 (1.00) |
0.338 (1.00) |
0.216 (1.00) |
0.776 (1.00) |
1 (1.00) |
|
| ANKRD7 | 6 (3%) | 166 |
0.996 (1.00) |
0.00346 (1.00) |
0.688 (1.00) |
0.194 (1.00) |
0.363 (1.00) |
0.467 (1.00) |
0.192 (1.00) |
0.527 (1.00) |
1 (1.00) |
0.45 (1.00) |
0.677 (1.00) |
0.462 (1.00) |
0.298 (1.00) |
|
| OLAH | 7 (4%) | 165 |
0.567 (1.00) |
0.255 (1.00) |
0.704 (1.00) |
0.2 (1.00) |
0.0696 (1.00) |
0.653 (1.00) |
0.726 (1.00) |
0.712 (1.00) |
1 (1.00) |
0.0215 (1.00) |
1 (1.00) |
0.715 (1.00) |
1 (1.00) |
|
| TMEM195 | 11 (6%) | 161 |
0.443 (1.00) |
0.647 (1.00) |
0.349 (1.00) |
0.558 (1.00) |
0.876 (1.00) |
0.319 (1.00) |
1 (1.00) |
0.564 (1.00) |
1 (1.00) |
0.0924 (1.00) |
0.378 (1.00) |
0.721 (1.00) |
0.797 (1.00) |
|
| KRTAP11-1 | 6 (3%) | 166 |
0.195 (1.00) |
0.133 (1.00) |
0.22 (1.00) |
0.982 (1.00) |
0.126 (1.00) |
0.393 (1.00) |
0.306 (1.00) |
0.899 (1.00) |
1 (1.00) |
0.148 (1.00) |
0.579 (1.00) |
1 (1.00) |
||
| OR6N2 | 7 (4%) | 165 |
0.675 (1.00) |
0.899 (1.00) |
0.704 (1.00) |
0.3 (1.00) |
0.688 (1.00) |
0.653 (1.00) |
0.493 (1.00) |
0.774 (1.00) |
1 (1.00) |
0.533 (1.00) |
0.43 (1.00) |
0.945 (1.00) |
1 (1.00) |
|
| PRIM2 | 10 (6%) | 162 |
0.347 (1.00) |
0.134 (1.00) |
0.0452 (1.00) |
0.551 (1.00) |
0.184 (1.00) |
0.487 (1.00) |
0.505 (1.00) |
0.354 (1.00) |
1 (1.00) |
0.479 (1.00) |
0.0379 (1.00) |
0.199 (1.00) |
0.756 (1.00) |
|
| C14ORF177 | 5 (3%) | 167 |
0.391 (1.00) |
0.802 (1.00) |
1 (1.00) |
0.999 (1.00) |
0.561 (1.00) |
0.401 (1.00) |
1 (1.00) |
0.152 (1.00) |
1 (1.00) |
0.479 (1.00) |
1 (1.00) |
1 (1.00) |
||
| FAM48B1 | 10 (6%) | 162 |
0.911 (1.00) |
0.81 (1.00) |
0.111 (1.00) |
0.985 (1.00) |
0.929 (1.00) |
0.396 (1.00) |
0.383 (1.00) |
0.172 (1.00) |
1 (1.00) |
0.00258 (1.00) |
0.408 (1.00) |
0.0797 (1.00) |
1 (1.00) |
|
| KCNS2 | 7 (4%) | 165 |
0.53 (1.00) |
0.000819 (1.00) |
0.25 (1.00) |
0.945 (1.00) |
0.00249 (1.00) |
0.392 (1.00) |
0.363 (1.00) |
0.204 (1.00) |
0.502 (1.00) |
0.564 (1.00) |
0.461 (1.00) |
0.133 (1.00) |
||
| C7ORF58 | 17 (10%) | 155 |
0.404 (1.00) |
0.71 (1.00) |
0.8 (1.00) |
0.0764 (1.00) |
0.426 (1.00) |
0.233 (1.00) |
0.88 (1.00) |
0.314 (1.00) |
0.661 (1.00) |
0.232 (1.00) |
0.00581 (1.00) |
0.195 (1.00) |
1 (1.00) |
|
| OR14A16 | 12 (7%) | 160 |
0.43 (1.00) |
0.266 (1.00) |
0.774 (1.00) |
0.996 (1.00) |
0.551 (1.00) |
0.708 (1.00) |
0.556 (1.00) |
0.766 (1.00) |
1 (1.00) |
0.629 (1.00) |
0.892 (1.00) |
0.28 (1.00) |
0.0634 (1.00) |
|
| EPHA7 | 11 (6%) | 161 |
0.348 (1.00) |
0.888 (1.00) |
0.115 (1.00) |
0.994 (1.00) |
0.686 (1.00) |
0.152 (1.00) |
1 (1.00) |
0.398 (1.00) |
1 (1.00) |
0.426 (1.00) |
0.17 (1.00) |
0.687 (1.00) |
0.134 (1.00) |
|
| SERPINB13 | 9 (5%) | 163 |
0.0422 (1.00) |
0.693 (1.00) |
0.181 (1.00) |
0.0709 (1.00) |
0.474 (1.00) |
0.239 (1.00) |
1 (1.00) |
0.43 (1.00) |
0.594 (1.00) |
0.891 (1.00) |
0.433 (1.00) |
0.296 (1.00) |
1 (1.00) |
|
| CDH18 | 22 (13%) | 150 |
0.12 (1.00) |
0.351 (1.00) |
0.369 (1.00) |
0.953 (1.00) |
0.306 (1.00) |
0.644 (1.00) |
0.698 (1.00) |
