E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.005 0.068 -9999.0 0.0 -0.309 15.0 15.0 KLHL20 -0.0 0.053 0.169 2.0 -0.212 8.0 10.0 CYFIP2 0.016 0.043 -9999.0 0.0 -0.336 5.0 5.0 Rac1/GDP -0.011 0.063 0.383 2.0 -0.258 6.0 8.0 ENAH -0.005 0.068 -9999.0 0.0 -0.314 15.0 15.0 AP1M1 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.027 0.027 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.015 0.026 -9999.0 0.0 -0.143 9.0 9.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.045 0.03 -9999.0 0.0 -0.19 3.0 3.0 RAPGEF1 -0.01 0.06 0.212 1.0 -0.287 10.0 11.0 CTNND1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.005 0.073 -9999.0 0.0 -0.316 16.0 16.0 CRK -0.012 0.06 -9999.0 0.0 -0.311 12.0 12.0 E-cadherin/gamma catenin/alpha catenin 0.039 0.023 -9999.0 0.0 -0.204 2.0 2.0 alphaE/beta7 Integrin 0.028 0.018 -9999.0 0.0 -0.238 1.0 1.0 IQGAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.022 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.034 0.017 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.003 0.064 -9999.0 0.0 -0.314 13.0 13.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.027 0.017 -9999.0 0.0 -0.135 2.0 2.0 MLLT4 0.02 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.053 0.059 0.216 35.0 -0.177 3.0 38.0 PI3K -0.033 0.021 -9999.0 0.0 -0.17 2.0 2.0 ARF6 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.029 0.022 -9999.0 0.0 -0.238 2.0 2.0 TIAM1 0.017 0.038 -9999.0 0.0 -0.336 4.0 4.0 E-cadherin(dimer)/Ca2+ 0.046 0.023 -9999.0 0.0 -0.177 2.0 2.0 AKT1 -0.017 0.027 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.019 0.027 -9999.0 0.0 -0.336 2.0 2.0 RhoA/GDP -0.011 0.067 0.383 2.0 -0.255 5.0 7.0 actin cytoskeleton organization 0.004 0.047 0.168 8.0 -0.155 8.0 16.0 CDC42/GDP -0.012 0.066 0.383 2.0 -0.256 6.0 8.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.008 0.018 -9999.0 0.0 -0.184 3.0 3.0 ITGB7 0.02 0.019 -9999.0 0.0 -0.336 1.0 1.0 RAC1 0.019 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.05 0.025 -9999.0 0.0 -0.189 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.034 0.019 -9999.0 0.0 -0.171 2.0 2.0 mol:GDP -0.011 0.072 0.401 2.0 -0.292 6.0 8.0 CDC42/GTP/IQGAP1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.013 0.06 -9999.0 0.0 -0.257 4.0 4.0 RAC1/GTP/IQGAP1 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.005 0.042 0.165 9.0 -0.16 3.0 12.0 NME1 0.055 0.097 0.331 39.0 -9999.0 0.0 39.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.002 0.061 -9999.0 0.0 -0.315 11.0 11.0 regulation of cell-cell adhesion -0.027 0.019 -9999.0 0.0 -0.154 2.0 2.0 WASF2 -0.003 0.024 0.078 1.0 -9999.0 0.0 1.0 Rap1/GTP -0.025 0.03 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.035 -9999.0 0.0 -0.183 3.0 3.0 CCND1 0.004 0.042 0.149 7.0 -0.18 4.0 11.0 VAV2 -0.007 0.123 -9999.0 0.0 -0.596 11.0 11.0 RAP1/GDP -0.021 0.046 -9999.0 0.0 -0.226 3.0 3.0 adherens junction assembly -0.003 0.064 -9999.0 0.0 -0.308 13.0 13.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.035 0.032 -9999.0 0.0 -0.181 3.0 3.0 E-cadherin/beta catenin 0.004 0.023 -9999.0 0.0 -0.282 2.0 2.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.006 0.071 -9999.0 0.0 -0.313 16.0 16.0 PIK3CA 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.005 0.065 -9999.0 0.0 -0.327 10.0 10.0 E-cadherin/beta catenin/alpha catenin 0.039 0.022 -9999.0 0.0 -0.204 2.0 2.0 ITGAE 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.005 0.075 -9999.0 0.0 -0.322 16.0 16.0