Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.006 0.031 -9999.0 0.0 -0.177 7.0 7.0 epithelial cell differentiation 0.041 0.022 -9999.0 0.0 -0.175 2.0 2.0 CYFIP2 0.016 0.043 -9999.0 0.0 -0.336 5.0 5.0 ENAH -0.018 0.061 0.403 2.0 -0.238 1.0 3.0 EGFR 0.017 0.037 0.331 1.0 -0.336 3.0 4.0 EPHA2 0.016 0.043 -9999.0 0.0 -0.336 5.0 5.0 MYO6 -0.018 0.046 0.432 2.0 -0.173 2.0 4.0 CTNNB1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.039 0.026 -9999.0 0.0 -0.204 3.0 3.0 AQP5 -0.061 0.168 0.441 3.0 -0.375 67.0 70.0 CTNND1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.018 0.047 0.429 2.0 -9999.0 0.0 2.0 regulation of calcium-dependent cell-cell adhesion -0.098 0.079 0.162 3.0 -0.173 172.0 175.0 EGF 0.074 0.124 0.331 63.0 -0.336 3.0 66.0 NCKAP1 0.022 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.025 0.081 0.238 1.0 -0.314 22.0 23.0 cortical microtubule organization 0.041 0.022 -9999.0 0.0 -0.175 2.0 2.0 GO:0000145 -0.017 0.045 0.418 2.0 -0.163 2.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.046 0.023 -9999.0 0.0 -0.177 2.0 2.0 MLLT4 0.02 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.034 0.026 -9999.0 0.0 -0.17 5.0 5.0 ARF6 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.04 0.036 -9999.0 0.0 -0.189 5.0 5.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.01 0.045 0.423 2.0 -9999.0 0.0 2.0 PVRL2 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.019 0.047 0.432 2.0 -0.173 2.0 4.0 ARF6/GTP 0.043 0.037 -9999.0 0.0 -0.18 4.0 4.0 CDH1 0.019 0.027 -9999.0 0.0 -0.336 2.0 2.0 EGFR/EGFR/EGF/EGF 0.042 0.054 0.248 1.0 -0.173 6.0 7.0 RhoA/GDP 0.042 0.023 -9999.0 0.0 -0.171 2.0 2.0 actin cytoskeleton organization -0.02 0.044 0.412 2.0 -0.177 2.0 4.0 IGF-1R heterotetramer 0.02 0.019 -9999.0 0.0 -0.336 1.0 1.0 GIT1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.02 0.019 -9999.0 0.0 -0.336 1.0 1.0 IGF1 0.018 0.042 0.331 1.0 -0.336 4.0 5.0 DIAPH1 0.013 0.129 -9999.0 0.0 -0.532 14.0 14.0 Wnt receptor signaling pathway -0.041 0.022 0.175 2.0 -9999.0 0.0 2.0 RHOA 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.035 0.029 -9999.0 0.0 -0.191 6.0 6.0 CTNNA1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.02 0.044 0.415 2.0 -0.18 2.0 4.0 EFNA1 0.017 0.021 -9999.0 0.0 -0.336 1.0 1.0 LPP -0.022 0.045 0.206 10.0 -9999.0 0.0 10.0 Ephrin A1/EPHA2 0.027 0.038 -9999.0 0.0 -0.191 7.0 7.0 SEC6/SEC8 -0.026 0.02 -9999.0 0.0 -0.174 1.0 1.0 MGAT3 -0.099 0.08 0.163 3.0 -0.175 172.0 175.0 HGF/MET 0.022 0.057 -9999.0 0.0 -0.178 22.0 22.0 HGF 0.009 0.076 0.331 3.0 -0.336 14.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.006 0.031 -9999.0 0.0 -0.178 7.0 7.0 actin cable formation 0.01 0.092 0.343 11.0 -0.251 3.0 14.0 KIAA1543 -0.021 0.033 0.174 8.0 -0.165 2.0 10.0 KIFC3 -0.024 0.026 -9999.0 0.0 -0.173 3.0 3.0 NCK1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.017 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.019 0.046 0.432 2.0 -0.173 1.0 3.0 NCK1/GIT1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.041 0.022 -9999.0 0.0 -0.175 2.0 2.0 EXOC4 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.022 0.034 0.339 1.0 -0.173 2.0 3.0 PIP5K1C -0.018 0.047 0.432 2.0 -9999.0 0.0 2.0 LIMA1 0.022 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.005 0.084 0.345 7.0 -0.271 1.0 8.0 adherens junction assembly -0.027 0.101 0.343 7.0 -0.456 8.0 15.0 IGF-1R heterotetramer/IGF1 0.032 0.034 -9999.0 0.0 -0.171 7.0 7.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.014 0.073 0.331 5.0 -0.336 11.0 16.0 PLEKHA7 -0.021 0.035 0.339 1.0 -9999.0 0.0 1.0 mol:GTP 0.039 0.036 -9999.0 0.0 -0.188 5.0 5.0 establishment of epithelial cell apical/basal polarity 0.019 0.098 0.318 12.0 -9999.0 0.0 12.0 cortical actin cytoskeleton stabilization 0.006 0.031 -9999.0 0.0 -0.177 7.0 7.0 regulation of cell-cell adhesion -0.02 0.044 0.412 2.0 -0.177 2.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.006 0.031 -9999.0 0.0 -0.178 7.0 7.0