0.73 (1.00) |
0.867 (1.00) |
1 (1.00) |
0.339 (1.00) |
0.229 (1.00) |
0.919 (1.00) |
0.175 (1.00) |
| CTNNA2 | 20 (12%) | 152 |
0.35 (1.00) |
0.84 (1.00) |
1 (1.00) |
0.0052 (1.00) |
1 (1.00) |
0.647 (1.00) |
0.186 (1.00) |
0.743 (1.00) |
1 (1.00) |
0.873 (1.00) |
0.205 (1.00) |
0.8 (1.00) |
0.273 (1.00) |
|
| OR5T2 | 8 (5%) | 164 |
0.181 (1.00) |
0.304 (1.00) |
0.0712 (1.00) |
0.998 (1.00) |
0.814 (1.00) |
0.339 (1.00) |
0.414 (1.00) |
0.0734 (1.00) |
0.163 (1.00) |
0.423 (1.00) |
0.827 (1.00) |
0.322 (1.00) |
1 (1.00) |
|
| APCS | 4 (2%) | 168 |
0.203 (1.00) |
0.0168 (1.00) |
0.626 (1.00) |
0.997 (1.00) |
0.601 (1.00) |
0.496 (1.00) |
0.561 (1.00) |
0.522 (1.00) |
1 (1.00) |
0.255 (1.00) |
0.612 (1.00) |
0.0295 (1.00) |
1 (1.00) |
|
| IFNA7 | 5 (3%) | 167 |
0.5 (1.00) |
0.776 (1.00) |
0.662 (1.00) |
0.934 (1.00) |
0.0571 (1.00) |
0.0727 (1.00) |
1 (1.00) |
0.0307 (1.00) |
1 (1.00) |
0.831 (1.00) |
0.594 (1.00) |
0.38 (1.00) |
0.298 (1.00) |
|
| UGT2B10 | 11 (6%) | 161 |
0.859 (1.00) |
0.0284 (1.00) |
0.115 (1.00) |
0.314 (1.00) |
0.143 (1.00) |
0.218 (1.00) |
1 (1.00) |
0.414 (1.00) |
0.602 (1.00) |
0.415 (1.00) |
0.456 (1.00) |
0.557 (1.00) |
0.694 (1.00) |
|
| PPP3CA | 3 (2%) | 169 |
0.239 (1.00) |
0.0949 (1.00) |
1 (1.00) |
0.711 (1.00) |
0.397 (1.00) |
1 (1.00) |
0.651 (1.00) |
0.0231 (1.00) |
0.487 (1.00) |
0.553 (1.00) |
||||
| TBX5 | 11 (6%) | 161 |
0.675 (1.00) |
0.0523 (1.00) |
0.115 (1.00) |
0.973 (1.00) |
0.0587 (1.00) |
0.478 (1.00) |
1 (1.00) |
0.687 (1.00) |
1 (1.00) |
0.118 (1.00) |
0.179 (1.00) |
0.453 (1.00) |
0.448 (1.00) |
|
| VN1R2 | 7 (4%) | 165 |
0.58 (1.00) |
0.212 (1.00) |
0.704 (1.00) |
0.875 (1.00) |
0.127 (1.00) |
0.393 (1.00) |
1 (1.00) |
1 (1.00) |
0.129 (1.00) |
0.74 (1.00) |
0.43 (1.00) |
0.138 (1.00) |
0.116 (1.00) |
|
| ADAMTS18 | 17 (10%) | 155 |
0.315 (1.00) |
0.713 (1.00) |
0.31 (1.00) |
0.195 (1.00) |
0.296 (1.00) |
0.576 (1.00) |
0.273 (1.00) |
0.975 (1.00) |
1 (1.00) |
0.734 (1.00) |
0.869 (1.00) |
0.871 (1.00) |
1 (1.00) |
|
| PSG6 | 11 (6%) | 161 |
0.124 (1.00) |
0.562 (1.00) |
0.349 (1.00) |
0.959 (1.00) |
0.232 (1.00) |
0.236 (1.00) |
0.334 (1.00) |
0.464 (1.00) |
1 (1.00) |
0.533 (1.00) |
1 (1.00) |
0.72 (1.00) |
0.56 (1.00) |
|
| CCDC73 | 11 (6%) | 161 |
0.476 (1.00) |
0.594 (1.00) |
0.551 (1.00) |
0.102 (1.00) |
0.26 (1.00) |
0.754 (1.00) |
0.813 (1.00) |
0.84 (1.00) |
0.272 (1.00) |
0.196 (1.00) |
0.675 (1.00) |
0.656 (1.00) |
0.26 (1.00) |
|
| OR10G8 | 8 (5%) | 164 |
0.29 (1.00) |
0.993 (1.00) |
0.145 (1.00) |
0.971 (1.00) |
0.2 (1.00) |
0.331 (1.00) |
0.745 (1.00) |
0.502 (1.00) |
0.55 (1.00) |
0.0375 (1.00) |
0.109 (1.00) |
0.68 (1.00) |
0.0364 (1.00) |
|
| OR51I1 | 6 (3%) | 166 |
0.132 (1.00) |
0.296 (1.00) |
1 (1.00) |
0.883 (1.00) |
0.126 (1.00) |
0.85 (1.00) |
1 (1.00) |
0.624 (1.00) |
0.448 (1.00) |
0.763 (1.00) |
0.642 (1.00) |
0.321 (1.00) |
0.116 (1.00) |
|
| GPR101 | 9 (5%) | 163 |
0.337 (1.00) |
0.446 (1.00) |
0.51 (1.00) |
0.793 (1.00) |
0.318 (1.00) |
0.254 (1.00) |
0.169 (1.00) |
0.257 (1.00) |
0.594 (1.00) |
0.571 (1.00) |
0.0169 (1.00) |
0.67 (1.00) |
0.302 (1.00) |
|
| IRX1 | 7 (4%) | 165 |
0.926 (1.00) |
0.843 (1.00) |
0.25 (1.00) |
1 (1.00) |
0.878 (1.00) |
0.177 (1.00) |
0.493 (1.00) |
0.255 (1.00) |
0.502 (1.00) |
0.234 (1.00) |
0.692 (1.00) |
0.522 (1.00) |
0.581 (1.00) |
|
| STAC3 | 3 (2%) | 169 |
0.00472 (1.00) |
0.958 (1.00) |
1 (1.00) |
0.969 (1.00) |
0.00698 (1.00) |
0.235 (1.00) |
0.0471 (1.00) |
0.184 (1.00) |
1 (1.00) |
0.382 (1.00) |
0.126 (1.00) |
|||
| BCHE | 9 (5%) | 163 |
0.99 (1.00) |
0.505 (1.00) |
0.734 (1.00) |
1 (1.00) |
0.706 (1.00) |
0.585 (1.00) |
0.336 (1.00) |
0.173 (1.00) |
1 (1.00) |
0.354 (1.00) |
0.195 (1.00) |
0.589 (1.00) |
0.708 (1.00) |
|
| CNGA2 | 11 (6%) | 161 |
0.432 (1.00) |
0.344 (1.00) |
0.349 (1.00) |
0.157 (1.00) |
0.647 (1.00) |
0.0678 (1.00) |
1 (1.00) |
0.587 (1.00) |
1 (1.00) |
0.803 (1.00) |
0.675 (1.00) |
0.966 (1.00) |
0.797 (1.00) |
|
| FTSJD1 | 6 (3%) | 166 |
0.581 (1.00) |
0.837 (1.00) |
0.688 (1.00) |
1 (1.00) |
0.419 (1.00) |
0.622 (1.00) |
1 (1.00) |
0.673 (1.00) |
1 (1.00) |
0.66 (1.00) |
0.318 (1.00) |
0.234 (1.00) |
1 (1.00) |
|
| MAGEC2 | 8 (5%) | 164 |
0.974 (1.00) |
0.371 (1.00) |
0.728 (1.00) |
0.428 (1.00) |
0.415 (1.00) |
0.161 (1.00) |
0.557 (1.00) |
0.565 (1.00) |
0.163 (1.00) |
0.486 (1.00) |
0.792 (1.00) |
0.897 (1.00) |
1 (1.00) |
|
| OR10T2 | 7 (4%) | 165 |
0.885 (1.00) |
0.93 (1.00) |
1 (1.00) |
0.994 (1.00) |
0.164 (1.00) |
0.24 (1.00) |
0.726 (1.00) |
0.548 (1.00) |
0.502 (1.00) |
0.0689 (1.00) |
0.069 (1.00) |
0.944 (1.00) |
0.433 (1.00) |
|
| OR4L1 | 7 (4%) | 165 |
0.141 (1.00) |
0.527 (1.00) |
1 (1.00) |
1 (1.00) |
0.32 (1.00) |
1 (1.00) |
0.0943 (1.00) |
1 (1.00) |
0.129 (1.00) |
0.789 (1.00) |
0.275 (1.00) |
0.362 (1.00) |
0.5 (1.00) |
|
| RIT2 | 3 (2%) | 169 |
0.729 (1.00) |
0.251 (1.00) |
0.594 (1.00) |
0.000384 (0.904) |
0.179 (1.00) |
0.0188 (1.00) |
0.46 (1.00) |
0.081 (1.00) |
1 (1.00) |
0.00146 (1.00) |
0.649 (1.00) |
|||
| OR2T8 | 8 (5%) | 164 |
0.772 (1.00) |
0.901 (1.00) |
0.728 (1.00) |
0.391 (1.00) |
0.663 (1.00) |
0.29 (1.00) |
1 (1.00) |
0.32 (1.00) |
0.163 (1.00) |
0.0871 (1.00) |
0.677 (1.00) |
0.367 (1.00) |
||
| NPFFR2 | 10 (6%) | 162 |
0.107 (1.00) |
0.362 (1.00) |
0.755 (1.00) |
0.981 (1.00) |
0.496 (1.00) |
0.0838 (1.00) |
0.297 (1.00) |
0.153 (1.00) |
1 (1.00) |
0.741 (1.00) |
0.397 (1.00) |
0.83 (1.00) |
0.177 (1.00) |
|
| CHM | 6 (3%) | 166 |
0.073 (1.00) |
0.553 (1.00) |
0.688 (1.00) |
0.127 (1.00) |
0.419 (1.00) |
1 (1.00) |
0.0417 (1.00) |
0.065 (1.00) |
0.448 (1.00) |
0.578 (1.00) |
0.424 (1.00) |
0.5 (1.00) |
||
| OR4D10 | 5 (3%) | 167 |
0.613 (1.00) |
0.792 (1.00) |
0.662 (1.00) |
0.468 (1.00) |
0.229 (1.00) |
0.824 (1.00) |
0.644 (1.00) |
0.783 (1.00) |
1 (1.00) |
0.285 (1.00) |
1 (1.00) |
0.508 (1.00) |
0.5 (1.00) |
|
| OR5D13 | 4 (2%) | 168 |
0.518 (1.00) |
0.000299 (0.704) |
1 (1.00) |
0.996 (1.00) |
0.283 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.326 (1.00) |
1 (1.00) |
||||
| FOXI1 | 8 (5%) | 164 |
0.86 (1.00) |
0.0985 (1.00) |
1 (1.00) |
0.0126 (1.00) |
0.267 (1.00) |
0.104 (1.00) |
0.745 (1.00) |
0.29 (1.00) |
1 (1.00) |
0.152 (1.00) |
0.0671 (1.00) |
1 (1.00) |
||
| FAM47B | 14 (8%) | 158 |
0.788 (1.00) |
0.0773 (1.00) |
0.414 (1.00) |
0.714 (1.00) |
0.0214 (1.00) |
0.414 (1.00) |
0.738 (1.00) |
0.487 (1.00) |
1 (1.00) |
0.182 (1.00) |
0.0321 (1.00) |
0.178 (1.00) |
0.453 (1.00) |
|
| OR5K3 | 7 (4%) | 165 |
0.354 (1.00) |
0.714 (1.00) |
0.704 (1.00) |
0.943 (1.00) |
0.287 (1.00) |
0.339 (1.00) |
1 (1.00) |
0.366 (1.00) |
0.502 (1.00) |
0.627 (1.00) |
0.787 (1.00) |
0.303 (1.00) |
0.404 (1.00) |
|
| HOXB3 | 10 (6%) | 162 |
0.178 (1.00) |
0.838 (1.00) |
0.000301 (0.709) |
0.00888 (1.00) |
0.165 (1.00) |
0.754 (1.00) |
1 (1.00) |
0.947 (1.00) |
1 (1.00) |
0.511 (1.00) |
0.433 (1.00) |
0.451 (1.00) |
1 (1.00) |
|
| PTN | 4 (2%) | 168 |
0.718 (1.00) |
0.985 (1.00) |
1 (1.00) |
0.996 (1.00) |
0.145 (1.00) |
0.496 (1.00) |
0.156 (1.00) |
0.522 (1.00) |
1 (1.00) |
0.754 (1.00) |
||||
| SAMD7 | 6 (3%) | 166 |
0.923 (1.00) |
0.928 (1.00) |
0.688 (1.00) |
0.172 (1.00) |
1 (1.00) |
0.325 (1.00) |
1 (1.00) |
0.621 (1.00) |
1 (1.00) |
0.871 (1.00) |
0.677 (1.00) |
0.645 (1.00) |
1 (1.00) |
|
| BIRC8 | 6 (3%) | 166 |
0.88 (1.00) |
0.312 (1.00) |
1 (1.00) |
0.00205 (1.00) |
0.621 (1.00) |
0.85 (1.00) |
1 (1.00) |
0.899 (1.00) |
1 (1.00) |
0.641 (1.00) |
0.883 (1.00) |
0.274 (1.00) |
0.197 (1.00) |
|
| OR51A7 | 7 (4%) | 165 |
0.151 (1.00) |
0.185 (1.00) |
0.455 (1.00) |
0.999 (1.00) |
0.481 (1.00) |
1 (1.00) |
0.726 (1.00) |
0.917 (1.00) |
0.129 (1.00) |
0.611 (1.00) |
0.201 (1.00) |
1 (1.00) |
||
| TYR | 10 (6%) | 162 |
0.616 (1.00) |
0.759 (1.00) |
0.755 (1.00) |
0.407 (1.00) |
0.429 (1.00) |
0.693 (1.00) |
0.636 (1.00) |
0.713 (1.00) |
0.601 (1.00) |
0.869 (1.00) |
1 (1.00) |
0.528 (1.00) |
0.024 (1.00) |
|
| TGFB2 | 6 (3%) | 166 |
0.562 (1.00) |
0.749 (1.00) |
1 (1.00) |
0.172 (1.00) |
0.109 (1.00) |
0.622 (1.00) |
1 (1.00) |
0.673 (1.00) |
1 (1.00) |
0.482 (1.00) |
0.461 (1.00) |
0.664 (1.00) |
1 (1.00) |
|
| GPR158 | 18 (10%) | 154 |
0.651 (1.00) |
0.623 (1.00) |
0.621 (1.00) |
0.976 (1.00) |
0.253 (1.00) |
0.885 (1.00) |
1 (1.00) |
0.756 (1.00) |
0.676 (1.00) |
0.168 (1.00) |
0.0307 (1.00) |
0.802 (1.00) |
1 (1.00) |
|
| MTTP | 6 (3%) | 166 |
0.945 (1.00) |
0.144 (1.00) |
0.415 (1.00) |
0.982 (1.00) |
0.419 (1.00) |
1 (1.00) |
0.424 (1.00) |
0.341 (1.00) |
0.0978 (1.00) |
0.521 (1.00) |
0.554 (1.00) |
0.145 (1.00) |
0.5 (1.00) |
|
| COL25A1 | 11 (6%) | 161 |
0.205 (1.00) |
0.99 (1.00) |
1 (1.00) |
0.0427 (1.00) |
0.448 (1.00) |
0.758 (1.00) |
0.528 (1.00) |
0.955 (1.00) |
0.602 (1.00) |
0.19 (1.00) |
0.271 (1.00) |
0.952 (1.00) |
0.323 (1.00) |
|
| RB1 | 7 (4%) | 165 |
0.1 (1.00) |
0.29 (1.00) |
0.25 (1.00) |
0.303 (1.00) |
0.481 (1.00) |
0.764 (1.00) |
0.0102 (1.00) |
1 (1.00) |
1 (1.00) |
0.838 (1.00) |
0.827 (1.00) |
0.961 (1.00) |
0.5 (1.00) |
|
| CYLC1 | 6 (3%) | 166 |
0.0186 (1.00) |
0.429 (1.00) |
0.688 (1.00) |
0.172 (1.00) |
0.243 (1.00) |
1 (1.00) |
1 (1.00) |
0.313 (1.00) |
0.448 (1.00) |
0.579 (1.00) |
0.862 (1.00) |
0.328 (1.00) |
0.581 (1.00) |
|
| CYP4V2 | 6 (3%) | 166 |
0.468 (1.00) |
0.953 (1.00) |
0.0952 (1.00) |
0.172 (1.00) |
0.243 (1.00) |
0.26 (1.00) |
0.0949 (1.00) |
0.195 (1.00) |
1 (1.00) |
0.843 (1.00) |
0.831 (1.00) |
0.219 (1.00) |
0.5 (1.00) |
|
| FGF14 | 7 (4%) | 165 |
0.0078 (1.00) |
0.911 (1.00) |
0.049 (1.00) |
0.875 (1.00) |
0.0415 (1.00) |
0.764 (1.00) |
0.726 (1.00) |
0.173 (1.00) |
0.502 (1.00) |
0.24 (1.00) |
0.787 (1.00) |
0.116 (1.00) |
0.65 (1.00) |
|
| GC | 5 (3%) | 167 |
0.661 (1.00) |
0.743 (1.00) |
0.0191 (1.00) |
0.0651 (1.00) |
0.229 (1.00) |
0.599 (1.00) |
1 (1.00) |
0.87 (1.00) |
1 (1.00) |
0.666 (1.00) |
0.929 (1.00) |
0.99 (1.00) |
1 (1.00) |
|
| LCE1F | 4 (2%) | 168 |
0.639 (1.00) |
0.303 (1.00) |
0.126 (1.00) |
0.689 (1.00) |
0.463 (1.00) |
0.143 (1.00) |
1 (1.00) |
0.0621 (1.00) |
1 (1.00) |
0.412 (1.00) |
0.258 (1.00) |
0.0161 (1.00) |
||
| RBM19 | 14 (8%) | 158 |
0.814 (1.00) |
0.249 (1.00) |
0.414 (1.00) |
0.255 (1.00) |
0.868 (1.00) |
0.138 (1.00) |
0.161 (1.00) |
0.346 (1.00) |
0.623 (1.00) |
0.526 (1.00) |
0.338 (1.00) |
0.241 (1.00) |
0.56 (1.00) |
|
| C2ORF51 | 5 (3%) | 167 |
0.784 (1.00) |
0.499 (1.00) |
0.662 (1.00) |
0.999 (1.00) |
0.229 (1.00) |
0.599 (1.00) |
1 (1.00) |
0.87 (1.00) |
1 (1.00) |
0.57 (1.00) |
0.929 (1.00) |
0.194 (1.00) |
0.581 (1.00) |
|
| CNKSR2 | 8 (5%) | 164 |
0.566 (1.00) |
0.058 (1.00) |
1 (1.00) |
0.0117 (1.00) |
0.35 (1.00) |
1 (1.00) |
0.0181 (1.00) |
1 (1.00) |
1 (1.00) |
0.312 (1.00) |
0.733 (1.00) |
0.233 (1.00) |
0.0115 (1.00) |
|
| DIO2 | 6 (3%) | 166 |
0.358 (1.00) |
0.931 (1.00) |
0.688 (1.00) |
0.913 (1.00) |
0.856 (1.00) |
0.105 (1.00) |
0.138 (1.00) |
0.131 (1.00) |
1 (1.00) |
0.633 (1.00) |
0.518 (1.00) |
0.176 (1.00) |
0.298 (1.00) |
|
| FRG1 | 6 (3%) | 166 |
0.0821 (1.00) |
0.365 (1.00) |
0.22 (1.00) |
1 (1.00) |
0.621 (1.00) |
0.733 (1.00) |
1 (1.00) |
0.899 (1.00) |
1 (1.00) |
0.655 (1.00) |
0.461 (1.00) |
0.801 (1.00) |
1 (1.00) |
|
| PIP | 5 (3%) | 167 |
0.62 (1.00) |
0.862 (1.00) |
0.662 (1.00) |
0.468 (1.00) |
0.0276 (1.00) |
1 (1.00) |
1 (1.00) |
0.699 (1.00) |
1 (1.00) |
0.416 (1.00) |
0.929 (1.00) |
0.5 (1.00) |
||
| SLITRK2 | 19 (11%) | 153 |
0.487 (1.00) |
0.743 (1.00) |
0.628 (1.00) |
0.00116 (1.00) |
0.0117 (1.00) |
0.943 (1.00) |
0.788 (1.00) |
0.864 (1.00) |
1 (1.00) |
0.0641 (1.00) |
0.0744 (1.00) |
0.0113 (1.00) |
0.385 (1.00) |
|
| GABRA5 | 11 (6%) | 161 |
0.786 (1.00) |
0.848 (1.00) |
0.756 (1.00) |
0.997 (1.00) |
0.937 (1.00) |
0.64 (1.00) |
0.66 (1.00) |
0.383 (1.00) |
1 (1.00) |
0.242 (1.00) |
0.804 (1.00) |
0.927 (1.00) |
1 (1.00) |
|
| OR4A16 | 8 (5%) | 164 |
0.925 (1.00) |
0.412 (1.00) |
0.472 (1.00) |
0.644 (1.00) |
0.293 (1.00) |
0.535 (1.00) |
0.745 (1.00) |
0.708 (1.00) |
1 (1.00) |
0.734 (1.00) |
0.036 (1.00) |
0.404 (1.00) |
0.433 (1.00) |
|
| MBD1 | 6 (3%) | 166 |
0.474 (1.00) |
0.22 (1.00) |
1 (1.00) |
0.977 (1.00) |
0.145 (1.00) |
0.622 (1.00) |
1 (1.00) |
0.193 (1.00) |
0.448 (1.00) |
0.185 (1.00) |
0.883 (1.00) |
0.96 (1.00) |
1 (1.00) |
|
| NELL1 | 14 (8%) | 158 |
0.0396 (1.00) |
0.22 (1.00) |
1 (1.00) |
0.996 (1.00) |
0.358 (1.00) |
0.928 (1.00) |
0.1 (1.00) |
0.373 (1.00) |
0.368 (1.00) |
0.958 (1.00) |
0.353 (1.00) |
0.284 (1.00) |
1 (1.00) |
|
| STXBP5L | 12 (7%) | 160 |
0.184 (1.00) |
0.169 (1.00) |
0.148 (1.00) |
0.999 (1.00) |
0.551 (1.00) |
0.264 (1.00) |
0.372 (1.00) |
0.323 (1.00) |
0.606 (1.00) |
0.647 (1.00) |
0.295 (1.00) |
0.286 (1.00) |
0.347 (1.00) |
|
| SLC10A2 | 7 (4%) | 165 |
0.274 (1.00) |
0.918 (1.00) |
0.704 (1.00) |
0.00511 (1.00) |
0.773 (1.00) |
1 (1.00) |
1 (1.00) |
0.844 (1.00) |
1 (1.00) |
0.777 (1.00) |
0.013 (1.00) |
0.192 (1.00) |
0.367 (1.00) |
|
| DYTN | 10 (6%) | 162 |
0.264 (1.00) |
0.00187 (1.00) |
1 (1.00) |
0.0616 (1.00) |
0.532 (1.00) |
0.0961 (1.00) |
0.79 (1.00) |
0.235 (1.00) |
0.601 (1.00) |
0.735 (1.00) |
0.0193 (1.00) |
0.151 (1.00) |
1 (1.00) |
|
| SLITRK4 | 15 (9%) | 157 |
0.324 (1.00) |
0.656 (1.00) |
0.175 (1.00) |
0.993 (1.00) |
0.291 (1.00) |
0.357 (1.00) |
0.642 (1.00) |
0.701 (1.00) |
0.00625 (1.00) |
0.0345 (1.00) |
0.0664 (1.00) |
0.272 (1.00) |
0.708 (1.00) |
'CNBD1 MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'
P value = 8.55e-05 (Chi-square test), Q value = 0.2
Table S1. Gene #19: 'CNBD1 MUTATION STATUS' versus Clinical Feature #5: 'HISTOLOGICAL.TYPE'
| nPatients | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | MUCINOUS (COLLOID) ADENOCARCINOMA |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ALL | 2 | 39 | 114 | 1 | 2 | 2 | 2 | 2 | 5 | 1 | 2 |
| CNBD1 MUTATED | 0 | 4 | 4 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
| CNBD1 WILD-TYPE | 2 | 35 | 110 | 1 | 2 | 0 | 2 | 2 | 5 | 1 | 2 |
Figure S1. Get High-res Image Gene #19: 'CNBD1 MUTATION STATUS' versus Clinical Feature #5: 'HISTOLOGICAL.TYPE'
'LRRIQ3 MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'
P value = 2.48e-05 (Chi-square test), Q value = 0.059
Table S2. Gene #31: 'LRRIQ3 MUTATION STATUS' versus Clinical Feature #5: 'HISTOLOGICAL.TYPE'
| nPatients | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | MUCINOUS (COLLOID) ADENOCARCINOMA |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ALL | 2 | 39 | 114 | 1 | 2 | 2 | 2 | 2 | 5 | 1 | 2 |
| LRRIQ3 MUTATED | 2 | 5 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| LRRIQ3 WILD-TYPE | 0 | 34 | 111 | 1 | 2 | 2 | 2 | 2 | 5 | 1 | 2 |
Figure S2. Get High-res Image Gene #31: 'LRRIQ3 MUTATION STATUS' versus Clinical Feature #5: 'HISTOLOGICAL.TYPE'
'U2AF1 MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'
P value = 1.18e-08 (Chi-square test), Q value = 2.8e-05
Table S3. Gene #39: 'U2AF1 MUTATION STATUS' versus Clinical Feature #5: 'HISTOLOGICAL.TYPE'
| nPatients | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | MUCINOUS (COLLOID) ADENOCARCINOMA |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ALL | 2 | 39 | 114 | 1 | 2 | 2 | 2 | 2 | 5 | 1 | 2 |
| U2AF1 MUTATED | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
| U2AF1 WILD-TYPE | 2 | 37 | 112 | 1 | 2 | 0 | 2 | 2 | 5 | 1 | 2 |
Figure S3. Get High-res Image Gene #39: 'U2AF1 MUTATION STATUS' versus Clinical Feature #5: 'HISTOLOGICAL.TYPE'
'GBA3 MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'
P value = 1.34e-06 (Chi-square test), Q value = 0.0032
Table S4. Gene #56: 'GBA3 MUTATION STATUS' versus Clinical Feature #5: 'HISTOLOGICAL.TYPE'
| nPatients | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | MUCINOUS (COLLOID) ADENOCARCINOMA |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ALL | 2 | 39 | 114 | 1 | 2 | 2 | 2 | 2 | 5 | 1 | 2 |
| GBA3 MUTATED | 0 | 0 | 5 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 |
| GBA3 WILD-TYPE | 2 | 39 | 109 | 1 | 0 | 2 | 2 | 2 | 4 | 1 | 2 |
Figure S4. Get High-res Image Gene #56: 'GBA3 MUTATION STATUS' versus Clinical Feature #5: 'HISTOLOGICAL.TYPE'
'OR2W5 MUTATION STATUS' versus 'NUMBERPACKYEARSSMOKED'
P value = 2.56e-05 (t-test), Q value = 0.06
Table S5. Gene #91: 'OR2W5 MUTATION STATUS' versus Clinical Feature #11: 'NUMBERPACKYEARSSMOKED'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 114 | 40.0 (25.7) |
| OR2W5 MUTATED | 4 | 55.0 (3.5) |
| OR2W5 WILD-TYPE | 110 | 39.4 (26.0) |
Figure S5. Get High-res Image Gene #91: 'OR2W5 MUTATION STATUS' versus Clinical Feature #11: 'NUMBERPACKYEARSSMOKED'
'AKR1B10 MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'
P value = 9.3e-06 (Chi-square test), Q value = 0.022
Table S6. Gene #93: 'AKR1B10 MUTATION STATUS' versus Clinical Feature #5: 'HISTOLOGICAL.TYPE'
| nPatients | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | MUCINOUS (COLLOID) ADENOCARCINOMA |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ALL | 2 | 39 | 114 | 1 | 2 | 2 | 2 | 2 | 5 | 1 | 2 |
| AKR1B10 MUTATED | 0 | 0 | 2 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| AKR1B10 WILD-TYPE | 2 | 39 | 112 | 1 | 1 | 1 | 2 | 2 | 5 | 1 | 2 |
Figure S6. Get High-res Image Gene #93: 'AKR1B10 MUTATION STATUS' versus Clinical Feature #5: 'HISTOLOGICAL.TYPE'
'DACH1 MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'
P value = 4.58e-05 (Chi-square test), Q value = 0.11
Table S7. Gene #94: 'DACH1 MUTATION STATUS' versus Clinical Feature #5: 'HISTOLOGICAL.TYPE'
| nPatients | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | MUCINOUS (COLLOID) ADENOCARCINOMA |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ALL | 2 | 39 | 114 | 1 | 2 | 2 | 2 | 2 | 5 | 1 | 2 |
| DACH1 MUTATED | 0 | 3 | 5 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 |
| DACH1 WILD-TYPE | 2 | 36 | 109 | 1 | 0 | 1 | 2 | 2 | 5 | 1 | 2 |
Figure S7. Get High-res Image Gene #94: 'DACH1 MUTATION STATUS' versus Clinical Feature #5: 'HISTOLOGICAL.TYPE'
'PYHIN1 MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'
P value = 9.21e-05 (Chi-square test), Q value = 0.22
Table S8. Gene #107: 'PYHIN1 MUTATION STATUS' versus Clinical Feature #5: 'HISTOLOGICAL.TYPE'
| nPatients | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | MUCINOUS (COLLOID) ADENOCARCINOMA |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ALL | 2 | 39 | 114 | 1 | 2 | 2 | 2 | 2 | 5 | 1 | 2 |
| PYHIN1 MUTATED | 0 | 2 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
| PYHIN1 WILD-TYPE | 2 | 37 | 111 | 1 | 1 | 2 | 2 | 2 | 5 | 0 | 2 |
Figure S8. Get High-res Image Gene #107: 'PYHIN1 MUTATION STATUS' versus Clinical Feature #5: 'HISTOLOGICAL.TYPE'
'OR13G1 MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'
P value = 1.08e-05 (Chi-square test), Q value = 0.025
Table S9. Gene #121: 'OR13G1 MUTATION STATUS' versus Clinical Feature #5: 'HISTOLOGICAL.TYPE'
| nPatients | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | MUCINOUS (COLLOID) ADENOCARCINOMA |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ALL | 2 | 39 | 114 | 1 | 2 | 2 | 2 | 2 | 5 | 1 | 2 |
| OR13G1 MUTATED | 0 | 3 | 3 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 |
| OR13G1 WILD-TYPE | 2 | 36 | 111 | 1 | 0 | 2 | 2 | 2 | 4 | 1 | 2 |
Figure S9. Get High-res Image Gene #121: 'OR13G1 MUTATION STATUS' versus Clinical Feature #5: 'HISTOLOGICAL.TYPE'
Methods & Data
Input
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Mutation data file = LUAD-TP.mutsig.cluster.txt
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Clinical data file = LUAD-TP.clin.merged.picked.txt
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Number of patients = 172
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Number of significantly mutated genes = 184
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Number of selected clinical features = 14
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Exclude genes that fewer than K tumors have mutations, K = 3
Survival analysis
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
Student's t-test analysis
For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between tumors with and without gene mutations using 't.test' function in R
Fisher's exact test
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
Chi-square test
For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R
Q value calculation
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
Download Results
This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.
References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Lehmann and Romano, Testing Statistical Hypotheses (3E ed.), New York: Springer. ISBN 0387988645 (2005)
[3] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[4] Greenwood and Nikulin, A guide to chi-squared testing, Wiley, New York. ISBN 047155779X (1996)
[5] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
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Broad Institute TCGA GDAC as part of the TCGA Research Network.
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